-
1
-
-
84901766047
-
Acetylation: A new key to unlock tau's role in neurodegeneration
-
Cook, C., Stankowski, J. N., Carlomagno, Y., Stetler, C. & Petrucelli, L. Acetylation: a new key to unlock tau's role in neurodegeneration. Alzheimers Res Ter 6, 29 (2014).
-
(2014)
Alzheimers Res ter
, vol.6
, pp. 29
-
-
Cook, C.1
Stankowski, J.N.2
Carlomagno, Y.3
Stetler, C.4
Petrucelli, L.5
-
2
-
-
79953087890
-
The acetylation of tau inhibits its function and promotes pathological tau aggregation
-
Cohen, T. J. et al. The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun 2, 252 (2011).
-
(2011)
Nat Commun
, vol.2
, pp. 252
-
-
Cohen, T.J.1
-
3
-
-
77957001697
-
Acetylation of tau inhibits its degradation and contributes to tauopathy
-
Min, S. W. et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67, 953-66 (2010).
-
(2010)
Neuron
, vol.67
, pp. 953-966
-
-
Min, S.W.1
-
4
-
-
84890357149
-
Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
-
Cook, C. et al. Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Hum Mol Genet 23, 104-16 (2014).
-
(2014)
Hum Mol Genet
, vol.23
, pp. 104-116
-
-
Cook, C.1
-
5
-
-
84943637753
-
Critical role of acetylation in tau-mediated neurodegeneration and cognitive defcits
-
Min, S. W. et al. Critical role of acetylation in tau-mediated neurodegeneration and cognitive defcits. Nat Med 21, 1154-62 (2015).
-
(2015)
Nat Med
, vol.21
, pp. 1154-1162
-
-
Min, S.W.1
-
6
-
-
84900556648
-
Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal Tau protein
-
Kamah, A. et al. Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal Tau protein. Biochemistry 53, 3020-32 (2014).
-
(2014)
Biochemistry
, vol.53
, pp. 3020-3032
-
-
Kamah, A.1
-
7
-
-
84857620173
-
Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
-
Irwin, D. J. et al. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain 135, 807-18 (2012).
-
(2012)
Brain
, vol.135
, pp. 807-818
-
-
Irwin, D.J.1
-
8
-
-
84876695265
-
Argyrophilic grain disease difers from other tauopathies by lacking tau acetylation
-
Grinberg, L. T. et al. Argyrophilic grain disease difers from other tauopathies by lacking tau acetylation. Acta Neuropathol 125, 581-93 (2013).
-
(2013)
Acta Neuropathol
, vol.125
, pp. 581-593
-
-
Grinberg, L.T.1
-
9
-
-
0034718571
-
Structure, microtubule interactions, and paired helical flament aggregation by tau mutants of frontotemporal dementias
-
Barghorn, S. et al. Structure, microtubule interactions, and paired helical flament aggregation by tau mutants of frontotemporal dementias. Biochemistry 39, 11714-21 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 11714-11721
-
-
Barghorn, S.1
-
10
-
-
11144258263
-
Mutations causing neurodegenerative tauopathies
-
Goedert, M. & Jakes, R. Mutations causing neurodegenerative tauopathies. Biochim Biophys Acta 1739, 240-50 (2005).
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 240-250
-
-
Goedert, M.1
Jakes, R.2
-
11
-
-
84907188956
-
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
-
Mizielinska, S. et al. C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science 345, 1192-4 (2014).
-
(2014)
Science
, vol.345
, pp. 1192-1194
-
-
Mizielinska, S.1
-
12
-
-
84931005949
-
Abeta43 is neurotoxic and primes aggregation of Abeta40 in vivo
-
Burnouf, S., Gorsky, M. K., Dols, J., Gronke, S. & Partridge, L. Abeta43 is neurotoxic and primes aggregation of Abeta40 in vivo. Ac ta Neuropathol 130, 35-47 (2015).
-
(2015)
Ac Ta Neuropathol
, vol.130
, pp. 35-47
-
-
Burnouf, S.1
Gorsky, M.K.2
Dols, J.3
Gronke, S.4
Partridge, L.5
-
13
-
-
0035958642
-
Tauopathy in Drosophila: Neurodegeneration without neurofbrillary tangles
-
Wittmann, C. W. et al. Tauopathy in Drosophila: neurodegeneration without neurofbrillary tangles. Science 293, 711-4 (2001).
-
(2001)
Science
, vol.293
, pp. 711-714
-
-
Wittmann, C.W.1
-
14
-
-
0037118247
-
Human wild-type tau interacts with wingless pathway components and produces neurofbrillary pathology in Drosophila
-
Jackson, G. R. et al. Human wild-type tau interacts with wingless pathway components and produces neurofbrillary pathology in Drosophila. Neuron 34, 509-19 (2002).
-
(2002)
Neuron
, vol.34
, pp. 509-519
-
-
Jackson, G.R.1
-
15
-
-
80455135061
-
Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice
-
Banks, A. S. et al. Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab 14, 587-97 (2011).
-
(2011)
Cell Metab
, vol.14
, pp. 587-597
-
-
Banks, A.S.1
-
16
-
-
84860864004
-
Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): Implications for production of glycine-conjugated signaling molecules
-
Waluk, D. P., Sucharski, F., Sipos, L., Silberring, J. & Hunt, M. C. Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules. J Biol Chem 287, 16158-67 (2012).
-
(2012)
J Biol Chem
, vol.287
, pp. 16158-16167
-
-
Waluk, D.P.1
Sucharski, F.2
Sipos, L.3
Silberring, J.4
Hunt, M.C.5
-
17
-
-
84937231854
-
Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation
-
de Boor, S. et al. Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation. Proc Natl Acad Sci USA 112, E3679-88 (2015).
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. E3679-E3688
-
-
De Boor, S.1
-
18
-
-
0028919756
-
Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast
-
Hecht, A., Laroche, T., Strahl-Bolsinger, S., Gasser, S. M. & Grunstein, M. Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell 80, 583-92 (1995).
-
(1995)
Cell
, vol.80
, pp. 583-592
-
-
Hecht, A.1
Laroche, T.2
Strahl-Bolsinger, S.3
Gasser, S.M.4
Grunstein, M.5
-
19
-
-
41349092785
-
Exploiting position efects and the gypsy retrovirus insulator to engineer precisely expressed transgenes
-
Markstein, M., Pitsouli, C., Villalta, C., Celniker, S. E. & Perrimon, N. Exploiting position efects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet 40, 476-83 (2008).
-
(2008)
Nat Genet
, vol.40
, pp. 476-483
-
-
Markstein, M.1
Pitsouli, C.2
Villalta, C.3
Celniker, S.E.4
Perrimon, N.5
-
20
-
-
0019793972
-
Fluorescence of photoreceptor cells observed in vivo
-
Franceschini, N., Kirschfeld, K. & Minke, B. Fluorescence of photoreceptor cells observed in vivo. Science 213, 1264-7 (1981).
-
(1981)
Science
, vol.213
, pp. 1264-1267
-
-
Franceschini, N.1
Kirschfeld, K.2
Minke, B.3
-
21
-
-
84858965241
-
Identifcation of oligomers at early stages of tau aggregation in Alzheimer's disease
-
Lasagna-Reeves, C. A. et al. Identifcation of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J 26, 1946-59 (2012).
-
(2012)
FASEB J
, vol.26
, pp. 1946-1959
-
-
Lasagna-Reeves, C.A.1
-
22
-
-
61849088424
-
Tau phosphorylation: The therapeutic challenge for neurodegenerative disease
-
Hanger, D. P., Anderton, B. H. & Noble, W. Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. T r e n d s Mol Med 15, 112-9 (2009).
-
(2009)
T R e N D S Mol Med
, vol.15
, pp. 112-119
-
-
Hanger, D.P.1
Anderton, B.H.2
Noble, W.3
-
23
-
-
84928143350
-
Drosophila models of Alzheimer's disease: Advances, limits, and perspectives
-
Bouleau, S. & Tricoire, H. Drosophila models of Alzheimer's disease: advances, limits, and perspectives. J Alzheimers Dis 45, 1015-38 (2015).
-
(2015)
J Alzheimers Dis
, vol.45
, pp. 1015-1038
-
-
Bouleau, S.1
Tricoire, H.2
-
24
-
-
77952549902
-
Abeta exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease
-
Folwell, J. et al. Abeta exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease. Exp Neurol 223, 401-9 (2010).
-
(2010)
Exp Neurol
, vol.223
, pp. 401-409
-
-
Folwell, J.1
-
25
-
-
84865074623
-
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity
-
Fatouros, C. et al. Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity. Hum Mol Genet 21, 3587-603 (2012).
-
(2012)
Hum Mol Genet
, vol.21
, pp. 3587-3603
-
-
Fatouros, C.1
-
26
-
-
84864382491
-
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau
-
Van der Jeugd, A. et al. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta Neuropathol 123, 787-805 (2012).
-
(2012)
Acta Neuropathol
, vol.123
, pp. 787-805
-
-
Van Der Jeugd, A.1
-
27
-
-
35748954923
-
The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy
-
Eckermann, K. et al. The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem 282, 31755-65 (2007).
-
(2007)
J Biol Chem
, vol.282
, pp. 31755-31765
-
-
Eckermann, K.1
-
28
-
-
0033070197
-
High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands
-
Rizzu, P. et al. High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands. Am J Hum Genet 64, 414-21 (1999).
-
(1999)
Am J Hum Genet
, vol.64
, pp. 414-421
-
-
Rizzu, P.1
-
29
-
-
84917706097
-
Oligomer formation of tau protein hyperphosphorylated in cells
-
Tepper, K. et al. Oligomer formation of tau protein hyperphosphorylated in cells. J Biol Chem 289, 34389-407 (2014).
-
(2014)
J Biol Chem
, vol.289
, pp. 34389-34407
-
-
Tepper, K.1
-
30
-
-
0036937699
-
Specifc tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
-
Augustinack, J. C., Schneider, A., Mandelkow, E. M. & Hyman, B. T. Specifc tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol 103, 26-35 (2002).
-
(2002)
Acta Neuropathol
, vol.103
, pp. 26-35
-
-
Augustinack, J.C.1
Schneider, A.2
Mandelkow, E.M.3
Hyman, B.T.4
-
31
-
-
0033850407
-
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
-
Buee, L., Bussiere, T., Buee-Scherrer, V., Delacourte, A. & Hof, P. R. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33, 95-130 (2000).
-
(2000)
Brain Res Brain Res Rev
, vol.33
, pp. 95-130
-
-
Buee, L.1
Bussiere, T.2
Buee-Scherrer, V.3
Delacourte, A.4
Hof, P.R.5
-
32
-
-
78649723354
-
Glial fbrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy
-
Colodner, K. J. & Feany, M. B. Glial fbrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J Neurosci 30, 16102-13 (2010).
-
(2010)
J Neurosci
, vol.30
, pp. 16102-16113
-
-
Colodner, K.J.1
Feany, M.B.2
-
33
-
-
84861758226
-
Trans-cellular propagation of Tau aggregation by fbrillar species
-
Kfoury, N., Holmes, B. B., Jiang, H., Holtzman, D. M. & Diamond, M. I. Trans-cellular propagation of Tau aggregation by fbrillar species. J Biol Chem 287, 19440-51 (2012).
-
(2012)
J Biol Chem
, vol.287
, pp. 19440-19451
-
-
Kfoury, N.1
Holmes, B.B.2
Jiang, H.3
Holtzman, D.M.4
Diamond, M.I.5
-
34
-
-
84903535019
-
Ectosomes: A new mechanism for non-exosomal secretion of tau protein
-
Dujardin, S. et al. Ectosomes: a new mechanism for non-exosomal secretion of tau protein. PLoS One 9, e100760 (2014).
-
(2014)
PLoS One
, vol.9
, pp. e100760
-
-
Dujardin, S.1
-
35
-
-
84945474523
-
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
-
Asai, H. et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci 18, 1584-93 (2015).
-
(2015)
Nat Neurosci
, vol.18
, pp. 1584-1593
-
-
Asai, H.1
-
36
-
-
0035940416
-
A conditional tissue-specifc transgene expression system using inducible GAL4
-
Osterwalder, T., Yoon, K. S., White, B. H. & Keshishian, H. A conditional tissue-specifc transgene expression system using inducible GAL4. Proc Natl Acad Sci USA 98, 12596-601 (2001).
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12596-12601
-
-
Osterwalder, T.1
Yoon, K.S.2
White, B.H.3
Keshishian, H.4
-
37
-
-
0028027088
-
Domains of tau protein and interactions with microtubules
-
Gustke, N., Trinczek, B., Biernat, J., Mandelkow, E. M. & Mandelkow, E. Domains of tau protein and interactions with microtubules. Biochemistry 33, 9511-22 (1994).
-
(1994)
Biochemistry
, vol.33
, pp. 9511-9522
-
-
Gustke, N.1
Trinczek, B.2
Biernat, J.3
Mandelkow, E.M.4
Mandelkow, E.5
-
38
-
-
0037386532
-
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
-
Greene, J. C. et al. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci USA 100, 4078-83 (2003).
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4078-4083
-
-
Greene, J.C.1
|