-
1
-
-
84872109456
-
The global prevalence of dementia: A systematic review and metaanalysis
-
e62
-
Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP (2013) The global prevalence of dementia: A systematic review and metaanalysis. Alzheimers Dement 9, 63-75 e62.
-
(2013)
Alzheimers Dement
, vol.9
, pp. 63-75
-
-
Prince, M.1
Bryce, R.2
Albanese, E.3
Wimo, A.4
Ribeiro, W.5
Ferri, C.P.6
-
2
-
-
0026088977
-
Segregation of a missense mutation in the amyloid-beta protein precursor gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, et al. (1991) Segregation of a missense mutation in the amyloid-beta protein precursor gene with familial Alzheimer's disease. Nature 349, 704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
-
3
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy JA, Higgins GA (1992) Alzheimer's disease: The amyloid cascade hypothesis. Science 256, 184-185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
4
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12, 383-388.
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
5
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
6
-
-
84903947419
-
Alzheimer's disease drug-development pipeline: Few candidates, frequent failures
-
Cummings JL, Morstorf T, ZhongK(2014) Alzheimer's disease drug-development pipeline: Few candidates, frequent failures. Alzheimers Res Ther 6, 37.
-
(2014)
Alzheimers Res Ther
, vol.6
, pp. 37
-
-
Cummings, J.L.1
Morstorf, T.2
Zhong, K.3
-
7
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
-
Karran E, Mercken M, De Strooper B (2011) The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics. Nat Rev Drug Discov 10, 698-712.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
8
-
-
78650403081
-
Reimagining Alzheimer's disease - an agebased hypothesis
-
Herrup K (2010) Reimagining Alzheimer's disease - an agebased hypothesis. J Neurosci 30, 16755-16762.
-
(2010)
J Neurosci
, vol.30
, pp. 16755-16762
-
-
Herrup, K.1
-
9
-
-
84903304968
-
The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives
-
SwerdlowRH, Burns JM, KhanSM(2014) The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives. Biochim Biophys Acta 1842, 1219-1231.
-
(2014)
Biochim Biophys Acta
, vol.1842
, pp. 1219-1231
-
-
Swerdlow, R.H.1
Burns, J.M.2
Khan, S.M.3
-
10
-
-
84875599536
-
Mitochondria-associated ER membranes in Alzheimer disease
-
Schon EA, Area-Gomez E (2013) Mitochondria-associated ER membranes in Alzheimer disease. Mol Cell Neurosci 55, 26-36.
-
(2013)
Mol Cell Neurosci
, vol.55
, pp. 26-36
-
-
Schon, E.A.1
Area-Gomez, E.2
-
12
-
-
79953792620
-
Traces of Drosophila memory
-
Davis RL (2011) Traces of Drosophila memory. Neuron 70, 8-19.
-
(2011)
Neuron
, vol.70
, pp. 8-19
-
-
Davis, R.L.1
-
13
-
-
80052464728
-
Learning and memory in Drosophila: Behavior, genetics, and neural systems
-
Kahsai L, Zars T (2011) Learning and memory in Drosophila: Behavior, genetics, and neural systems. Int Rev Neurobiol 99, 139-167.
-
(2011)
Int Rev Neurobiol
, vol.99
, pp. 139-167
-
-
Kahsai, L.1
Zars, T.2
-
14
-
-
79960770017
-
Genetics of sleep and sleep disorders
-
Sehgal A, Mignot E (2011) Genetics of sleep and sleep disorders. Cell 146, 194-207.
-
(2011)
Cell
, vol.146
, pp. 194-207
-
-
Sehgal, A.1
Mignot, E.2
-
15
-
-
84878618959
-
Lessons from sleeping flies: Insights from Drosophila melanogaster on the neuronal circuitry and importance of sleep
-
Potdar S, Sheeba V (2013) Lessons from sleeping flies: Insights from Drosophila melanogaster on the neuronal circuitry and importance of sleep. J Neurogenet 27, 23-42.
-
(2013)
J Neurogenet
, vol.27
, pp. 23-42
-
-
Potdar, S.1
Sheeba, V.2
-
16
-
-
80052288667
-
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: Isradipine as a candidate drug
-
Copenhaver PF, Anekonda TS, Musashe D, Robinson KM, Ramaker JM, Swanson TL, Wadsworth TL, Kretzschmar D, Woltjer RL, Quinn JF (2011) A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: Isradipine as a candidate drug. Dis Model Mech 4, 634-648.
-
(2011)
Dis Model Mech
, vol.4
, pp. 634-648
-
-
Copenhaver, P.F.1
Anekonda, T.S.2
Musashe, D.3
Robinson, K.M.4
Ramaker, J.M.5
Swanson, T.L.6
Wadsworth, T.L.7
Kretzschmar, D.8
Woltjer, R.L.9
Quinn, J.F.10
-
17
-
-
84878915977
-
Redundancy and divergence in the amyloid-beta protein precursor family
-
Shariati SA, De Strooper B (2013) Redundancy and divergence in the amyloid-beta protein precursor family. FEBS Lett 587, 2036-2045.
-
(2013)
FEBS Lett
, vol.587
, pp. 2036-2045
-
-
Shariati, S.A.1
De Strooper, B.2
-
18
-
-
0028914672
-
Expression in mouse embryos and in adult mouse brain of three members of the amyloid-beta protein precursor family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein
-
Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H (1995) Expression in mouse embryos and in adult mouse brain of three members of the amyloid-beta protein precursor family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience 65, 1009-1025.
-
(1995)
Neuroscience
, vol.65
, pp. 1009-1025
-
-
Lorent, K.1
Overbergh, L.2
Moechars, D.3
De Strooper, B.4
Van Leuven, F.5
Van Den Berghe, H.6
-
19
-
-
78650692019
-
In vivo regulation of amyloid-beta protein precursor neuronal splicing by microRNAs
-
Smith P, Al Hashimi A, Girard J, Delay C, Hebert SS (2011) In vivo regulation of amyloid-beta protein precursor neuronal splicing by microRNAs. J Neurochem 116, 240-247.
-
(2011)
J Neurochem
, vol.116
, pp. 240-247
-
-
Smith, P.1
Al Hashimi, A.2
Girard, J.3
Delay, C.4
Hebert, S.S.5
-
20
-
-
84862953172
-
Amyloid-beta protein precursor revisited: Neuron-specific expression and highly stable nature of soluble derivatives
-
Guo Q, Li H, Gaddam SS, Justice NJ, Robertson CS, Zheng H (2012) Amyloid-beta protein precursor revisited: Neuron-specific expression and highly stable nature of soluble derivatives. J Biol Chem 287, 2437-2445.
-
(2012)
J Biol Chem
, vol.287
, pp. 2437-2445
-
-
Guo, Q.1
Li, H.2
Gaddam, S.S.3
Justice, N.J.4
Robertson, C.S.5
Zheng, H.6
-
21
-
-
0028988801
-
Amyloid-beta precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, Stevens KA, Slunt HH, Sisoda SS, Chen HY, Van der Ploeg LH (1995) amyloid-beta precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81, 525-531.
-
(1995)
Cell
, vol.81
, pp. 525-531
-
-
Zheng, H.1
Jiang, M.2
Trumbauer, M.E.3
Sirinathsinghji, D.J.4
Hopkins, R.5
Smith, D.W.6
Heavens, R.P.7
Dawson, G.R.8
Boyce, S.9
Conner, M.W.10
Stevens, K.A.11
Slunt, H.H.12
Sisoda, S.S.13
Chen, H.Y.14
Van Der Ploeg, L.H.15
-
22
-
-
72449130946
-
Amyloid-beta protein precursor regulates Cav1.2 L-type calcium channel levels and function to influenceGABAergic short-term plasticity
-
Yang L, Wang Z, Wang B, Justice NJ, Zheng H (2009) Amyloid-beta protein precursor regulates Cav1.2 L-type calcium channel levels and function to influenceGABAergic short-term plasticity. J Neurosci 29, 15660-15668.
-
(2009)
J Neurosci
, vol.29
, pp. 15660-15668
-
-
Yang, L.1
Wang, Z.2
Wang, B.3
Justice, N.J.4
Zheng, H.5
-
23
-
-
77953810503
-
Beta amyloid-independent role of amyloid-beta protein precursor in generation and maintenance of dendritic spines
-
Lee KJ, Moussa CE, Lee Y, Sung Y, Howell BW, Turner RS, Pak DT, Hoe HS (2010) Beta amyloid-independent role of amyloid-beta protein precursor in generation and maintenance of dendritic spines. Neuroscience 169, 344-356.
-
(2010)
Neuroscience
, vol.169
, pp. 344-356
-
-
Lee, K.J.1
Moussa, C.E.2
Lee, Y.3
Sung, Y.4
Howell, B.W.5
Turner, R.S.6
Pak, D.T.7
Hoe, H.S.8
-
24
-
-
0034329291
-
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid-beta protein precursor family members
-
Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rulicke T, von Kretzschmar H, von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Muller U (2000) Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid-beta protein precursor family members. J Neurosci 20, 7951-7963.
-
(2000)
J Neurosci
, vol.20
, pp. 7951-7963
-
-
Heber, S.1
Herms, J.2
Gajic, V.3
Hainfellner, J.4
Aguzzi, A.5
Rulicke, T.6
Von Kretzschmar, H.7
Von Koch, C.8
Sisodia, S.9
Tremml, P.10
Lipp, H.P.11
Wolfer, D.P.12
Muller, U.13
-
25
-
-
67650383731
-
Amyloid-beta protein precursor and its homologues: A family of proteolysisdependent receptors
-
Jacobsen KT, Iverfeldt K (2009) Amyloid-beta protein precursor and its homologues: A family of proteolysisdependent receptors. Cell Mol Life Sci 66, 2299-2318.
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 2299-2318
-
-
Jacobsen, K.T.1
Iverfeldt, K.2
-
26
-
-
84878956537
-
Physiological functions of APP family proteins
-
Muller UC, Zheng H (2012) Physiological functions of APP family proteins. Cold Spring HarbPerspectMed2, a006288.
-
(2012)
Cold Spring HarbPerspectMed
, vol.2
, pp. a006288
-
-
Muller, U.C.1
Zheng, H.2
-
27
-
-
28644437291
-
The amyloidbeta precursor protein: Integrating structure with biological function
-
Reinhard C, Hebert SS, De Strooper B (2005) The amyloidbeta precursor protein: Integrating structure with biological function. EMBO J 24, 3996-4006.
-
(2005)
EMBO J
, vol.24
, pp. 3996-4006
-
-
Reinhard, C.1
Hebert, S.S.2
De Strooper, B.3
-
28
-
-
84905851549
-
Amyloid-beta protein precursor dimerization and synaptogenic function depend on copper binding to the growth factor-like domain
-
Baumkotter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, KlugW, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K, Kins S (2014) Amyloid-beta protein precursor dimerization and synaptogenic function depend on copper binding to the growth factor-like domain. J Neurosci 34, 11159-11172.
-
(2014)
J Neurosci
, vol.34
, pp. 11159-11172
-
-
Baumkotter, F.1
Schmidt, N.2
Vargas, C.3
Schilling, S.4
Weber, R.5
Wagner, K.6
Fiedler, S.7
Klug, W.8
Radzimanowski, J.9
Nickolaus, S.10
Keller, S.11
Eggert, S.12
Wild, K.13
Kins, S.14
-
29
-
-
0033301776
-
Neurite-outgrowth regulating functions of the amyloid protein precursor of Alzheimer's disease
-
Small DH, Clarris HL, Williamson TG, Reed G, Key B, Mok SS, Beyreuther K, Masters CL, Nurcombe V (1999) Neurite-outgrowth regulating functions of the amyloid protein precursor of Alzheimer's disease. J Alzheimers Dis 1, 275-285.
-
(1999)
J Alzheimers Dis
, vol.1
, pp. 275-285
-
-
Small, D.H.1
Clarris, H.L.2
Williamson, T.G.3
Reed, G.4
Key, B.5
Mok, S.S.6
Beyreuther, K.7
Masters, C.L.8
Nurcombe, V.9
-
30
-
-
0028213567
-
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth
-
Small DH, Nurcombe V, Reed G, Clarris H, Moir R, Beyreuther K, Masters CL (1994) A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci 14, 2117-2127.
-
(1994)
J Neurosci
, vol.14
, pp. 2117-2127
-
-
Small, D.H.1
Nurcombe, V.2
Reed, G.3
Clarris, H.4
Moir, R.5
Beyreuther, K.6
Masters, C.L.7
-
31
-
-
79851508882
-
Bringing order to protein disorder through comparative genomics and genetic interactions
-
Bellay J, Han S, Michaut M, Kim T, Costanzo M, Andrews BJ, Boone C, Bader GD, Myers CL, Kim PM (2011) Bringing order to protein disorder through comparative genomics and genetic interactions. Genome Biol 12, R14.
-
(2011)
Genome Biol
, vol.12
, pp. R14
-
-
Bellay, J.1
Han, S.2
Michaut, M.3
Kim, T.4
Costanzo, M.5
Andrews, B.J.6
Boone, C.7
Bader, G.D.8
Myers, C.L.9
Kim, P.M.10
-
32
-
-
4143105782
-
The X-ray structure of an antiparallel dimer of the human amyloid-beta protein precursor E2 domain
-
Wang Y, Ha Y (2004) The X-ray structure of an antiparallel dimer of the human amyloid-beta protein precursor E2 domain. Mol Cell 15, 343-353.
-
(2004)
Mol Cell
, vol.15
, pp. 343-353
-
-
Wang, Y.1
Ha, Y.2
-
33
-
-
18844473445
-
Expression and analysis of heparin-binding regions of the amyloid-beta protein precursor of Alzheimer's disease
-
Mok SS, Sberna G, Heffernan D, Cappai R, Galatis D, Clarris HJ, Sawyer WH, Beyreuther K, Masters CL, Small DH (1997) Expression and analysis of heparin-binding regions of the amyloid-beta protein precursor of Alzheimer's disease. FEBS Lett 415, 303-307.
-
(1997)
FEBS Lett
, vol.415
, pp. 303-307
-
-
Mok, S.S.1
Sberna, G.2
Heffernan, D.3
Cappai, R.4
Galatis, D.5
Clarris, H.J.6
Sawyer, W.H.7
Beyreuther, K.8
Masters, C.L.9
Small, D.H.10
-
34
-
-
0028071334
-
Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor
-
Roch JM, Masliah E, Roch-LevecqAC, SundsmoMP, Otero DA, Veinbergs I, Saitoh T (1994) Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor. Proc Natl Acad Sci U S A 91, 7450-7454.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 7450-7454
-
-
Roch, J.M.1
Masliah, E.2
Roch-Levecq, A.C.3
Sundsmo, M.P.4
Otero, D.A.5
Veinbergs, I.6
Saitoh, T.7
-
35
-
-
84862633779
-
Trafficking and proteolytic processing of APP
-
Haass C, Kaether C, Thinakaran G, Sisodia S (2012) Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med 2, a006270.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, pp. a006270
-
-
Haass, C.1
Kaether, C.2
Thinakaran, G.3
Sisodia, S.4
-
36
-
-
84655164281
-
Identification and biology of alpha-secretase
-
Vingtdeux V, Marambaud P (2012) Identification and biology of alpha-secretase. J Neurochem 120(Suppl 1), 34-45.
-
(2012)
J Neurochem
, vol.120
, pp. 34-45
-
-
Vingtdeux, V.1
Marambaud, P.2
-
37
-
-
84903190262
-
Function, therapeutic potential and cell biology of BACE proteases: Current status and future prospects
-
Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF (2014) Function, therapeutic potential and cell biology of BACE proteases: Current status and future prospects. J Neurochem 130, 4-28.
-
(2014)
J Neurochem
, vol.130
, pp. 4-28
-
-
Vassar, R.1
Kuhn, P.H.2
Haass, C.3
Kennedy, M.E.4
Rajendran, L.5
Wong, P.C.6
Lichtenthaler, S.F.7
-
38
-
-
0035816661
-
A transcriptionally correction of transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X, Sudhof TC (2001) A transcriptionally correction of transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115-120.
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
39
-
-
84891836688
-
The role of protein glycosylation in Alzheimer disease
-
Schedin-Weiss S,Winblad B, Tjernberg LO (2014) The role of protein glycosylation in Alzheimer disease. FEBS J 281, 46-62.
-
(2014)
FEBS J
, vol.281
, pp. 46-62
-
-
Schedin-Weiss, S.1
Winblad, B.2
Tjernberg, L.O.3
-
40
-
-
84879028412
-
Expression and function of APP and its metabolites outside the central nervous system
-
Puig KL, CombsCK(2013) Expression and function of APP and its metabolites outside the central nervous system. Exp Gerontol 48, 608-611.
-
(2013)
Exp Gerontol
, vol.48
, pp. 608-611
-
-
Puig, K.L.1
Combs, C.K.2
-
41
-
-
0037079991
-
Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid-beta protein precursor
-
White AR, Multhaup G, Galatis D, McKinstry WJ, Parker MW, Pipkorn R, Beyreuther K, Masters CL, Cappai R (2002) Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid-beta protein precursor. J Neurosci 22, 365-376.
-
(2002)
J Neurosci
, vol.22
, pp. 365-376
-
-
White, A.R.1
Multhaup, G.2
Galatis, D.3
McKinstry, W.J.4
Parker, M.W.5
Pipkorn, R.6
Beyreuther, K.7
Masters, C.L.8
Cappai, R.9
-
42
-
-
84862836856
-
Analysis of amyloid-beta protein precursor function in Drosophila melanogaster
-
Poeck B, Strauss R, Kretzschmar D (2012) Analysis of amyloid-beta protein precursor function in Drosophila melanogaster. Exp Brain Res 217, 413-421.
-
(2012)
Exp Brain Res
, vol.217
, pp. 413-421
-
-
Poeck, B.1
Strauss, R.2
Kretzschmar, D.3
-
43
-
-
58149503769
-
Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function
-
Carmine-Simmen K, Proctor T, Tschape J, Poeck B, Triphan T, Strauss R, Kretzschmar D (2009) Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function. Neurobiol Dis 33, 274-281.
-
(2009)
Neurobiol Dis
, vol.33
, pp. 274-281
-
-
Carmine-Simmen, K.1
Proctor, T.2
Tschape, J.3
Poeck, B.4
Triphan, T.5
Strauss, R.6
Kretzschmar, D.7
-
44
-
-
84898715213
-
LCMS based cleavage site profiling of the proteases ADAM10 and ADAM17 using proteome-derived peptide libraries
-
Tucher J, Linke D, Koudelka T, Cassidy L, Tredup C, Wichert R, Pietrzik C, Becker-Pauly C, TholeyA(2014) LCMS based cleavage site profiling of the proteases ADAM10 and ADAM17 using proteome-derived peptide libraries. J Proteome Res 13, 2205-2214.
-
(2014)
J Proteome Res
, vol.13
, pp. 2205-2214
-
-
Tucher, J.1
Linke, D.2
Koudelka, T.3
Cassidy, L.4
Tredup, C.5
Wichert, R.6
Pietrzik, C.7
Becker-Pauly, C.8
Tholey, A.9
-
45
-
-
84874585213
-
Amyloid-beta induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease
-
Um JW, Strittmatter SM (2013) Amyloid-beta induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease. Prion 7, 37-41.
-
(2013)
Prion
, vol.7
, pp. 37-41
-
-
Um, J.W.1
Strittmatter, S.M.2
-
46
-
-
84882941312
-
Characterizing affinity epitopes between prion protein and amyloid-beta using an epitope mapping immunoassay
-
Kang M, KimSY,An SS, JuYR(2013) Characterizing affinity epitopes between prion protein and amyloid-beta using an epitope mapping immunoassay. Exp Mol Med 45, e34.
-
(2013)
Exp Mol Med
, vol.45
, pp. e34
-
-
Kang, M.1
Kim, S.Y.2
An, S.S.3
Ju, Y.R.4
-
47
-
-
83555176204
-
Nuclear signalling by membrane protein intracellular domains: The AICD enigma
-
Beckett C, Nalivaeva NN, Belyaev ND, Turner AJ (2012) Nuclear signalling by membrane protein intracellular domains: The AICD enigma. Cell Signal 24, 402-409.
-
(2012)
Cell Signal
, vol.24
, pp. 402-409
-
-
Beckett, C.1
Nalivaeva, N.N.2
Belyaev, N.D.3
Turner, A.J.4
-
48
-
-
84870156483
-
Fe65 matters: New light on an old molecule
-
Minopoli G, Gargiulo A, Parisi S, Russo T (2012) Fe65 matters: New light on an old molecule. IUBMB Life 64, 936-942.
-
(2012)
IUBMB Life
, vol.64
, pp. 936-942
-
-
Minopoli, G.1
Gargiulo, A.2
Parisi, S.3
Russo, T.4
-
49
-
-
84864851202
-
Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model
-
Pirooznia SK, Sarthi J, Johnson AA, Toth MS, Chiu K, Koduri S, Elefant F (2012) Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model. PLoS One 7, e41776.
-
(2012)
PLoS One
, vol.7
-
-
Pirooznia, S.K.1
Sarthi, J.2
Johnson, A.A.3
Toth, M.S.4
Chiu, K.5
Koduri, S.6
Elefant, F.7
-
50
-
-
84901038404
-
FoxO mediates APP-induced AICDdependent cell death
-
Wang X, Wang Z, Chen Y, Huang X, Hu Y, Zhang R, Ho MS, Xue L (2014) FoxO mediates APP-induced AICDdependent cell death. Cell Death Dis 5, e1233.
-
(2014)
Cell Death Dis
, vol.5
, pp. e1233
-
-
Wang, X.1
Wang, Z.2
Chen, Y.3
Huang, X.4
Hu, Y.5
Zhang, R.6
Ho, M.S.7
Xue, L.8
-
51
-
-
0026783241
-
Human amyloid-beta protein precursor ameliorates behavioral deficit of flies deleted for Appl gene
-
Luo L,TullyT, WhiteK(1992) Human amyloid-beta protein precursor ameliorates behavioral deficit of flies deleted for Appl gene. Neuron 9, 595-605.
-
(1992)
Neuron
, vol.9
, pp. 595-605
-
-
Luo, L.1
Tully, T.2
White, K.3
-
52
-
-
21344431624
-
Fasciclin II signals new synapse formation through amyloid-beta protein precursor and the scaffolding protein dX11/Mint
-
Ashley J, Packard M, Ataman B, Budnik V (2005) Fasciclin II signals new synapse formation through amyloid-beta protein precursor and the scaffolding protein dX11/Mint. J Neurosci 25, 5943-5955.
-
(2005)
J Neurosci
, vol.25
, pp. 5943-5955
-
-
Ashley, J.1
Packard, M.2
Ataman, B.3
Budnik, V.4
-
53
-
-
0036312616
-
Expression and characterization of the Drosophila X11-like/Mint protein during neural development
-
Hase M, Yagi Y, Taru H, Tomita S, Sumioka A, Hori K, Miyamoto K, Sasamura T, Nakamura M, Matsuno K, Suzuki T (2002) Expression and characterization of the Drosophila X11-like/Mint protein during neural development. J Neurochem 81, 1223-1232.
-
(2002)
J Neurochem
, vol.81
, pp. 1223-1232
-
-
Hase, M.1
Yagi, Y.2
Taru, H.3
Tomita, S.4
Sumioka, A.5
Hori, K.6
Miyamoto, K.7
Sasamura, T.8
Nakamura, M.9
Matsuno, K.10
Suzuki, T.11
-
54
-
-
0033568874
-
The Drosophila amyloid-beta precursor protein homolog promotes synapse differentiation at the neuromuscular junction
-
Torroja L, Packard M, Gorczyca M, White K, Budnik V (1999) The Drosophila amyloid-beta precursor protein homolog promotes synapse differentiation at the neuromuscular junction. J Neurosci 19, 7793-7803.
-
(1999)
J Neurosci
, vol.19
, pp. 7793-7803
-
-
Torroja, L.1
Packard, M.2
Gorczyca, M.3
White, K.4
Budnik, V.5
-
55
-
-
9144248022
-
Specific functions of Drosophila amyloid precursor-like protein in the development of nervous system and nonneural tissues
-
LiY, LiuT, PengY,Yuan C, GuoA(2004) Specific functions of Drosophila amyloid precursor-like protein in the development of nervous system and nonneural tissues. J Neurobiol 61, 343-358.
-
(2004)
J Neurobiol
, vol.61
, pp. 343-358
-
-
Li, Y.1
Liu, T.2
Peng, Y.3
Yuan, C.4
Guo, A.5
-
56
-
-
28644449284
-
Amyloid-beta protein precursor promotes post-developmental neurite arborization in the Drosophila brain
-
Leyssen M, Ayaz D, Hebert SS, Reeve S, De Strooper B, Hassan BA (2005) Amyloid-beta protein precursor promotes post-developmental neurite arborization in the Drosophila brain. EMBO J 24, 2944-2955.
-
(2005)
EMBO J
, vol.24
, pp. 2944-2955
-
-
Leyssen, M.1
Ayaz, D.2
Hebert, S.S.3
Reeve, S.4
De Strooper, B.5
Hassan, B.A.6
-
57
-
-
84878272993
-
The Drosophila homologue of the amyloid-beta protein precursor is a conserved modulator of Wnt PCP signaling
-
Soldano A, Okray Z, Janovska P, Tmejová K, Reynaud E, Claeys A, Yan J, Atak ZK, De Strooper B, Dura JM, Bryja V, Hassan BA (2013) The Drosophila homologue of the amyloid-beta protein precursor is a conserved modulator of Wnt PCP signaling. PLoS Biol 11, e1001562.
-
(2013)
PLoS Biol
, vol.11
-
-
Soldano, A.1
Okray, Z.2
Janovska, P.3
Tmejová, K.4
Reynaud, E.5
Claeys, A.6
Yan, J.7
Atak, Z.K.8
De Strooper, B.9
Dura, J.M.10
Bryja, V.11
Hassan, B.A.12
-
58
-
-
33845516897
-
Drosophila homolog of APPBP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development
-
Kim HJ, Kim SH, Shim SO, Park E, Kim C, Kim K, Tanouye MA, Yim J (2007) Drosophila homolog of APPBP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development. Cell Death Diff 14, 103-115.
-
(2007)
Cell Death Diff
, vol.14
, pp. 103-115
-
-
Kim, H.J.1
Kim, S.H.2
Shim, S.O.3
Park, E.4
Kim, C.5
Kim, K.6
Tanouye, M.A.7
Yim, J.8
-
59
-
-
8144229817
-
Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila
-
Merdes G, Soba P, Loewer A, Bilic MV, Beyreuther K, Paro R (2004) Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J 23, 4082-4095.
-
(2004)
EMBO J
, vol.23
, pp. 4082-4095
-
-
Merdes, G.1
Soba, P.2
Loewer, A.3
Bilic, M.V.4
Beyreuther, K.5
Paro, R.6
-
60
-
-
84875610904
-
Beta amyloid protein precursor-like (Appl) is a Ras1/MAPK-regulated gene required for axonal targeting in Drosophila photoreceptor neurons
-
Mora N, Almudi I, Alsina B, Corominas M, Serras F (2013) beta amyloid protein precursor-like (Appl) is a Ras1/MAPK-regulated gene required for axonal targeting in Drosophila photoreceptor neurons. J Cell Sci 126, 53-59.
-
(2013)
J Cell Sci
, vol.126
, pp. 53-59
-
-
Mora, N.1
Almudi, I.2
Alsina, B.3
Corominas, M.4
Serras, F.5
-
61
-
-
78751473655
-
Drosophila amyloid-beta protein precursor-like is required for longterm memory
-
Goguel V, Belair AL, Ayaz D, Lampin-Saint-Amaux A, Scaplehorn N, Hassan BA, Preat T (2011) Drosophila amyloid-beta protein precursor-like is required for longterm memory. J Neurosci 31, 1032-1037.
-
(2011)
J Neurosci
, vol.31
, pp. 1032-1037
-
-
Goguel, V.1
Belair, A.L.2
Ayaz, D.3
Lampin-Saint-Amaux, A.4
Scaplehorn, N.5
Hassan, B.A.6
Preat, T.7
-
62
-
-
84887212473
-
Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening
-
Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, Okazawa H, Nabeshima Y (2009) Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening. PLoS One 4, e4466.
-
(2009)
PLoS One
, vol.4
, pp. e4466
-
-
Sone, M.1
Uchida, A.2
Komatsu, A.3
Suzuki, E.4
Ibuki, I.5
Asada, M.6
Shiwaku, H.7
Tamura, T.8
Hoshino, M.9
Okazawa, H.10
Nabeshima, Y.11
-
63
-
-
0037011118
-
The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and APPL processing
-
Tschaepe JA, Hammerschmied C, Muhlig-Versen M, Athenstaedt K, Daum G, Kretzschmar D (2002) The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and APPL processing. EMBO J 21, 6367-6376.
-
(2002)
EMBO J
, vol.21
, pp. 6367-6376
-
-
Tschaepe, J.A.1
Hammerschmied, C.2
Muhlig-Versen, M.3
Athenstaedt, K.4
Daum, G.5
Kretzschmar, D.6
-
64
-
-
84858156852
-
Amyloid-beta protein precursors are protective in Drosophila models of progressive neurodegeneration
-
Wentzell JS, Bolkan BJ, Carmine-Simmen K, Swanson TL, Musashe DT, Kretzschmar D (2012) Amyloid-beta protein precursors are protective in Drosophila models of progressive neurodegeneration. Neurobiol Dis 46, 78-87.
-
(2012)
Neurobiol Dis
, vol.46
, pp. 78-87
-
-
Wentzell, J.S.1
Bolkan, B.J.2
Carmine-Simmen, K.3
Swanson, T.L.4
Musashe, D.T.5
Kretzschmar, D.6
-
65
-
-
28644449284
-
Amyloid-beta protein precursor promotes post-developmental neurite arborization in the Drosophila brain
-
Leyssen M, Ayaz D, Hebert SS, Reeve S, De Strooper B, Hassan BA (2005) Amyloid-beta protein precursor promotes post-developmental neurite arborization in the Drosophila brain. EMBO J 24, 2944-2955.
-
(2005)
EMBO J
, vol.24
, pp. 2944-2955
-
-
Leyssen, M.1
Ayaz, D.2
Hebert, S.S.3
Reeve, S.4
De Strooper, B.5
Hassan, B.A.6
-
66
-
-
0028845388
-
Role of microtubuleassociated proteins in the control of microtubule assembly
-
Maccioni RB, Cambiazo V (1995) Role of microtubuleassociated proteins in the control of microtubule assembly. Physiol Rev 75, 835-864.
-
(1995)
Physiol Rev
, vol.75
, pp. 835-864
-
-
Maccioni, R.B.1
Cambiazo, V.2
-
67
-
-
33750120717
-
The MAP1 family of microtubule-associated proteins
-
Halpain S, Dehmelt L (2006) The MAP1 family of microtubule-associated proteins. Genome Biol 7, 224.
-
(2006)
Genome Biol
, vol.7
, pp. 224
-
-
Halpain, S.1
Dehmelt, L.2
-
68
-
-
19744382953
-
The MAP2/Tau family of microtubule-associated proteins
-
Dehmelt L, Halpain S (2005) The MAP2/Tau family of microtubule-associated proteins. Genome Biol 6, 204.
-
(2005)
Genome Biol
, vol.6
, pp. 204
-
-
Dehmelt, L.1
Halpain, S.2
-
69
-
-
35649028013
-
Interaction of tau protein with the dynactin complex
-
Magnani E, Fan J, Gasparini L, Golding M, Williams M, Schiavo G, Goedert M, Amos LA, Spillantini MG (2007) Interaction of tau protein with the dynactin complex. EMBO J 26, 4546-4554.
-
(2007)
EMBO J
, vol.26
, pp. 4546-4554
-
-
Magnani, E.1
Fan, J.2
Gasparini, L.3
Golding, M.4
Williams, M.5
Schiavo, G.6
Goedert, M.7
Amos, L.A.8
Spillantini, M.G.9
-
70
-
-
0028982504
-
Distribution of Big tau in the central nervous system of the adult and developing rat
-
Boyne LJ, Tessler A, Murray M, Fischer I (1995) Distribution of Big tau in the central nervous system of the adult and developing rat. J Comp Neurol 358, 279-293.
-
(1995)
J Comp Neurol
, vol.358
, pp. 279-293
-
-
Boyne, L.J.1
Tessler, A.2
Murray, M.3
Fischer, I.4
-
71
-
-
61849088424
-
Tau phosphorylation: The therapeutic challenge for neurodegenerative disease
-
Hanger DP, Anderton BH, Noble W (2009) Tau phosphorylation: The therapeutic challenge for neurodegenerative disease. Trends Mol Med 15, 112-119.
-
(2009)
Trends Mol Med
, vol.15
, pp. 112-119
-
-
Hanger, D.P.1
Anderton, B.H.2
Noble, W.3
-
72
-
-
49649119504
-
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases
-
Reynolds CH, Garwood CJ, Wray S, Price C, Kellie S, Perera T, Zvelebil M, Yang A, Sheppard PW, Varndell IM, Hanger DP, Anderton BH (2008) Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. J Biol Chem 283, 18177-18186.
-
(2008)
J Biol Chem
, vol.283
, pp. 18177-18186
-
-
Reynolds, C.H.1
Garwood, C.J.2
Wray, S.3
Price, C.4
Kellie, S.5
Perera, T.6
Zvelebil, M.7
Yang, A.8
Sheppard, P.W.9
Varndell, I.M.10
Hanger, D.P.11
Anderton, B.H.12
-
73
-
-
79961025441
-
Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau
-
Usardi A, Pooler AM, Seereeram A, Reynolds CH, Derkinderen P, Anderton B, Hanger DP, Noble W, Williamson R (2011) Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. FEBS J 278, 2927-2937.
-
(2011)
FEBS J
, vol.278
, pp. 2927-2937
-
-
Usardi, A.1
Pooler, A.M.2
Seereeram, A.3
Reynolds, C.H.4
Derkinderen, P.5
Anderton, B.6
Hanger, D.P.7
Noble, W.8
Williamson, R.9
-
74
-
-
84877906835
-
Tau pathology and neurodegeneration
-
Spillantini MG, Goedert M (2013) Tau pathology and neurodegeneration. Lancet Neurol 12, 609-622.
-
(2013)
Lancet Neurol
, vol.12
, pp. 609-622
-
-
Spillantini, M.G.1
Goedert, M.2
-
75
-
-
33947536100
-
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
-
Planel E, Richter KE, Nolan CE, Finley JE, Liu L, Wen Y, Krishnamurthy P, Herman M, Wang L, Schachter JB, Nelson RB, Lau LF, Duff KE (2007) Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. J Neurosci 27, 3090-3097.
-
(2007)
J Neurosci
, vol.27
, pp. 3090-3097
-
-
Planel, E.1
Richter, K.E.2
Nolan, C.E.3
Finley, J.E.4
Liu, L.5
Wen, Y.6
Krishnamurthy, P.7
Herman, M.8
Wang, L.9
Schachter, J.B.10
Nelson, R.B.11
Lau, L.F.12
Duff, K.E.13
-
76
-
-
84919466585
-
Lost after translation: Missorting of Tau protein and consequences for Alzheimer disease
-
Zempel H, Mandelkow E (2014) Lost after translation: Missorting of Tau protein and consequences for Alzheimer disease. Trends Neurosci 37, 721-732.
-
(2014)
Trends Neurosci
, vol.37
, pp. 721-732
-
-
Zempel, H.1
Mandelkow, E.2
-
77
-
-
0040141570
-
Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
-
Maas T, Eidenmuller J, Brandt R (2000) Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J Biol Chem 275, 15733-15740.
-
(2000)
J Biol Chem
, vol.275
, pp. 15733-15740
-
-
Maas, T.1
Eidenmuller, J.2
Brandt, R.3
-
78
-
-
1842432582
-
MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain
-
Roger B, Al-Bassam J, Dehmelt L, Milligan RA, Halpain S (2004) MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain. Curr Biol 14, 363-371.
-
(2004)
Curr Biol
, vol.14
, pp. 363-371
-
-
Roger, B.1
Al-Bassam, J.2
Dehmelt, L.3
Milligan, R.A.4
Halpain, S.5
-
79
-
-
0025335664
-
The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP-2, is also involved in actin binding
-
Correas I, Padilla R, Avila J (1990) The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP-2, is also involved in actin binding. Biochem J 269, 61-64.
-
(1990)
Biochem J
, vol.269
, pp. 61-64
-
-
Correas, I.1
Padilla, R.2
Avila, J.3
-
80
-
-
84899474632
-
Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers
-
Frandemiche ML, De Seranno S, Rush T, Borel E, Elie A, Arnal I, Lante F, Buisson A (2014) Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers. J Neurosci 34, 6084-6097.
-
(2014)
J Neurosci
, vol.34
, pp. 6084-6097
-
-
Frandemiche, M.L.1
De Seranno, S.2
Rush, T.3
Borel, E.4
Elie, A.5
Arnal, I.6
Lante, F.7
Buisson, A.8
-
81
-
-
71049158071
-
The proline-rich domain of tau plays a role in interactions with actin
-
He HJ,Wang XS, Pan R,Wang DL, Liu MN, He RQ (2009) The proline-rich domain of tau plays a role in interactions with actin. BMC Cell Biol 10, 81.
-
(2009)
BMC Cell Biol
, vol.10
, pp. 81
-
-
He, H.J.1
Wang, X.S.2
Pan, R.3
Wang, D.L.4
Liu, M.N.5
He, R.Q.6
-
82
-
-
77955322042
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
-
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J,Wolfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Gotz J (2010) Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 142, 387-397.
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
Van Eersel, J.6
Wolfing, H.7
Chieng, B.C.8
Christie, M.J.9
Napier, I.A.10
Eckert, A.11
Staufenbiel, M.12
Hardeman, E.13
Gotz, J.14
-
83
-
-
84896919828
-
Amajor role forTau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions
-
Violet M, Delattre L, Tardivel M, Sultan A, Chauderlier A, Caillierez R, Talahari S, Nesslany F, Lefebvre B, Bonnefoy E, Buee L, GalasMC(2014)Amajor role forTau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions. Front Cell Neurosci 8, 84.
-
(2014)
Front Cell Neurosci
, vol.8
, pp. 84
-
-
Violet, M.1
Delattre, L.2
Tardivel, M.3
Sultan, A.4
Chauderlier, A.5
Caillierez, R.6
Talahari, S.7
Nesslany, F.8
Lefebvre, B.9
Bonnefoy, E.10
Buee, L.11
Galas, M.C.12
-
84
-
-
84876459364
-
Physiological release of endogenous tau is stimulated by neuronal activity
-
Pooler AM, Phillips EC, Lau DH, Noble W, Hanger DP (2013) Physiological release of endogenous tau is stimulated by neuronal activity. EMBO Rep 14, 389-394.
-
(2013)
EMBO Rep
, vol.14
, pp. 389-394
-
-
Pooler, A.M.1
Phillips, E.C.2
Lau, D.H.3
Noble, W.4
Hanger, D.P.5
-
85
-
-
84863689574
-
Lessons from tau-deficient mice
-
Ke YD, Suchowerska AK, van der Hoven J, De Silva DM, Wu CW, van Eersel J, Ittner A, Ittner LM (2012) Lessons from tau-deficient mice. Int J Alzheimers Dis 2012, 873270.
-
(2012)
Int J Alzheimers Dis
, vol.2012
, pp. 873270
-
-
Ke, Y.D.1
Suchowerska, A.K.2
Van Der Hoven, J.3
De Silva, D.M.4
Wu, C.W.5
Van Eersel, J.6
Ittner, A.7
Ittner, L.M.8
-
86
-
-
84937558461
-
Loss of tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila
-
Bolkan BJ, Kretzschmar D (2014) Loss of tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila. Dev Neurobiol 74, 1210-1225.
-
(2014)
Dev Neurobiol
, vol.74
, pp. 1210-1225
-
-
Bolkan, B.J.1
Kretzschmar, D.2
-
87
-
-
77950940279
-
Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein
-
Feuillette S, Miguel L, Frébourg T, Campion D, Lecourtois M (2010) Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein. J Neurochem 113, 895-903.
-
(2010)
J Neurochem
, vol.113
, pp. 895-903
-
-
Feuillette, S.1
Miguel, L.2
Frébourg, T.3
Campion, D.4
Lecourtois, M.5
-
88
-
-
0034814018
-
Identification and characterization of the Drosophila tau homolog
-
Heidary G, Fortini ME (2001) Identification and characterization of the Drosophila tau homolog. Mech Dev 108, 171-178.
-
(2001)
Mech Dev
, vol.108
, pp. 171-178
-
-
Heidary, G.1
Fortini, M.E.2
-
89
-
-
79953087890
-
The acetylation of tau inhibits its function and promotes pathological tau aggregation
-
Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ, Lee VM (2011) The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun 2, 252.
-
(2011)
Nat Commun
, vol.2
, pp. 252
-
-
Cohen, T.J.1
Guo, J.L.2
Hurtado, D.E.3
Kwong, L.K.4
Mills, I.P.5
Trojanowski, J.Q.6
Lee, V.M.7
-
90
-
-
0041827252
-
The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium
-
Doerflinger H, Benton R, Shulman JM, Johnston St, D (2003) The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium. Development 130, 3965-3975.
-
(2003)
Development
, vol.130
, pp. 3965-3975
-
-
Doerflinger, H.1
Benton, R.2
Shulman, J.M.3
Johnston St, D.4
-
91
-
-
84871759268
-
Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated A toxicity in Drosophila
-
Lee S, Wang JW, Yu W, Lu B (2012) Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated A toxicity in Drosophila. Nat Commun 3, 1312.
-
(2012)
Nat Commun
, vol.3
, pp. 1312
-
-
Lee, S.1
Wang, J.W.2
Yu, W.3
Lu, B.4
-
92
-
-
0035958642
-
Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles
-
Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M, Feany MB (2001) Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles. Science 293, 711-714.
-
(2001)
Science
, vol.293
, pp. 711-714
-
-
Wittmann, C.W.1
Wszolek, M.F.2
Shulman, J.M.3
Salvaterra, P.M.4
Lewis, J.5
Hutton, M.6
Feany, M.B.7
-
93
-
-
0037118247
-
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
-
Jackson GR, Wiedau-Pazos M, Sang TK, Wagle N, Brown CA, Massachi S, Geschwind DH (2002) Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 34, 509-519.
-
(2002)
Neuron
, vol.34
, pp. 509-519
-
-
Jackson, G.R.1
Wiedau-Pazos, M.2
Sang, T.K.3
Wagle, N.4
Brown, C.A.5
Massachi, S.6
Geschwind, D.H.7
-
94
-
-
84979083907
-
Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3
-
Povellato G, Tuxworth RI, Hanger DP, Tear G (2014) Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3. Biol Open 3, 1-11.
-
(2014)
Biol Open
, vol.3
, pp. 1-11
-
-
Povellato, G.1
Tuxworth, R.I.2
Hanger, D.P.3
Tear, G.4
-
95
-
-
1542358895
-
PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila
-
Nishimura I,YangY, LuB(2004) PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. Cell 116, 671-682.
-
(2004)
Cell
, vol.116
, pp. 671-682
-
-
Nishimura, I.1
Yang, Y.2
Lu, B.3
-
96
-
-
81855172495
-
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation
-
Ambegaokar SS, Jackson GR (2011) Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet 20, 4947-4977.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 4947-4977
-
-
Ambegaokar, S.S.1
Jackson, G.R.2
-
97
-
-
76749101192
-
High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation
-
Azorsa DO, Robeson RH, Frost D, Meec hoovet B, Brautigam GR, Dickey C, Beaudry C, Basu GD, Holz DR, Hernandez JA, Bisanz KM, Gwinn L, Grover A, Rogers J, Reiman EM, Hutton M, Stephan DA, Mousses S, Dunckley T (2010) High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. BMC Genomics 11, 25.
-
(2010)
BMC Genomics
, vol.11
, pp. 25
-
-
Azorsa, D.O.1
Robeson, R.H.2
Frost, D.3
Meec Hoovet, B.4
Brautigam, G.R.5
Dickey, C.6
Beaudry, C.7
Basu, G.D.8
Holz, D.R.9
Hernandez, J.A.10
Bisanz, K.M.11
Gwinn, L.12
Grover, A.13
Rogers, J.14
Reiman, E.M.15
Hutton, M.16
Stephan, D.A.17
Mousses, S.18
Dunckley, T.19
-
98
-
-
34248219026
-
S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila
-
Steinhilb ML, Dias-Santagata D, Mulkearns EE, Shulman JM, Biernat J, Mandelkow EM, Feany MB (2007) S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila. J Neurosci Res 85, 1271-1278.
-
(2007)
J Neurosci Res
, vol.85
, pp. 1271-1278
-
-
Steinhilb, M.L.1
Dias-Santagata, D.2
Mulkearns, E.E.3
Shulman, J.M.4
Biernat, J.5
Mandelkow, E.M.6
Feany, M.B.7
-
99
-
-
31944434543
-
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model
-
Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB (2006) TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol 16, 230-241.
-
(2006)
Curr Biol
, vol.16
, pp. 230-241
-
-
Khurana, V.1
Lu, Y.2
Steinhilb, M.L.3
Oldham, S.4
Shulman, J.M.5
Feany, M.B.6
-
100
-
-
80052696800
-
Important neuronal toxicity of microtubule-bound Tau in vivo in Drosophila
-
Talmat-Amar Y, Arribat Y, Redt-Clouet C, Feuillette S, Bouge AL, Lecourtois M, Parmentier ML (2011) Important neuronal toxicity of microtubule-bound Tau in vivo in Drosophila. Hum Mol Genet 20, 3738-3745.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 3738-3745
-
-
Talmat-Amar, Y.1
Arribat, Y.2
Redt-Clouet, C.3
Feuillette, S.4
Bouge, A.L.5
Lecourtois, M.6
Parmentier, M.L.7
-
101
-
-
77955951998
-
Phosphorylation differentiates taudependent neuronal toxicity and dysfunction
-
Papanikolopoulou K, Kosmidis S, Grammenoudi S, Skoulakis EM (2010) Phosphorylation differentiates taudependent neuronal toxicity and dysfunction. Biochem Soc Trans 38, 981-987.
-
(2010)
Biochem Soc Trans
, vol.38
, pp. 981-987
-
-
Papanikolopoulou, K.1
Kosmidis, S.2
Grammenoudi, S.3
Skoulakis, E.M.4
-
102
-
-
29444442794
-
APP locus duplication causes autosomal dominant earlyonset Alzheimer disease with cerebral amyloid angiopathy
-
Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerriere A, Vital A, Dumanchin C, Feuillette S, Brice A, Vercelletto M, Dubas F, Frebourg T, Campion D (2006) APP locus duplication causes autosomal dominant earlyonset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38, 24-26.
-
(2006)
Nat Genet
, vol.38
, pp. 24-26
-
-
Rovelet-Lecrux, A.1
Hannequin, D.2
Raux, G.3
Le Meur, N.4
Laquerriere, A.5
Vital, A.6
Dumanchin, C.7
Feuillette, S.8
Brice, A.9
Vercelletto, M.10
Dubas, F.11
Frebourg, T.12
Campion, D.13
-
103
-
-
33749620072
-
A Drosophila model of Alzheimer's disease
-
Crowther DC, Page R, Chandraratna D, LomasDA(2006)A Drosophila model of Alzheimer's disease. Methods Enzymol 412, 234-255.
-
(2006)
Methods Enzymol
, vol.412
, pp. 234-255
-
-
Crowther, D.C.1
Page, R.2
Chandraratna, D.3
Lomas, D.A.4
-
104
-
-
58149380019
-
Drosophila models of Alzheimer's amyloidosis: The challenge of dissecting the complex mechanisms of toxicity of amyloid-beta 42
-
Iijima K, Iijima-Ando K (2008) Drosophila models of Alzheimer's amyloidosis: The challenge of dissecting the complex mechanisms of toxicity of amyloid-beta 42. J Alzheimers Dis 15, 523-540.
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 523-540
-
-
Iijima, K.1
Iijima-Ando, K.2
-
105
-
-
84887869663
-
Drosophila melanogaster as a model organism for Alzheimer's disease
-
Prussing K, Voigt A, Schulz JB (2013) Drosophila melanogaster as a model organism for Alzheimer's disease. Mol Neurodegener 8, 35.
-
(2013)
Mol Neurodegener
, vol.8
, pp. 35
-
-
Prussing, K.1
Voigt, A.2
Schulz, J.B.3
-
106
-
-
34047106848
-
Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila
-
Blard O, Feuillette S, Bou J, Chaumette B, Frebourg T, Campion D, Lecourtois M (2007) Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila. Hum Mol Genet 16, 555-566.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 555-566
-
-
Blard, O.1
Feuillette, S.2
Bou, J.3
Chaumette, B.4
Frebourg, T.5
Campion, D.6
Lecourtois, M.7
-
107
-
-
0346361872
-
Genetic modifiers of tauopathy in Drosophila
-
Shulman JM, FeanyMB(2003) Genetic modifiers of tauopathy in Drosophila. Genetics 165, 1233-1242.
-
(2003)
Genetics
, vol.165
, pp. 1233-1242
-
-
Shulman, J.M.1
Feany, M.B.2
-
108
-
-
45149093564
-
Identification of novel genes that modify phenotypes induced by Alzheimer's amyloid-beta overexpression in Drosophila
-
CaoW, Song HJ, Gangi T,Kelkar A, Antani I, Garza D,Konsolaki M (2008) Identification of novel genes that modify phenotypes induced by Alzheimer's amyloid-beta overexpression in Drosophila. Genetics 178, 1457-1471.
-
(2008)
Genetics
, vol.178
, pp. 1457-1471
-
-
Cao, W.1
Song, H.J.2
Gangi, T.3
Kelkar, A.4
Antani, I.5
Garza, D.6
Konsolaki, M.7
-
109
-
-
64049096553
-
Fenton chemistry and oxidative stress mediate the toxicity of the amyloid-beta peptide in a Drosophila model of Alzheimer's disease
-
Rival T, Page RM, Chandraratna DS, Sendall TJ, Ryder E, Liu B, Lewis H, Rosahl T, Hider R, Camargo LM, Shearman MS, Crowther DC, LomasDA(2009) Fenton chemistry and oxidative stress mediate the toxicity of the amyloid-beta peptide in a Drosophila model of Alzheimer's disease. Eur J Neurosci 29, 1335-1347.
-
(2009)
Eur J Neurosci
, vol.29
, pp. 1335-1347
-
-
Rival, T.1
Page, R.M.2
Chandraratna, D.S.3
Sendall, T.J.4
Ryder, E.5
Liu, B.6
Lewis, H.7
Rosahl, T.8
Hider, R.9
Camargo, L.M.10
Shearman, M.S.11
Crowther, D.C.12
Lomas, D.A.13
-
110
-
-
66149108459
-
Identifying genes that interact with Drosophila presenilin and amyloid-beta protein precursor
-
van de Hoef DL, Hughes J, Livne-Bar I, Garza D, Konsolaki M, Boulianne GL (2009) Identifying genes that interact with Drosophila presenilin and amyloid-beta protein precursor. Genesis 47, 246-260.
-
(2009)
Genesis
, vol.47
, pp. 246-260
-
-
Van De Hoef, D.L.1
Hughes, J.2
Livne-Bar, I.3
Garza, D.4
Konsolaki, M.5
Boulianne, G.L.6
-
111
-
-
5744248243
-
Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases
-
Ghosh S, Feany MB (2004) Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. Hum Mol Genet 13, 2011-2018.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 2011-2018
-
-
Ghosh, S.1
Feany, M.B.2
-
112
-
-
70350455072
-
Axonal transport defects in neurodegenerative diseases
-
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST (2009) Axonal transport defects in neurodegenerative diseases. J Neurosci 29, 12776-12786.
-
(2009)
J Neurosci
, vol.29
, pp. 12776-12786
-
-
Morfini, G.A.1
Burns, M.2
Binder, L.I.3
Kanaan, N.M.4
Lapointe, N.5
Bosco, D.A.6
Brown, R.H.7
Brown, H.8
Tiwari, A.9
Hayward, L.10
Edgar, J.11
Nave, K.A.12
Garberrn, J.13
Atagi, Y.14
Song, Y.15
Pigino, G.16
Brady, S.T.17
-
113
-
-
0033529031
-
Neuronal overexpression of APPL, the Drosophila homologue of the amyloid-beta protein precursor (APP), disrupts axonal transport
-
Torroja L, Chu H, Kotovsky I, White K (1999) Neuronal overexpression of APPL, the Drosophila homologue of the amyloid-beta protein precursor (APP), disrupts axonal transport. Curr Biol 9, 489-492.
-
(1999)
Curr Biol
, vol.9
, pp. 489-492
-
-
Torroja, L.1
Chu, H.2
Kotovsky, I.3
White, K.4
-
114
-
-
0035829720
-
Disruption of axonal transport and neuronal viability by amyloid-beta protein precursor mutations in Drosophila
-
Gunawardena S, Goldstein LSB (2001) Disruption of axonal transport and neuronal viability by amyloid-beta protein precursor mutations in Drosophila. Neuron 32, 389-401.
-
(2001)
Neuron
, vol.32
, pp. 389-401
-
-
Gunawardena, S.1
Goldstein, L.S.B.2
-
115
-
-
54949151536
-
Amyloid-beta protein precursor-induced axonopathies are independent of amyloid-beta peptides
-
Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS (2008) Amyloid-beta protein precursor-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet 17, 3474-3486.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 3474-3486
-
-
Stokin, G.B.1
Almenar-Queralt, A.2
Gunawardena, S.3
Rodrigues, E.M.4
Falzone, T.5
Kim, J.6
Lillo, C.7
Mount, S.L.8
Roberts, E.A.9
McGowan, E.10
Williams, D.S.11
Goldstein, L.S.12
-
116
-
-
28444496758
-
APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila
-
Horiuchi D, Barkus RV, Pilling AD, Gassman A, Saxton WM (2005) APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila. Curr Biol 15, 2137-2141.
-
(2005)
Curr Biol
, vol.15
, pp. 2137-2141
-
-
Horiuchi, D.1
Barkus, R.V.2
Pilling, A.D.3
Gassman, A.4
Saxton, W.M.5
-
117
-
-
34547473554
-
Control of a kinesin-cargo linkage mechanism by JNK pathway kinases
-
Horiuchi D, Collins CA, Bhat P, Barkus RV, Diantonio A, Saxton WM (2007) Control of a kinesin-cargo linkage mechanism by JNK pathway kinases. Curr Biol 17, 1313-1317.
-
(2007)
Curr Biol
, vol.17
, pp. 1313-1317
-
-
Horiuchi, D.1
Collins, C.A.2
Bhat, P.3
Barkus, R.V.4
Diantonio, A.5
Saxton, W.M.6
-
118
-
-
84884680215
-
Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3beta signaling
-
Shaw JL, Chang KT (2013) Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3beta signaling. PLoS Genet 9, e1003792.
-
(2013)
PLoS Genet
, vol.9
-
-
Shaw, J.L.1
Chang, K.T.2
-
119
-
-
32544447773
-
Overexpression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
-
Chee F, Mudher A, Newman TA, Cuttle M, Lovestone S, Shepherd D (2006) Overexpression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Biochem Soc Trans 34, 88-90.
-
(2006)
Biochem Soc Trans
, vol.34
, pp. 88-90
-
-
Chee, F.1
Mudher, A.2
Newman, T.A.3
Cuttle, M.4
Lovestone, S.5
Shepherd, D.6
-
120
-
-
77952549902
-
Abeta exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease
-
Folwell J, Cowan CM, Ubhi KK, Shiabh H, Newman TA, Shepherd D, Mudher A (2010) Abeta exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease. Exp Neurol 223, 401-409.
-
(2010)
Exp Neurol
, vol.223
, pp. 401-409
-
-
Folwell, J.1
Cowan, C.M.2
Ubhi, K.K.3
Shiabh, H.4
Newman, T.A.5
Shepherd, D.6
Mudher, A.7
-
121
-
-
84877272372
-
X11/Mint genes control polarized localization of axonal membrane proteins in vivo
-
Gross GG, Lone GM, Leung LK, Hartenstein V, Guo M (2013) X11/Mint genes control polarized localization of axonal membrane proteins in vivo. J Neurosci 33, 8575-8586.
-
(2013)
J Neurosci
, vol.33
, pp. 8575-8586
-
-
Gross, G.G.1
Lone, G.M.2
Leung, L.K.3
Hartenstein, V.4
Guo, M.5
-
122
-
-
0035875072
-
Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol
-
ChengY, Endo K,Wu K, Rodan AR, Heberlein U, Davis RL (2001) Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol. Cell 105, 757-768.
-
(2001)
Cell
, vol.105
, pp. 757-768
-
-
Cheng, Y.1
Endo, K.2
Wu, K.3
Rodan, A.R.4
Heberlein, U.5
Davis, R.L.6
-
123
-
-
84895923250
-
The Wnt/planar cell polarity pathway component Vangl2 induces synapse formation through direct control of Ncadherin
-
Nagaoka T, Ohashi R, Inutsuka A, Sakai S, Fujisawa N, Yokoyama M, Huang YH, Igarashi M, Kishi M (2014) The Wnt/planar cell polarity pathway component Vangl2 induces synapse formation through direct control of Ncadherin. Cell Rep 6, 916-927.
-
(2014)
Cell Rep
, vol.6
, pp. 916-927
-
-
Nagaoka, T.1
Ohashi, R.2
Inutsuka, A.3
Sakai, S.4
Fujisawa, N.5
Yokoyama, M.6
Huang, Y.H.7
Igarashi, M.8
Kishi, M.9
-
124
-
-
34548317186
-
A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies
-
Ubhi KK, Shaibah H, Newman TA, Shepherd D, Mudher A (2007) A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies. Invert Neurosci 7, 165-171.
-
(2007)
Invert Neurosci
, vol.7
, pp. 165-171
-
-
Ubhi, K.K.1
Shaibah, H.2
Newman, T.A.3
Shepherd, D.4
Mudher, A.5
-
125
-
-
84872760710
-
Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's disease
-
Huang JK, Ma PL, Ji SY, Zhao XL, Tan JX, Sun XJ, Huang FD (2013) Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's disease. Neurobiol Dis 51, 161-167.
-
(2013)
Neurobiol Dis
, vol.51
, pp. 161-167
-
-
Huang, J.K.1
Ma, P.L.2
Ji, S.Y.3
Zhao, X.L.4
Tan, J.X.5
Sun, X.J.6
Huang, F.D.7
-
126
-
-
77957340852
-
Phosphorylation alters tau distribution and elongates life span in Drosophila
-
Yeh PA, Chang CJ, Tu PH, Wilson HI, Chien JY, Tang CY, Su MT (2010) Phosphorylation alters tau distribution and elongates life span in Drosophila. J Alzheimers Dis 21, 543-556.
-
(2010)
J Alzheimers Dis
, vol.21
, pp. 543-556
-
-
Yeh, P.A.1
Chang, C.J.2
Tu, P.H.3
Wilson, H.I.4
Chien, J.Y.5
Tang, C.Y.6
Su, M.T.7
-
127
-
-
33947286683
-
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
-
Fulga TA, Elson-Schwab I, KhuranaV, Steinhilb ML, Spires TL, Hyman BT, Feany MB (2007) Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nat Cell Biol 9, 139-148.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 139-148
-
-
Fulga, T.A.1
Elson-Schwab, I.2
Khurana, V.3
Steinhilb, M.L.4
Spires, T.L.5
Hyman, B.T.6
Feany, M.B.7
-
128
-
-
84865352799
-
Tau promotes neurodegeneration via DRP1 mislocalization in vivo
-
DuBoff B, Gotz J, Feany MB (2012) Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron 75, 618-632.
-
(2012)
Neuron
, vol.75
, pp. 618-632
-
-
Duboff, B.1
Gotz, J.2
Feany, M.B.3
-
129
-
-
77955516967
-
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains
-
Feuillette S, Deramecourt V, Laquerriere A, Duyckaerts C, Delisle MB, Maurage CA, Blum D, Buee L, Frebourg T, Campion D, LecourtoisM(2010) Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains. Brain Res 1345, 182-189.
-
(2010)
Brain Res
, vol.1345
, pp. 182-189
-
-
Feuillette, S.1
Deramecourt, V.2
Laquerriere, A.3
Duyckaerts, C.4
Delisle, M.B.5
Maurage, C.A.6
Blum, D.7
Buee, L.8
Frebourg, T.9
Campion, D.10
Lecourtois, M.11
-
130
-
-
84876554957
-
Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model
-
Johnson AA, Sarthi J, Pirooznia SK, Reube W, Elefant F (2013) Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model. J Neurosci 33, 7535-7547.
-
(2013)
J Neurosci
, vol.33
, pp. 7535-7547
-
-
Johnson, A.A.1
Sarthi, J.2
Pirooznia, S.K.3
Reube, W.4
Elefant, F.5
-
131
-
-
33947177730
-
Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity
-
Arendt T, Bruckner MK (2007) Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity. Biochim Biophys Acta 1772, 413-421.
-
(2007)
Biochim Biophys Acta
, vol.1772
, pp. 413-421
-
-
Arendt, T.1
Bruckner, M.K.2
-
132
-
-
77953427229
-
The involvement of cell cycle events in the pathogenesis of Alzheimer's disease
-
Herrup K (2010) The involvement of cell cycle events in the pathogenesis of Alzheimer's disease. Alzheimers Res Ther 2, 13.
-
(2010)
Alzheimers Res Ther
, vol.2
, pp. 13
-
-
Herrup, K.1
-
133
-
-
84860862964
-
The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease
-
HerrupK(2012) The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer's disease. Front Biosci (Elite Ed) 4, 2101-2109.
-
(2012)
Front Biosci (Elite Ed)
, vol.4
, pp. 2101-2109
-
-
Herrup, K.1
-
134
-
-
60649083945
-
Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease
-
Lee HG, Casadesus G, Zhu X, Castellani RJ, McShea A, Perry G, Petersen RB, Bajic V, Smith MA (2009) Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease. Neurochem Int 54, 84-88.
-
(2009)
Neurochem Int
, vol.54
, pp. 84-88
-
-
Lee, H.G.1
Casadesus, G.2
Zhu, X.3
Castellani, R.J.4
McShea, A.5
Perry, G.6
Petersen, R.B.7
Bajic, V.8
Smith, M.A.9
-
135
-
-
77954568360
-
Selective cell death of hyperploid neurons in Alzheimer's disease
-
Arendt T, Bruckner MK, Mosch B, Losche A (2010) Selective cell death of hyperploid neurons in Alzheimer's disease. Am J Pathol 177, 15-20.
-
(2010)
Am J Pathol
, vol.177
, pp. 15-20
-
-
Arendt, T.1
Bruckner, M.K.2
Mosch, B.3
Losche, A.4
-
136
-
-
32544459388
-
Ectopic cell cycle events link human Alzheimer's disease and amyloidbeta protein precursor transgenic mouse models
-
Yang Y, Varvel NH, Lamb BT, Herrup K (2006) Ectopic cell cycle events link human Alzheimer's disease and amyloidbeta protein precursor transgenic mouse models. J Neurosci 26, 775-784.
-
(2006)
J Neurosci
, vol.26
, pp. 775-784
-
-
Yang, Y.1
Varvel, N.H.2
Lamb, B.T.3
Herrup, K.4
-
137
-
-
84877879701
-
Amyloid-beta signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease
-
Seward ME, Swanson E, Norambuena A, Reimann A, Cochran JN, Li R, Roberson ED, Bloom GS (2013) Amyloid-beta signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease. J Cell Sci 126, 1278-1286.
-
(2013)
J Cell Sci
, vol.126
, pp. 1278-1286
-
-
Seward, M.E.1
Swanson, E.2
Norambuena, A.3
Reimann, A.4
Cochran, J.N.5
Li, R.6
Roberson, E.D.7
Bloom, G.S.8
-
138
-
-
77957254409
-
Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease
-
Iijima K, Gatt A, Iijima-Ando K (2010) Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. Hum Mol Genet 19, 2947-2957.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 2947-2957
-
-
Iijima, K.1
Gatt, A.2
Iijima-Ando, K.3
-
139
-
-
84896719812
-
Tau promotes neurodegeneration through global chromatin relaxation
-
Frost B, Hemberg M, Lewis J, Feany MB (2014) Tau promotes neurodegeneration through global chromatin relaxation. Nat Neurosci 17, 357-366.
-
(2014)
Nat Neurosci
, vol.17
, pp. 357-366
-
-
Frost, B.1
Hemberg, M.2
Lewis, J.3
Feany, M.B.4
-
140
-
-
77952482205
-
ADNAdamage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration
-
Iijima-Ando K, Zhao L, Gatt A, Shenton C, Iijima K (2010) ADNAdamage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration. Hum Mol Genet 19, 1930-1938.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 1930-1938
-
-
Iijima-Ando, K.1
Zhao, L.2
Gatt, A.3
Shenton, C.4
Iijima, K.5
-
141
-
-
33846080531
-
Oxidative stress mediates tau-induced neurodegeneration in Drosophila
-
Dias-Santagata D, Fulga TA, Duttaroy A, FeanyMB (2007) Oxidative stress mediates tau-induced neurodegeneration in Drosophila. J Clin Invest 117, 236-245.
-
(2007)
J Clin Invest
, vol.117
, pp. 236-245
-
-
Dias-Santagata, D.1
Fulga, T.A.2
Duttaroy, A.3
Feany, M.B.4
-
142
-
-
81455157378
-
Mitochondrial dysfunction - The beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-beta toxicity
-
Eckert A, Schmitt K, Gotz J (2011) Mitochondrial dysfunction-the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-beta toxicity. Alzheimers Res Ther 3, 15.
-
(2011)
Alzheimers Res Ther
, vol.3
, pp. 15
-
-
Eckert, A.1
Schmitt, K.2
Gotz, J.3
-
143
-
-
33745310123
-
Surgical morbidity associated with radical trachelectomy and radical hysterectomy
-
Alexander-Sefre F, Chee N, Spencer C, Menon U, Shepherd JH (2006) Surgical morbidity associated with radical trachelectomy and radical hysterectomy. Gynecol Oncol 101, 450-454.
-
(2006)
Gynecol Oncol
, vol.101
, pp. 450-454
-
-
Alexander-Sefre, F.1
Chee, N.2
Spencer, C.3
Menon, U.4
Shepherd, J.H.5
-
144
-
-
84866150232
-
Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1
-
Iijima-Ando K, Sekiya M, Maruko-Otake A, Ohtake Y, Suzuki E, Lu B, Iijima KM (2012) Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. PLoS Genet 8, e1002918.
-
(2012)
PLoS Genet
, vol.8
-
-
Iijima-Ando, K.1
Sekiya, M.2
Maruko-Otake, A.3
Ohtake, Y.4
Suzuki, E.5
Lu, B.6
Iijima, K.M.7
-
145
-
-
84881555354
-
Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Abeta42-induced Alzheimer's disease-like symptoms
-
Lang M, Fan Q, Wang L, Zheng Y, Xiao G, Wang X, Wang W, Zhong Y, Zhou B (2013) Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Abeta42-induced Alzheimer's disease-like symptoms. Neurobiol Aging 34, 2604-2612.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 2604-2612
-
-
Lang, M.1
Fan, Q.2
Wang, L.3
Zheng, Y.4
Xiao, G.5
Wang, X.6
Wang, W.7
Zhong, Y.8
Zhou, B.9
-
146
-
-
84860549387
-
Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates abeta pathology in a Drosophila model of Alzheimer's disease
-
Lang M, Wang L, Fan Q, Xiao G, Wang X, Zhong Y, Zhou B (2012) Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates abeta pathology in a Drosophila model of Alzheimer's disease. PLoS Genet 8, e1002683.
-
(2012)
PLoS Genet
, vol.8
-
-
Lang, M.1
Wang, L.2
Fan, Q.3
Xiao, G.4
Wang, X.5
Zhong, Y.6
Zhou, B.7
-
147
-
-
84863750775
-
Ageing increases vulnerability to abeta42 toxicity in Drosophila
-
Rogers I,Kerr F, Martinez P, Hardy J, Lovestone S, Partridge L (2012) Ageing increases vulnerability to abeta42 toxicity in Drosophila. PLoS One 7, e40569.
-
(2012)
PLoS One
, vol.7
-
-
Rogers, I.1
Kerr, F.2
Martinez, P.3
Hardy, J.4
Lovestone, S.5
Partridge, L.6
-
148
-
-
80052641987
-
Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease
-
Kerr F, Augustin H, Piper MD, Gandy C, Allen MJ, Lovestone S, Partridge L (2011) Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease. Neurobiol Aging 32, 1977-1989.
-
(2011)
Neurobiol Aging
, vol.32
, pp. 1977-1989
-
-
Kerr, F.1
Augustin, H.2
Piper, M.D.3
Gandy, C.4
Allen, M.J.5
Lovestone, S.6
Partridge, L.7
-
149
-
-
33745512110
-
Specific age-related signatures in Drosophila body parts transcriptome
-
Girardot F, Lasbleiz C, Monnier V, Tricoire H (2006) Specific age-related signatures in Drosophila body parts transcriptome. BMC Genomics 7, 69.
-
(2006)
BMC Genomics
, vol.7
, pp. 69
-
-
Girardot, F.1
Lasbleiz, C.2
Monnier, V.3
Tricoire, H.4
-
150
-
-
58049196869
-
The Toll - >NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila
-
Tan L, Schedl P, Song HJ, Garza D, Konsolaki M (2008) The Toll - >NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila. PLoS One 3, e3966.
-
(2008)
PLoS One
, vol.3
, pp. e3966
-
-
Tan, L.1
Schedl, P.2
Song, H.J.3
Garza, D.4
Konsolaki, M.5
-
151
-
-
84858264276
-
ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila
-
Petersen AJ, Rimkus SA, Wassarman DA (2012) ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila. Proc Natl Acad Sci U S A 109, E656-E664.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. E656-E664
-
-
Petersen, A.J.1
Rimkus, S.A.2
Wassarman, D.A.3
-
152
-
-
84879232559
-
Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission
-
Mohamed NV, Herrou T, Plouffe V, Piperno N, Leclerc N (2013) Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission. Eur J Neurosci 37, 1939-1948.
-
(2013)
Eur J Neurosci
, vol.37
, pp. 1939-1948
-
-
Mohamed, N.V.1
Herrou, T.2
Plouffe, V.3
Piperno, N.4
Leclerc, N.5
-
153
-
-
84888306100
-
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
-
Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen KV, Geller F, Sottejeau Y, Harold D, Dourlen P, Grenier-Boley B, Kamatani Y, Delepine B, Demiautte F, Zelenika D, Zommer N, Hamdane M, Bellenguez C, Dartigues JF, Hauw JJ, Letronne F, Ayral AM, Sleegers K, Schellens A, Broeck LV, Engelborghs S, De Deyn PP, Vandenberghe R, O'Donovan M, Owen M, Epelbaum J, Mercken M, Karran E, Bantscheff M, Drewes G, Joberty G, Campion D, Octave JN, Berr C, Lathrop M, Callaerts P, Mann D, Williams J, Buee L, Dewachter I, Van Broeckhoven C, Amouyel P, Moechars D, Dermaut B, Lambert JC (2013) Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry 18, 1225-1234.
-
(2013)
Mol Psychiatry
, vol.18
, pp. 1225-1234
-
-
Chapuis, J.1
Hansmannel, F.2
Gistelinck, M.3
Mounier, A.4
Van Cauwenberghe, C.5
Kolen, K.V.6
Geller, F.7
Sottejeau, Y.8
Harold, D.9
Dourlen, P.10
Grenier-Boley, B.11
Kamatani, Y.12
Delepine, B.13
Demiautte, F.14
Zelenika, D.15
Zommer, N.16
Hamdane, M.17
Bellenguez, C.18
Dartigues, J.F.19
Hauw, J.J.20
Letronne, F.21
Ayral, A.M.22
Sleegers, K.23
Schellens, A.24
Broeck, L.V.25
Engelborghs, S.26
De Deyn, P.P.27
Vandenberghe, R.28
O'donovan, M.29
Owen, M.30
Epelbaum, J.31
Mercken, M.32
Karran, E.33
Bantscheff, M.34
Drewes, G.35
Joberty, G.36
Campion, D.37
Octave, J.N.38
Berr, C.39
Lathrop, M.40
Callaerts, P.41
Mann, D.42
Williams, J.43
Buee, L.44
Dewachter, I.45
Van Broeckhoven, C.46
Amouyel, P.47
Moechars, D.48
Dermaut, B.49
Lambert, J.C.50
more..
-
154
-
-
84892971323
-
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms
-
Shulman JM, Imboywa S, Giagtzoglou N, Powers MP, Hu Y, Devenport D, Chipendo P, Chibnik LB, Diamond A, Perrimon N, Brown NH, De Jager PL, Feany MB (2014) Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet 23, 870-877.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 870-877
-
-
Shulman, J.M.1
Imboywa, S.2
Giagtzoglou, N.3
Powers, M.P.4
Hu, Y.5
Devenport, D.6
Chipendo, P.7
Chibnik, L.B.8
Diamond, A.9
Perrimon, N.10
Brown, N.H.11
De Jager, P.L.12
Feany, M.B.13
-
155
-
-
84869016210
-
Anovel inhibitor of amyloid beta (Abeta) peptide aggregation: From high throughput screening to efficacy in an animal model of Alzheimer disease
-
McKoy AF, Chen J, Schupbach T, HechtMH(2012)Anovel inhibitor of amyloid beta (Abeta) peptide aggregation: From high throughput screening to efficacy in an animal model of Alzheimer disease. J Biol Chem 287, 38992-39000.
-
(2012)
J Biol Chem
, vol.287
, pp. 38992-39000
-
-
McKoy, A.F.1
Chen, J.2
Schupbach, T.3
Hecht, M.H.4
-
156
-
-
78049427560
-
Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset drosophila model of Alzheimer's disease
-
Sofola O, Kerr F, Rogers I, Killick R, Augustin H, Gandy C, Allen MJ, Hardy J, Lovestone S, Partridge L (2010) Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset drosophila model of Alzheimer's disease. PLoS Genet 6, e1001087.
-
(2010)
PLoS Genet
, vol.6
-
-
Sofola, O.1
Kerr, F.2
Rogers, I.3
Killick, R.4
Augustin, H.5
Gandy, C.6
Allen, M.J.7
Hardy, J.8
Lovestone, S.9
Partridge, L.10
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