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Volumn 240, Issue 9, 2015, Pages 1183-1196

Thyroid hormone alleviates demyelination induced by cuprizone through its role in remyelination during the remission period

Author keywords

Corpus callosum; Multiple sclerosis; Myelin; Oligodendrocyte; Thyroid hormone

Indexed keywords

CUPRIZONE; LIOTHYRONINE; MYELIN BASIC PROTEIN; PROPYLTHIOURACIL; THYROID HORMONE;

EID: 84960446833     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370214565975     Document Type: Article
Times cited : (37)

References (68)
  • 2
    • 0032576636 scopus 로고    scopus 로고
    • Demyelinating diseases—new pathological insights, new therapeutic targets
    • Waxman SG. Demyelinating diseases—new pathological insights, new therapeutic targets. N Engl J Med 1998;338:323–5
    • (1998) N Engl J Med , vol.338 , pp. 323-325
    • Waxman, S.G.1
  • 3
    • 0032145489 scopus 로고    scopus 로고
    • Axon loss in multiple sclerosis
    • Scolding N, Franklin R. Axon loss in multiple sclerosis. Lancet 1998;352:340–1
    • (1998) Lancet , vol.352 , pp. 340-341
    • Scolding, N.1    Franklin, R.2
  • 4
    • 0034449943 scopus 로고    scopus 로고
    • Multiple sclerosis: Epidemiology, genetics, classification, natural history, and clinical outcome measures
    • Wingerchuk DM, Weinshenker BG. Multiple sclerosis: epidemiology, genetics, classification, natural history, and clinical outcome measures. Neuroimaging Clin N Am 2000;10:611–24, vii
    • (2000) Neuroimaging Clin N Am , vol.10 , pp. 611-624
    • Wingerchuk, D.M.1    Weinshenker, B.G.2
  • 5
    • 84977951226 scopus 로고    scopus 로고
    • Natural history of MS symptoms: Perceived disease impact across disease span in nine neurologic domains among enrollees in North American Research Committee on Multiple Sclerosis (NARCOMS) Registry
    • Kister I, Chamot E, Salter A, Cutter G, Bacon T, Kalina J, Herbert J. Natural history of MS symptoms: perceived disease impact across disease span in nine neurologic domains among enrollees in North American Research Committee on Multiple Sclerosis (NARCOMS) Registry. Neurology 2012;78:19–27
    • (2012) Neurology , vol.78 , pp. 19-27
    • Kister, I.1    Chamot, E.2    Salter, A.3    Cutter, G.4    Bacon, T.5    Kalina, J.6    Herbert, J.7
  • 6
    • 77949541595 scopus 로고    scopus 로고
    • Natural history of multiple sclerosis
    • Vukusic S, Confavreux C. Natural history of multiple sclerosis. Presse Med 2010;39:359–62
    • (2010) Presse Med , vol.39 , pp. 359-362
    • Vukusic, S.1    Confavreux, C.2
  • 7
    • 12344279024 scopus 로고    scopus 로고
    • Natural history of multiple sclerosis
    • Kantarci OH, Weinshenker BG. Natural history of multiple sclerosis. Neurol Clin 2005;23:17–38
    • (2005) Neurol Clin , vol.23 , pp. 17-38
    • Kantarci, O.H.1    Weinshenker, B.G.2
  • 8
    • 43549113832 scopus 로고    scopus 로고
    • Natural history of secondaryprogressive multiple sclerosis
    • Tremlett H, Zhao Y, Devonshire V. Natural history of secondaryprogressive multiple sclerosis. Multiple Sclerosis 2008;14:314–24
    • (2008) Multiple Sclerosis , vol.14 , pp. 314-324
    • Tremlett, H.1    Zhao, Y.2    Devonshire, V.3
  • 9
    • 73349133703 scopus 로고    scopus 로고
    • The natural history of primary progressive multiple sclerosis
    • Koch M, Kingwell E, Rieckmann P, Tremlett H. The natural history of primary progressive multiple sclerosis. Neurology 2009;73:1996–2002
    • (2009) Neurology , vol.73 , pp. 1996-2002
    • Koch, M.1    Kingwell, E.2    Rieckmann, P.3    Tremlett, H.4
  • 11
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: An overview
    • Lassmann H, Bruck W, Lucchinetti CF. The immunopathology of multiple sclerosis: an overview. Brain Pathol 2007;17:210–8
    • (2007) Brain Pathol , vol.17 , pp. 210-218
    • Lassmann, H.1    Bruck, W.2    Lucchinetti, C.F.3
  • 12
    • 0037122960 scopus 로고    scopus 로고
    • Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    • Chang A, Tourtellotte WW, Rudick R, Trapp BD. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med 2002;346:165–73
    • (2002) N Engl J Med , vol.346 , pp. 165-173
    • Chang, A.1    Tourtellotte, W.W.2    Rudick, R.3    Trapp, B.D.4
  • 14
    • 84906791093 scopus 로고    scopus 로고
    • Mechanisms regulating the development of oligodendrocytes and central nervous system myelin
    • Mitew S, Hay CM, Peckham H, Xiao J, Koenning M, Emery B. Mechanisms regulating the development of oligodendrocytes and central nervous system myelin. Neuroscience 2014;276:29–47
    • (2014) Neuroscience , vol.276 , pp. 29-47
    • Mitew, S.1    Hay, C.M.2    Peckham, H.3    Xiao, J.4    Koenning, M.5    Emery, B.6
  • 15
    • 65349103656 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of iodothyronines and nerve growth factor in patients with multiple sclerosis and neuromyelitis optica
    • Jiang Y, Yang Y, Zhang B, Peng F, Bao J, Hu X. Cerebrospinal fluid levels of iodothyronines and nerve growth factor in patients with multiple sclerosis and neuromyelitis optica. Neuro Endocrinol Lett 2009;30:85–90
    • (2009) Neuro Endocrinol Lett , vol.30 , pp. 85-90
    • Jiang, Y.1    Yang, Y.2    Zhang, B.3    Peng, F.4    Bao, J.5    Hu, X.6
  • 16
    • 0033957316 scopus 로고    scopus 로고
    • A cell-intrinsic timer that operates during oligodendrocyte development
    • Durand B, Raff M. A cell-intrinsic timer that operates during oligodendrocyte development. Bioessays 2000;22:64–71
    • (2000) Bioessays , vol.22 , pp. 64-71
    • Durand, B.1    Raff, M.2
  • 17
    • 0035903457 scopus 로고    scopus 로고
    • Two molecularly distinct intracellular pathways to oligodendrocyte differentiation: Role of a p53 family protein
    • Tokumoto YM, Tang DG, Raff MC. Two molecularly distinct intracellular pathways to oligodendrocyte differentiation: role of a p53 family protein. EMBO J 2001;20:5261–8
    • (2001) EMBO J , vol.20 , pp. 5261-5268
    • Tokumoto, Y.M.1    Tang, D.G.2    Raff, M.C.3
  • 19
    • 0032721901 scopus 로고    scopus 로고
    • From neural stem cells to myelinating oligodendrocytes
    • Rogister B, Ben-Hur T, Dubois-Dalcq M. From neural stem cells to myelinating oligodendrocytes. Mol Cell Neurosci 1999;14:287–300
    • (1999) Mol Cell Neurosci , vol.14 , pp. 287-300
    • Rogister, B.1    Ben-Hur, T.2    Dubois-Dalcq, M.3
  • 20
    • 79951679138 scopus 로고    scopus 로고
    • Transdifferentiation of tadpole pancreatic acinar cells to duct cells mediated by Notch and stromelysin-3
    • Mukhi S, Brown DD. Transdifferentiation of tadpole pancreatic acinar cells to duct cells mediated by Notch and stromelysin-3. Dev Biol 2011;351:311–7
    • (2011) Dev Biol , vol.351 , pp. 311-317
    • Mukhi, S.1    Brown, D.D.2
  • 21
    • 47549088244 scopus 로고    scopus 로고
    • Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination
    • Franco PG, Silvestroff L, Soto EF, Pasquini JM. Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination. Exp Neurol 2008;212:458–67
    • (2008) Exp Neurol , vol.212 , pp. 458-467
    • Franco, P.G.1    Silvestroff, L.2    Soto, E.F.3    Pasquini, J.M.4
  • 24
    • 84859914779 scopus 로고    scopus 로고
    • Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination
    • Silvestroff L, Bartucci S, Pasquini J, Franco P. Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination. Exp Neurol 2012;235:357–67
    • (2012) Exp Neurol , vol.235 , pp. 357-367
    • Silvestroff, L.1    Bartucci, S.2    Pasquini, J.3    Franco, P.4
  • 25
    • 74049160870 scopus 로고    scopus 로고
    • Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle
    • Taylor LC, Gilmore W, Ting JP-Y, Matsushima GK. Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle. J Neurosci Res 2010;88:391–402
    • (2010) J Neurosci Res , vol.88 , pp. 391-402
    • Taylor, L.C.1    Gilmore, W.2    Ting, J.-Y.3    Matsushima, G.K.4
  • 26
  • 27
    • 33947250100 scopus 로고    scopus 로고
    • Behavioral deficits in the cuprizone-induced murine model of demyelination/remyelination
    • Franco-Pons N, Torrente M, Colomina MT, Vilella E. Behavioral deficits in the cuprizone-induced murine model of demyelination/remyelination. Toxicol Lett 2007;169:205–13
    • (2007) Toxicol Lett , vol.169 , pp. 205-213
    • Franco-Pons, N.1    Torrente, M.2    Colomina, M.T.3    Vilella, E.4
  • 28
    • 46849098585 scopus 로고    scopus 로고
    • Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
    • Kuhlmann T, Miron V, Cui Q, Wegner C, Antel J, Bruck W. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 2008;131:1749–58
    • (2008) Brain , vol.131 , pp. 1749-1758
    • Kuhlmann, T.1    Miron, V.2    Cui, Q.3    Wegner, C.4    Antel, J.5    Bruck, W.6
  • 29
    • 77957658807 scopus 로고    scopus 로고
    • Christakos A,Miller SD, Soliven, Popko B. A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination
    • Traka M, Arasi K, Avila RL, Podojil JR, Christakos A,Miller SD, Soliven, Popko B. A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination. Brain 2010;133:3017–29
    • (2010) Brain , vol.133 , pp. 3017-3029
    • Traka, M.1    Arasi, K.2    Avila, R.L.3    Podojil, J.R.4
  • 30
    • 79961014765 scopus 로고    scopus 로고
    • Interaction of the attenuated recombinant rIHNV-Gvhsv GFP virus with macrophages from rainbow trout (Oncorhynchus mykiss)
    • Romero A, Dios S, Bremont M, Figueras A, Novoa B. Interaction of the attenuated recombinant rIHNV-Gvhsv GFP virus with macrophages from rainbow trout (Oncorhynchus mykiss). Vet Immunol Immunopathol 2011;140:119–29
    • (2011) Vet Immunol Immunopathol , vol.140 , pp. 119-129
    • Romero, A.1    Dios, S.2    Bremont, M.3    Figueras, A.4    Novoa, B.5
  • 31
    • 0031796527 scopus 로고    scopus 로고
    • The natural history of multiple sclerosis: Update 1998
    • Weinshenker BG. The natural history of multiple sclerosis: update 1998. Semin Neurol 1998;18:301–7
    • (1998) Semin Neurol , vol.18 , pp. 301-307
    • Weinshenker, B.G.1
  • 32
    • 0024504359 scopus 로고
    • The natural history of multiple sclerosis: A geographically based study. I. Clinical course and disability
    • Weinshenker BG, Bass B, Rice GP, Noseworthy J, Carriere W, Baskerville J, Ebers GC. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 1989;112:133–46
    • (1989) Brain , vol.112 , pp. 133-146
    • Weinshenker, B.G.1    Bass, B.2    Rice, G.P.3    Noseworthy, J.4    Carriere, W.5    Baskerville, J.6    Ebers, G.C.7
  • 33
    • 74949120123 scopus 로고    scopus 로고
    • Clinical prognostic factors in multiple sclerosis: A natural history review
    • Degenhardt A, Ramagopalan SV, Scalfari A, Ebers GC. Clinical prognostic factors in multiple sclerosis: a natural history review. Nat Rev Neurol 2009;5:672–82
    • (2009) Nat Rev Neurol , vol.5 , pp. 672-682
    • Degenhardt, A.1    Ramagopalan, S.V.2    Scalfari, A.3    Ebers, G.C.4
  • 34
    • 67349277156 scopus 로고    scopus 로고
    • Natural history comparisons of primary and secondary progressive multiple sclerosis reveals differences and similarities
    • Tremlett H, Zhao Y, Devonshire V. Natural history comparisons of primary and secondary progressive multiple sclerosis reveals differences and similarities. J Neurol 2009;256:374–81
    • (2009) J Neurol , vol.256 , pp. 374-381
    • Tremlett, H.1    Zhao, Y.2    Devonshire, V.3
  • 35
    • 0018410045 scopus 로고
    • Remyelination in multiple sclerosis
    • Prineas JW, Connell F. Remyelination in multiple sclerosis. Ann Neurol 1979;5:22–31
    • (1979) Ann Neurol , vol.5 , pp. 22-31
    • Prineas, J.W.1    Connell, F.2
  • 36
    • 0035784003 scopus 로고    scopus 로고
    • The response of adult oligodendrocyte progenitors to demyelination in EAE
    • Reynolds R, Cenci di Bello I, Dawson M, Levine J. The response of adult oligodendrocyte progenitors to demyelination in EAE. Prog Brain Res 2001;132:165–74
    • (2001) Prog Brain Res , vol.132 , pp. 165-174
    • Reynolds, R.1    Cenci Di Bello, I.2    Dawson, M.3    Levine, J.4
  • 38
    • 54249124952 scopus 로고    scopus 로고
    • Remyelination in the CNS: From biology to therapy
    • Franklin RJ, Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 2008;9:839–55
    • (2008) Nat Rev Neurosci , vol.9 , pp. 839-855
    • Franklin, R.J.1    Ffrench-Constant, C.2
  • 39
    • 29444434481 scopus 로고    scopus 로고
    • Regional brain atrophy evolves differently in patients with multiple sclerosis according to clinical phenotype
    • Pagani E, Rocca MA, Gallo A, Rovaris M, Martinelli V, Comi G, Filippi M. Regional brain atrophy evolves differently in patients with multiple sclerosis according to clinical phenotype. Am J Neuroradiol 2005;26:341–6
    • (2005) Am J Neuroradiol , vol.26 , pp. 341-346
    • Pagani, E.1    Rocca, M.A.2    Gallo, A.3    Rovaris, M.4    Martinelli, V.5    Comi, G.6    Filippi, M.7
  • 40
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: An immune or neurodegenerative disorder?
    • Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 2008;31:247–69
    • (2008) Annu Rev Neurosci , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 41
    • 56349127789 scopus 로고    scopus 로고
    • Genomic effects of once-weekly, intramuscular interferon- beta1a treatment after the first dose and on chronic dosing: Relationships to 5-year clinical outcomes in multiple sclerosis patients
    • Weinstock-Guttman B, Bhasi K, Badgett D, Tamano-Blanco M, Minhas M, Feichter J, Patrick K, Munschauer F, Bakshi R, Ramanathan M. Genomic effects of once-weekly, intramuscular interferon- beta1a treatment after the first dose and on chronic dosing: relationships to 5-year clinical outcomes in multiple sclerosis patients. J Neuroimmunol 2008;205:113–25
    • (2008) J Neuroimmunol , vol.205 , pp. 113-125
    • Weinstock-Guttman, B.1    Bhasi, K.2    Badgett, D.3    Tamano-Blanco, M.4    Minhas, M.5    Feichter, J.6    Patrick, K.7    Munschauer, F.8    Bakshi, R.9    Ramanathan, M.10
  • 42
    • 77649337857 scopus 로고    scopus 로고
    • Long-term treatment of multiple sclerosis with glatiramer acetate: Natural history of the subtypes of anti-glatiramer acetate antibodies and their correlation with clinical efficacy
    • Karussis D, Teitelbaum D, Sicsic C, Brenner T. Long-term treatment of multiple sclerosis with glatiramer acetate: natural history of the subtypes of anti-glatiramer acetate antibodies and their correlation with clinical efficacy. J Neuroimmunol 2010;220:125–30
    • (2010) J Neuroimmunol , vol.220 , pp. 125-130
    • Karussis, D.1    Teitelbaum, D.2    Sicsic, C.3    Brenner, T.4
  • 46
    • 79958830010 scopus 로고    scopus 로고
    • [Hypothyroidism]
    • Zulewski H. [Hypothyroidism]. Ther Umsch 2011;68:315–20
    • (2011) Ther Umsch , vol.68 , pp. 315-320
    • Zulewski, H.1
  • 47
    • 0027531737 scopus 로고
    • Neonatal hypothyroidism affects the timely expression of myelinassociated glycoprotein in the rat brain
    • Rodriguez-Pena A, Ibarrola N, Iniguez MA, Munoz A, Bernal J. Neonatal hypothyroidism affects the timely expression of myelinassociated glycoprotein in the rat brain. J Clin Invest 1993;91:812–8
    • (1993) J Clin Invest , vol.91 , pp. 812-818
    • Rodriguez-Pena, A.1    Ibarrola, N.2    Iniguez, M.A.3    Munoz, A.4    Bernal, J.5
  • 48
    • 0023161138 scopus 로고
    • Thyroid hormones and brain development
    • Dussault JH, Ruel J. Thyroid hormones and brain development. Annu Rev Physiol 1987;49:321–34
    • (1987) Annu Rev Physiol , vol.49 , pp. 321-334
    • Dussault, J.H.1    Ruel, J.2
  • 49
    • 0030602033 scopus 로고    scopus 로고
    • Evidence for the existence of at least two timing mechanisms that contribute to oligodendrocyte generation in vitro
    • Ibarrola N, Mayer-Proschel M, Rodriguez-Pena A, Noble M. Evidence for the existence of at least two timing mechanisms that contribute to oligodendrocyte generation in vitro. Dev Biol 1996;180:1–21
    • (1996) Dev Biol , vol.180 , pp. 1-21
    • Ibarrola, N.1    Mayer-Proschel, M.2    Rodriguez-Pena, A.3    Noble, M.4
  • 50
    • 0030704327 scopus 로고    scopus 로고
    • Effects of thyroid hormone on embryonic oligodendrocyte precursor cell development in vivo and in vitro
    • Ahlgren SC, Wallace H, Bishop J, Neophytou C, Raff MC. Effects of thyroid hormone on embryonic oligodendrocyte precursor cell development in vivo and in vitro. Mol Cell Neurosci 1997;9:420–32
    • (1997) Mol Cell Neurosci , vol.9 , pp. 420-432
    • Ahlgren, S.C.1    Wallace, H.2    Bishop, J.3    Neophytou, C.4    Raff, M.C.5
  • 51
    • 0037011105 scopus 로고    scopus 로고
    • Normal timing of oligodendrocyte development depends on thyroid hormone receptor alpha 1 (TR alpha 1)
    • Billon N, Jolicoeur C, Tokumoto Y, Vennstrom B, Raff M. Normal timing of oligodendrocyte development depends on thyroid hormone receptor alpha 1 (TR alpha 1). EMBO J 2002;21:6452–60
    • (2002) EMBO J , vol.21 , pp. 6452-6460
    • Billon, N.1    Jolicoeur, C.2    Tokumoto, Y.3    Vennstrom, B.4    Raff, M.5
  • 52
    • 0032403531 scopus 로고    scopus 로고
    • Thyroid hormone receptor isoforms are sequentially expressed in oligodendrocyte lineage cells during rat cerebral development
    • Carre JL, Demerens C, Rodriguez-Pena A, Floch HH, Vincendon G, Sarlieve LL. Thyroid hormone receptor isoforms are sequentially expressed in oligodendrocyte lineage cells during rat cerebral development. J Neurosci Res 1998;54:584–94
    • (1998) J Neurosci Res , vol.54 , pp. 584-594
    • Carre, J.L.1    Demerens, C.2    Rodriguez-Pena, A.3    Floch, H.H.4    Vincendon, G.5    Sarlieve, L.L.6
  • 53
    • 0032080566 scopus 로고    scopus 로고
    • Cell-intrinsic timers and thyroid hormone regulate the probability of cell-cycle withdrawal and differentiation of oligodendrocyte precursor cells
    • Gao FB, Apperly J, Raff M. Cell-intrinsic timers and thyroid hormone regulate the probability of cell-cycle withdrawal and differentiation of oligodendrocyte precursor cells. Dev Biol 1998;197:54–66
    • (1998) Dev Biol , vol.197 , pp. 54-66
    • Gao, F.B.1    Apperly, J.2    Raff, M.3
  • 55
    • 77649338761 scopus 로고    scopus 로고
    • Thyroid hormone prevents cognitive deficit in a mouse model of Alzheimer’s disease
    • Fu AL, Zhou CY, Chen X. Thyroid hormone prevents cognitive deficit in a mouse model of Alzheimer’s disease. Neuropharmacology 2010;58:722–9
    • (2010) Neuropharmacology , vol.58 , pp. 722-729
    • Fu, A.L.1    Zhou, C.Y.2    Chen, X.3
  • 56
    • 84872614351 scopus 로고    scopus 로고
    • Alterations in local thyroid hormone signaling in the hippocampus of the SAMP8 mouse at younger ages: Association with delayed myelination and behavioral abnormalities
    • Sawano E, Negishi T, Aoki T, Murakami M, Tashiro T. Alterations in local thyroid hormone signaling in the hippocampus of the SAMP8 mouse at younger ages: association with delayed myelination and behavioral abnormalities. J Neurosci Res 2013;91:382–92
    • (2013) J Neurosci Res , vol.91 , pp. 382-392
    • Sawano, E.1    Negishi, T.2    Aoki, T.3    Murakami, M.4    Tashiro, T.5
  • 59
    • 0037022609 scopus 로고    scopus 로고
    • Thyroid hormone activates oligodendrocyte precursors and increases a myelinforming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis
    • Calza L, Fernandez M, Giuliani A, Aloe L, Giardino L. Thyroid hormone activates oligodendrocyte precursors and increases a myelinforming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis. Proc Natl Acad Sci USA 2002;99:3258–63
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3258-3263
    • Calza, L.1    Fernandez, M.2    Giuliani, A.3    Aloe, L.4    Giardino, L.5
  • 61
    • 0035380377 scopus 로고    scopus 로고
    • [Cell-intrinsic timer regulating oligodendrocyte development]
    • Kondo T. [Cell-intrinsic timer regulating oligodendrocyte development]. Tanpakushitsu Kakusan Koso 2001;46:821–8
    • (2001) Tanpakushitsu Kakusan Koso , vol.46 , pp. 821-828
    • Kondo, T.1
  • 62
    • 0018345863 scopus 로고
    • Thyroxine increases nerve growth factor concentration in adult mouse brain
    • Walker P, Weichsel ME Jr, Fisher DA, Guo SM. Thyroxine increases nerve growth factor concentration in adult mouse brain. Science 1979;204:427–9
    • (1979) Science , vol.204 , pp. 427-429
    • Walker, P.1    Weichsel, M.E.2    Fisher, D.A.3    Guo, S.M.4
  • 63
    • 0346219195 scopus 로고    scopus 로고
    • Remyelination in multiple sclerosis: A new role for neurotrophins?
    • Althaus HH. Remyelination in multiple sclerosis: a new role for neurotrophins? Prog Brain Res 2004;146:415–32
    • (2004) Prog Brain Res , vol.146 , pp. 415-432
    • Althaus, H.H.1
  • 65
    • 0026758968 scopus 로고
    • Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody
    • Linington C, Engelhardt B, Kapocs G, Lassman H. Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody. J Neuroimmunol 1992;40:219–24
    • (1992) J Neuroimmunol , vol.40 , pp. 219-224
    • Linington, C.1    Engelhardt, B.2    Kapocs, G.3    Lassman, H.4
  • 66
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
    • Kornek B, Storch MK, Weissert R, Wallstroem E, Stefferl A, Olsson T, Linington C, Schmidbauer M, Lassmann H. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 2000;157:267–76
    • (2000) Am J Pathol , vol.157 , pp. 267-276
    • Kornek, B.1    Storch, M.K.2    Weissert, R.3    Wallstroem, E.4    Stefferl, A.5    Olsson, T.6    Linington, C.7    Schmidbauer, M.8    Lassmann, H.9


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