A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination

Brain

Volumn 133, Issue 10, 2010, Pages 3017-3029

  Traka, Maria ^a   Arasi, Kavin ^a   Avila, Robin L ^a   Podojil, Joseph R ^b   Christakos, Athena ^a   Miller, Stephen D ^b   Soliven, Betty ^a   Popko, Brian ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

demyelination; multiple sclerosis; myelin; oligodendrocyte; remyelination

Indexed keywords

MYELIN; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; BRAIN STEM; CELL LOSS; CEREBELLUM; DEMYELINATING DISEASE; EVOKED SOMATOSENSORY RESPONSE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CONDUCTION; NONHUMAN; OLIGODENDROGLIA; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMYELINIZATION; SPINAL CORD; TREMOR; ANIMAL; ELECTROPHYSIOLOGY; FLOW CYTOMETRY; GENETICS; MYELIN SHEATH; NERVE FIBER; NERVE REGENERATION; PATHOLOGY; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ROTAROD TEST; TRANSGENIC MOUSE;

ANIMALS; AXONS; DEMYELINATING DISEASES; ELECTROPHYSIOLOGY; FLOW CYTOMETRY; MICE; MICE, TRANSGENIC; MYELIN SHEATH; NERVE REGENERATION; NEURAL CONDUCTION; OLIGODENDROGLIA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ROTAROD PERFORMANCE TEST;

EID: 77957658807     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq247     Document Type: Article

References (36)

1. Benjamins JA, Morell P. Proteins of myelin and their metabolism. Neurochem Res 1978; 3: 137-74.
2. Benjamins JA, Morell P, Hartman BK, Agrawal HC. Central nervous system myelin. In: Lajtha A, editor. Handbook in neurochemistry. New York: Plenum Press; 1984. p. 361-415.
3. Blakemore WF, Franklin RJ. Remyelination in experimental models of toxin-induced demyelination. Curr Top Microbiol Immunol 2008; 318: 193-212.
4. Brockschnieder D, Lappe-Siefke C, Goebbels S, Boesl MR, Nave KA, Riethmacher D. Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination. Mol Cell Biol 2004; 24: 7636-42.
5. Brockschnieder D, Pechmann Y, Sonnenberg-Riethmacher E, Riethmacher D. An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus. Genesis 2006; 44: 322-7.
6. Buch T, Heppner FL, Tertilt C, Heinen TJ, Kremer M, Wunderlich FT, et al. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2005; 2: 419-26.
7. Collier RJ. Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century. Toxicon 2001; 39: 1793-803.
8. Dangata YY, Kaufman MH. Morphometric analysis of the postnatal mouse optic nerve following prenatal exposure to alcohol. J Anat 1997; 191 (Pt 1): 49-56.
9. Doerflinger NH, Macklin WB, Popko B. Inducible site-specific recombination in myelinating cells. Genesis 2003; 35: 63-72.
10. Duncan ID, Brower A, Kondo Y, Curlee JF Jr, Schultz RD. Extensive remyelination of the CNS leads to functional recovery. Proc Natl Acad Sci USA 2009; 106: 6832-6.
11. Dupree JL, Coetzee T, Blight A, Suzuki K, Popko B. Myelin galactolipids are essential for proper node of Ranvier formation in the CNS. J Neurosci 1998; 18: 1642-9.
12. Franklin RJ, Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 2008; 9: 839-55.
13. Hickey WF, Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 1988; 239: 290-2.
14. Ip CW, Kroner A, Bendszus M, Leder C, Kobsar I, Fischer S, et al. Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendro-cytes. J Neurosci 2006; 26: 8206-16.
15. Ivanova A, Signore M, Caro N, Greene ND, Copp AJ, Martinez-Barbera JP. In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis 2005; 43: 129-35.
16. Kassmann CM, Lappe-Siefke C, Baes M, Brugger B, Mildner A, Werner HB, et al. Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes. Nat Genet 2007; 39: 969-76.
17. Khaing ZZ, Blum M. Detection of cell proliferation and cell fate in adult CNS using BrdU double-label immunohistochemistry. Methods Mol Med 2003; 79: 499-505.
18. Kotter MR, Li WW, Zhao C, Franklin RJ. Myelin impairs CNS remyelina-tion by inhibiting oligodendrocyte precursor cell differentiation. J Neurosci 2006; 26: 328-32.
19. Masahira N, Takebayashi H, Ono K, Watanabe K, Ding L, Furusho M, et al. Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol 2006; 293: 358-69.
20. Mathis C, Hindelang C, LeMeur M, Borrelli E. A transgenic mouse model for inducible and reversible dysmyelination. J Neurosci 2000; 20: 7698-705.
21. Matthews AE, Weiss SR, Paterson Y. Murine hepatitis virus-a model for virus-induced CNS demyelination. J Neurovirol 2002; 8: 76-85.
22. Maxwell IH, Maxwell F, Glode LM. Regulated expression of a diphtheria toxin A-chain gene transfected into human cells: possible strategy for inducing cancer cell suicide. Cancer Res 1986; 46: 4660-4.
23. McMahon EJ, Bailey SL, Castenada CV, Waldner H, Miller SD. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat Med 2005; 11: 335-9.
24. Miller DJ, Rodriguez M. Spontaneous and induced remyelination in multiple sclerosis and the Theiler's virus model of central nervous system demyelination. Microsc Res Tech 1995; 32: 230-45.
25. Mix E, Meyer-Rienecker H, Zettl UK. Animal models of multiple sclerosis for the development and validation of novel therapies-potential and limitations. J Neurol 2008; 255 (Suppl 6): 7-14.
26. Nave KA. Myelination and the trophic support of long axons. Nat Rev Neurosci 2010; 11: 275-83.
27. Nave KA, Trapp BD. Axon-glial signaling and the glial support of axon function. Annu Rev Neurosci 2008; 31: 535-61.
28. Palmiter RD, Behringer RR, Quaife CJ, Maxwell F, Maxwell IH, Brinster RL. Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell 1987; 50: 435-43.
29. Ponomarev ED, Shriver LP, Maresz K, Dittel BN. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J Neurosci Res 2005; 81: 374-89.
30. Sedgwick JD, Schwender S, Imrich H, Dorries R, Butcher GW, ter Meulen V. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc Natl Acad Sci USA 1991; 88: 7438-42.
31. Srinivas S, Watanabe T, Lin CS, William CM, Tanabe Y, Jessell TM, et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 2001; 1: 4.
32. Traka M, Wollmann RL, Cerda SR, Dugas J, Barres BA, Popko B. Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS. J Neurosci 2008; 28: 11537-49.
33. Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 2008; 31: 247-69.
34. Vargas ME, Barres BA. Why is Wallerian degeneration in the CNS so slow? Annu Rev Neurosci 2007; 30: 153-79.
35. Witte ME, Geurts JJ, de Vries HE, van der Valk P, van Horssen J. Mitochondrial dysfunction: a potential link between neuroinflamma-tion and neurodegeneration? Mitochondrion 2010; 10: 411-18.
36. Yamaizumi M, Mekada E, Uchida T, Okada Y. One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell 1978; 15: 245-50.