Age-related changes in D-aspartate oxidase promoter methylation control extracellular D-aspartate levels and prevent precocious cell death during brain aging

Journal of Neuroscience

Volumn 36, Issue 10, 2016, Pages 3064-3078

  Punzo, Daniela ^a,b   Errico, Francesco ^c,d   Cristino, Luigia ^a   Sacchi, Silvia ^e,f   Keller, Simona ^a,d   Belardo, Carmela ^b   Luongo, Livio ^b   Nuzzo, Tommaso ^b,c   Imperatore, Roberta ^a   Florio, Ermanno ^a,d   De Novellis, Vito ^b   Affinito, Ornella ^a,d   Migliarini, Sara ^g   Maddaloni, Giacomo ^g   Sisalli, Maria Josè ^a   Pasqualetti, Massimo ^g,h   Pollegioni, Loredano ^e,f   Maione, Sabatino ^b   Chiariotti, Lorenzo ^a,d   Usiello, Alessandro ^b,c  

^a CNR   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF INSUBRIA   (Italy)

^f POLITECNICO DI MILANO   (Italy)

^g UNIVERSITY OF PISA   (Italy)

^h ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Aging; D amino acids; DNA methylation; Neurodegeneration; NMDA receptor

Indexed keywords

ASPARTATE OXIDASE; AZACITIDINE; CASPASE 3; DECITABINE; DEXTRO ASPARTIC ACID; LIPOFUSCIN; MESSENGER RNA; ENZYME INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ADULT; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN AGING; CONTROLLED STUDY; DEMETHYLATION; DNA EXTRACTION; DNA METHYLATION; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; EPIGENETICS; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MICRODIALYSIS; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROMOTER REGION; PYRAMIDAL NERVE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SUBSTANTIA NIGRA PARS COMPACTA; TRANSCRIPTION INITIATION; AGE; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; C57BL MOUSE; CELL DEATH; CYTOLOGY; DRUG EFFECTS; GENETICS; MAMMALIAN EMBRYO; METABOLISM; METHYLATION; NERVE CELL; NEWBORN; PHYSIOLOGY; TRANSGENIC MOUSE;

AGE FACTORS; AGING; ANIMALS; ANIMALS, NEWBORN; AZACITIDINE; BRAIN; CELL DEATH; D-ASPARTATE OXIDASE; D-ASPARTIC ACID; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; MALE; METHYLATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; PROMOTER REGIONS, GENETIC; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER;

EID: 84960419825     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3881-15.2016     Document Type: Article

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