Increased d-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice

Neurobiology of Aging

Volumn 32, Issue 12, 2011, Pages 2229-2243

  Errico, Francesco ^a   Nisticò, Robert ^b,c   Napolitano, Francesco ^a   Mazzola, Carmen ^a   Astone, Dalila ^a,f   Pisapia, Teresa ^a   Giustizieri, Michela ^b,g   D'Aniello, Antimo ^d   Mercuri, Nicola B ^b   Usiello, Alessandro ^a,e  

^a CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c UNIVERSITY OF CALABRIA   (Italy)

^d STAZIONE ZOOLOGICA ANTON DOHRN   (Italy)

^e SECOND UNIVERSITY OF NAPLES   (Italy)

^f UNIVERSITY OF VERONA   (Italy)

^g ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Brain aging; D Aspartate; Hippocampus; NMDA receptors; Reference memory; Synaptic plasticity

Indexed keywords

DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A;

AGED; AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HIPPOCAMPUS; LONG TERM CARE; LONG TERM POTENTIATION; MALE; MAZE TEST; MEMORY; MENTAL DETERIORATION; NERVE CELL PLASTICITY; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; TREATMENT DURATION;

AGING; ANIMALS; BRAIN; D-ASPARTIC ACID; EXCITATORY POSTSYNAPTIC POTENTIALS; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; NEURONAL PLASTICITY; SYNAPSES; UP-REGULATION;

EID: 80053625200     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2010.01.002     Document Type: Article

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