Myristoylated alanine-rich protein kinase substrate (MARCKS) regulates small GTPase rac1 and cdc42 activity and is a critical mediator of vascular smooth muscle cell migration in intimal hyperplasia formation

Journal of the American Heart Association

Volumn 4, Issue 10, 2015, Pages

  Yu, Dan ^a,b   Makkar, George ^b   Strickland, Dudley K ^b   Blanpied, Thomas A ^b   Stumpo, Deborah J ^c   Blackshear, Perry J ^c   Sarkar, Rajabrata ^b   Monahan, Thomas S ^a,b  

^a BALTIMORE VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Membrane lipids; Migration; Rac1; Restenosis; Vascular smooth muscle

Indexed keywords

ACTIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PLATELET DERIVED GROWTH FACTOR; PROTEIN CDC42; RAC1 PROTEIN; CDC42 PROTEIN, MOUSE; MEMBRANE PROTEIN; MYRISTOYLATED ALANINE-RICH C KINASE SUBSTRATE; NEUROPEPTIDE; POLYPHOSPHOINOSITIDE; RAC1 PROTEIN, HUMAN; RAC1 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; BINDING AFFINITY; CAROTID ARTERY LIGATION; CELL DIFFERENTIATION; CELL MEMBRANE; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CYTOSOL; ENZYME PHOSPHORYLATION; GENE; GENE CONTROL; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MARCKS GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN INTERACTION; SMOOTH MUSCLE CELL; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; C57BL MOUSE; CAROTID ARTERY INJURIES; CELL CULTURE; CELL MOTION; DEFICIENCY; DISEASE MODEL; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HYPERPLASIA; KNOCKOUT MOUSE; METABOLISM; NEOINTIMA; PATHOLOGY; PHOSPHORYLATION; PROTEIN TRANSPORT; PSEUDOPODIUM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTOR; VASCULAR SMOOTH MUSCLE;

ANIMALS; CAROTID ARTERY INJURIES; CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HUMANS; HYPERPLASIA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; NEUROPEPTIDES; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; PROTEIN TRANSPORT; PSEUDOPODIA; RAC1 GTP-BINDING PROTEIN; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 84960410180     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.002255     Document Type: Article

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