Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER)

Journal of Biological Chemistry

Volumn 287, Issue 36, 2012, Pages 30336-30345

  Satomi Kobayashi, Seimi ^a   Kinugasa, Mitsuo ^a   Kobayashi, Reiko ^a   Hatakeyama, Kinta ^b   Kurogane, Yusuke ^a   Ishida, Tatsuro ^a   Emoto, Noriaki ^a,c   Asada, Yujiro ^b   Takai, Yoshimi ^a   Hirata, Ken Ichi ^a   Rikitake, Yoshiyuki ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MIYAZAKI   (Japan)

^c KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ATHEROSCLEROTIC PLAQUE; BONE MORPHOGENETIC PROTEINS; DOWN-REGULATION; HUMAN CORONARY ARTERIES; MODE OF ACTION; OSTEOBLAST MARKERS; OSTEOBLAST-LIKE CELLS; RNA INTERFERENCE; SMOOTH MUSCLE ACTINS; UP-REGULATION; VASCULAR CALCIFICATION; VASCULAR SMOOTH MUSCLE CELLS;

BIOMINERALIZATION; OLIGONUCLEOTIDES; PHOSPHATASES; PHOSPHORYLATION; RNA; TRANSCRIPTION FACTORS;

ENDOTHELIAL CELLS;

ALKALINE PHOSPHATASE; ALPHA SMOOTH MUSCLE ACTIN; BONE MORPHOGENETIC PROTEIN BINDING ENDOTHELIAL CELL PRECURSOR DERIVED REGULATOR; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN DECOY OLIGONUCLEOTIDE; MESSENGER RNA; OLIGONUCLEOTIDE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT BONE MORPHOGENETIC PROTEIN BINDING ENDOTHELIAL CELL PRECURSOR DERIVED REGULATOR; RECOMBINANT PROTEIN; REGULATOR PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY CALCIFICATION; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL DIFFERENTIATION; CELL STIMULATION; CONTROLLED STUDY; CORONARY ARTERY; DOWN REGULATION; GENE SILENCING; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; MINERALIZATION; MOUSE; NEOINTIMA; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR RING;

ACTINS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BONE MORPHOGENETIC PROTEIN 2; CALCINOSIS; CARRIER PROTEINS; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORONARY VESSELS; FEMALE; HUMANS; I-KAPPA B PROTEINS; MALE; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; ORGAN CULTURE TECHNIQUES; OSTEOBLASTS; PHOSPHORYLATION; PLAQUE, ATHEROSCLEROTIC;

VERTEBRATA;

EID: 84865765250     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.329110     Document Type: Article

References (26)

1. van der Zee, S., Baber, U., Elmariah, S., Winston, J., and Fuster, V. (2009) Cardiovascular risk factors in patients with chronic kidney disease. Nat. Rev. Cardiol. 6, 580-589
2. Rennenberg, R. J., Kessels, A. G., Schurgers, L. J., van Engelshoven, J. M., de Leeuw, P. W., and Kroon, A. A. (2009) Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis. Vasc. Health Risk Manag. 5, 185-197
3. Callister, T. Q., Raggi, P., Cooil, B., Lippolis, N. J., and Russo, D. J. (1998) Effect of HMG-CoA reductase inhibitors on coronary artery disease as assessed by electron-beam computed tomography. N. Engl. J. Med. 339, 1972-1978
4. Armstrong, Z. B., Boughner, D. R., Drangova, M., and Rogers, K. A. (2011) Angiotensin II type 1 receptor blocker inhibits arterial calcification in a pre-clinical model. Cardiovasc Res. 90, 165-170
5. Persy, V., and D'Haese, P. (2009) Vascular calcification and bone disease: the calcification paradox. Trends Mol. Med. 15, 405-416
6. Shanahan, C. M., Cary, N. R., Salisbury, J. R., Proudfoot, D., Weissberg, P. L., and Edmonds, M. E. (1999) Medial localization of mineralization- regulating proteins in association with Mönckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification. Circulation 100, 2168-2176
7. Conley, C. A., Silburn, R., Singer, M. A., Ralston, A., Rohwer-Nutter, D., Olson, D. J., Gelbart, W., and Blair, S. S. (2000) Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila. Development 127, 3947-3959
8. Binnerts, M. E., Wen, X., Canté-Barrett, K., Bright, J., Chen, H. T., Asundi, V., Sattari, P., Tang, T., Boyle, B., Funk, W., and Rupp, F. (2004) Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. Biochem. Biophys. Res. Commun. 315, 272-280
9. Moser, M., Binder, O., Wu, Y., Aitsebaomo, J., Ren, R., Bode, C., Bautch, V. L., Conlon, F. L., and Patterson, C. (2003) BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol. Cell Biol. 23, 5664-5679
10. Serpe, M., Umulis, D., Ralston, A., Chen, J., Olson, D. J., Avanesov, A., Othmer, H., O'Connor, M. B., and Blair, S. S. (2008) The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila. Dev. Cell 14, 940-953
11. Ikeya, M., Kawada, M., Kiyonari, H., Sasai, N., Nakao, K., Furuta, Y., and Sasai, Y. (2006) Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development 133, 4463-4473
12. Kikumori, T., Kambe, F., Nagaya, T., Imai, T., Funahashi, H., and Seo, H. (1998) Activation of transcriptionally active nuclear factor-κB by tumor necrosis factor-α and its inhibition by antioxidants in rat thyroid FRTL-5 cells. Endocrinology 139, 1715-1722
13. Nakano-Kurimoto, R., Ikeda, K., Uraoka, M., Nakagawa, Y., Yutaka, K., Koide, M., Takahashi, T., Matoba, S., Yamada, H., Okigaki, M., and Matsubara, H. (2009) Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition. Am. J. Physiol. Heart Circ. Physiol. 297, H1673-H1684
14. Shimizu, H., Nakagami, H., Tsukamoto, I., Morita, S., Kunugiza, Y., Tomita, T., Yoshikawa, H., Kaneda, Y., Ogihara, T., and Morishita, R. (2006) NFκB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts. Gene Therapy 13, 933-941
15. Helbing, T., Rothweiler, R., Ketterer, E., Goetz, L., Heinke, J., Grundmann, S., Duerschmied, D., Patterson, C., Bode, C., and Moser, M. (2011) BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium. Blood 118, 5040-5049
16. Boström, K., Watson, K. E., Horn, S., Wortham, C., Herman, I. M., and Demer, L. L. (1993) Bone morphogenetic protein expression in human atherosclerotic lesions. J. Clin. Invest. 91, 1800-1809
17. Li, X., Yang, H. Y., and Giachelli, C. M. (2008) BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. Atherosclerosis 199, 271-277
18. Shao, J. S., Cheng, S. L., Sadhu, J., and Towler, D. A. (2010) Inflammation and the osteogenic regulation of vascular calcification: a review and perspective. Hypertension 55, 579-592
19. Cho, H. H., Shin, K. K., Kim, Y. J., Song, J. S., Kim, J. M., Bae, Y. C., Kim, C. D., and Jung, J. S. (2010) NF-kappaB activation stimulates osteogenic differentiation of mesenchymal stem cells derived from human adipose tissue by increasing TAZ expression. J. Cell Physiol. 223, 168-177
20. Zhang, J. L., Qiu, L. Y., Kotzsch, A., Weidauer, S., Patterson, L., Hammerschmidt, M., Sebald, W., and Mueller, T. D. (2008) Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding. Dev. Cell 14, 739-750
21. Heinke, J., Wehofsits, L., Zhou, Q., Zoeller, C., Baar, K. M., Helbing, T., Laib, A., Augustin, H., Bode, C., Patterson, C., and Moser, M. (2008) BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Circ. Res. 103, 804-812
22. Yu, P. B., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., Lin, H. Y., Bloch, K. D., and Peterson, R. T. (2008) Nat. Chem. Biol. 4, 33-41
23. Ashique, A. M., Fu, K., and Richman, J. M. (2002) Endogenous bone morphogenetic proteins regulate outgrowth and epithelial survival during avian lip fusion. Development 129, 4647-4660
24. Zebboudj, A. F., Shin, V., and Boström, K. (2003) Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells. J. Cell Biochem. 90, 756-765
25. Kelley, R., Ren, R., Pi, X., Wu, Y., Moreno, I., Willis, M., Moser, M., Ross, M., Podkowa, M., Attisano, L., and Patterson, C. (2009) A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J. Cell Biol. 184, 597-609
26. Yamazaki, M., Fukushima, H., Shin, M., Katagiri, T., Doi, T., Takahashi, T., and Jimi, E. (2009) Tumor necrosis factor α represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-κB. J. Biol. Chem. 284, 35987-35995