Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice

Annals of Neurology

Volumn 79, Issue 3, 2016, Pages 387-403

  Capone, Carmen ^a,b   Cognat, Emmanuel ^a,b   Ghezali, Lamia ^a,b   Baron Menguy, Céline ^a,b   Aubin, Déborah ^a,b   Mesnard, Laurent ^c,d   Stöhr, Heidi ^e   Domenga Denier, Valérie ^a,b   Nelson, Mark T ^f,g   Joutel, Anne ^a,b  

^a INSERM   (France)

^b DHU Neurovasc   (France)

^c Urgences Néphrologiques et Transplantation Rénale Hôpital Tenon 4   (France)

^d HÔPITAL TENON   (France)

^e UNIVERSITY OF REGENSBURG   (Germany)

^f UNIVERSITY OF VERMONT   (United States)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MYELIN; NOTCH3 RECEPTOR; SYNAPSIN; SYNAPSIN 3; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG; VITRONECTIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE-4;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERY CONSTRICTION; ARTERY DIAMETER; ARTICLE; AUTOREGULATION; BRAIN BLOOD FLOW; BRAIN DAMAGE; BRAIN FUNCTION; CADASIL; CEREBROVASCULAR DISEASE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DOWN REGULATION; EX VIVO STUDY; GENE DOSAGE; GENE LOCUS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENOTYPE; HAPLOINSUFFICIENCY; HETEROZYGOTE; HUMAN; HYPEREMIA; IN VIVO STUDY; INTRON; MALE; MOUSE; MUSCLE DEVELOPMENT; NERVE STIMULATION; NEUROPATHOLOGY; NONHUMAN; PHASE 1 CLINICAL TRIAL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; VASOMOTOR DISORDER; WHITE MATTER; WHITE MATTER LESION; ANIMAL; BRAIN; BRAIN CIRCULATION; C57BL MOUSE; INFANT; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; BRAIN; CADASIL; CEREBROVASCULAR CIRCULATION; HUMANS; INFANT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; TISSUE INHIBITOR OF METALLOPROTEINASES; VITRONECTIN;

EID: 84960396672     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24573     Document Type: Article

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