Brain microvascular accumulation and distribution of the NOTCH3 ectodomain and granular osmiophilic material in CADASIL

Journal of Neuropathology and Experimental Neurology

Volumn 72, Issue 5, 2013, Pages 416-431

  Yamamoto, Yumi ^a,b   Craggs, Lucinda J L ^a   Watanabe, Atsushi ^c   Booth, Trevor ^d   Attems, Johannes ^a   Low, Roger W C ^a   Oakley, Arthur E ^a   Kalaria, Raj N ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Blood brain barrier; CADASIL; Electron microscopy; Granular osmiophilic material; NOTCH3; Small vessel disease; Vascular dementia; White matter

Indexed keywords

GRANULAR OSMIOPHILIC MATERIAL; NOTCH3 ECTODOMAIN; NOTCH3 ECTODOMAIN ANTIBODY; NOTCH3 RECEPTOR; OSMIUM; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ARTERIOLE; ARTICLE; BRAIN ARTERY; BRAIN BLOOD VESSEL; BRAIN CAPILLARY; CADASIL; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GRAY MATTER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOGOLD LABELING; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MENINX; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SENSITIVITY AND SPECIFICITY; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VASCULAR SMOOTH MUSCLE CELL; WHITE MATTER;

ADULT; AGED; AGED, 80 AND OVER; BRAIN; CADASIL; CYTOPLASMIC GRANULES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROCIRCULATION; MIDDLE AGED; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NOTCH;

EID: 84876680267     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e31829020b5     Document Type: Article

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