Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II

Journal of Biological Chemistry

Volumn 287, Issue 53, 2012, Pages 44083-44096

  Basu, Ratnadeep ^a,b   Fans, Dong ^a,b   Kandalams, Vijay ^a,b   Lee, Jiwon ^a,b   Das, Subhash K ^a,b   Wang, Xiuhua ^a,b   Baldwin, Troy A ^a   Oudit, Gavin Y ^a,b   Kassiri, Zamaneh ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MAZANKOWSKI ALBERTA HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL AORTA; ABDOMINAL AORTIC ANEURYSMS; ANGIOTENSIN II; AORTIC ANEURYSMS; AORTIC WALLS; BONE MARROW; BROAD SPECTRUM; EXTRACELLULAR MATRICES; MALE MOUSE; MATRIX METALLOPROTEINASES; METALLOPROTEINASES; MMP INHIBITOR; PROTEIN DEGRADATION; PROTEOLYTIC ACTIVITIES; REGULATORY FUNCTIONS; TISSUE INHIBITOR; UP-REGULATION; VASCULAR REMODELING; WILD-TYPE CONTROLS;

ENZYME INHIBITION; MAMMALS; PATHOLOGY; PROTEINS; TISSUE;

BLOOD VESSELS;

ANGIOTENSIN II; COLLAGEN; ELASTIN; GELATINASE A; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; PD 166793; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG;

ABDOMINAL AORTA ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA RUPTURE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME ACTIVATION; GENE DELETION; GENE FUNCTION; GENE LOSS; GENETIC ASSOCIATION; MATRIX METALLOPROTEINASE GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SURVIVAL; TIMP3 GENE; UPREGULATION; VASCULITIS; WILD TYPE;

ANGIOTENSIN II; ANIMALS; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, VIRUS;

ANIMALIA; MUS;

EID: 84871740203     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.425652     Document Type: Article

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