Archetypal Argl69Cys Mutation in NOTCH3 Does Not Drive the Pathogenesis in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leucoencephalopathy via a Loss-of-Function Mechanism

Stroke

Volumn 45, Issue 3, 2014, Pages 842-849

  Cognat, Emmanuel ^a   Baron Menguy, Celine ^a   Domenga Denier, Valdrie ^a   Cleophax, Sabine ^a   Fouillade, Charles ^a   Monet Lepretre, Marie ^a   Dewerchin, Mieke ^b   Joutel, Anne ^a  

^a INSERM   (France)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Cadasil; Etiology; Mouse; Mouse models; Notch3 protein

Indexed keywords

MYELIN; NOTCH3 RECEPTOR; ANTIESTROGEN; NOTCH RECEPTOR; NOTCH3 PROTEIN, MOUSE; TAMOXIFEN;

ADULT; AGING; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ARTERY; CADASIL; CAPSULA INTERNA; CELL VACUOLE; CONTROLLED STUDY; FIMBRIA; GENE LOCUS; GENE OVEREXPRESSION; GENE TARGETING; HAPLOINSUFFICIENCY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WHITE MATTER LESION; ANIMAL; BRAIN; C57BL MOUSE; ETIOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMAGE PROCESSING; KNOCKOUT MOUSE; MOUSE MODELS; MUTATION; PATHOLOGY; PHYSIOLOGY;

CADASIL; ETIOLOGY; MOUSE MODELS; NOTCH3 PROTEIN, MOUSE;

ANIMALS; BRAIN; CADASIL; CEREBRAL ARTERIES; ESTROGEN ANTAGONISTS; GENE EXPRESSION REGULATION; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, NOTCH; TAMOXIFEN; TRANSCRIPTION, GENETIC;

EID: 84904470135     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.003339     Document Type: Article

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