Downregulation of protein kinase PKR activation by porcine reproductive and respiratory syndrome virus at its early stage infection

Veterinary Microbiology

Volumn 187, Issue , 2016, Pages 1-7

  Xiao, Yueqiang ^a,b   Ma, Zexu ^a   Wang, Rong ^a   Yang, Liping ^a   Nan, Yuchen ^a   Zhang, Yan Jin ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b SHANDONG PEANUT RESEARCH INSTITUTE   (China)

Author keywords

EIF2 ; Innate immunity; PKR inhibition; Porcine reproductive and respiratory syndrome virus (PRRSV); Protein kinase PKR; Pulmonary alveolar macrophages (PAMs)

Indexed keywords

INITIATION FACTOR 2ALPHA; PROTEIN KINASE R; POLYINOSINIC POLYCYTIDYLIC ACID;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS ENTRY; VIRUS INACTIVATION; VIRUS INFECTION; VIRUS REPLICATION; WESTERN BLOTTING; ANIMAL; CELL LINE; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PIG; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; VIROLOGY;

ANIMALS; CELL LINE; DOWN-REGULATION; EIF-2 KINASE; ENZYME ACTIVATION; MACROPHAGES, ALVEOLAR; PHOSPHORYLATION; POLY I-C; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SWINE; VIRUS REPLICATION;

EID: 84960387555     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2016.03.004     Document Type: Article

References (29)

1. Clemens M.J. PKR-a protein kinase regulated by double-stranded RNA. Int. J. Biochem. Cell Biol. 1997, 29:945-949.
2. Dauber B., Schneider J., Wolff T. Double-stranded RNA binding of influenza B virus nonstructural NS1 protein inhibits protein kinase R but is not essential to antagonize production of alpha/beta interferon. J. Virol. 2006, 80:11667-11677.
3. Dey M., Mann B.R., Anshu A., Mannan M.A. Activation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop. J. Biol. Chem. 2014, 289:5747-5757.
4. Faaberg K.S., Balasuriya U.B., Brinton M.A., Gorbalenya A.E., Leung F.C.-C., Nauwynck H., Snijder E.J., Stadejek T., Yang H., Yoo D. Family arteriviridae. Virus Taxonomy, Ninth Report of the International Committee on Taxonomy of Viruses 2011, Elsevier Academic Press, London. A.M.Q. King (Ed.).
5. Garcia M.A., Gil J., Ventoso I., Guerra S., Domingo E., Rivas C., Esteban M. Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol. Mol. Biol. Rev. 2006, 70:1032-1060.
6. Garcia M.A., Meurs E.F., Esteban M. The dsRNA protein kinase PKR: virus and cell control. Biochimie 2007, 89:799-811.
7. He D., Overend C., Ambrogio J., Maganti R.J., Grubman M.J., Garmendia A.E. Marked differences between MARC-145 cells and swine alveolar macrophages in IFNbeta-induced activation of antiviral state against PRRSV. Vet. Immunol. Immunopathol. 2011, 139:57-60.
8. Holtkamp D.J., Kliebenstein J.B., Neumann E.J., Zimmerman J., Rotto H., Yoder T.K., Wang C., Yeske P., Mowrer C., Haley C. Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on U.S. pork producers. J. Swine Health Prod. 2013, 21:72-84.
9. Kappes M.A., Miller C.L., Faaberg K.S. Highly divergent strains of porcine reproductive and respiratory syndrome virus incorporate multiple isoforms of nonstructural protein 2 into virions. J. Virol. 2013, 87:13456-13465.
10. Kim H.S., Kwang J., Yoon I.J., Joo H.S., Frey M.L. Enhanced replication of porcine reproductive and respiratory syndrome (PRRS) virus in a homogeneous subpopulation of MA-104 cell line. Arch. Virol. 1993, 133:477-483.
11. Li S., Min J.Y., Krug R.M., Sen G.C. Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA. Virology 2006, 349:13-21.
12. Lu Y., Wambach M., Katze M.G., Krug R.M. Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor. Virology 1995, 214:222-228.
13. Majumdar R., Maitra U. Regulation of GTP hydrolysis prior to ribosomal AUG selection during eukaryotic translation initiation. EMBO J. 2005, 24:3737-3746.
14. Meulenberg J.J. PRRSV, the virus. Vet. Res. 2000, 31:11-21.
15. Nan Y., Wang R., Shen M., Faaberg K.S., Samal S.K., Zhang Y.J. Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate. Virology 2012, 432:261-270.
16. Patel D., Opriessnig T., Stein D.A., Halbur P.G., Meng X.J., Iversen P.L., Zhang Y.J. Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication. Antiviral Res. 2008, 77:95-107.
17. Patel D., Stein D.A., Zhang Y.J. Morpholino oligomer-mediated protection of porcine pulmonary alveolar macrophages from arterivirus-induced cell death. Antivir. Ther. 2009, 14:899-909.
18. Patel D., Nan Y., Shen M., Ritthipichai K., Zhu X., Zhang Y.J. Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear translocation. J. Virol. 2010, 84:11045-11055.
19. Rossow K.D., Collins J.E., Goyal S.M., Nelson E.A., Christopher Hennings J., Benfield D.A. Pathogenesis of porcine reproductive and respiratory syndrome virus infection in gnotobiotic pigs. Vet. Pathol. 1995, 32:361-373.
20. Rowland R.R., Robinson B., Stefanick J., Kim T.S., Guanghua L., Lawson S.R., Benfield D.A. Inhibition of porcine reproductive and respiratory syndrome virus by interferon-gamma and recovery of virus replication with 2-aminopurine. Arch. Virol. 2001, 146:539-555.
21. Sudhakar A., Ramachandran A., Ghosh S., Hasnain S.E., Kaufman R.J., Ramaiah K.V. Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of eIF2B. Biochemistry 2000, 39:12929-12938.
22. Sun Y., Han M., Kim C., Calvert J.G., Yoo D. Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus. Viruses 2012, 4:424-446.
23. Tu Y.C., Yu C.Y., Liang J.J., Lin E., Liao C.L., Lin Y.L. Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A. J. Virol. 2012, 86:10347-10358.
24. Wang R., Zhang Y.J. Antagonizing interferon-mediated immune response by porcine reproductive and respiratory syndrome virus. BioMed Res. Int. 2014, 315470.
25. Wang X., Zhang H., Abel A.M., Nelson E. Protein kinase R (PKR) plays a pro-viral role in porcine reproductive and respiratory syndrome virus (PRRSV) replication by modulating viral gene transcription. Arch. Virol. 2016, 161:327-333.
26. Williams B.R. PKR; a sentinel kinase for cellular stress. Oncogene 1999, 18:6112-6120.
27. Zhang Y.J., Stein D.A., Fan S.M., Wang K.Y., Kroeker A.D., Meng X.J., Iversen P.L., Matson D.O. Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers. Vet. Microbiol. 2006, 117:117-129.
28. Zhang Y.J., Wang K.Y., Stein D.A., Patel D., Watkins R., Moulton H.M., Iversen P.L., Matson D.O. Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers. Antiviral Res. 2007, 73:12-23.
29. Zhang L., Alter H.J., Wang H., Jia S., Wang E., Marincola F.M., Shih J.W., Wang R.Y. The modulation of hepatitis C virus 1a replication by PKR is dependent on NF-kB mediated interferon beta response in Huh7.5.1 cells. Virology 2013, 438:28-36.