Ion Channels in Cardiac Fibroblasts: Link to mechanically gated channels and their regulation

Mechanically Gated Channels and their Regulation

Volumn , Issue , 2012, Pages 215-244

  Abramochkin, Denis V ^a   Lozinsky, Ilya ^a   Kamkin, Andre ^a  

^a PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

Ca2+ activated K+ current; Cardiac fibroblasts; Delayed rectifier current; Inward rectifier potassium current; Mechanically gated currents; Non selective cation currents; Transient potassium current; TTX sensitive sodium voltage gated current; Voltage gated proton current; Volume sensitive chloride current

Indexed keywords

CELL CULTURE; CHLORINE COMPOUNDS; ELECTRIC RECTIFIERS; FIBROBLASTS; HEART; POSITIVE IONS; POTASSIUM; POTASSIUM CHLORIDE; POWER QUALITY; RECTIFYING CIRCUITS; SODIUM;

ACTION POTENTIAL DURATIONS; CARDIAC FIBROBLASTS; CARDIOMYOCYTES; DELAYED RECTIFIER; HYPERPOLARIZATION; MEMBRANE POTENTIALS; POTASSIUM CURRENTS; PROTON CURRENT;

TRANSIENTS;

EID: 84960362020     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-5073-9_7     Document Type: Chapter

References (71)

1. Adler CP, RinglageWP, Bohm N (1981) DNS-Gehalt und Zellzahl in Herz und Leber von Kindern. Pathol Res Pract 172: 25-41
2. Baumgarten CM, Clemo HF (2003) Swelling-activated chloride channels in cardiac physiology and pathophysiology. Prog Biophys Mol Biol 82: 25-42
3. Benamer N, Maati HMO, Demolombe S, Cantereau A, Delwail A, Bois P, Bescond J, Faivre J (2009) Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts. J Mol Cell Cardiol 46: 508-517
4. Benamer N, Fares N, Bois P, Faivre J (2011) Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts. Biochem Biophys Res Commun 408: 6-11
5. Boyett MR, Honjo H, Kodama I (2000) The sinoatrial node, a heterogenous pacemaker structure. Cardiovasc Res 47: 658-687
6. Camelliti P, Borg TK, Kohl P (2005) Structural and functional characterization of cardiac fibroblasts. Cardiovasc Res 65: 40-51
7. Carver W, Fuseler JW (2010) Mechanical stretch-induced reorganization of the cytoskeleton and the small GTPase Rac in cardiac fibroblasts. In: Mechanosensitivity in Cells and Tissues 3. Mechanosensitivity of the Heart. Andre Kamkin and Irina Kiseleva (eds.). Springer, Berlin, pp 35-54
8. + currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts. Am J Physiol Heart Circ Physiol 288: H2931-H2939
9. Clapham DE, Runnels LW, Strubing C (2001) The trp ion channel family. Nat Rev Neurosci 2: 387-396
10. Coetzee WA, Amarillo Y, Chiu J, Chow A, Lau D, McCormack T, Moreno H, Nadal MS, Ozaita A, Pountney D, Saganich M, Vega-Saenz de Miera E, Rudy B (1999) Molecular diversity of K1 channels. Ann NY Acad Sci 868: 233-285
11. Decoursey TE (2003) Voltage-gated proton channels and other proton transfer pathways. Physiol Rev 83: 475-579
12. Du X, Gao Z, Lau C, Chiu S, Tse H, Baumgarten CM, Li G (2004) Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases. J Gen Physiol 123: 427-439
13. El Chemaly A, Guinamard R, Demion M, Fares N, Jebara V, Faivre JF, Bois P (2006) A voltage-activated proton current in human cardiac fibroblasts. Biochem Biophys Res Commun 340(2): 512-516
14. Goshima K (1970) Formation of nexuses and electrotonic transmission between myocardial and FL cells in monolayer culture. Exp Cell Res 63(1): 124-130
15. Goshima K, Tonomura Y (1969) Synchronized beating of embryonic mouse myocardial cells mediated by FL cells in monolayer culture. Exp Cell Res 56(2): 387-392
16. Hamill OP, Martinac B (2001) Molecular basis of mechanotransduction in living cells. Physiol Rev 81(2): 685-740
17. Hatano N, Itoh Y, Muraki K (2009) Cardiac fibroblasts have functional TRPV4 activated by 4α-phorbol 12,13-didecanoate. Life Sci 85: 808-814
18. He M, Liu W, Sun H, Wu W, Liu J, Tse H, Lau C, LiG (2011) Effects of ion channels on proliferation in cultured human cardiac fibroblasts. J Mol Cell Cardiol 51: 198-206
19. Hiraoka M, Kawano S, Hirano Y, Furukawa T (1998) Role of cardiac chloride currents in changes in action potential characteristics and arrhythmias. Cardiovasc Res 40: 23-33
20. +]c in ventricular myocytes. Prog Biophys Mol Biol 82(1-3): 43-56
21. Kaab S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF (1998) Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 98: 1383-1393
22. Kamkin A, Kiseleva I, Kircheis R, Kositzky G (1988) Abhandlungen der Akademie der Wissenschaften der DDR (Abteilung Mathematik - Naturwissenschaft - Technik) 1: 103
23. Kamkin A, Kiseleva I, Wagner KD, Lammerich A, Bohm J, Persson PB, Günther J (1999) Mechanically induced potentials in fibroblasts from human right atrium. Exp Physiol 84: 347-356
24. Kamkin A, Kiseleva I, Isenberg G (2000) Stretch-activated currents in ventricular myocytes: amplitude and arrhythmogenic effects increase with hypertrophy. Cardiovasc Res 48(3): 409-420
25. KamkinA, Kiseleva I, Wagner KD, Scholz H, Theres H, KazanskiV, Lozinsky I, Gunther J, Isenberg G (2001) Mechanically induced potentials in rat atrial fibroblasts depend on actin and tubulin polymerisation. Pflugers Arch 442: 487-497
26. Kamkin A, Kiseleva I, Wagner KD, Pylaev A, Leiterer KP, Theres H, Scholz H, Günther J, Isenberg G (2002) A possible role for atrial fibroblasts in postinfarction bradycardia. Am J Physiol 282: H842-H849
27. Kamkin A, Kiseleva I, Isenberg G (2003a) Activation and inactivation of a non-selective cation conductance by local mechanical deformation of acutely isolated cardiac fibroblasts. Cardiovasc Res 57: 793-803
28. Kamkin A, Kiseleva I, Isenberg G, Wagner KD, Günther J, Theres H, Scholz H (2003b) Cardiac fibroblasts and the mechano-electric feedback mechanism in healthy and diseased hearts. Prog Biophys Mol Biol 82: 111-120
29. Kamkin A, Kiseleva I, Wagner KD, Lozinsky I, Günther J, Scholz H (2003c) Mechanically induced potentials in atrial fibroblasts from rat hearts are sensitive to hypoxia/reoxygenation. Pflügers Arch 446: 169-174
30. KamkinA, Kirischuk S, Kiseleva I (2010a) Single mechano-gated channels activated by mechanical deformation of acutely isolated cardiac fibroblasts from rats. Acta Physiol 199: 277-292
31. Kamkin A, Kiseleva I, Lozinsky I (2010b) The role of mechanosensitive fibroblasts in the heart: evidence from acutely isolated single cells, cultured cells and from intracellular microelectrode recordings on multicellular preparations from healthy and diseased cardiac tissue. In: Mechanosensitivity in Cells and Tissues 3. Mechanosensitivity of the Heart. Andre Kamkin and Irina Kiseleva (eds.) Springer, Berlin, pp 239-266
32. Kamkin A, Scholz H, Kiseleva I (2011) Cardiac fibroblasts in normal and diseased heart: single mechanically-gated ion channels, mechanosensitive currents and mechanically induced potentials in isolated cells and tissue. In: Turner NA (ed) The cardiac fibroblast. Research Signpost, Kerala, pp 1-16
33. Kiseleva IS, Kamkin AG, Kircheis R, Kositski GI (1987) Intercellular electrotonic interactions in the cardiac sinus node in the frog. Dokl Akad Nauk SSSR, 292(6): 1502-1505
34. Kiseleva I, Kamkin A, Kohl P, Lab M (1996) Calcium and mechanically induced potentials in fibroblasts of rat atrium. Cardiovasc Res 32: 98-111
35. Kiseleva I, Kamkin A, Pylaev A, Kondratjev D, Leiterer KP, Theres H, Wagner KD, Persson PB, Günther J (1998) Electrophysiological properties of mechanosensitive atrial fibroblasts from chronic infarcted rat heart. J Mol Cell Cardiol 30: 1083-1093
36. Kohl P, Camelliti P, Burton FL, Smith GL (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. J Electrocardiol 38: 45-50
37. Lammerding J, Kamm PD, Lee RT (2004) Mechanotransduction in cardiac myocytes. Ann N Y Acad Sci 1015: 53-70
38. Li G, Sun H, Chen J, ZhouY, Tse H, Lau C (2009) Characterization of Multiple Ion Channels in Cultured Human Cardiac Fibroblasts. PLoS ONE 4(10): e7307. doi: 10.1371/journal.pone.0007307
39. Lopatin AN, Nichols CG (2001) Inward rectifiers in the heart: an update on IK1. J Mol Cell Cardiol 33: 625-638
40. Meissner M, Weissgerber P, Londono JEC, Prenen J, Link S, Ruppenthal S, Molkentin JD, Lipp P, Nilius B, Freichel M, Flockerzi V (2011) Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene. J BiolChem 286(18): 15875-15882
41. Montell C (2005) The TRP superfamily of cation channels. Sci STKE 2005: 1-24
42. Nilius B, Talavera K, Owsianik G, Prenen J, Droogmans G, Voets T (2005) Gating of TRP channels: a voltage connection? J Physiol 567: 35-44
43. Okada Y, Yada T, Ohno-Shosaku T, Oiki S, Ueda S, Machida K (1984) Exogenous ATP induces electrical membrane responses in fibroblasts. Exp Cell Res 152: 552-557
44. Oren RV, Clancy CE (2010) Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. PLOS Comp Biol 6(12): e1001041. doi: 10.1371/journal.pcbi.1001041
45. Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (2001) The molecular physiology of the cardiac transient outward potassium current Ito in normal and diseased myocardium. J Mol Cell Cardiol 33: 851-872
46. Owsianik G, Talavera K, Voets T, Nilius B (2006) Permeation and selectivity of TRP channels. Annu Rev Physiol 68: 685-717
47. Roden DM, Balser JR, George AL Jr (2002) Cardiac ion channels. Annu Rev Physiol 64: 431-475
48. Rodrigues AR, Arantes EC, Monje F, Stuhmer W, Varanda WA (2003) Tityustoxin-K(alpha) blockade of the voltage-gated potassium channel Kv1.3. Br J Pharmacol 139: 1180-1186
49. Rook MB, van GinnekenACG, De Jonge B, El Aoumari A, Gros D, Jongsma HJ (1992) Differences in gap junction channels between cardiac myocytes, fibroblasts, and heterologous pairs. Cell Physiol 32: C959-C977
50. Rose RA, Giles WR (2008) Natriuretic peptide C receptor signaling in the heart and vasculature. J Physiol 586(2): 353-366
51. Rose RA, Hatano N, Ohya S, Imaizumi Y, Giles WR (2007) C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signaling. J Physiol 580(1): 255-274
52. Sachs F, Morris CE (1998) Mechanosensitive ion channels in nonspecialized cells. Rev Physiol Biochem Pharmacol 132: 1-77
53. + channels in postischaemic heart. Clin Exp Pharmacol Physiol 29: 324-329
54. Schram G, Pourrier M, Nattel S (2002) Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circ Res 90: 939-950
55. + currents activated by depolarization in cardiac fibroblasts. Biophys J 88: 3924-3935
56. Shieh C-C, Coghlan M, Sullivan JP, Gopalakrishnan M (2000) Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev 52: 557-594
57. Spach MS, Boineau JP (1997) Microfibrosis produces electrical load variations due to loss of sideto-side cell connections: a major mechanism of structural heart disease arrhythmias. Pacing Clin Electrophysiol 20: 397-413
58. Tamargo J, Caballero R, Gomez R, Valenzuela C, Delpon E (2004) Pharmacology of cardiac potassium channels. Cardiovasc Res 62: 9-33
59. Thampatty B, Wang J (2008) Mechanobiology of fibroblasts. In: Mechanosensitivity in Cells and Tissues 1. Mechanosensitive ion channels. Andre Kamkin and Irina Kiseleva (eds.) Springer, Berlin, pp 351-378
60. Tombola F, Ulbrich MH, Isacoff EY (2008) The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron 58: 546-556
61. Tsuchiya W, Okada Y, Yano J, Inouye A, Sasaki S, Doida Y (1981) Effects of cytochalasin B and local anesthetics on electrical and morphological properties in L cells. Exp Cell Res 133: 83-92
62. Vergara C, Latorre R, Marrion NV, Adelman JP (1998) Calcium-activated potassium channels. Curr Opin Neurobiol 8(3): 321-329
63. Vliegen HW, Van Der Laarse A, Cornelisse CJ, Eulderink F (1991) Myocardial changes in pressure overload-induced left ventricular hypertrophy. A study on tissue composition, polyploidization and multinucleation. Eur Heart J 12: 488-494
64. +channels: regulation of a transient outward current by protein kinase C. Am J Physiol Heart Circ Physiol 294: H1010-H1017
65. ca-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts. J Membr Biol 213: 175-185
66. + channel from human atrium. Circ Res 76: 343-350
67. Wolk R, Cobbe SM, Hicks MN, Kane KA (1999) Functional, structural, and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy. Pharmacol Ther 84: 207-231
68. + channel in human and mouse hearts. J Biol Chem 278(49): 49085-49094
69. Yellen G (2002) The voltage-gated potassium channels and their relatives. Nature 419: 35-42
70. Yue L, Xie J, Nattel S (2011) Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res 89: 744-753
71. Zhang Y, Gao F, Popov VL, Wen JW, Hamill OP (2000) Mechanically gated channel activity in cytoskeleton-deficient plasma membrane blebs and vesicles from Xenopus oocytes. J Physiol 523: 117-130