Modulation of Hexadecyl-LPA-Mediated Activation of Mast Cells and Microglia by a Chemical Probe for LPA5

ChemBioChem

Volumn 17, Issue 9, 2016, Pages 861-865

  Kozian, Detlef H ^a   Von Haeften, Elisabeth ^b   Joho, Sabrina ^a   Czechtizky, Werngard ^a   Anumala, Upendra R ^c   Roux, Pascale ^d   Dudda, Angela ^a   Evers, Andreas ^a   Nazare, Marc ^c  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b Merck Chemicals GmbH   (Germany)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^d SANOFI   (France)

Author keywords

inflammation; inhibitors; lysophosphatidic acids; mast cells; microglia

Indexed keywords

CALCIUM ION; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 5; LYSOPHOSPHATIDIC ACID RECEPTOR 5 INHIBITOR; MONOCYTE CHEMOTACTIC PROTEIN 1; RECEPTOR BLOCKING AGENT; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHOLIPID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; ATHEROSCLEROTIC PLAQUE; CACO 2 CELL LINE; CALCIUM TRANSPORT; CELL ACTIVATION; CELL CULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; EC50; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MAST CELL; MAXIMUM PLASMA CONCENTRATION; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPATHIC PAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HALF LIFE TIME; KINETICS; METABOLISM; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; CELL LINE; CELL MEMBRANE PERMEABILITY; CHEMOKINE CCL2; GENE EXPRESSION; HALF-LIFE; HUMANS; KINETICS; LYSOPHOSPHOLIPIDS; MALE; MAST CELLS; MICE; MICE, INBRED C57BL; MICROGLIA; MICROSOMES, LIVER; RECEPTORS, LYSOPHOSPHATIDIC ACID;

EID: 84960194761     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201500559     Document Type: Article

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