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Volumn 1861, Issue 5, 2016, Pages 430-438

Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice

Author keywords

Adiposity; Browning; Fatty acid oxidation; Mitochondria; mTOR; UCP 1

Indexed keywords

ADIPONECTIN; CCAAT ENHANCER BINDING PROTEIN BETA; FATTY ACID; GLUCOSE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; MESSENGER RNA; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; ADIPOQ PROTEIN, MOUSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TUMOR SUPPRESSOR PROTEIN;

EID: 84960193621     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2016.02.023     Document Type: Article
Times cited : (37)

References (39)
  • 1
    • 70350418625 scopus 로고    scopus 로고
    • MTOR signaling at a glance
    • M. Laplante, and D.M. Sabatini mTOR signaling at a glance J. Cell Sci. 122 2009 3589 3594
    • (2009) J. Cell Sci. , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 2
    • 84874655800 scopus 로고    scopus 로고
    • The multifaceted role of mTORC1 in the control of lipid metabolism
    • S.J. Ricoult, and B.D. Manning The multifaceted role of mTORC1 in the control of lipid metabolism EMBO Rep. 14 2013 242 251
    • (2013) EMBO Rep. , vol.14 , pp. 242-251
    • Ricoult, S.J.1    Manning, B.D.2
  • 3
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • M. Laplante, and D.M. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 6
    • 54849431380 scopus 로고    scopus 로고
    • Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
    • P. Polak, N. Cybulski, J.N. Feige, J. Auwerx, M.A. Ruegg, and M.N. Hall Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration Cell Metab. 8 2008 399 410
    • (2008) Cell Metab. , vol.8 , pp. 399-410
    • Polak, P.1    Cybulski, N.2    Feige, J.N.3    Auwerx, J.4    Ruegg, M.A.5    Hall, M.N.6
  • 7
    • 77953218866 scopus 로고    scopus 로고
    • Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
    • V.P. Houde, S. Brule, W.T. Festuccia, P.G. Blanchard, K. Bellmann, Y. Deshaies, and A. Marette Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue Diabetes 59 2010 1338 1348
    • (2010) Diabetes , vol.59 , pp. 1338-1348
    • Houde, V.P.1    Brule, S.2    Festuccia, W.T.3    Blanchard, P.G.4    Bellmann, K.5    Deshaies, Y.6    Marette, A.7
  • 9
    • 0034823939 scopus 로고    scopus 로고
    • Rapamycin-sensitive phase of 3T3-L1 preadipocyte differentiation after clonal expansion
    • A. Gagnon, S. Lau, and A. Sorisky Rapamycin-sensitive phase of 3T3-L1 preadipocyte differentiation after clonal expansion J. Cell. Physiol. 189 2001 14 22
    • (2001) J. Cell. Physiol. , vol.189 , pp. 14-22
    • Gagnon, A.1    Lau, S.2    Sorisky, A.3
  • 10
    • 7044234995 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor-γ activity by mammalian target of rapamycin and amino acids in adipogenesis
    • J.E. Kim, and J. Chen Regulation of peroxisome proliferator-activated receptor-γ activity by mammalian target of rapamycin and amino acids in adipogenesis Diabetes 53 2004 2748 2756
    • (2004) Diabetes , vol.53 , pp. 2748-2756
    • Kim, J.E.1    Chen, J.2
  • 14
    • 84880906852 scopus 로고    scopus 로고
    • Mechanistic target of rapamycin controls homeostasis of adipogenesis
    • M.S. Yoon, C. Zhang, Y. Sun, C.J. Schoenherr, and J. Chen Mechanistic target of rapamycin controls homeostasis of adipogenesis J. Lipid Res. 54 2013 2166 2173
    • (2013) J. Lipid Res. , vol.54 , pp. 2166-2173
    • Yoon, M.S.1    Zhang, C.2    Sun, Y.3    Schoenherr, C.J.4    Chen, J.5
  • 17
    • 77954412017 scopus 로고    scopus 로고
    • Basal adrenergic tone is required for maximal stimulation of rat brown adipose tissue UCP1 expression by chronic PPAR-gamma activation
    • W.T. Festuccia, P.G. Blanchard, D. Richard, and Y. Deshaies Basal adrenergic tone is required for maximal stimulation of rat brown adipose tissue UCP1 expression by chronic PPAR-gamma activation Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 2010 R159 R167
    • (2010) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.299 , pp. R159-R167
    • Festuccia, W.T.1    Blanchard, P.G.2    Richard, D.3    Deshaies, Y.4
  • 20
    • 84865826544 scopus 로고    scopus 로고
    • Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells
    • M. Spinazzi, A. Casarin, V. Pertegato, L. Salviati, and C. Angelini Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells Nat. Protoc. 7 2012 1235 1246
    • (2012) Nat. Protoc. , vol.7 , pp. 1235-1246
    • Spinazzi, M.1    Casarin, A.2    Pertegato, V.3    Salviati, L.4    Angelini, C.5
  • 21
    • 84892727198 scopus 로고    scopus 로고
    • What we talk about when we talk about fat
    • E.D. Rosen, and B.M. Spiegelman What we talk about when we talk about fat Cell 156 2014 20 44
    • (2014) Cell , vol.156 , pp. 20-44
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 22
    • 79953177846 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation
    • H.L. Kenerson, M.M. Yeh, and R.S. Yeung Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation PLoS One 6 2011 e18075
    • (2011) PLoS One , vol.6
    • Kenerson, H.L.1    Yeh, M.M.2    Yeung, R.S.3
  • 24
    • 77951166692 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage
    • P. Chakrabarti, T. English, J. Shi, C.M. Smas, and K.V. Kandror Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage Diabetes 59 2010 775 781
    • (2010) Diabetes , vol.59 , pp. 775-781
    • Chakrabarti, P.1    English, T.2    Shi, J.3    Smas, C.M.4    Kandror, K.V.5
  • 25
    • 36749081539 scopus 로고    scopus 로고
    • MTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
    • J.T. Cunningham, J.T. Rodgers, D.H. Arlow, F. Vazquez, V.K. Mootha, and P. Puigserver mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex Nature 450 2007 736 740
    • (2007) Nature , vol.450 , pp. 736-740
    • Cunningham, J.T.1    Rodgers, J.T.2    Arlow, D.H.3    Vazquez, F.4    Mootha, V.K.5    Puigserver, P.6
  • 26
    • 33748752151 scopus 로고    scopus 로고
    • The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
    • S.M. Schieke, D. Phillips, J.P. McCoy Jr., A.M. Aponte, R.F. Shen, R.S. Balaban, and T. Finkel The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity J. Biol. Chem. 281 2006 27643 27652
    • (2006) J. Biol. Chem. , vol.281 , pp. 27643-27652
    • Schieke, S.M.1    Phillips, D.2    McCoy, J.P.3    Aponte, A.M.4    Shen, R.F.5    Balaban, R.S.6    Finkel, T.7
  • 27
    • 84949115098 scopus 로고    scopus 로고
    • PPARs and ERRs: molecular mediators of mitochondrial metabolism
    • W. Fan, and R. Evans PPARs and ERRs: molecular mediators of mitochondrial metabolism Curr. Opin. Cell Biol. 33 2015 49 54
    • (2015) Curr. Opin. Cell Biol. , vol.33 , pp. 49-54
    • Fan, W.1    Evans, R.2
  • 29
    • 34548317506 scopus 로고    scopus 로고
    • C/EBPbeta reprograms white 3T3-L1 preadipocytes to a Brown adipocyte pattern of gene expression
    • G. Karamanlidis, A. Karamitri, K. Docherty, D.G. Hazlerigg, and M.A. Lomax C/EBPbeta reprograms white 3T3-L1 preadipocytes to a Brown adipocyte pattern of gene expression J. Biol. Chem. 282 2007 24660 24669
    • (2007) J. Biol. Chem. , vol.282 , pp. 24660-24669
    • Karamanlidis, G.1    Karamitri, A.2    Docherty, K.3    Hazlerigg, D.G.4    Lomax, M.A.5
  • 30
    • 84875909085 scopus 로고    scopus 로고
    • Molecular and genetic crosstalks between mTOR and ERRalpha are key determinants of rapamycin-induced nonalcoholic fatty liver
    • C. Chaveroux, L.J. Eichner, C.R. Dufour, A. Shatnawi, A. Khoutorsky, G. Bourque, N. Sonenberg, and V. Giguere Molecular and genetic crosstalks between mTOR and ERRalpha are key determinants of rapamycin-induced nonalcoholic fatty liver Cell Metab. 17 2013 586 598
    • (2013) Cell Metab. , vol.17 , pp. 586-598
    • Chaveroux, C.1    Eichner, L.J.2    Dufour, C.R.3    Shatnawi, A.4    Khoutorsky, A.5    Bourque, G.6    Sonenberg, N.7    Giguere, V.8
  • 31
    • 34347261400 scopus 로고    scopus 로고
    • Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha
    • D. Debevec, M. Christian, D. Morganstein, A. Seth, B. Herzog, M. Parker, and R. White Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha Mol. Endocrinol. 21 2007 1581 1592
    • (2007) Mol. Endocrinol. , vol.21 , pp. 1581-1592
    • Debevec, D.1    Christian, M.2    Morganstein, D.3    Seth, A.4    Herzog, B.5    Parker, M.6    White, R.7
  • 32
    • 84921912380 scopus 로고    scopus 로고
    • Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch
    • X. Xiang, H. Lan, H. Tang, F. Yuan, Y. Xu, J. Zhao, Y. Li, and W. Zhang Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch Diabetes 64 2015 519 528
    • (2015) Diabetes , vol.64 , pp. 519-528
    • Xiang, X.1    Lan, H.2    Tang, H.3    Yuan, F.4    Xu, Y.5    Zhao, J.6    Li, Y.7    Zhang, W.8
  • 34
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • A.H. Berg, T.P. Combs, X. Du, M. Brownlee, and P.E. Scherer The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat. Med. 7 2001 947 953
    • (2001) Nat. Med. , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 35
    • 0035663963 scopus 로고    scopus 로고
    • Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
    • T.P. Combs, A.H. Berg, S. Obici, P.E. Scherer, and L. Rossetti Endogenous glucose production is inhibited by the adipose-derived protein Acrp30 J. Clin. Invest. 108 2001 1875 1881
    • (2001) J. Clin. Invest. , vol.108 , pp. 1875-1881
    • Combs, T.P.1    Berg, A.H.2    Obici, S.3    Scherer, P.E.4    Rossetti, L.5


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