PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Alves, Maria M ^a   Fuhler, Gwenny M ^a   Queiroz, Karla C S ^b   Scholma, Jetse ^a   Goorden, Susan ^a   Anink, Jasper ^c   Arnold Spek, C ^b   Hoogeveen Westerveld, Marianne ^a   Bruno, Marco J ^a   Nellist, Mark ^a   Elgersma, Ype ^a   Aronica, Eleonora ^c,d   Peppelenbosch, Maikel P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

P21 ACTIVATED KINASE; PROTEIN BINDING; RAC PROTEIN; TARGET OF RAPAMYCIN KINASE; TUBERIN; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL; CELL LINE; CELL MOTION; DRUG EFFECTS; ENZYME ACTIVATION; FIBROBLAST; GENE DELETION; GENE INACTIVATION; GENETICS; HUMAN; METABOLISM; MOLECULARLY TARGETED THERAPY; MOUSE; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUBEROUS SCLEROSIS;

ANIMALS; CELL LINE; CELL MOVEMENT; ENZYME ACTIVATION; FIBROBLASTS; GENE DELETION; GENE KNOCKOUT TECHNIQUES; HUMANS; MICE; MOLECULAR TARGETED THERAPY; P21-ACTIVATED KINASES; PHOSPHORYLATION; PROTEIN BINDING; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 84942362111     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14534     Document Type: Article

References (0)