Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling

Circulation

Volumn 133, Issue 15, 2016, Pages 1458-1471

  Bénard, Ludovic ^a   Oh, Jae Gyun ^a   Cacheux, Marine ^a   Lee, Ahyoung ^a   Nonnenmacher, Mathieu ^a   Matasic, Daniel S ^a   Kohlbrenner, Erik ^a   Kho, Changwon ^a   Pavoine, Catherine ^b   Hajjar, Roger J ^a   Hulot, Jean Sébastien ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

calcium; genetic therapy; heart failure; Stim1 protein, mouse; TOR complex 2

Indexed keywords

BETA CATENIN; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; CASPASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE B; SHORT HAIRPIN RNA; STROMAL INTERACTION MOLECULE 1; TDZD 8; UNCLASSIFIED DRUG; AKT1 PROTEIN, MOUSE; CALCIUM CHANNEL; CARRIER PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GSK3B PROTEIN, MOUSE; MULTIPROTEIN COMPLEX; RICTOR PROTEIN, MOUSE; SMALL INTERFERING RNA; STIM1 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ADENO ASSOCIATED VIRUS 9; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIAC MUSCLE CELL; CELL MEMBRANE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; GENE SILENCING; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HYDROPHOBICITY; IN VIVO GENE TRANSFER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CALCIUM SIGNALING; CARDIOMEGALY; CHEMISTRY; DISEASE MODEL; GENETICS; HEART VENTRICLE REMODELING; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN PROCESSING; RNA INTERFERENCE;

AMINO ACID MOTIFS; ANIMALS; CALCIUM CHANNELS; CALCIUM SIGNALING; CARDIOMEGALY; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HEART FAILURE; MALE; MICE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN INTERACTION MAPPING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, SMALL INTERFERING; STROMAL INTERACTION MOLECULE 1; TOR SERINE-THREONINE KINASES; VENTRICULAR REMODELING;

EID: 84960145572     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.115.020678     Document Type: Article

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