Bromodomain and extra-terminal domain bromodomain inhibition prevents synovial inflammation via blocking IκB kinase-dependent NF-κB activation in rheumatoid fibroblast-like synoviocytes

Rheumatology (United Kingdom)

Volumn 55, Issue 1, 2016, Pages 173-184

  Xiao, Youjun ^a   Liang, Liuqin ^a   Huang, Mingcheng ^a   Qiu, Qian ^a   Zeng, Shan ^a   Shi, Maohua ^a   Zou, Yaoyao ^a   Ye, Yujin ^a   Yang, Xiuyan ^a   Xu, Hanshi ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Bromodomain and extra terminal domain; Fibroblast like synoviocytes; I B kinase; NF B; Rheumatoid arthritis

Indexed keywords

4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; ADAPTOR PROTEIN; BRD2 PROTEIN; BRD3 PROTEIN; BRD4 PROTEIN; BRDT PROTEIN; BROMODOMAIN INHIBITOR; COLLAGENASE 3; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; SHORT HAIRPIN RNA; STROMELYSIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; COLLAGEN-INDUCED ARTHRITIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; JOINT DESTRUCTION; LUCIFERASE ASSAY; MALE; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RHEUMATOID FIBROBLAST LIKE SYNOVIOCYTE; SYNOVIOCYTE; SYNOVITIS; WESTERN BLOTTING;

EID: 84960110543     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kev312     Document Type: Article

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