메뉴 건너뛰기




Volumn 4, Issue 6, 2015, Pages 743-751

Predictive factors of activity of anti-programmed death-1/programmed death ligand-1 drugs: Immunohistochemistry analysis

Author keywords

Biomarker; Immunohistochemistry (IHC); Immunotherapy; PD 1; Programmed death ligand 1 (PD L1)

Indexed keywords


EID: 84960091837     PISSN: 22186751     EISSN: 22264477     Source Type: Journal    
DOI: 10.3978/j.issn.2218-6751.2015.12.10     Document Type: Review
Times cited : (32)

References (75)
  • 2
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma SV, Bell DW, Settleman J, et al. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 2007;7:169-81.
    • (2007) Nat Rev Cancer , vol.7 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3
  • 3
    • 84870317500 scopus 로고    scopus 로고
    • The introduction of systematic genomic testing for patients with non-smallcell lung cancer
    • Cardarella S, Ortiz TM, Joshi VA, et al. The introduction of systematic genomic testing for patients with non-smallcell lung cancer. J Thorac Oncol 2012;7:1767-74.
    • (2012) J Thorac Oncol , vol.7 , pp. 1767-1774
    • Cardarella, S.1    Ortiz, T.M.2    Joshi, V.A.3
  • 4
    • 0036384579 scopus 로고    scopus 로고
    • Prognostic factors in non-small cell lung cancer: a decade of progress
    • Brundage MD, Davies D, Mackillop WJ. Prognostic factors in non-small cell lung cancer: a decade of progress. Chest 2002;122:1037-57.
    • (2002) Chest , vol.122 , pp. 1037-1057
    • Brundage, M.D.1    Davies, D.2    Mackillop, W.J.3
  • 5
    • 0026653868 scopus 로고
    • Interleukin-2 and interferon-alpha in the treatment of patients with advanced non-small-cell lung cancer
    • Jansen RL, Slingerland R, Goey SH, et al. Interleukin-2 and interferon-alpha in the treatment of patients with advanced non-small-cell lung cancer. J Immunother (1991) 1992;12:70-3.
    • (1992) J Immunother (1991) , vol.12 , pp. 70-73
    • Jansen, R.L.1    Slingerland, R.2    Goey, S.H.3
  • 6
    • 84855341896 scopus 로고    scopus 로고
    • Current status of immunotherapy for the treatment of lung cancer
    • Murala S, Alli V, Kreisel D, et al. Current status of immunotherapy for the treatment of lung cancer. J Thorac Dis 2010;2:237-44.
    • (2010) J Thorac Dis , vol.2 , pp. 237-244
    • Murala, S.1    Alli, V.2    Kreisel, D.3
  • 7
    • 52649163840 scopus 로고    scopus 로고
    • Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer
    • Al-Shibli KI, Donnem T, Al-Saad S, et al. Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer. Clin Cancer Res 2008;14:5220-7.
    • (2008) Clin Cancer Res , vol.14 , pp. 5220-5227
    • Al-Shibli, K.I.1    Donnem, T.2    Al-Saad, S.3
  • 8
    • 53149083361 scopus 로고    scopus 로고
    • Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer
    • Kawai O, Ishii G, Kubota K, et al. Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer. Cancer 2008;113:1387-95.
    • (2008) Cancer , vol.113 , pp. 1387-1395
    • Kawai, O.1    Ishii, G.2    Kubota, K.3
  • 9
    • 77955093008 scopus 로고    scopus 로고
    • CD8+ T cells expressing IL-10 are associated with a favourable prognosis in lung cancer
    • Miotto D, Lo Cascio N, Stendardo M, et al. CD8+ T cells expressing IL-10 are associated with a favourable prognosis in lung cancer. Lung Cancer 2010;69:355-60.
    • (2010) Lung Cancer , vol.69 , pp. 355-360
    • Miotto, D.1    Lo Cascio, N.2    Stendardo, M.3
  • 10
    • 84879637291 scopus 로고    scopus 로고
    • Reciprocal relationship between myeloid-derived suppressor cells and T cells
    • Nagaraj S, Youn JI, Gabrilovich DI. Reciprocal relationship between myeloid-derived suppressor cells and T cells. J Immunol 2013;191:17-23.
    • (2013) J Immunol , vol.191 , pp. 17-23
    • Nagaraj, S.1    Youn, J.I.2    Gabrilovich, D.I.3
  • 11
    • 77951877847 scopus 로고    scopus 로고
    • Tumorinfiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer
    • Shimizu K, Nakata M, Hirami Y, et al. Tumorinfiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer. J Thorac Oncol 2010;5:585-90.
    • (2010) J Thorac Oncol , vol.5 , pp. 585-590
    • Shimizu, K.1    Nakata, M.2    Hirami, Y.3
  • 12
    • 84864954385 scopus 로고    scopus 로고
    • Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention
    • Jadus MR, Natividad J, Mai A, et al. Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention. Clin Dev Immunol 2012;2012:160724.
    • (2012) Clin Dev Immunol , vol.2012 , pp. 160724
    • Jadus, M.R.1    Natividad, J.2    Mai, A.3
  • 13
    • 77957273623 scopus 로고    scopus 로고
    • TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
    • Yao Z, Fenoglio S, Gao DC, et al. TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proc Natl Acad Sci U S A 2010;107:15535-40.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15535-15540
    • Yao, Z.1    Fenoglio, S.2    Gao, D.C.3
  • 14
    • 77957330204 scopus 로고    scopus 로고
    • PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer
    • Baratelli F, Lee JM, Hazra S, et al. PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer. Am J Transl Res 2010;2:356-67.
    • (2010) Am J Transl Res , vol.2 , pp. 356-367
    • Baratelli, F.1    Lee, J.M.2    Hazra, S.3
  • 15
    • 33646368439 scopus 로고    scopus 로고
    • Is downregulation of MHC class I antigen expression in human non-small cell lung cancer associated with prolonged survival?
    • Ramnath N, Tan D, Li Q, et al. Is downregulation of MHC class I antigen expression in human non-small cell lung cancer associated with prolonged survival? Cancer Immunol Immunother 2006;55:891-9.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 891-899
    • Ramnath, N.1    Tan, D.2    Li, Q.3
  • 16
    • 84890980389 scopus 로고    scopus 로고
    • Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer
    • Drake CG, Lipson EJ, Brahmer JR. Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer. Nat Rev Clin Oncol 2014;11:24-37.
    • (2014) Nat Rev Clin Oncol , vol.11 , pp. 24-37
    • Drake, C.G.1    Lipson, E.J.2    Brahmer, J.R.3
  • 17
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles T, Eder JP, Fine GD, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014;515:558-62.
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3
  • 18
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 2012;24:207-12.
    • (2012) Curr Opin Immunol , vol.24 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 19
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992;11:3887-95.
    • (1992) EMBO J , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3
  • 20
    • 84886948036 scopus 로고    scopus 로고
    • B7 family checkpoint regulators in immune regulation and disease
    • Ceeraz S, Nowak EC, Noelle RJ. B7 family checkpoint regulators in immune regulation and disease. Trends Immunol 2013;34:556-63.
    • (2013) Trends Immunol , vol.34 , pp. 556-563
    • Ceeraz, S.1    Nowak, E.C.2    Noelle, R.J.3
  • 21
    • 65349118810 scopus 로고    scopus 로고
    • PD-1 signaling in primary T cells
    • Riley JL. PD-1 signaling in primary T cells. Immunol Rev 2009;229:114-25.
    • (2009) Immunol Rev , vol.229 , pp. 114-125
    • Riley, J.L.1
  • 22
    • 42649125225 scopus 로고    scopus 로고
    • PD-1 and its ligands in tolerance and immunity
    • Keir ME, Butte MJ, Freeman GJ, et al. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008;26:677-704.
    • (2008) Annu Rev Immunol , vol.26 , pp. 677-704
    • Keir, M.E.1    Butte, M.J.2    Freeman, G.J.3
  • 23
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • Francisco LM, Salinas VH, Brown KE, et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009;206:3015-29.
    • (2009) J Exp Med , vol.206 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3
  • 24
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte MJ, Keir ME, Phamduy TB, et al. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007;27:111-22.
    • (2007) Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3
  • 25
    • 46749114315 scopus 로고    scopus 로고
    • Interaction of human PD-L1 and B7-1
    • Butte MJ, Peña-Cruz V, Kim MJ, et al. Interaction of human PD-L1 and B7-1. Mol Immunol 2008;45:3567-72.
    • (2008) Mol Immunol , vol.45 , pp. 3567-3572
    • Butte, M.J.1    Peña-Cruz, V.2    Kim, M.J.3
  • 26
    • 10344220548 scopus 로고    scopus 로고
    • Costimulatory B7-H1 in renal cell carcinoma patients:Indicator of tumor aggressiveness and potential therapeutic target
    • Thompson RH, Gillett MD, Cheville JC, et al. Costimulatory B7-H1 in renal cell carcinoma patients:Indicator of tumor aggressiveness and potential therapeutic target. Proc Natl Acad Sci U S A 2004;101:17174-9.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17174-17179
    • Thompson, R.H.1    Gillett, M.D.2    Cheville, J.C.3
  • 27
    • 84875238628 scopus 로고    scopus 로고
    • Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung
    • Boland JM, Kwon ED, Harrington SM, et al. Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung. Clin Lung Cancer 2013;14:157-63.
    • (2013) Clin Lung Cancer , vol.14 , pp. 157-163
    • Boland, J.M.1    Kwon, E.D.2    Harrington, S.M.3
  • 28
    • 84891534246 scopus 로고    scopus 로고
    • Programmed death ligand-1 expression in non-small cell lung cancer
    • Velcheti V, Schalper KA, Carvajal DE, et al. Programmed death ligand-1 expression in non-small cell lung cancer. Lab Invest 2014;94:107-16.
    • (2014) Lab Invest , vol.94 , pp. 107-116
    • Velcheti, V.1    Schalper, K.A.2    Carvajal, D.E.3
  • 29
    • 84937629074 scopus 로고    scopus 로고
    • PD-L1 expression is a favorable prognostic factor in early stage non-small cell carcinoma
    • Cooper WA, Tran T, Vilain RE, et al. PD-L1 expression is a favorable prognostic factor in early stage non-small cell carcinoma. Lung Cancer 2015;89:181-8.
    • (2015) Lung Cancer , vol.89 , pp. 181-188
    • Cooper, W.A.1    Tran, T.2    Vilain, R.E.3
  • 30
    • 84928898064 scopus 로고    scopus 로고
    • The prognostic significance of PD-L1 in bladder cancer
    • Huang Y, Zhang SD, McCrudden C, et al. The prognostic significance of PD-L1 in bladder cancer. Oncol Rep 2015;33:3075-84.
    • (2015) Oncol Rep , vol.33 , pp. 3075-3084
    • Huang, Y.1    Zhang, S.D.2    McCrudden, C.3
  • 31
    • 84949539261 scopus 로고    scopus 로고
    • Tumor PD-L1 expression, immune cell correlates and PD-1+ lymphocytes in sentinel lymph node melanoma metastases
    • Kakavand H, Vilain RE, Wilmott JS, et al. Tumor PD-L1 expression, immune cell correlates and PD-1+ lymphocytes in sentinel lymph node melanoma metastases. Mod Pathol 2015;28:1535-44.
    • (2015) Mod Pathol , vol.28 , pp. 1535-1544
    • Kakavand, H.1    Vilain, R.E.2    Wilmott, J.S.3
  • 32
    • 84960407098 scopus 로고    scopus 로고
    • PD-L1 expression and prognostic impact in glioblastoma
    • Epub ahead of print
    • Nduom EK, Wei J, Yaghi NK, et al. PD-L1 expression and prognostic impact in glioblastoma. Neuro Oncol 2015. [Epub ahead of print].
    • (2015) Neuro Oncol
    • Nduom, E.K.1    Wei, J.2    Yaghi, N.K.3
  • 33
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • 127ra37
    • Taube JM, Anders RA, Young GD, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012;4:127ra37.
    • (2012) Sci Transl Med , vol.4
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3
  • 34
    • 84898843963 scopus 로고    scopus 로고
    • Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma
    • Zhang Y, Wang L, Li Y, et al. Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma. Onco Targets Ther 2014;7:567-73.
    • (2014) Onco Targets Ther , vol.7 , pp. 567-573
    • Zhang, Y.1    Wang, L.2    Li, Y.3
  • 35
    • 63149085789 scopus 로고    scopus 로고
    • MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gammainduced B7-H1 expression in cholangiocytes
    • Gong AY, Zhou R, Hu G, et al. MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gammainduced B7-H1 expression in cholangiocytes. J Immunol 2009;182:1325-33.
    • (2009) J Immunol , vol.182 , pp. 1325-1333
    • Gong, A.Y.1    Zhou, R.2    Hu, G.3
  • 36
    • 33846118474 scopus 로고    scopus 로고
    • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
    • Parsa AT, Waldron JS, Panner A, et al. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat Med 2007;13:84-8.
    • (2007) Nat Med , vol.13 , pp. 84-88
    • Parsa, A.T.1    Waldron, J.S.2    Panner, A.3
  • 37
    • 58249112908 scopus 로고    scopus 로고
    • PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer
    • Crane CA, Panner A, Murray JC, et al. PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer. Oncogene 2009;28:306-12.
    • (2009) Oncogene , vol.28 , pp. 306-312
    • Crane, C.A.1    Panner, A.2    Murray, J.C.3
  • 38
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells
    • 200ra116
    • Spranger S, Spaapen RM, Zha Y, et al. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Sci Transl Med 2013;5:200ra116.
    • (2013) Sci Transl Med , vol.5
    • Spranger, S.1    Spaapen, R.M.2    Zha, Y.3
  • 39
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • Dong H, Zhu G, Tamada K, et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999;5:1365-9.
    • (1999) Nat Med , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3
  • 40
    • 43549115533 scopus 로고    scopus 로고
    • B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
    • Azuma T, Yao S, Zhu G, et al. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 2008;111:3635-43.
    • (2008) Blood , vol.111 , pp. 3635-3643
    • Azuma, T.1    Yao, S.2    Zhu, G.3
  • 41
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    • Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004;4:336-47.
    • (2004) Nat Rev Immunol , vol.4 , pp. 336-347
    • Chen, L.1
  • 42
    • 34547794178 scopus 로고    scopus 로고
    • PD-1 and PD-1 ligands:from discovery to clinical application
    • Okazaki T, Honjo T. PD-1 and PD-1 ligands:from discovery to clinical application. Int Immunol 2007;19:813-24.
    • (2007) Int Immunol , vol.19 , pp. 813-824
    • Okazaki, T.1    Honjo, T.2
  • 43
    • 84886421073 scopus 로고    scopus 로고
    • Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer-- response
    • Sznol M, Chen L. Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer-- response. Clin Cancer Res 2013;19:5542.
    • (2013) Clin Cancer Res , vol.19 , pp. 5542
    • Sznol, M.1    Chen, L.2
  • 44
    • 44349150012 scopus 로고    scopus 로고
    • Inhibitory B7-family molecules in the tumour microenvironment
    • Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 2008;8:467-77.
    • (2008) Nat Rev Immunol , vol.8 , pp. 467-477
    • Zou, W.1    Chen, L.2
  • 45
    • 84890284474 scopus 로고    scopus 로고
    • Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer
    • Duraiswamy J, Freeman GJ, Coukos G. Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer. Cancer Res 2013;73:6900-12.
    • (2013) Cancer Res , vol.73 , pp. 6900-6912
    • Duraiswamy, J.1    Freeman, G.J.2    Coukos, G.3
  • 46
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002;8:793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 47
    • 4444317516 scopus 로고    scopus 로고
    • PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
    • Sheppard KA, Fitz LJ, Lee JM, et al. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett 2004;574:37-41.
    • (2004) FEBS Lett , vol.574 , pp. 37-41
    • Sheppard, K.A.1    Fitz, L.J.2    Lee, J.M.3
  • 48
    • 34247532726 scopus 로고    scopus 로고
    • Clinical significance and therapeutic potential of the programmed death-1 ligand/ programmed death-1 pathway in human pancreatic cancer
    • Nomi T, Sho M, Akahori T, et al. Clinical significance and therapeutic potential of the programmed death-1 ligand/ programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res 2007;13:2151-7.
    • (2007) Clin Cancer Res , vol.13 , pp. 2151-2157
    • Nomi, T.1    Sho, M.2    Akahori, T.3
  • 49
    • 33645736792 scopus 로고    scopus 로고
    • Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    • Thompson RH, Kuntz SM, Leibovich BC, et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res 2006;66:3381-5.
    • (2006) Cancer Res , vol.66 , pp. 3381-3385
    • Thompson, R.H.1    Kuntz, S.M.2    Leibovich, B.C.3
  • 50
    • 33846658404 scopus 로고    scopus 로고
    • Significance of B7-H1 overexpression in kidney cancer
    • Thompson RH, Kwon ED. Significance of B7-H1 overexpression in kidney cancer. Clin Genitourin Cancer 2006;5:206-11.
    • (2006) Clin Genitourin Cancer , vol.5 , pp. 206-211
    • Thompson, R.H.1    Kwon, E.D.2
  • 51
    • 33745491116 scopus 로고    scopus 로고
    • Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance
    • Wu C, Zhu Y, Jiang J, et al. Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem 2006;108:19-24.
    • (2006) Acta Histochem , vol.108 , pp. 19-24
    • Wu, C.1    Zhu, Y.2    Jiang, J.3
  • 52
    • 84960171202 scopus 로고    scopus 로고
    • Evaluation of PD-L1 Expression and Associated Tumor-Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma
    • Epub ahead of print
    • Vassilakopoulou M, Avgeris M, Velcheti V, et al. Evaluation of PD-L1 Expression and Associated Tumor-Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma. Clin Cancer Res 2015. [Epub ahead of print].
    • (2015) Clin Cancer Res
    • Vassilakopoulou, M.1    Avgeris, M.2    Velcheti, V.3
  • 53
    • 84949532787 scopus 로고    scopus 로고
    • Enhanced expression of PD L1 in cervical intraepithelial neoplasia and cervical cancers
    • Mezache L, Paniccia B, Nyinawabera A, et al. Enhanced expression of PD L1 in cervical intraepithelial neoplasia and cervical cancers. Mod Pathol 2015;28:1594-602.
    • (2015) Mod Pathol , vol.28 , pp. 1594-1602
    • Mezache, L.1    Paniccia, B.2    Nyinawabera, A.3
  • 54
    • 84960171203 scopus 로고    scopus 로고
    • PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma
    • Epub ahead of print
    • Sabbatino F, Villani V, Yearley JH, et al. PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma. Clin Cancer Res 2015. [Epub ahead of print].
    • (2015) Clin Cancer Res
    • Sabbatino, F.1    Villani, V.2    Yearley, J.H.3
  • 55
    • 84945443762 scopus 로고    scopus 로고
    • Associations among pretreatment tumor necrosis and the expression of HIF-1α and PD-L1 in advanced oral squamous cell carcinoma and the prognostic impact thereof
    • Chen TC, Wu CT, Wang CP, et al. Associations among pretreatment tumor necrosis and the expression of HIF-1α and PD-L1 in advanced oral squamous cell carcinoma and the prognostic impact thereof. Oral Oncol 2015;51:1004-10.
    • (2015) Oral Oncol , vol.51 , pp. 1004-1010
    • Chen, T.C.1    Wu, C.T.2    Wang, C.P.3
  • 56
    • 84946488591 scopus 로고    scopus 로고
    • Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck
    • Thierauf J, Veit JA, Affolter A, et al. Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck. Melanoma Res 2015;25:503-9.
    • (2015) Melanoma Res , vol.25 , pp. 503-509
    • Thierauf, J.1    Veit, J.A.2    Affolter, A.3
  • 57
    • 84970978445 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas
    • Kim S, Kim MY, Koh J, et al. Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas. Eur J Cancer 2015;51:2698-707.
    • (2015) Eur J Cancer , vol.51 , pp. 2698-2707
    • Kim, S.1    Kim, M.Y.2    Koh, J.3
  • 58
    • 84928615785 scopus 로고    scopus 로고
    • Clinicopathological and prognostic significance of programmed cell death ligand1 (PD-L1) expression in patients with non-small cell lung cancer: a meta-analysis
    • Pan ZK, Ye F, Wu X, et al. Clinicopathological and prognostic significance of programmed cell death ligand1 (PD-L1) expression in patients with non-small cell lung cancer: a meta-analysis. J Thorac Dis 2015;7:462-70.
    • (2015) J Thorac Dis , vol.7 , pp. 462-470
    • Pan, Z.K.1    Ye, F.2    Wu, X.3
  • 59
    • 84923072443 scopus 로고    scopus 로고
    • Association of PDL1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer
    • Azuma K, Ota K, Kawahara A, et al. Association of PDL1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer. Ann Oncol 2014;25:1935-40.
    • (2014) Ann Oncol , vol.25 , pp. 1935-1940
    • Azuma, K.1    Ota, K.2    Kawahara, A.3
  • 60
    • 84931054440 scopus 로고    scopus 로고
    • The association between PD-L1 and EGFR status and the prognostic value of PDL1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs
    • Tang Y, Fang W, Zhang Y, et al. The association between PD-L1 and EGFR status and the prognostic value of PDL1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs. Oncotarget 2015;6:14209-19.
    • (2015) Oncotarget , vol.6 , pp. 14209-14219
    • Tang, Y.1    Fang, W.2    Zhang, Y.3
  • 61
    • 84942849158 scopus 로고    scopus 로고
    • Induction of PDL1 Expression by the EML4-ALK Oncoprotein and Downstream Signaling Pathways in Non-Small Cell Lung Cancer
    • Ota K, Azuma K, Kawahara A, et al. Induction of PDL1 Expression by the EML4-ALK Oncoprotein and Downstream Signaling Pathways in Non-Small Cell Lung Cancer. Clin Cancer Res 2015;21:4014-21.
    • (2015) Clin Cancer Res , vol.21 , pp. 4014-4021
    • Ota, K.1    Azuma, K.2    Kawahara, A.3
  • 62
    • 33947407689 scopus 로고    scopus 로고
    • Liverinfiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression
    • Radziewicz H, Ibegbu CC, Fernandez ML, et al. Liverinfiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 2007;81:2545-53.
    • (2007) J Virol , vol.81 , pp. 2545-2553
    • Radziewicz, H.1    Ibegbu, C.C.2    Fernandez, M.L.3
  • 63
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, Wherry EJ, Masopust D, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006;439:682-7.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3
  • 64
    • 84924854179 scopus 로고    scopus 로고
    • Nivolumab for advanced squamous cell lung cancer: what are the next steps?
    • de Mello RA, Pousa I, Pereira D. Nivolumab for advanced squamous cell lung cancer: what are the next steps? Lancet Oncol 2015;16:234-5.
    • (2015) Lancet Oncol , vol.16 , pp. 234-235
    • de Mello, R.A.1    Pousa, I.2    Pereira, D.3
  • 65
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer
    • Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. N Engl J Med 2015;373:123-35.
    • (2015) N Engl J Med , vol.373 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 66
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 2015;372:2018-28.
    • (2015) N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 67
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012;366:2455-65.
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 68
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014;515:563-7.
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J.C.2    Kowanetz, M.3
  • 69
    • 84937544496 scopus 로고    scopus 로고
    • Assays for predicting and monitoring responses to lung cancer immunotherapy
    • Teixidó C, Karachaliou N, González-Cao M, et al. Assays for predicting and monitoring responses to lung cancer immunotherapy. Cancer Biol Med 2015;12:87-95.
    • (2015) Cancer Biol Med , vol.12 , pp. 87-95
    • Teixidó, C.1    Karachaliou, N.2    González-Cao, M.3
  • 70
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 71
    • 56049096751 scopus 로고    scopus 로고
    • Technical pitfalls potentially affecting diagnoses in immunohistochemistry
    • Bussolati G, Leonardo E. Technical pitfalls potentially affecting diagnoses in immunohistochemistry. J Clin Pathol 2008;61:1184-92.
    • (2008) J Clin Pathol , vol.61 , pp. 1184-1192
    • Bussolati, G.1    Leonardo, E.2
  • 72
    • 79955518331 scopus 로고    scopus 로고
    • Overall survival and PD-L1 expression in metastasized malignant melanoma
    • Gadiot J, Hooijkaas AI, Kaiser AD, et al. Overall survival and PD-L1 expression in metastasized malignant melanoma. Cancer 2011;117:2192-201.
    • (2011) Cancer , vol.117 , pp. 2192-2201
    • Gadiot, J.1    Hooijkaas, A.I.2    Kaiser, A.D.3
  • 73
    • 33845787470 scopus 로고    scopus 로고
    • Heat-induced antigen retrieval: mechanisms and application to histochemistry
    • Yamashita S. Heat-induced antigen retrieval: mechanisms and application to histochemistry. Prog Histochem Cytochem 2007;41:141-200.
    • (2007) Prog Histochem Cytochem , vol.41 , pp. 141-200
    • Yamashita, S.1
  • 74
    • 22244483775 scopus 로고    scopus 로고
    • Technical aspects of immunohistochemistry
    • Ramos-Vara JA. Technical aspects of immunohistochemistry. Vet Pathol 2005;42:405-26.
    • (2005) Vet Pathol , vol.42 , pp. 405-426
    • Ramos-Vara, J.A.1
  • 75
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 2014;515:568-71.
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1    Harview, C.L.2    Yearley, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.