메뉴 건너뛰기




Volumn 4, Issue 6, 2015, Pages 775-783

Crocin inhibits cell proliferation and enhances cisplatin and pemetrexed chemosensitivity in lung cancer cells

Author keywords

Cisplatin; Crocin; Lung adenocarcinoma; ; Pemetrexed

Indexed keywords


EID: 84960080698     PISSN: 22186751     EISSN: 22264477     Source Type: Journal    
DOI: 10.3978/j.issn.2218-6751.2015.11.03     Document Type: Article
Times cited : (76)

References (32)
  • 1
    • 9644268896 scopus 로고    scopus 로고
    • Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials
    • Abdullaev FI, Espinosa-Aguirre JJ. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect Prev 2004;28:426-32.
    • (2004) Cancer Detect Prev , vol.28 , pp. 426-432
    • Abdullaev, F.I.1    Espinosa-Aguirre, J.J.2
  • 2
    • 84865335235 scopus 로고    scopus 로고
    • Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms
    • Kang C, Lee H, Jung ES, et al. Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms. Food Chem 2012;135:2350-8.
    • (2012) Food Chem , vol.135 , pp. 2350-2358
    • Kang, C.1    Lee, H.2    Jung, E.S.3
  • 3
    • 0036377909 scopus 로고    scopus 로고
    • Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.)
    • Abdullaev FI. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Exp Biol Med (Maywood) 2002;227:20-5.
    • (2002) Exp Biol Med (Maywood) , vol.227 , pp. 20-25
    • Abdullaev, F.I.1
  • 4
    • 77953536106 scopus 로고    scopus 로고
    • Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: A histopathological study
    • Das I, Das S, Saha T. Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: A histopathological study. Acta Histochem 2010;112:317-27.
    • (2010) Acta Histochem , vol.112 , pp. 317-327
    • Das, I.1    Das, S.2    Saha, T.3
  • 5
    • 67349161842 scopus 로고    scopus 로고
    • An overview of structural features of DNA and RNA complexes with saffron compounds: Models and antioxidant activity
    • Kanakis CD, Tarantilis PA, Pappas C, et al. An overview of structural features of DNA and RNA complexes with saffron compounds: Models and antioxidant activity. J Photochem Photobiol B 2009;95:204-12.
    • (2009) J Photochem Photobiol B , vol.95 , pp. 204-212
    • Kanakis, C.D.1    Tarantilis, P.A.2    Pappas, C.3
  • 6
    • 65349160963 scopus 로고    scopus 로고
    • Further examination of antiradical properties of Crocus sativus stigmas extract rich in crocins
    • Ordoudi SA, Befani CD, Nenadis N, et al. Further examination of antiradical properties of Crocus sativus stigmas extract rich in crocins. J Agric Food Chem 2009;57:3080-6.
    • (2009) J Agric Food Chem , vol.57 , pp. 3080-3086
    • Ordoudi, S.A.1    Befani, C.D.2    Nenadis, N.3
  • 7
    • 27744563733 scopus 로고    scopus 로고
    • Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin
    • Lee IA, Lee JH, Baek NI, et al. Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin. Biol Pharm Bull 2005;28:2106-10.
    • (2005) Biol Pharm Bull , vol.28 , pp. 2106-2110
    • Lee, I.A.1    Lee, J.H.2    Baek, N.I.3
  • 8
    • 24944531320 scopus 로고    scopus 로고
    • Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits
    • Zheng S, Qian Z, Tang F, et al. Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits. Biochem Pharmacol 2005;70:1192-9.
    • (2005) Biochem Pharmacol , vol.70 , pp. 1192-1199
    • Zheng, S.1    Qian, Z.2    Tang, F.3
  • 9
    • 75249099832 scopus 로고    scopus 로고
    • Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastuctural alterations in isoproterenol-induced cardiotoxicity in rats
    • Goyal SN, Arora S, Sharma AK, et al. Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastuctural alterations in isoproterenol-induced cardiotoxicity in rats. Phytomedicine 2010;17:227-32.
    • (2010) Phytomedicine , vol.17 , pp. 227-232
    • Goyal, S.N.1    Arora, S.2    Sharma, A.K.3
  • 10
    • 84925875616 scopus 로고    scopus 로고
    • Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin
    • Lari P, Abnous K, Imenshahidi M, et al. Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicol Ind Health 2015;31:367-76.
    • (2015) Toxicol Ind Health , vol.31 , pp. 367-376
    • Lari, P.1    Abnous, K.2    Imenshahidi, M.3
  • 11
    • 84864649588 scopus 로고    scopus 로고
    • Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells
    • Mehri S, Abnous K, Mousavi SH, et al. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol 2012;32:227-35.
    • (2012) Cell Mol Neurobiol , vol.32 , pp. 227-235
    • Mehri, S.1    Abnous, K.2    Mousavi, S.H.3
  • 13
    • 0034255942 scopus 로고    scopus 로고
    • In vitro studies on the selective cytotoxic effect of crocetin and quercetin
    • Jagadeeswaran R, Thirunavukkarasu C, Gunasekaran P, et al. In vitro studies on the selective cytotoxic effect of crocetin and quercetin. Fitoterapia 2000;71:395-9.
    • (2000) Fitoterapia , vol.71 , pp. 395-399
    • Jagadeeswaran, R.1    Thirunavukkarasu, C.2    Gunasekaran, P.3
  • 14
    • 60849103487 scopus 로고    scopus 로고
    • Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model
    • Dhar A, Mehta S, Dhar G, et al. Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol Cancer Ther 2009;8:315-23.
    • (2009) Mol Cancer Ther , vol.8 , pp. 315-323
    • Dhar, A.1    Mehta, S.2    Dhar, G.3
  • 15
    • 78651485607 scopus 로고    scopus 로고
    • Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases
    • Chryssanthi DG, Dedes PG, Karamanos NK, et al. Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases. Planta Med 2011;77:146-51.
    • (2011) Planta Med , vol.77 , pp. 146-151
    • Chryssanthi, D.G.1    Dedes, P.G.2    Karamanos, N.K.3
  • 16
    • 0642339654 scopus 로고    scopus 로고
    • Studies on the pharmacological effects of saffron(Crocus sativus L.)--a review
    • Deng Y, Guo ZG, Zeng ZL, et al. Studies on the pharmacological effects of saffron(Crocus sativus L.)--a review. Zhongguo Zhong Yao Za Zhi 2002;27:565-8.
    • (2002) Zhongguo Zhong Yao Za Zhi , vol.27 , pp. 565-568
    • Deng, Y.1    Guo, Z.G.2    Zeng, Z.L.3
  • 17
    • 84862266081 scopus 로고    scopus 로고
    • Saffron offers protection from liver cancer
    • Harrington M. Saffron offers protection from liver cancer. Lab Anim (NY) 2011;40:289.
    • (2011) Lab Anim (NY) , vol.40 , pp. 289
    • Harrington, M.1
  • 18
    • 82155184517 scopus 로고    scopus 로고
    • Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial
    • Kianbakht S, Ghazavi A. Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial. Phytother Res 2011;25:1801-5.
    • (2011) Phytother Res , vol.25 , pp. 1801-1805
    • Kianbakht, S.1    Ghazavi, A.2
  • 19
    • 84868592522 scopus 로고    scopus 로고
    • Convolvulus galaticus, Crocus antalyensis, and Lilium candidum extracts show their antitumor activity through induction of p53-mediated apoptosis on human breast cancer cell line MCF-7 cells
    • Tokgun O, Akca H, Mammadov R, et al. Convolvulus galaticus, Crocus antalyensis, and Lilium candidum extracts show their antitumor activity through induction of p53-mediated apoptosis on human breast cancer cell line MCF-7 cells. J Med Food 2012;15:1000-5.
    • (2012) J Med Food , vol.15 , pp. 1000-1005
    • Tokgun, O.1    Akca, H.2    Mammadov, R.3
  • 20
    • 78649760813 scopus 로고    scopus 로고
    • Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity
    • Yamauchi M, Tsuruma K, Imai S, et al. Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity. Eur J Pharmacol 2011;650:110-9.
    • (2011) Eur J Pharmacol , vol.650 , pp. 110-119
    • Yamauchi, M.1    Tsuruma, K.2    Imai, S.3
  • 21
    • 77955382371 scopus 로고    scopus 로고
    • Extraction of crocin from saffron (Crocus sativus) using molecularly imprinted polymer solid-phase extraction
    • Mohajeri SA, Hosseinzadeh H, Keyhanfar F, et al. Extraction of crocin from saffron (Crocus sativus) using molecularly imprinted polymer solid-phase extraction. J Sep Sci 2010;33:2302-9.
    • (2010) J Sep Sci , vol.33 , pp. 2302-2309
    • Mohajeri, S.A.1    Hosseinzadeh, H.2    Keyhanfar, F.3
  • 22
    • 84860710284 scopus 로고    scopus 로고
    • Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation
    • Umigai N, Tanaka J, Tsuruma K, et al. Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation. Curr Neurovasc Res 2012;9:102-9.
    • (2012) Curr Neurovasc Res , vol.9 , pp. 102-109
    • Umigai, N.1    Tanaka, J.2    Tsuruma, K.3
  • 23
    • 84875263484 scopus 로고    scopus 로고
    • Crocin, a dietary colorant, mitigates cyclophosphamideinduced organ toxicity by modulating antioxidant status and inflammatory cytokines
    • Jnaneshwari S, Hemshekhar M, Santhosh MS, et al. Crocin, a dietary colorant, mitigates cyclophosphamideinduced organ toxicity by modulating antioxidant status and inflammatory cytokines. J Pharm Pharmacol 2013;65:604-14.
    • (2013) J Pharm Pharmacol , vol.65 , pp. 604-614
    • Jnaneshwari, S.1    Hemshekhar, M.2    Santhosh, M.S.3
  • 24
    • 84873627337 scopus 로고    scopus 로고
    • Crocetin induces cytotoxicity in colon cancer cells via p53-independent mechanisms
    • Li CY, Huang WF, Wang QL, et al. Crocetin induces cytotoxicity in colon cancer cells via p53-independent mechanisms. Asian Pac J Cancer Prev 2012;13:3757-61.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 3757-3761
    • Li, C.Y.1    Huang, W.F.2    Wang, Q.L.3
  • 25
    • 84872686984 scopus 로고    scopus 로고
    • Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation
    • Noureini SK, Wink M. Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation. Asian Pac J Cancer Prev 2012;13:2305-9.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 2305-2309
    • Noureini, S.K.1    Wink, M.2
  • 26
    • 84890059100 scopus 로고    scopus 로고
    • Saffron and natural carotenoids: Biochemical activities and anti-tumor effects
    • Bolhassani A, Khavari A, Bathaie SZ. Saffron and natural carotenoids: Biochemical activities and anti-tumor effects. Biochim Biophys Acta 2014;1845:20-30.
    • (2014) Biochim Biophys Acta , vol.1845 , pp. 20-30
    • Bolhassani, A.1    Khavari, A.2    Bathaie, S.Z.3
  • 27
    • 0343819945 scopus 로고    scopus 로고
    • Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat
    • García-Olmo DC, Riese HH, Escribano J, et al. Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat. Nutr Cancer 1999;35:120-6.
    • (1999) Nutr Cancer , vol.35 , pp. 120-126
    • García-Olmo, D.C.1    Riese, H.H.2    Escribano, J.3
  • 28
    • 0030047682 scopus 로고    scopus 로고
    • Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro
    • Escribano J, Alonso GL, Coca-Prados M, et al. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett 1996;100:23-30.
    • (1996) Cancer Lett , vol.100 , pp. 23-30
    • Escribano, J.1    Alonso, G.L.2    Coca-Prados, M.3
  • 29
    • 33745953345 scopus 로고    scopus 로고
    • Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies
    • Magesh V, Singh JP, Selvendiran K, et al. Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Mol Cell Biochem 2006;287:127-35.
    • (2006) Mol Cell Biochem , vol.287 , pp. 127-135
    • Magesh, V.1    Singh, J.P.2    Selvendiran, K.3
  • 30
    • 80053057926 scopus 로고    scopus 로고
    • Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form
    • Mousavi SH, Moallem SA, Mehri S, et al. Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form. Pharm Biol 2011;49:1039-45.
    • (2011) Pharm Biol , vol.49 , pp. 1039-1045
    • Mousavi, S.H.1    Moallem, S.A.2    Mehri, S.3
  • 31
    • 84873048568 scopus 로고    scopus 로고
    • Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells
    • Hoshyar R, Bathaie SZ, Sadeghizadeh M. Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells. DNA Cell Biol 2013;32:50-7.
    • (2013) DNA Cell Biol , vol.32 , pp. 50-57
    • Hoshyar, R.1    Bathaie, S.Z.2    Sadeghizadeh, M.3
  • 32
    • 84874572641 scopus 로고    scopus 로고
    • The efficacy of Chinese herbal medicine as an adjunctive therapy for advanced non-small cell lung cancer: a systematic review and meta-analysis
    • Li SG, Chen HY, Ou-Yang CS, et al. The efficacy of Chinese herbal medicine as an adjunctive therapy for advanced non-small cell lung cancer: a systematic review and meta-analysis. PLoS One 2013;8:e57604.
    • (2013) PLoS One , vol.8 , pp. e57604
    • Li, S.G.1    Chen, H.Y.2    Ou-Yang, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.