Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms

Food Chemistry

Volumn 135, Issue 4, 2012, Pages 2350-2358

  Kang, Changkeun ^a   Lee, Hyunkyoung ^a   Jung, Eun Sun ^a   Seyedian, Ramin ^a   Jo, Mina ^a   Kim, Jehein ^a   Kim, Jong Shu ^a   Kim, Euikyung ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

AMPK; Glucose uptake; Insulin sensitivity; Saffron; Skeletal muscle cells

Indexed keywords

AMPK; GLUCOSE UPTAKE; INSULIN SENSITIVITY; SAFFRON; SKELETAL MUSCLE CELLS;

CELLS; ENZYME ACTIVITY; GLUCOSE; INSULIN; METABOLISM; MUSCULOSKELETAL SYSTEM; PHOSPHORYLATION;

FOOD ADDITIVES;

CROCUS SATIVUS EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CROCUS SATIVUS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; INSULIN SENSITIVITY; MEDICINAL PLANT; MOUSE; MUSCLE CELL; NONHUMAN; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CROCUS; DIABETES MELLITUS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN RESISTANCE; MAP KINASE SIGNALING SYSTEM; MICE; MUSCLE CELLS; MUSCLE, SKELETAL; PLANT EXTRACTS; UP-REGULATION;

CROCUS SATIVUS;

EID: 84865335235     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.06.092     Document Type: Article

References (36)

1. F. Abdullaev, and J. Espinosa-Aguirre Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials Cancer Detection and Prevention 28 2004 426432
2. K. Abe, and H. Saito Effects of saffron extract and its constituent crocin on learning behaviour and long term potentiation Phytotherapy Research 14 2000 149152
3. K. Alberti, P. Zimmet, and J. Shaw Metabolic syndromea new world-wide definition. A consensus statement from the international diabetes federation Diabetic Medicine 23 2006 469480
4. D.R. Alessi, and P. Cohen Mechanism of activation and function of protein kinase B Current Opinion in Genetics & Development 8 1998 5562
5. D. Carling The AMP-activated protein kinase cascade-a unifying system for energy control Trends in Biochemical Science 29 2004 1824
6. R. DeFronzo, E. Jacot, E. Jequier, E. Maeder, J. Wahren, and J.P. Felber The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization Diabetes 30 1981 10001007
7. L. Fryer, and D. Carling AMP-activated protein kinase and the metabolic syndrome Biochemical Society Transactions 33 2005 362366
8. S.Y. He, Z.Y. Qian, F.T. Tang, N. Wen, G.L. Xu, and L. Sheng Effect of crocin on experimental atherosclerosis in quails and its mechanisms Life Sciences 77 2005 907921
9. H. Hosseinzadeh, and H.M. Younesi Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice BMC Pharmacology 2 2002 7
10. Y.C. Huang, W.L. Chang, S.F. Huang, C.Y. Lin, H.C. Lin, and T.C. Chang Pachymic acid stimulates glucose uptake through enhanced GLUT4 expression and translocation European Journal of Pharmacology 648 2010 3949
11. K. Inoki, T. Zhu, and K.L. Guan TSC2 mediates cellular energy response to control cell growth and survival Cell 115 2003 577590
12. C. Kang, Y.B. Jin, H. Lee, M. Cha, E.T. Sohn, J. Moon, C. Park, S. Chun, E.S. Jung, J.S. Hong, S.B. Kim, J.S. Kim, and E. Kim Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways Food and Chemical Toxicology 48 2010 509516
13. C. Kang, and E. Kim Synergistic effect of curcumin and insulin on muscle cell glucose metabolism Food and Chemical Toxicology 48 2010 23662373
14. J.H. Kim, J.M. Park, E.K. Kim, J.O. Lee, S.K. Lee, J.H. Jung, G.Y. You, S.H. Park, P.G. Suh, and H.S. Kim Curcumin stimulates glucose uptake through AMPK p38 MAPK pathways in L6 myotube cells Journal of Cellular Physiology 223 2010 771778
15. D. Konrad, R. Somwar, G. Sweeney, K. Yaworsky, M. Hayashi, T. Ramlal, and A. Klip The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: Potential role of p38 mitogen-activated protein kinase in GLUT4 activation Diabetes 50 2001 14641471
16. S. Kovacic, C.L. Soltys, A.J. Barr, I. Shiojima, K. Walsh, and J.R. Dyck Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart Journal of Biological Chemistry 278 2003 3942239427
17. Y.S. Lee, W.S. Kim, K.H. Kim, M.J. Yoon, H.J. Cho, Y. Shen, J.M. Ye, C.H. Lee, W.K. Oh, C.T. Kim, C. Hohnen-Behrens, A. Gosby, E.W. Kraegen, D.E. James, and J.B. Kim Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states Diabetes 55 2006 22562264
18. H.B. Li, Y. Ge, X.X. Zheng, and L. Zhang Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase European Journal of Pharmacology 588 2008 165169
19. D. Mohajeri, G. Mousavi, and Y. Doustar Antihyperglycemic and pancreas-protective effects of Crocus sativus L. (Saffron) stigma ethanolic extract on rats with alloxan-induced diabetes Journal of Biological Sciences 9 2009 302310
20. G. Montagut, S. Onnockx, M. Vaqué, C. Bladé, M. Blay, J. Fernández-Larrea, G. Pujadas, M.J. Salvadó, L. Arola, I. Pirson, A. Ardévol, and M. Pinent Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin Journal of Nutritional Biochemistry 21 2010 476481
21. T. Mosmann Rapid colourimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays Journal of Immunological Methods 65 1983 5563
22. A. Pelletier, E. Joly, M. Prentki, and L. Coderre Adenosine 5'-monophosphate-activated protein kinase and p38 mitogen-activated protein kinase participate in the stimulation of glucose uptake by dinitrophenol in adult cardiomyocytes Endocrinology 146 2005 22852294
23. M. Pinent, A. Castell, I. Baiges, G. Montagut, L. Arola, and A. Ardévol Bioactivity of flavonoids on insulin secreting cells Comprehensive Reviews in Food Science and Food Safety 7 2008 299308
24. J. Rios, M. Recio, R. Giner, and S. Manez An update review of saffron and its active constituents Phytotherapy Research 10 1996 189193
25. S. Sampathu, S. Shivashankar, Y. Lewis, and A. Wood Saffron (Crocus sativus Linn.) Cultivation, processing, chemistry and standardization Critical Reviews in Food Science and Nutrition 20 1984 123157
26. K. Sato, M. Iemitsu, K. Aizawa, and R. Ajisaka Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle American Journal of Physiology Endocrinology Metabolism 294 2008 E961968
27. S. Schenk, M. Saberi, and J.M. Olefsky Insulin sensitivity: Modulation by nutrients and inflammation Journal of Clinical Investigation 118 2008 29923002
28. M. Schmidt, G. Betti, and A. Hensel Saffron in phytotherapy: Pharmacology and clinical uses Wiener Medizinische Wochenschrift 157 2007 315319
29. A.G. Smith, and G.E. Muscat Skeletal muscle and nuclear hormone receptors: Implications for cardiovascular and metabolic disease International Journal of Biochemistry and Cell Biology 37 2005 20472063
30. K. Srinivasan Plant foods in the management of diabetes mellitus: Spices as beneficial antidiabetic food adjuncts International Journal of Food Sciences and Nutrition 56 2005 399414
31. A. Tzatsos, and K.V. Kandror Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation Molecular and Cellular Biology 26 2006 6376
32. K. Ueki, R. Yamamoto-Honda, Y. Kaburagi, T. Yamauchi, K. Tobe, B.M. Burgering, P.J. Coffer, I. Komuro, Y. Akanuma, Y. Yazaki, and T. Kadowaki Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis Journal of Biological Chemistry 273 1998 53155322
33. S.H. Um, F. Frigerio, M. Watanabe, F. Picard, M. Joaquin, M. Sticker, S. Fumagalli, P.R. Allegrini, S.C. Kozma, J. Auwerx, and G. Thomas Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity Nature 431 2004 200205
34. D.L. Williamson, D.R. Bolster, S.R. Kimball, and L.S. Jefferson Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR American Journal of Physiology Endocrinology Metabolism 291 2006 E8089
35. D.L. Williamson, N. Kubica, S.R. Kimball, and L.S. Jefferson Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle Journal of Physiology 573 2006 497510
36. D. Zheng, P.S. MacLean, S.C. Pohnert, J.B. Knight, A.L. Olson, W.W. Winder, and G.L. Dohm Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase Journal of Applied Physiology 91 2001 10731083