Crocin, a dietary colorant mitigates cyclophosphamide-induced organ toxicity by modulating antioxidant status and inflammatory cytokines

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 4, 2013, Pages 604-614

  Jnaneshwari, Sadashivaiah ^a   Hemshekhar, Mahadevappa ^a   Santhosh, Martin Sebastin ^a   Sunitha, Kabburahalli ^a   Thushara, Rammohan ^a   Thirunavukkarasu, Chinnasamy ^b   Kemparaju, Kempaiah ^a   Girish, Kesturu Subbaiah ^a  

^a UNIVERSITY OF MYSORE   (India)

^b PONDICHERRY UNIVERSITY   (India)

Author keywords

crocin; cyclophosphamide; hepatotoxicity; inflammation; oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CATALASE; CROCIN; CYCLOPHOSPHAMIDE; CYTOKINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPID; PROTEIN; REACTIVE OXYGEN METABOLITE; SILYMARIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CYCLOPHOSPHAMIDE INDUCED ORGAN TOXICITY; DRUG EFFICACY; DRUG TOXICITY; HISTOPATHOLOGY; KIDNEY; LIPID OXIDATION; LIVER; LIVER PROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; SINGLE DRUG DOSE; SPLEEN;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTIOXIDANTS; BIOLOGICAL MARKERS; CAROTENOIDS; CYCLOPHOSPHAMIDE; CYTOKINES; DRUG-INDUCED LIVER INJURY; FOOD COLORING AGENTS; HYDROGEN PEROXIDE; LIPID PEROXIDATION; LIVER; OXIDATIVE STRESS; OXIDOREDUCTASES; PROTEIN CARBONYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 84875263484     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12016     Document Type: Article

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