Human embryos commonly form abnormal nuclei during development: A mechanism of DNA damage, embryonic aneuploidy, and developmental arrest

Human Reproduction

Volumn 31, Issue 2, 2016, Pages 312-323

  Kort, Daniel H ^a,e   Chia, Gloryn ^a   Treff, Nathan R ^b,c   Tanaka, Akemi J ^a   Xing, Tongji ^c   Vensand, Lauren Bauer ^d   Micucci, Stephanie ^a   Prosser, Robert ^a   Lobo, Roger A ^a   Sauer, Mark V ^a   Egli, Dieter ^a,d  

^a Columbia University College of Physicians and Surg ^*  (United States)

^b Reproductive Medicine Assoc   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d New York Stem Cell Foundation Laboratory   (United States)

^e MONMOUTH MEDICAL CENTER   (United States)

Author keywords

DNA damage; Micronucleation; Mitosis; Mosaicism; Preimplantation development

Indexed keywords

DNA; EXTRANUCLEAR DNA; UNCLASSIFIED DRUG;

ANEUPLOIDY; ARTICLE; BLASTOCYST; CENTROMERE; CHROMOSOME ABERRATION; CHROMOSOME MOSAICISM; CONFOCAL MICROSCOPY; CRYOPRESERVATION; CYTOGENETICS; DNA DAMAGE; FERTILIZATION IN VITRO; HUMAN EMBRYO; IMMUNOHISTOCHEMISTRY; KARYOTYPING; MITOSIS RATE; MOSAICISM; OOCYTE CLEAVAGE; PREIMPLANTATION EMBRYO; CELL NUCLEUS; CYTOLOGY; EMBRYO DEVELOPMENT; HUMAN; ULTRASTRUCTURE;

ANEUPLOIDY; BLASTOCYST; CELL NUCLEUS; DNA DAMAGE; EMBRYONIC DEVELOPMENT; HUMANS; IMMUNOHISTOCHEMISTRY;

EID: 84959905977     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev281     Document Type: Article

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