Binucleated and micronucleated blastomeres in embryos derived from human assisted reproduction cycles

Reproductive BioMedicine Online

Volumn 9, Issue 5, 2004, Pages 511-520

  Meriano, James ^a   Clark, Christine ^a   Cadesky, Ken ^a   Laskin, Carl A ^a,b  

^a Lifequest Centre for Reproductive Medicine   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Binucleate; Embryo; FISH; Micronucleate; Multinucleate; Time lapse

Indexed keywords

LEUPRORELIN;

ADULT; ARTICLE; BLASTOCYST; BLASTOMERE; CELL DIVISION; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CLINICAL OBSERVATION; CLINICAL PRACTICE; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISSOLUTION; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MEDICAL PHOTOGRAPHY; NIDATION; PHENOTYPE; PREGNANCY RATE; PROSPECTIVE STUDY; REPRODUCTIVE PROCEDURES; SIBLING; STATISTICAL SIGNIFICANCE; TIME;

EID: 8744271264     PISSN: 14726483     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1472-6483(10)61635-5     Document Type: Article

References (36)

1. Albertini DF, Sanfins A, Combelles C 2003 Origins and manifestations of oocyte maturation competencies. Reproductive BioMedicine Online 6, 410-415.
2. Alikani M, Calderone G, Tomkin G et al 2000 Cleavage anomalies in early human embryos and survival after prolonged culture in vitro Human Reproduction 15, 2634-2643.
3. Alikani M, Cohen J 1995 Patterns of cell fragmentation in the human embryo. Journal of Assisted Reproduction and Genetics 12 285.
4. Antczak M, Van Blerkom J 1999 Temporal and spatial aspects of fragmentation in early human embryos: possible effects on developmental competence and association with the differential elimination of regulatory proteins from polarized domains. Human Reproduction 14, 429-447.
5. Balaban B, Bulent U, Isiklar A et al 2001 The effect of pronuclear morphology on embryo quality parameters and blastocyst transfer outcome. Human Reproduction 16, 2357-2361.
6. Balakier H, Cadesky K 1997 The frequency and developmental capability of human embryo containing multinucleated blastomeres. Human Reproduction 12, 800-804.
7. Balakier H, Sojecki A, Motamedi G, Librach C 2004 Time-dependant capability of human oocytes for activation and pronuclear formation during MII arrest. Human Reproduction 19, 982-987.
8. Boiso I, Merce M, Santalo J et al. 2002 A confocal microscopy analysis of the spindle and chromosome configurations of human oocytes cryopreserved at the germinal vesicle and metaphase II stage. Human Reproduction 17, 1885-1891.
9. Coskun S, Hellani A, Jaroudi K et al 2003 Nucleolar precursors body distribution in pronuclei is correlated to chromosomal abnormalities in embryos. Reproductive BioMedicine Online 7, 86-90.
10. Evsikov S, Verlinsky Y 1998 Mosaicism in the inner cell mass of human blastocysts. Human Reproduction 13, 3151-3155.
11. Gardener,D, Schoolcraft W, Waglet L et al 1998 A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization. Human Reproduction 13, 3434-3440.
12. Greenblatt E, Meriano J, Casper RF 1995 Type of stimulation protocol affects oocyte maturity, fertilization rate and cleavage rate after intracytoplasmic sperm injection. Fertility and Sterility 3, 557-563.
13. Hardarson T, Hanson C, Sjorgren A et al 2001. Human embryos with unevenly sized blastomeres have lower pregnancy and implantation rates: Indications for aneuploidy and multinucleation. Human Reproduction 16, 313-318.
14. Jackson KV, Ginsburg E, Hornstein M et al 1998 Multinucleation in normally fertilized embryos is associated with an accelerated ovulation induction response and lower implantation and pregnancy rates in in-vitro fertilization-embryo transfer cycles. Fertility and Sterility 70, 60-66.
15. Jurisicova A, Varmuza S, Casper RF 1996 Programmed cell death and human embryo fragmentation. Molecular Human Reproduction 6 801-809.
16. Jurisicova A, Antenos M, Varmuza S et al 2003 Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakari gene product and Caspase-3 in blastomere fragmentation. Molecular Human Reproduction 9, 133-141.
17. Kligman I, Benadiva C, Alikani M, Munné S 1996 The presence of multinucleated blastomeres in human embryos is correlated with chromosomal abnormalities. Human Reproduction 11, 1492-1498.
18. Meriano J, Alexis J, Visram-Zaver S et al 2001 Tracking of oocyte dysmorphisms for ICSI patients may prove relevant to the outcome in subsequent patient cycles. Human Reproduction 10, 2118-2123.
19. Munné S, Cohen J 1993 Unsuitability of multinucleated human blastomeres for implantation genetic diagnosis. Human Reproduction 8, 1120-1125.
20. Munné S, Alikani M, Cohen J 1994 Monospermic polyploidy and atypical embryo morphology. Human Reproduction 9, 506-510.
21. Munné S, Dailey T, Finkelstein M, Weir HU 1996 Reduction in signal overlap results in increased FISH effieciency: implications for PGD. Journal of Assisted Reproduction and Genetics 13, 149-156.
22. Nogueira D, Staessen C, Van de Velde H, Van Steirteghem A 2000 Nuclear status and cytogenetics of embryos derived from in vitro-matured oocytes. Fertility and Sterility 74, 295-298.
23. Pelinck MJ, De Vos M, Dekens M et al 1998 Embryos cultured in vitro with multinucleated blastomeres have poor implantation potential in human in-vitro fertilization and intracytoplasmic sperm injection. Human Reproduction 13, 960-963.
24. Pickering SJ, Braude PR, Johnson MH et al. 1990 Transient cooling to room temperature can cause irreversible disruption of the meiotic spindle in the human oocyte. Fertility and Sterility 54, 102-108.
25. Pickering SJ, Taylor A, Johnson MH, Braude PR 1995 An analysis of multinucleated blastomere formation in human embryos. Human Reproduction 10, 1912-1922.
26. Racowski K, Combelles C, Nureddin A et al. 2003 Day 3 and day 5 morphological predictors of embryo viability. Reproductive BioMedicine Online 6, 323-331.
27. Scott LA, Smith S 1998 The successful use of pronuclear embryo transfers the day following oocyte retrieval. Human Reproduction 13, 1003-1013.
28. Staessen, C, Van Steirteghem A 1998 The genetic constitution of multinuclear blastomeres and their derivative daughter blastomeres. Human Reproduction 13, 1625-1631.
29. Tesarik J, Greco E 1999 The probability of abnormal preimplantation development can be predicted by single static observation on pronuclear stage morphology. Human Reproduction 14, 1318-1323.
30. Tesarik J, Kopecny V, Plachot M, Mandelbaum J 1987 Ultrastructural and autoradiographic observations on multinucleated blastomeres of human cleaving embryos obtained by in-vitro fertilization. Human Reproduction 2, 127-136.
31. Van Blerkom J, Antczak M, Schrader R 1997 The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor levels and perifollicular blood flow characteristics. Human Reproduction 12, 1047-1055.
32. Van Blerkom J, Davis P, Alexander S 2001 A Microscopic and biochemical study of fragmentation phenotypes in stage-appropriate human embryos. Human Reproduction 16, 719-729
33. Van Royen E, Mangelschots K Vercruyssen M et al. 2003 Multinucleation in cleavage stage embryos. Human Reproduction 18 1062-1069.
34. Veeck L 1999 An Atlas of Human Gametes and Conceptuses. Parthenon Publishing Group, NY, London, pp. 156-157.
35. Winston NJ, Johnson MH, Braude PR 1993 Assessment of the cellular DNA content of whole mounted mouse and human oocytes and of blastomeres containing single or multiple nuclei. Zygote 1, 17-25.
36. Zenzes MT, Casper RF 1992 Cytogenetics of human oocytes, zygotes, and embryo after in vitro fertilization. Human Genetics 88, 367-375.