'Moonlighting' surface antigens: A paradigm for autoantibody pathogenicity in neurology?

Brain

Volumn 139, Issue 2, 2016, Pages 304-306

  Irani, Sarosh R ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPHYSIN; AMPHIPHYSIN ANTIBODY; AUTOANTIBODY; ENDOPHILIN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE ANTIBODY; IMMUNOGLOBULIN G; MEMBRANE ANTIGEN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; NERVE PROTEIN;

AMYGDALOID NUCLEUS; ANTIGEN ANTIBODY COMPLEX; BREAST CARCINOMA; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL FEATURE; GABAERGIC SYSTEM; HISTOPATHOLOGY; IMMUNOTHERAPY; NEUROLOGY; NEUROTRANSMISSION; NOTE; PATHOGENICITY; PLASMAPHERESIS; PRIORITY JOURNAL; SMALL CELL LUNG CANCER; STIFF MAN SYNDROME; ANIMAL; FEMALE; HUMAN; NERVE ENDING; PREGNANCY; SYNAPSE VESICLE; ULTRASTRUCTURE;

ANIMALS; AUTOANTIBODIES; FEMALE; HUMANS; NERVE TISSUE PROTEINS; PREGNANCY; PRESYNAPTIC TERMINALS; SYNAPTIC VESICLES;

EID: 84959888823     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv364     Document Type: Note

References (14)

1. Chang T, Alexopoulos H, Pettingill P, McMenamin M, Deacon R, Erdelyi F, et al. Immunization against GAD induces antibody binding to GAD-independent antigens and brainstem GABAergic neuronal loss. PLoS One 2013; 8: e72921
2. Dahm L, Ott C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S, et al. Seroprevalence of autoantibodies against brain antigens in health and disease. Ann Neurol 2014; 76: 82-94
3. Geis C, Grünewald B, Weishaupt A, Wultsch T, Toyka KV, Reif A, et al. Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer. J Neural Transm 2012; 119: 981-5
4. Geis C, Weishaupt A, Hallermann S, Grunewald B, Wessig C, Wultsch T, et al. Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition. Brain 2010; 133: 3166-80
5. Hansen N, Grünewald B, Weishaupt A, Colaço MN, Toyka KV, Sommer C, et al. Human Stiff person syndrome IgGcontaining high-titer anti-GAD65 autoantibodies induce motor dysfunction in rats. Exp Neurol 2013; 239: 202-9
6. Irani SR, Gelfand JM, Al-Diwani A, Vincent A. Cell-surface central nervous system autoantibodies: Clinical relevance and emerging paradigms. Ann Neurol 2014; 76: 168-84
7. Lancaster E, Lai M, Peng X, Hughes E, Constantinescu R, Raizer J, et al. Antibodies to the GABAB receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol 2010; 9: 67-76
8. Leypoldt F, Armangue T, Dalmau J. Autoimmune encephalopathies. Ann NY Acad Sci 2015; 1338: 94-114
9. Pittock SJ, Lucchinetti CF, Parisi JE, Benarroch EE, Mokri B, Stephan CL, et al. Amphiphysin autoimmunity: paraneoplastic accompaniments. Ann Neurol 2005; 58: 96-107
10. Sommer C, Weishaupt A, Brinkhoff J, Biko L, Wessig C, Gold R, et al. Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin. Lancet 2005; 365: 1406-11
11. Tanaka K, Tanaka M, Igarashi S, Onodera O, Miyatake T, Tsuji S. Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody. 2.Passive transfer of murine mononuclear cells activated with recombinant Yo protein to paraneoplastic cerebellar degeneration lymphocytes in severe combined immunodeficiency mice. Clin Neurol Neurosurg 1995; 97: 101-5
12. Varley J, Vincent A, Irani SR. Clinical and experimental studies of potentially pathogenic brain-directed autoantibodies: current knowledge and future directions. J Neurol 2015; 262: 1081-95
13. Werner C, Pauli M, Doose S, Weishaupt A, Haselmann H, Grunewald B, et al. Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition. Brain 2016; 139: 365-79
14. Wessig C, Klein R, Schneider MF, Toyka KV, Naumann M, Sommer C. Neuropathology and binding studies in anti-amphiphysin-associated stiff-person syndrome. Neurology 2003; 61: 195-8.