Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer

Journal of Neural Transmission

Volumn 119, Issue 8, 2012, Pages 981-985

  Geis, Christian ^a   Grünewald, Benedikt ^a   Weishaupt, Andreas ^a   Wultsch, Thomas ^a   Toyka, Klaus V ^a   Reif, Andreas ^a   Sommer, Claudia ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Amygdala; Anti amphiphysin antibodies; Anxiety; Passive transfer; Stiff person syndrome

Indexed keywords

AMPHIPHYSIN; AMPHIPHYSIN ANTIBODY; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STIFF MAN SYNDROME;

ANIMALS; ANXIETY; AUTOANTIBODIES; AUTOANTIGENS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; INJECTIONS, SPINAL; NERVE TISSUE PROTEINS; RATS; RATS, INBRED LEW; STIFF-PERSON SYNDROME;

EID: 84865116494     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0773-3     Document Type: Article

References (18)

1. Ameli R, Snow J, Rakocevic G, Dalakas MC (2005) A neuropsychological assessment of phobias in patients with stiff person syndrome. Neurology 64:1961-1963 (Pubitemid 40800718)
2. Bergado-Acosta JR, Sangha S, Narayanan RT, Obata K, Pape HC, Stork O (2008) Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory. Learn Mem 15:163-171 (Pubitemid 351439146)
3. Dalakas MC (2009) Stiff person syndrome: advances in pathogenesis and therapeutic interventions. Curr Treat Options Neurol 11:102-110
4. Dalakas MC, Li M, Fujii M, Jacobowitz DM (2001) Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology 57:780-784 (Pubitemid 32845494)
5. Di Paolo G, Sankaranarayanan S, Wenk MR, Daniell L, Perucco E, Caldarone BJ, Flavell R, Picciotto MR, Ryan TA, Cremona O, De Camilli P (2002) Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron 33:789-804 (Pubitemid 34219249)
6. Folli F, Solimena M, Cofiell R, Austoni M, Tallini G, Fassetta G, Bates D, Cartlidge N, Bottazzo GF, Piccolo G et al (1993) Autoantibodies to a 128-kd synaptic protein in three women with the stiff-man syndrome and breast cancer. N Engl J Med 328:546-551 (Pubitemid 23053831)
7. Geis C, Beck M, Jablonka S, Weishaupt A, Toyka KV, Sendtner M, Sommer C (2009) Stiff person syndrome associated anti-amphiphysin antibodies reduce GABA associated [Ca(2 +)]i rise in embryonic motoneurons. Neurobiol Dis 36:191-199
8. Geis C, Weishaupt A, Hallermann S, Grunewald B, Wessig C, Wultsch T, Reif A, Byts N, Beck M, Jablonka S, Boettger MK, Uceyler N, Fouquet W, Gerlach M, Meinck HM, Siren AL, Sigrist SJ, Toyka KV, Heckmann M, Sommer C (2010) Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition. Brain 133:3166-3180
9. Geis C, Weishaupt A, Grunewald B, Wultsch T, Reif A, Gerlach M, Dirkx R, Solimena M, Perani D, Heckmann M, Toyka KV, Folli F, Sommer C (2011) Human stiff-person syndrome IgG induces anxious behavior in rats. PLoS One 6:e16775
10. Holmoy T, Geis C (2010) The immunological basis for treatment of stiff person syndrome. J Neuroimmunol 231(1-2):55-60
11. Lancaster E, Martinez-Hernandez E, Dalmau J (2011) Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology 77:179-189
12. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P (1990) Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med 322:1555-1560 (Pubitemid 20176695)
13. Sommer C, Weishaupt A, Brinkhoff J, Biko L, Wessig C, Gold R, Toyka KV (2005) Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin. Lancet 365:1406-1411 (Pubitemid 40523735)
14. Stich O, Jarius S, Kleer B, Rasiah C, Voltz R, Rauer S (2007) Specific antibody index in cerebrospinal fluid from patients with central and peripheral paraneoplastic neurological syndromes. J Neuroimmunol 183:220-224 (Pubitemid 46204909)
15. Vincent A, Bien CG, Irani SR, Waters P (2011) Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 10:759-772
16. Wessig C, Klein R, Schneider MF, Toyka KV, Naumann M, Sommer C (2003) Neuropathology and binding studies in anti-amphiphysin-associated stiff-person syndrome. Neurology 61:195-198 (Pubitemid 36875300)
17. Wultsch T, Chourbaji S, Fritzen S, Kittelt S, Grunblatt E, Gerlach M, Gutknecht L, Chizat F, Golfier G, Schmitt A, Gass P, Lesch KP, Reif A (2007) Behavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals. J Neural Transm Suppl 72:69-85
18. Yaksh TL, Rudy TA (1976) Chronic catheterization of the spinal subarachnoid space. Physiol Behav 17:1031-1036 (Pubitemid 8063691)