Immunization against GAD Induces Antibody Binding to GAD-Independent Antigens and Brainstem GABAergic Neuronal Loss

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Chang, Thashi ^a,d   Alexopoulos, Harry ^a   Pettingill, Philippa ^a   McMenamin, Mary ^b   Deacon, Robert ^b   Erdelyi, Ferenc ^c   Szabó, Gabor ^c   Buckley, Camilla J ^a   Vincent, Angela ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d UNIVERSITY OF COLOMBO   (Sri Lanka)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ANTIGEN; ENHANCED GREEN FLUORESCENT PROTEIN; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 65 ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; BRAIN STEM; CELL CULTURE; CELL LOSS; CEREBELLUM; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; FEMALE; IMMUNIZATION; IMMUNODIFFUSION; MALE; MOUSE; NERVE CELL; NONHUMAN; PATHOGENESIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; STIFF MAN SYNDROME; TREATMENT RESPONSE;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNITY; CELLS, CULTURED; CEREBELLUM; FEMALE; GABAERGIC NEURONS; GAMMA-AMINOBUTYRIC ACID; GENES, REPORTER; GLUTAMATE DECARBOXYLASE; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNIZATION; MALE; MICE; MICE, TRANSGENIC; MUTANT CHIMERIC PROTEINS; PROTEIN BINDING; PROTEIN TRANSPORT; STIFF-PERSON SYNDROME;

EID: 84884227313     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072921     Document Type: Article

References (32)

1. Moersch FP, Woltman HW, (1956) Progressive fluctuating muscular rigidity and spasm ("stiff-man" syndrome); report of a case and some observations in 13 other cases. Mayo Clin Proc 31: 421-427.
2. Duddy ME, Baker MR, (2009) Stiff person syndrome. Front Neurol Neurosci 26: 147-165.
3. Meinck HM, Faber L, Morgenthaler N, Seissler J, Maile S, et al. (2001) Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases. J Neurol Neurosurg Psychiatry 71: 100-103.
4. Meinck HM, Thompson PD, (2002) Stiff man syndrome and related conditions. Mov Disord 17: 853-866.
5. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P, (1990) Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med 322: 1555-1560.
6. Solimena M, De Camilli P, (1991) Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus. Trends Neurosci 14: 452-457.
7. Dalakas MC, Fujii M, Li M, McElroy B, (2000) The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome. Neurology 55: 1531-1535.
8. Levy LM, Dalakas MC, Floeter MK, (1999) The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid. Ann Intern Med 131: 522-530.
9. Rose NR, Bona C, (1993) Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol Today 14: 426-430.
10. Patrick J, Lindstrom J, (1973) Autoimmune response to acetylcholine receptor. Science 180: 871-872.
11. Kowal C, DeGiorgio LA, Nakaoka T, Hetherington H, Huerta PT, et al. (2004) Cognition and immunity; antibody impairs memory. Immunity 21: 179-188.
12. Vincent A, Bien CG, Irani SR, Waters P, (2011) Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 10: 759-772.
13. Geis C, Weishaupt A, Hallermann S, Grunewald B, Wessig C, et al. (2010) Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition. Brain 133: 3166-3180.
14. Hansen N, Grunewald B, Weishaupt A, Colaco MN, Toyka KV, et al. (2013) Human Stiff person syndrome IgG-containing high-titer anti-GAD65 autoantibodies induce motor dysfunction in rats. Exp Neurol 239: 202-209.
15. Geis C, Weishaupt A, Grunewald B, Wultsch T, Reif A, et al. (2011) Human stiff-person syndrome IgG induces anxious behavior in rats. PLoS One 6: e16775.
16. Brager DH, Luther PW, Erdelyi F, Szabo G, Alger BE, (2003) Regulation of exocytosis from single visualized GABAergic boutons in hippocampal slices. J Neurosci 23: 10475-10486.
17. Deacon RM, (2006) Burrowing in rodents: a sensitive method for detecting behavioral dysfunction. Nat Protoc 1: 118-121.
18. Deacon RM, Brook RC, Meyer D, Haeckel O, Ashcroft FM, et al. (2006) Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2. Physiol Behav 87: 723-733.
19. Huettner JE, Baughman RW, (1986) Primary culture of identified neurons from the visual cortex of postnatal rats. J Neurosci 6: 3044-3060.
20. Bilimoria PM, Bonni A, (2008) Cultures of cerebellar granule neurons. CSH Protoc 2008: pdb prot5107.
21. Luddens H, Pritchett DB, Kohler M, Killisch I, Keinanen K, et al. (1990) Cerebellar GABAA receptor selective for a behavioural alcohol antagonist. Nature 346: 648-651.
22. Chang T, Alexopoulos H, McMenamin M, Carvajal A, Alexander S, et al. (2013) Neuronal surface and GAD autoantibodies in non-paraneoplastic stiff person syndrome. JAMA Neurology doi: 10.1001/jamaneurol.2013.3499.
23. Baekkeskov S, Kanaani J, Jaume JC, Kash S, (2000) Does GAD have a unique role in triggering IDDM? J Autoimmun 15: 279-286.
24. Bischof F, Bins A, Durr M, Zevering Y, Melms A, et al. (2004) A structurally available encephalitogenic epitope of myelin oligodendrocyte glycoprotein specifically induces a diversified pathogenic autoimmune response. J Immunol 173: 600-606.
25. Reichling DB, Basbaum AI, (1990) Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: I. GABA-immunoreactive projection neurons in the periaqueductal gray and nucleus raphe magnus. J Comp Neurol 302: 370-377.
26. Schwartz-Giblin S, McCarthy MM, Robbins A, (1996) The medullary reticular formation is a site of muscle relaxant action of diazepam on deep back and neck muscles in the female rat. Brain Res 710: 178-188.
27. Holstege JC, Bongers CM, (1991) A glycinergic projection from the ventromedial lower brainstem to spinal motoneurons. An ultrastructural double labeling study in rat. Brain Res 566: 308-315.
28. Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, et al. (2006) Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nat Genet 38: 245-250.
29. Burton AR, Baquet Z, Eisenbarth GS, Tisch R, Smeyne R, et al. (2010) Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells. J Immunol 184: 4863-4870.
30. Bien CG, Vincent A, Barnett MH, Becker AJ, Blumcke I, et al. (2012) Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. Brain 135: 1622-1638.
31. Honnorat J, Saiz A, Giometto B, Vincent A, Brieva L, et al. (2001) Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patients. Arch Neurol 58: 225-230.
32. Malter MP, Helmstaedter C, Urbach H, Vincent A, Bien CG, (2010) Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. Ann Neurol 67: 470-478.