Human Stiff person syndrome IgG-containing high-titer anti-GAD65 autoantibodies induce motor dysfunction in rats

Experimental Neurology

Volumn 239, Issue 1, 2013, Pages 202-209

  Hansen, Niels ^a,b   Grünewald, Benedikt ^a,c   Weishaupt, Andreas ^a   Colaço, Maria Nandini ^a   Toyka, Klaus V ^a   Sommer, Claudia ^a   Geis, Christian ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Antibodies; GABAergic dysfunction; GAD65; Intraventricular passive transfer; Motor dysfunction; Supraspinal motor circuits

Indexed keywords

GLUTAMATE DECARBOXYLASE 65 ANTIBODY; IMMUNOGLOBULIN G;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANXIETY; ARTICLE; BALANCE DISORDER; BEHAVIOR; CAPSULA INTERNA; CASE REPORT; COMORBIDITY; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE SEVERITY; FEMALE; GLOBUS PALLIDUS; GRIP STRENGTH; HOFFMANN REFLEX; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INTERNEURON; MALE; MOTOR CONTROL; MOTOR DYSFUNCTION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR DYSFUNCTION; STIFF MAN SYNDROME; SYNAPTIC TRANSMISSION; THALAMUS; WALKING DIFFICULTY;

ANIMALS; ANXIETY; AUTOANTIBODIES; BEHAVIOR, ANIMAL; DYSKINESIA, DRUG-INDUCED; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLUTAMATE DECARBOXYLASE; H-REFLEX; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SPINAL; MALE; MIDDLE AGED; MOTOR SKILLS; RATS; RATS, INBRED LEW; STIFF-PERSON SYNDROME;

EID: 84868546044     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.10.013     Document Type: Article

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