Injectable alginate/hydroxyapatite gel scaffold combined with gelatin microspheres for drug delivery and bone tissue engineering

Materials Science and Engineering C

Volumn 63, Issue , 2016, Pages 274-284

  Yan, Jingxuan ^a   Miao, Yuting ^a   Tan, Huaping ^a   Zhou, Tianle ^a   Ling, Zhonghua ^b   Chen, Yong ^b   Xing, Xiaodong ^a   Hu, Xiaohong ^c  

^a NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b JINLING HOSPITAL   (China)

^c JINLING INSTITUTE OF TECHNOLOGY   (China)

Author keywords

Alginate; Drug delivery; Hydrogels; Hydroxyapatite; Microspheres; Tissue engineering

Indexed keywords

ALGINATE; BIOMECHANICS; BONE; CALCIUM; CALCIUM CARBONATE; CROSSLINKING; DRUG DELIVERY; GELATION; HYDROGELS; HYDROXYAPATITE; MECHANICAL PROPERTIES; MICROSPHERES; OSTEOBLASTS; PH; POSITIVE IONS; SCAFFOLDS (BIOLOGY); STRAIN; TISSUE;

BIOACTIVE PROPERTIES; BONE TISSUE ENGINEERING; DEGRADATION BEHAVIOR; GELATIN MICROSPHERES; HYDROXYAPATITE (HAP); ORGANIC/INORGANIC HYBRIDS; PHYSICAL PERFORMANCE; TETRACYCLINE HYDROCHLORIDE;

TISSUE ENGINEERING;

ALGINIC ACID; DRUG CARRIER; GELATIN; GLUCURONIC ACID; HEXURONIC ACID; HYDROGEL; HYDROXYAPATITE; MICROSPHERE; TETRACYCLINE;

CELL LINE; CELL SURVIVAL; CHEMISTRY; COMPRESSIVE STRENGTH; DRUG EFFECTS; DRUG RELEASE; FLOW KINETICS; HUMAN; HYDROGEL; METABOLISM; PH; POROSITY; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING; TOXICITY;

ALGINATES; CELL LINE; CELL SURVIVAL; COMPRESSIVE STRENGTH; DRUG CARRIERS; DRUG LIBERATION; DURAPATITE; GELATIN; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; HYDROGELS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POROSITY; RHEOLOGY; TETRACYCLINE; TISSUE ENGINEERING;

EID: 84959569738     PISSN: 09284931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.msec.2016.02.071     Document Type: Article

References (37)

1. M. Ochi, Y. Uchio, M. Tobita, and et al. Current concepts in tissue engineering technique for repair of cartilage defect Artif. Organs 25 2001 172 179
2. J.S. Temenoff, and A.G. Mikos Review: tissue engineering for regeneration of articular cartilage Biomaterials 21 2000 431 440
3. R. Cancedda, B. Dozin, P. Giannoni, and et al. Tissue engineering and cell therapy of cartilage and bone Matrix Biol. 22 2003 81 91
4. H. Tan, M. Fan, Y. Ma, and et al. Injectable gel scaffold based on biopolymer microspheres via enzymatic reaction Adv. Healthc. Mater. 3 2014 1769 1775
5. R.G. LeBaron, and K.A. Athanasiou Ex vivo synthesis of articular cartilage Biomaterials 21 2000 2575 2587
6. S. Yan, T. Wang, L. Feng, and et al. Injectable in situ self-cross-linking hydrogels based on poly (l-glutamic acid) and alginate for cartilage tissue engineering Biomacromolecules 15 2014 4495 4508
7. H. Tan, and K.G. Marra Injectable, biodegradable hydrogels for tissue engineering applications Materials 3 2010 1746 1767
8. H. Tan, Q. Shen, X. Jia, and et al. Injectable nano-hybrid scaffold for biopharmaceuticals delivery and soft tissue engineering Macromol. Rapid Commun. 33 2012 2015 2022
9. J.L. Drury, and D.J. Mooney Hydrogels for tissue engineering: scaffold design variables and applications Biomaterials 24 2003 4337 4351
10. H. Tan, X. Gao, J. Sun, and et al. Doubly stimulus-induced stem cell aggregation during differentiation on biopolymer hydrogel substrate Chem. Commun. 49 2013 11554 11556
11. K. Rezwan, Q.Z. Chen, J.J. Blaker, and et al. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering Biomaterials 27 2006 3413 3431
12. S. Yang, K.F. Leong, Z. Du, and et al. The design of scaffolds for use in tissue engineering. Part I. Traditional factors Tissue Eng. 7 2001 679 689
13. B. Balakrishnan, and A. Jayakrishnan Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds Biomaterials 26 2005 3941 3951
14. M. Fan, Y. Ma, J. Mao, and et al. Cytocompatible in situ forming chitosan/hyaluronan hydrogels via a metal-free click chemistry for soft tissue engineering Acta Biomater. 20 2015 60 68
15. S.N. Pawar, and K.J. Edgar Alginate derivatization: a review of chemistry, properties and applications Biomaterials 33 2012 3279 3305
16. K.Y. Lee, and D.J. Mooney Alginate: properties and biomedical applications Prog. Ploym. Sci. 37 2012 106 126
17. H.R. Lin, and Y.J. Yeh Porous alginate/hydroxyapatite composite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies J. Biomed. Mater. Res. A 71 2004 52 65
18. J. Sun, and H. Tan Alginate-based biomaterials for regenerative medicine applications Materials 6 2013 1285 1309
19. L. Pighinelli, and M. Kucharska Properties and structure of microcrystalline chitosan and hydroxyapatite composites J. Biomed. Nanotechnol. 5 2014 128
20. L. Lu, Y.S. Qi, C.R. Zhou, and et al. Rapidly in situ forming biodegradable hydrogels by combining alginate and hydroxyapatite nanocrystal Sci. China Ser. E 53 2010 272 277
21. H. Tan, J. Wu, L. Lao, and et al. Gelatin/chitosan/hyaluronan scaffold integrated with PLGA microspheres for cartilage tissue engineering Acta Biomater. 5 2009 328 337
22. M.A. Vandelli, F. Rivasi, P. Guerra, and et al. Gelatin microspheres crosslinked with D, L-glyceraldehyde as a potential drug delivery system: preparation, characterisation, in vitro and in vivo studies Int. J. Pharm. 215 2001 175 184
23. A.H. Nguyen, J. McKinney, T. Miller, and et al. Gelatin methacrylate microspheres for controlled growth factor release Acta Biomater. 13 2015 101 110
24. X. Hu, J. Zhou, N. Zhang, and et al. Preparation and properties of an injectable scaffold of poly (lactic-co-glycolic acid) microparticles/chitosan hydrogel J. Mech. Behav. Biomed. 1 2008 352 359
25. I.F. Farrés, and I.T. Norton Formation kinetics and rheology of alginate fluid gels produced by in-situ calcium release Food Hydrocoll. 40 2014 76 84
26. J.A. Yang, J. Yeom, B.W. Hwang, and et al. In situ-forming injectable hydrogels for regenerative medicine Prog. Polym. Sci. 39 2014 1973 1986
27. K.I. Draget, K. Østgaard, and O. Smidsrød Homogeneous alginate gels: a technical approach Carbohydr. Polym. 14 1990 159 178
28. C.K. Kuo, and P.X. Ma Maintaining dimensions and mechanical properties of ionically crosslinked alginate hydrogel scaffolds in vitro J. Biomed. Mater. Res. A 84 2008 899 907
29. C.K. Kuo, and P.X. Ma Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: part 1. Structure, gelation rate and mechanical properties Biomaterials 22 2001 511 521
30. P.K. Vemula, E. Boilard, A. Syed, and et al. On-demand drug delivery from self-assembled nanofibrous gels: a new approach for treatment of proteolytic disease J. Biomed. Mater. Res. A 97 2011 103 110
31. H. Tan, C.R. Chu, K.A. Payne, and et al. Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering Biomaterials 30 2009 2499 2506
32. H. Tan, H. Li, J.P. Rubin, and et al. Controlled gelation and degradation rates of injectable hyaluronic acid-based hydrogels through a double crosslinking strategy J. Tissue Eng. Regen. Med. 5 2011 790 797
33. H. Tan, C. Xiao, J. Sun, and et al. Biological self-assembly of injectable hydrogel as cell scaffold via specific nucleobase pairing Chem. Commun. 48 2012 10289 10291
34. M.J. Moura, M.M. Figueiredo, and M.H. Gil Rheological study of genipin cross-linked chitosan hydrogels Biomacromolecule 8 2007 3823 3829
35. B. Balakrishnan, N. Joshi, A. Jayakrishnan, and et al. Self-crosslinked oxidized alginate/gelatin hydrogel as injectable, adhesive biomimetic scaffolds for cartilage regeneration Acta Biomater. 10 2014 3650 3663
36. H. Tan, J.P. Rubin, and K.G. Marra Direct synthesis of biodegradable polysaccharide derivative hydrogels through aqueous Diels-Alder chemistry Macromol. Rapid Commun. 32 2011 905 911
37. H. Tan, C.M. Ramirez, N. Miljkovic, and et al. Thermosensitive injectable hyaluronic acid hydrogel for adipose tissue engineering Biomaterials 30 2009 6844 6853