Preparation and properties of an injectable scaffold of poly(lactic-co-glycolic acid) microparticles/chitosan hydrogel

Journal of the Mechanical Behavior of Biomedical Materials

Volumn 1, Issue 4, 2008, Pages 352-359

  Hu, Xiaohong ^a,b   Zhou, Jie ^a,b   Zhang, Nan ^a,b   Tan, Huaping ^a,b   Gao, Changyou ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Chitosan; Chondrocytes; Hydrogel; Particles; PLGA

Indexed keywords

BIOMEDICAL FIELDS; CARBON BONDS; CHITOSAN DERIVATIVES; CHITOSAN HYDROGEL; CHONDROCYTE; COMPOSITE HYDROGEL; ELASTIC STIFFNESS; GENE CARRIERS; HYDROGEL; IN-VITRO; MECHANICAL STRENGTHS; POLY LACTIC CO GLYCOLIC ACID (PLAGA); POLY(D ,L-LACTIC ACID-CO-GLYCOLIC ACID) (PLGA); STORAGE MODULUS; SWELLING RATIO (SR); UV IRRADIATIONS; WATER SOLUBLE;

AMINES; BLENDING; CELL CULTURE; CHEMOTHERAPY; CHITIN; CHITOSAN; COAGULATION; COLLOIDS; DRUG DELIVERY; DRUG DOSAGE; ELASTIC MODULI; GELATION; GENE TRANSFER; GRANULAR MATERIALS; PROTEINS; SCAFFOLDS;

HYDROGELS;

BIOMATERIAL; CHITOSAN; GELATIN; POLYGLACTIN; WATER;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL CULTURE; CONTROLLED STUDY; CROSS LINKING; EAR CARTILAGE; GELATION; HYDROGEL; INJECTION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RABBIT; SCANNING ELECTRON MICROSCOPY; SOLUBILITY; SYNTHESIS;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; CHITOSAN; CHONDROCYTES; HYDROGEL; INJECTIONS; LACTIC ACID; MATERIALS TESTING; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; RABBITS; TISSUE ENGINEERING;

EID: 48549083789     PISSN: 17516161     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmbbm.2008.02.001     Document Type: Article

References (32)

1. Balakrishnan B., and Jayakrishnan A. Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds. Biomaterials 26 (2005) 3941-3951
2. Bodmeier R., and McGinity J.W. Solvent selection in the preparation of poly(D,L-lactide) microspheres prepared by the solvent evaporation method. Int. J. Pharm. 43 (1986) 179-186
3. Chen F.M., Zhao Y.M., Sun H.H., Jin T., Wang Q.T., Zhou W., Wu Z.F., and Jin Y. Novel glycidyl methacrylated dextran (Dex-GMA)/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins: Formulation and characteristics. J. Control. Release 118 (2007) 65-77
4. Chenite A., Chaput C., Wang D., Combes C., Bushmann M.D., Hoemann C.D., Leroux J.C., Atkinson B.L., Binette F., and Selmani A. Novel injectable neutral solutions of chitosan from biodegradable gels in situ. Biomaterials 21 (2000) 2155-2161
5. Chung, Y.I., 2007, Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex. Journal of Controlled Release, doi:10.1016/j.jconrel.2007.05.029
6. Dimpy G., Charles H.T., and Molly S.S. Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord. Biomaterials 27 (2006) 2370-2379
7. Drury J.L., and Mooney D.J. Hydrogels for tissue engineering: Scaffold design variables and applications. Biomaterials 24 (2003) 4337-4351
8. Emily H., Anthony L., and Michele M. Synthesis and characterization of an injectable hydrogel with tunable mechanical properties for soft tissue repair. Biomacromolecules 7 (2006) 3223-3228
9. Hamed G.R. Reinforcement of rubber. Rubber Chemistry and Technology 73 (2000) 524-533
10. Hoffman A.S. Hydrogels for biomedical applications. Adv. Drug. Deliv. Rev. 54 (2002) 3-12
11. Hollinger J.O., and Battistone G.C. Biodegradable bone repair materials.Synthetic polymers and ceramics. Clin. Orthop. Rel. Res. 207 (1986) 290-305
12. Hong Y., Mao Z.W., Wang H.L., Gao C.Y., and Shen J.C. Covalently crosslinked chitosan hydrogel formed at neutral pH and body Temperature. J. Biomed. Mater. Res. 79A (2006) 913-922
13. Hong Y., Song H.Q., Gong Y.H., Mao Z.W., Gao C.Y., and Shen J.C. Covalently crosslinked chitosan hydrogel: Properties of in vitro degradation and chondrocyte encapsulation. Acta Biomaterialia 3 (2007) 23-31
14. Ibusuki S., Fuji Y., Iwamoto Y., and Matsude T. Tissue-engineered cartilage using an injectable and in situ gelable thermoreponsive gelatin: Fabrication and in vitro performance. Tissue Engineering 9 (2003) 371-384
15. Jain R.A. Manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 21 (2000) 2475-2490
16. Jiang W., Gupta R.K., Deshpande M.C., and Schwendeman S.P. Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv. Drug. Deliv. Rev. 57 (2005) 391-410
17. Kretlow J.D., Klouda L., and Mikos A.G. Injectable matrices and scaffolds for drug delivery in tissue engineering. Adv. Drug. Deliv. Rev. 59 (2007) 236-273
18. Lee K.Y., Kong H.J., Larson R.G., and Mooney D.J. Hydrogel formation via cell crosslinking. Adv. Mater. 15 (2003) 1828-1832
19. Lee K.Y., and Mooney D.J. Hydrogels for tissue engineering. Chem. Rev. 101 (2001) 1869-1880
20. Li Q., Williams C.G., Danny D.N.S., Wang J., Leong K., and Elisseeff J.H. Photocrosslinkable polysaccharides based on chondroitin sulfate. J. Biomed. Mater. Res. 68A (2004) 28-33
21. Lin C.C., and Metters A.T. Hydrogels in controlled release formulations: Network design and mathematical modeling. Adv. Drug Deliv. Rev. 58 (2006) 1379-1408
22. Malafaya P.B., Silva G.A., and Reis R.L. Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv. Drug Deliv. Rev. 59 (2007) 207-233
23. Marc S., Juergen S., Wim E.H., and Wim J. J. Control. Release 119 (2007) 301-312
24. Mow V.C., Ratcliffe A., and Poole A.R. Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures. Biomaterials 13 (1992) 67-97
25. Tememoff J.S., and Mikos A.G. Injectable biodegradable materials for orthopedic tissue engineering. Biomaterials 21 (2000) 2405-2412
26. Wang D.A., Varghese S., Sharma B., Strehin I., Fermanian S., Gorham J., Fairbrother D.H., Cascio B., and Elisseeff J.H. Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration. Nat. Mater. 6 (2007) 385-392
27. Wang D.A., Williams C.G., Li Q., Sharma B., and Elisseeff J.H. Synthesis and characterization of a novel degradable phosphate-containing hydrogel. Biomaterials 24 (2003) 3969-3980
28. Williams C.G., Malik A.N., Kim T.K., Manson P.N., and Elisseeff J.H. Variable cytocompatibility of six cell lines with photoinitiators used for polymerizing hydrogels and cell encapsulation. Biomaterials 26 (2005) 1211-1218
29. Yoon J.J., Song S.H., Lee D.S., and Park T.G. Immobilization of cell adhesive RGD peptide onto the surface of highly porous biodegradable polymer scaffolds fabricated by gas foaming/salt leaching methode. Biomaterials 25 (2004) 5613-5620
30. Young S., Wong M., Tabata Y., and Mikos A.G. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J. Control. Release 109 (2005) 256-274
31. Zhang X.Z., Lewis P.J., and Chu C.C. Fabrication and characterization of a smart drug delivery system: Microsphere in hydrogel. Biomaterials 26 (2005) 3299-3309
32. Zheng C.H., Gao J.Q., Zhang Y.P., and Liang W.Q. A protein delivery system: Biodegradable alginate-chitosan-poly(lactic-co-glycolic acid) composite microspheres. Biochem. Biophys. Res. Commun. 323 (2004) 1321-1327