Gelatin methacrylate microspheres for controlled growth factor release

Acta Biomaterialia

Volumn 13, Issue , 2015, Pages 101-110

  Nguyen, Anh H ^a   McKinney, Jay ^a   Miller, Tobias ^a   Bongiorno, Tom ^a   McDevitt, Todd C ^a,b  

^a Emory University   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Gelatin; Growth factor delivery; Methacrylate; Microsphere

Indexed keywords

AUTOMOBILE MANUFACTURE; BINDING ENERGY; CELL CULTURE; CHEMICAL MODIFICATION; FLUORIDATION; MESH GENERATION; MICROSPHERES;

CONTROLLED GROWTH; CROSS-LINKING DENSITY; DELIVERY VEHICLE; GELATIN; GLUTARALDEHYDES; GROWTH FACTOR DELIVERY; GROWTH FACTOR RELEASE; MESH SIZE; METHACRYLATE; MICRO PARTICLES;

TISSUE ENGINEERING;

GELATIN METHACRYLATE; GROWTH FACTOR; MICROSPHERE; UNCLASSIFIED DRUG; DELAYED RELEASE FORMULATION; FIBROBLAST GROWTH FACTOR 2; GELATIN; HYDROGEL; METHACRYLIC ACID; METHACRYLIC ACID DERIVATIVE;

ARTICLE; CONTROLLED DRUG RELEASE; CROSS LINKING; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; PARTICLE SIZE; PRIORITY JOURNAL; YOUNG MODULUS; ANIMAL; BOVINE; CHEMISTRY; DELAYED RELEASE FORMULATION; HUMAN; HYDROGEL;

ANIMALS; CATTLE; DELAYED-ACTION PREPARATIONS; FIBROBLAST GROWTH FACTOR 2; GELATIN; HUMANS; HYDROGELS; METHACRYLATES; MICROSPHERES;

EID: 84920719227     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.11.028     Document Type: Article

References (45)

1. M. Yamamoto, Y. Ikada, and Y. Tabata Controlled release of growth factors based on biodegradation of gelatin hydrogel J Biomater Sci, Polym Ed 2001 77 88
2. S. Young, M. Wong, Y. Tabata, and A.G. Mikos Gelatin as a delivery vehicle for the controlled release of bioactive molecules J Controlled Release 109 2005 256 274
3. Z.S. Patel, H. Ueda, M. Yamamoto, Y. Tabata, and A.G. Mikos In vitro and in vivo release of vascular endothelial growth factor from gelatin microparticles and biodegradable composite scaffolds Pharm Res 25 2008 2370 2378
4. Y. Zhao, Z. Liu, C. Pan, Z. Li, J. Zhou, and J. Wang Preparation of gelatin microspheres encapsulated with bFGF for therapeutic angiogenesis in a canine ischemic hind limb J Biomater Sci, Polym Ed 2011 665 682
5. Y. Tabata, A. Nagano, and Y. Ikada Biodegradation of hydrogel carrier incorporating fibroblast growth factor Tissue Eng 5 1999 127 138
6. T.A. Holland, J.K.V. Tessmar, Y. Tabata, and A.G. Mikos Transforming growth factor-β1 release from oligo(poly(ethylene glycol) fumarate) hydrogels in conditions that model the cartilage wound healing environment J Controlled Release 94 2004 101 114
7. T.A. Holland, Y. Tabata, and A.G. Mikos Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering J Controlled Release 101 2005 111 125
8. A. Cittadini, M.G. Monti, V. Petrillo, G. Esposito, G. Imparato, and A. Luciani Complementary therapeutic effects of dual delivery of insulin-like growth factor-1 and vascular endothelial growth factor by gelatin microspheres in experimental heart failure Eur J Heart Fail 13 2011 1264 1274
9. T. Ogawa, T. Akazawa, and Y. Tabata In vitro proliferation and chondrogenic differentiation of rat bone marrow stem cells cultured with gelatin hydrogel microspheres for TGF-beta1 release J Biomater Sci, Polym Ed 21 2010 609 621
10. L.D. Solorio, E.L. Vieregge, C.D. Dhami, P.N. Dang, and E. Alsberg Engineered cartilage via self-assembled hMSC sheets with incorporated biodegradable gelatin microspheres releasing transforming growth factor-β1 J Controlled Release 158 2012 224 232
11. K. Hayashi, and Y. Tabata Preparation of stem cell aggregates with gelatin microspheres to enhance biological functions Acta Biomater 7 2011 2797 2803
12. P.R. Baraniak, M.T. Cooke, R. Saeed, M.A. Kinney, K.M. Fridley, and T.C. McDevitt Stiffening of human mesenchymal stem cell spheroid microenvironments induced by incorporation of gelatin microparticles J Mech Behav Biomed Mater 11 2012 63 71
13. L.D. Solorio, C.D. Dhami, P.N. Dang, E.L. Vieregge, and E. Alsberg Spatiotemporal regulation of chondrogenic differentiation with controlled delivery of transforming growth factor-β1 from gelatin microspheres in mesenchymal stem cell aggregates Stem Cells Trans Med 1 2012 632 639
14. A.M. Bratt-Leal, R.L. Carpenedo, M.D. Ungrin, P.W. Zandstra, and T.C. McDevitt Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation Biomaterials 32 2011 48 56
15. Z.S. Patel, M. Yamamoto, H. Ueda, Y. Tabata, and A.G. Mikos Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2 Acta Biomater 4 2008 1126 1138
16. H. Liang, and W. Chang Crosslinking structures of gelatin hydrogels crosslinked with genipin or a water soluble carbodiimide J Appl Polym Sci 91 2004 4017 4026
17. L.O. Damink, and P. Dijkstra Glutaraldehyde as a crosslinking agent for collagen-based biomaterials J Mater Sci Mater Med 4530 1995
18. P. Hardy, A. Nicholls, and H. Rydon The nature of the cross-linking of proteins by glutaraldehyde part 1. Interaction of glutaraldehyde with the amino-groups of 6-aminohexanoic acid and of a-N-acetyl-lysine JCS Perkin I 1969 958 962
19. E. Woodroof Use of glutaraldehyde and formaldehyde to process tissue heart values J Bioeng 2 1978 1 9
20. A. Bigi, G. Cojazzi, S. Panzavolta, K. Rubini, and N. Roveri Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking Biomaterials 22 2001 763 768
21. K. Iwanaga, T. Yabuta, M. Kakemi, K. Morimoto, Y. Tabata, and Y. Ikada Usefulness of microspheres composed of gelatin with various cross-linking density J Microencapsul 20 2003 767 776
22. H.W. Sung, R.N. Huang, L.L.H. Huang, and C.C. Tsai In vitro evaluation of cytotoxicity of a naturally occurring cross-linking reagent for biological tissue fixation J Biomater Sci, Polym Ed 10 1999 63 78
23. J. Ruijgrok, J. de Wijn, and M. Boon Glutaraldehyde crosslinking of collagen: effects of time, temperature, concentration and presoaking as measured by shrinkage temperature Clin Mater 17 1994 23 27
24. E. Hoch, C. Schuh, T. Hirth, G.E.M. Tovar, and K. Borchers Stiff gelatin hydrogels can be photo-chemically synthesized from low viscous gelatin solutions using molecularly functionalized gelatin with a high degree of methacrylation J Mater Sci Mater Med 23 2012 2607 2617
25. A. Van Den Bulcke, B. Bogdanov, N. De Rooze, E.H. Schacht, M. Cornelissen, and H. Berghmans Structural and rheological properties of methacrylamide modified gelatin hydrogels Biomacromolecules 1 2000 31 38
26. M. Sutter, J. Siepmann, W.E. Hennink, and W. Jiskoot Recombinant gelatin hydrogels for the sustained release of proteins J Controlled Release 119 2007 301 312
27. J.W. Nichol, S.T. Koshy, H. Bae, C.M. Hwang, S. Yamanlar, and A. Khademhosseini Cell-laden microengineered gelatin methacrylate hydrogels Biomaterials 31 2010 5536 5544
28. A. Barbetta, M. Dentini, E.M. Zannoni, and M.E. De Stefano Tailoring the porosity and morphology of gelatin-methacrylate polyHIPE scaffolds for tissue engineering applications Langmuir 21 2005 12333 12341
29. X. Hu, L. Ma, C. Wang, and C. Gao Gelatin hydrogel prepared by photo-initiated polymerization and loaded with TGF-beta1 for cartilage tissue engineering Macromol Biosci 9 2009 1194 1201
30. T.T. Goodman, P.L. Olive, and S.H. Pun Increased nanoparticle penetration in collagenase-treated multicellular spheroids Int J Nanomed 2 2007 265 274
31. J.W. Nichol, and A. Khademhosseini Modular tissue engineering: engineering biological tissues from the bottom up Soft Matter 5 2009 1312 1319
32. J. Jung, and J. Oh Cell-induced flow-focusing instability in gelatin methacrylate microdroplet generation Biomicrofluidics 8 2014 036503
33. T. Hsien, and G.L. Rorrer Heterogeneous cross-linking of chitosan gel beads: kinetics, modeling, and influence on cadmium ion adsorption capacity Ind Eng Chem Res 1997 3631 3638
34. D.L. Elbert, and J.A. Hubbell Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering Biomacromolecules 2 2001 430 441
35. S. Bresler, E. Kazbekov, and V. Shadrin Study of radical polymerization by means of ESR Die Makromol Chemie 1974 2875 2880
36. E. Pulieri, V. Chiono, G. Ciardelli, G. Vozzi, A. Ahluwalia, and C. Domenici Chitosan/gelatin blends for biomedical applications J Biomed Mater Res Part A 86 2008 311 322
37. S. Tajima, and Y. Tabata Preparation and functional evaluation of cell aggregates incorporating gelatin microspheres with different degradabilities J Tissue Eng Regen Med 2012
38. Y.C. Chen, R.Z. Lin, H. Qi, Y. Yang, H. Bae, and J.M. Melero-Martin Functional human vascular network generated in photocrosslinkable gelatin methacrylate hydrogels Adv Funct Mater 22 2012 2027 2039
39. H.O. Ho, C.W. Lin, and M.T. Sheu Diffusion characteristics of collagen film J Controlled Release 77 2001 97 105
40. W. Dai, and T. Barbari Hydrogel membranes with mesh size asymmetry based on the gradient crosslinking of poly(vinyl alcohol) J Memb Sci 156 1999 67 79
41. V. Gonçalves, M. Laranjeira, V. Fávere, and R. Pedrosa Effect of crosslinking agents on chitosan microspheres in controlled release of diclofenac sodium Polímeros 15 2005 6 12
42. O.F. Khan, J. Jean-Francois, and M.V. Sefton MMP levels in the response to degradable implants in the presence of a hydroxamate-based matrix metalloproteinase sequestering biomaterial in vivo J Biomed Mater Res A 93 2010 1368 1379
43. F. Chen, M. Zhang, and Z. Wu Toward delivery of multiple growth factors in tissue engineering Biomaterials 31 2010 6279 6308
44. R.L. Carpenedo, A.M. Bratt-Leal, R.A. Marklein, S.A. Seaman, N.J. Bowen, and J.F. McDonald Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules Biomaterials 30 2009 2507 2515
45. K.A. Purpura, A.M. Bratt-Leal, K.A. Hammersmith, T.C. McDevitt, and P.W. Zandstra Systematic engineering of 3D pluripotent stem cell niches to guide blood development Biomaterials 33 2012 1271 1280