Current therapeutic role and medicinal potential of Scutellaria barbata in Traditional Chinese Medicine and Western research

Journal of Ethnopharmacology

Volumn 182, Issue , 2016, Pages 170-180

  Tao, Geyang ^a   Balunas, Marcy J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Cancer; Ethnopharmacology; Scutellaria barbata; Traditional Chinese Medicine; Western medicine

Indexed keywords

HERBACEOUS AGENT; PLANT EXTRACT; SCUTELLARIA BARBATA EXTRACT;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BITTER TASTE; BRONCHITIS; CANCER GROWTH; CANCER THERAPY; CHINESE MEDICINE; DECREASED APPETITE; ETHNOPHARMACOLOGY; HEDYOTIS; HUMAN; INFLAMMATION; INSECT BITE; LOBELIA; LUNG CANCER; NEOPLASM; PHARYNGITIS; PRECANCER; SCUTELLARIA BARBATA; SEMI STRUCTURED INTERVIEW; SKIN INFECTION; THERAPY EFFECT; UPPER RESPIRATORY TRACT INFECTION; URINARY TRACT INFECTION; WESTERN MEDICINE; XEROSTOMIA; ZINGIBER; MEDICAL RESEARCH; PHYTOTHERAPY; QUESTIONNAIRE;

BIOMEDICAL RESEARCH; HUMANS; MEDICINE, CHINESE TRADITIONAL; PHYTOTHERAPY; PLANT EXTRACTS; SURVEYS AND QUESTIONNAIRES;

EID: 84959547115     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.02.012     Document Type: Article

References (30)

1. V.P. Androutsopoulos, K. Ruparelia, R.R. Arroo, A.M. Tsatsakis, and D.A. Spandidos CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells Toxicology 264 2009 162 170
2. Bionovo. Bionovo Restructures Work Force Management Compensation Restructured. Available at: (http://bionovo.com/investors/pr/MjAxMjAzMDkyMDAw) (accessed 01.04.15).
3. M.J. Campbell, B. Hamilton, M. Shoemaker, M. Tagliaferri, I. Cohen, and D. Tripathy Antiproliferative activity of Chinese medicinal herbs on breast cancer cells in vitro Anticancer Res. 22 2002 3843 3852
4. L.G. Chen, L.Y. Hung, K.W. Tsai, Y.S. Pan, Y.D. Tsai, Y.Z. Li, and Y.W. Liu Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells Mol. Nutr. Food Res. 52 2008 1349 1357
5. V. Chen, R.E. Staub, S. Baggett, R. Chimmani, M. Tagliaferri, I. Cohen, and E. Shtivelman Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle PLoS One 7 2012 e30107
6. K. Chia Prevention and Treatment of Carcinoma in Traditional Chinese Medicine 1985 Commercial Press Hong Kong
7. Dharmananda, S., 2004. Institute for Traditional Medicine and Preventive Health Care. Oldenlandia and Scutellaria: Antitoxin and anticancer herbs. Available at: (http://www.itmonline.org/arts/oldenlandia.htm) (accessed 21.10.14).
8. S. Fong, M. Shoemaker, J. Cadaoas, A. Lo, W. Liao, M. Tagliaferri, I. Cohen, and E. Shtivelman Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells Cancer Biol. Ther. 7 2008 577 586
9. T. Gong, C.F. Wang, J.R. Yuan, Y. Li, J.F. Gu, B.J. Zhao, L. Zhang, X.B. Jia, L. Feng, and S.L. Liu Inhibition of tumor growth and Immunomodulatory effects of Flavonoids and Scutebarbatines of Scutellaria barbata D.Don in Lewis-Bearing C57BL/6 Mice Evid. Based Complement. Altern. Med. 2015 2015 630760
10. T.J. Kaptchuck The Web That has no Weaver: Understanding Chinese Medicine 2000 Contemporary Books Lincolnwood, IL
11. D.I. Kim, T.K. Lee, I.S. Lim, H. Kim, Y.C. Lee, and C.H. Kim Regulation of IGF-I production and proliferation of Human leiomyomal smooth muscle cells by Scutellaria barbata D. don in vitro: Isolation of flavonoids of apigenin and luteolin as acting compounds Toxicol. Appl. Pharmacol. 205 2005 213 224
12. J. Klawitter, J. Klawitter, J. Gurshtein, K. Corby, S. Fong, M. Tagliaferri, L. Quattrochi, I. Cohen, E. Shtivelman, and U. Christians Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: A combined proteomic and metabolomic study Int. J. Cancer 129 2011 2945 2957
13. Li, X, Hedge, I. Scutellaria barbata D. Don. Available at: (http://www.efloras.org/florataxon.aspx?flora-id=2&taxon-id=200020287) (accessed 01.03.14).
14. C.N. Marconett, T.J. Morgenstern, A.K. San Roman, S.N. Sundar, A.K. Singhal, and G.L. Firestone BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype Cancer Biol. Ther. 10 2010 397 405
15. A.T. Perez, B. Arun, D. Tripathy, M.A. Tagliaferri, H.S. Shaw, G.G. Kimmick, I. Cohen, E. Shtivelman, K.A. Caygill, D. Grady, M. Schactman, and C.L. Shapiro A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer Breast Cancer Res. Treat. 120 2010 111 118
16. H. Rugo, E. Shtivelman, A. Perez, C. Vogel, S. Franco, E. Tan Chiu, M. Melisko, M. Tagliaferri, I. Cohen, M. Shoemaker, Z. Tran, and D. Tripathy Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer Breast Cancer Res. Treat. 105 2007 17 28
17. Y. Sato, S. Suzaki, T. Nishikawa, M. Kihara, H. Shibata, and T. Higuti Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant staphylococcus aureus J. Ethnopharmacol. 72 2000 483 488
18. A.L. Shiau, Y.T. Shen, J.L. Hsieh, C.L. Wu, and C.H. Lee Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1α in lung tumor Environ. Toxicol. 29 2014 363 370
19. M. Shoemaker, B. Hamilton, S.H. Dairkee, I. Cohen, and M.J. Campbell In vitro anticancer activity of twelve Chinese medicinal herbs Phytother. Res. 19 2005 649 651
20. B.Y.Y. Wang, and H.H.L. Wong An evidence-based perspective of Scutellaria barbata (skullcap) for cancer patients W.C.S. Cho, Evidence-Based Anticancer Materia Medica 2011 Springer Science & Business Media 155
21. World Health Organization, 2012. Health Service Delivery Profile: China. Available at: (http://www.wpro.who.int/health-services/service-delivery-profile-china.pdf?ua=1) (accessed 20.01.16).
22. Y.F. Wu, and D.F. Chen Anti-complementary effect of polysaccharide B3-PS1 in Herba Scutellariae Barbatae (Scutellaria barbata) Immunopharmacol. Immunotoxicol. 31 2009 696 701
23. J. Yang, G. Yang, G. Hou, Q. Liu, W. Hu, P.U. Zhao, and Y.I. He Scutellaria barbata D. don polysaccharides inhibit the growth of Calu-3 xenograft tumors via suppression of the HER2 pathway and angiogenesis Oncol. Lett. 9 2015 2721 2725
24. X. Yang, Y. Yang, S. Tang, H. Tang, G. Yang, Q. Xu, and J. Wu Anti-tumor effect of polysaccharides from Scutellaria barbata D. don on the 95-D xenograft model via inhibition of the C-met pathway J. Pharmacol. Sci. 125 2014 255 263
25. C. Ye, and Q. Huang Extraction of polysaccharides from herbal Scutellaria barbata D. don (Ban-Zhi-Lian) and their antioxidant activity Carbohydr. Polym. 89 2012 1131 1137
26. Y.C. Yeh, H.Y. Chen, S.H. Yang, Y.H. Lin, J.H. Chiu, Y.H. Lin, and J.L. Chen Hedyotis diffusa combined with Scutellaria barbata are the core treatment of Chinese herbal medicine used for breast cancer patients: A population-based study Evid. Based Complement. Altern. Med. 2014 2014 202378
27. Y. Yoshida, M.Q. Wang, J.N. Liu, B.E. Shan, and U. Yamashita Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular Int. J. Immunopharmacol. 19 1997 359 370
28. J. Yu, J. Lei, H. Yu, X. Cai, and G. Zou Chemical composition and antimicrobial activity of the essential oil of Scutellaria barbata Phytochem 65 2004 881 884
29. C. Yuan, E.J. Bieber, and B.A. Bauer Traditional Chinese Medicine 2011 CRC Press New York, NY, USA
30. Zhu, B., Wang, H. (Eds.), 2011. Basic Theories of Traditional Chinese Medicine. Jessica Kingsley Publishers, London.