Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: Isolation of flavonoids of apigenin and luteolin as acting compounds

Toxicology and Applied Pharmacology

Volumn 205, Issue 3, 2005, Pages 213-224

  Kim, Dong Il ^a   Lee, Tae Kyun ^a   Lim, Ig Seob ^a   Kim, Hwa ^a   Lee, Young Choon ^b   Kim, Cheorl Ho ^a  

^a Dongguk University   (South Korea)

^b Dong A University   (South Korea)

Author keywords

Apigenin; Apoptosis; Cell proliferation; Fibroids; Flavonoids; HCG; HCG LH receptor; IGF I mRNA; Leiomyoma; Leiomyomal cells; Luteolin; Myometrium; Scutellaria barbata D. Don (Lamiaceae); Uterus

Indexed keywords

APIGENIN; BAICALIN; BERBERINE; FLAVANOID; LUTEOLIN; PLANT EXTRACT; RESVERATROL; SCUTELLARIA BARBATA EXTRACT; SOMATOMEDIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL COUNT; CELL PROLIFERATION; CHINA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; KOREA; MEDICINAL PLANT; SCUTELLARIA BARBATA; UTERUS MYOMA;

ADULT; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APIGENIN; APOPTOSIS; CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LEIOMYOMA; LUTEOLIN; MYOCYTES, SMOOTH MUSCLE; MYOMETRIUM; PLANT STEMS; RNA, MESSENGER; SCUTELLARIA; WATER;

SCUTELLARIA BARBATA;

EID: 19444363893     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.10.007     Document Type: Article

References (43)

1. G.D. Adamson Treatment of uterine fibroids: current findings with gonadotropin-releasing hormone agonists Am. J. Obstet. Gynecol. 166 1992 746 751
2. K.D. Boehm, M. Daimon, and I. Godoreski Expression of the insulin-like and platelet derived growth factor genes in human uterine tissues Mol. Reprod. Dev. 27 1990 93 101
3. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 253
4. M.L. Brandi Flavonoids: biochemical effects and therapeutic applications Bone Miner. 19 1992 S3 S14 (Suppl.)
5. Y. Chandrasekhar, J. Heiner, and C. Osuamkpe Insulin-like growth factor I and II binding in human myometrium and leiomyomas Am. J. Obstet. Gynecol. 166 1992 64 69
6. D. Cohen, M.T. Mazur, M.A. Jozefczyk, and S.Z.A. Badawy Hyalinization and cellular changes in uterine leiomyomata after gonadotropin releasing hormone agonist therapy J. Reprod. Med. 194 1994 377 380
7. S. Ducki, J.A. Hadfield, N.J. Lawrence, C.Y. Liu, A.T. McGown, and X. Zhang Isolation of E-1-(4′-Hydroxyphenyl)-but-1-en-3-one from Scutellaria barbata Planta Med. 62 2 1996 185 186
8. D.M. Durnam, and R.P. Palmiter A practical approach for quantifying specific mRNA by solution hybridization Anal. Biochem. 13 1983 385 393
9. K. Englund Gene expression and tissue concentrations of IGF-I in human myometrium and fibroids under different hormonal conditions Mol. Hum. Reprod. 6 2000 915 920
10. A.J. Friedman, S.M. Lobel, M.S. Rein, and R.L. Barbieri Efficacy and safety considerations in women with uterine leiomyomas treated with gonadotropin-releasing hormone agonists: the estrogen threshold hypothesis Am. J. Obstet. Gynecol. 163 1990 1114 1119
11. F. Fullas, R.A. Hussain, H.B. Chai, J.M. Pezzuto, D.D. Soejarto, and A.D. Kinghorn Cytotoxic constituents of Baccharis gaudichaudiana J. Nat. Products 57 1994 801 807
12. L.C. Giudice, J.C. Irwin, and B.A. Dsupin Insulin-like growth factor (IGF), IGF binding protein (IGFBP), and IGF receptor gene expression and IGFBP synthesis in human uterine leiomyomata Hum. Reprod. 8 1993 1796 1806
13. F. Han, J. Hu, and H. Xu Effects of some Chinese herbal medicine and green tea antagonizing mutagenesis caused by cigarette tar Zhonghua Yufang Yixue Zazhi 31 1997 71 74
14. B. Havsteen Flavonoids, a class of natural products of high pharmacological potency Biochem. Pharmacol. 32 1983 1141 1148
15. M.R. Hendrickson, and R.L. Kempson The normal myometrium J.L. Bennington Surgical Pathology of the Uterine Corpus 1980 Saunders Philadelphia 439 451
16. R.E. Humbel Insulin-like growth factor I and II, a review Eur. J. Biochem. 190 1990 445 462
17. Jiangsu New Medical College Dictionary of Chinese Materia Medica 1977 Science and Technology Press of Shanghai Shanghai, China
18. J.I. Jones, and D.R. Clemmons Insulin-like growth factors and their binding proteins: biological actions Endocr. Rev. 16 1995 3 34
19. H.S. Lee, Y.E. Eom, and D.O. Eom Narrowbore high performance liquid chromatography of berberine and palmatine in crude drugs and pharmaceuticals with ion-pair extraction using cobalt thiocyanate reagent Pharm. Biomed. Anal. 21 1999 59 63
20. T.K. Lee, D.K. Lee, D.I. Kim, Y.C. Lee, Y.C. Chang, and C.H. Kim Inhibitory effects of Scutellaria barbata D. Don on human uterine leiomyomal proliferation through cell cycle analysis Int. Immunopharmacol. 4 2004 447 454
21. T.K. Lee, H.L. Cho, D.I. Kim, Y.C. Lee, and C.H. Kim Scutellaria barbata D. Don induces c-fos gene expression in human uterine leiomyomal cells by activating β2-adrenergic receptors Int. J. Gynecol. Cancer 14 2004 526 531
22. A.S. Lev-Toaff, B.G. Coleman, and P.H. Arger Leiomyomas in pregnancy: sonographic study Radiology 164 1987 375 380
23. J.K. Lin, Y.C. Liang, and S.Y. Lin-Shiau Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade Biochem. Pharmacol. 58 1998 911 915
24. O.H. Lowry, N.J. Rosebrough, and L. Farr Protein measurement with the folin phenol reagent J. Biol. Chem. 193 1951 265 275
25. T. Misaki, K. Sagara, M. Ojima, S. Kakizawa, T. Oshima, and H. Yoshizawa Simultaneous determination of berberine, palmatine and coptisine in crude drugs and oriental pharmaceutical preparations by ion-pair high-performance liquid chromatography Chem. Pharm. Bull. 30 1982 354 357
26. A.A. Murphy, L.M. Kettel, and A.J. Morales Regression of uterine leiomyomata in response to the antiprogesterone RU 486: dose response effect Fertil. Steril. 64 1995 187 190
27. D. Pathak, K. Pathak, and A.K. Singla Flavonoids as medicinal agents-Recent advances Fitoterapia 62 1991 371 389
28. Z. Puzigaca, G.M. Prelevic, and Z. Sretenovic Differential reduction in the volume of leiomyoma and uterus during buserelin treatment Gynecol. Endocrinol. 8 1994 39 43
29. M.S. Rein, A.J. Friedman, and M.R. Pandian The secretion of insulin-like growth factors I and II by explant cultures of fibroids and myometrium from women treated with a gonadotropin-releasing hormone agonist Obstet. Gynecol. 76 1990 388 394
30. M.J. Rossi, N. Chegini, and B.J. Masterson Presence of epidermal growth factor, platelet-derived growth factor, and their receptors in human myometrial tissue and smooth muscle cells: their action in smooth muscle cells in vitro Endocrinology 130 1992 1716 1727
31. Y. Sato, S. Suzaki, T. Nishikawa, M. Kihara, H. Shibata, and T. Higuti Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus J. Ethnopharmacol. 72 2000 438 483
32. Y. Sato, S. Suzaki, T. Nishikawa, M. Kihara, H. Shibata, and T. Higuti Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus J. Ethnopharmacol. 72 3 2000 483 488
33. C.J. Sherr, and J.M. Roberts Inhibitors of mammalian G1 cyclin-dependent kinases Genes Dev. 9 1995 1149 1163
34. Y. Stjernholm, L. Sahlin, and S. Akerberg Cervical ripening in humans: potential roles of estrogen, progesterone, and insulin-like growth factor-I Am. J. Obstet. Gynecol. 174 1996 1065 1071
35. L.T.M. Van der Ven, T. Gloudemans, and P.J.M. Roholl Growth advantage of human leiomyoma cells compared to normal smooth muscle cells due to enhanced sensitivity for insulin-like growth factor I Int. J. Cancer 59 1994 422 434
36. B.J. Vollenhoven, A.C. Herington, and D.L. Healy Messenger ribonucleic acid expression of the insulin-like growth factors and their binding proteins in uterine fibroids and myometrium J. Clin. Endocrinol. Metab. 76 1993 1106 1110
37. B.Y. Wong, B.H. Lau, P.P. Tadi, and R.W. Teel Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of aflatoxin B1 Mutat. Res. 279 3 1992 209 216
38. B.Y. Wong, B.H. Lau, and R.W. Teel Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide Cancer Lett. 62 2 1992 123 131
39. B.Y. Wong, B.H. Lau, T. Yamasaki, and R.W. Teel Modulation of cytochrome P-450IA1-mediated mutagenicity, DNA binding and metabolism of benzo[a]pyrene by Chinese medicinal herbs Cancer Lett. 68 1 1993 75 82
40. B.Y. Wong, B.H. Lau, T. Yamasaki, and R.W. Teel Inhibition of dexamethasone-induced cytochrome P450-mediated mutagenicity and metabolism of aflatoxin B1 by Chinese medicinal herbs Eur. J. Cancer Prev. 2 1993 351 356
41. B.Y. Wong, B.H. Lau, T.Y. Jia, and C.P. Wan Oldenlandia diffusa and Scutellaria barbata augment macrophage oxidative burst and inhibit tumor growth Cancer Biother. Radiopharm. 11 1996 51 56
42. F. Yang, W.J. de Villiers, C.J. McClain, and G.W. Varilek Green tea polyphenols block endotoxin-induced tumor necrosis factor-Production and lethality in a murine model J. Nutr. 128 1998 2334 2340
43. J.L. Zhang, Q.M. Che, S.Z. Li, and T.H. Zhou Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR J. Asian Nat. Prod. Res. 5 4 2003 249 256