Anti-tumor effect of polysaccharides from Scutellaria barbata d. don on the 95-D xenograft model via inhibition of the C-met pathway

Journal of Pharmacological Sciences

Volumn 125, Issue 3, 2014, Pages 255-263

  Yang, Xiaokun ^a,b   Yang, Yadong ^a   Tang, Shuqian ^a   Tang, Hui ^a   Yang, Guihong ^a   Xu, Qiaoyu ^a   Wu, Jinjin ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

95 D cell line; C Met; Lung cancer; Polysaccharides Scutellaria barbata (PSB); Receptor tyrosine kinase

Indexed keywords

CD31 ANTIGEN; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; POLYSACCHARIDE; PROTEIN KINASE B; SCATTER FACTOR RECEPTOR; ANTINEOPLASTIC AGENT; ONCOPROTEIN; PLANT EXTRACT; SCUTELLARIA BARBATA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CAPILLARY DENSITY; CARCINOMA CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; IC 50; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG CARCINOMA; METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SCUTELLARIA BARBATA; SIGNAL TRANSDUCTION; TUMOR INVASION; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CARCINOMA; CELL TRANSFORMATION; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; LUNG NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHYTOTHERAPY; TUMOR CELL LINE; VASCULARIZATION; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; HETEROGRAFTS; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; ONCOGENE PROTEIN V-AKT; PHYTOTHERAPY; PLANT EXTRACTS; POLYSACCHARIDES; PROTO-ONCOGENE PROTEINS C-MET; SIGNAL TRANSDUCTION;

EID: 84904699768     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13276FP     Document Type: Article

References (34)

1. Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, et al. A family of transmembrane proteins with homology to the c-Met-hepatocyte growth factor receptor. Proc Natl Acad Sci U S A. 1996;93:674-678. (Pubitemid 26041148)
2. Sattler M, Salgia R. c-Met and hepatocyte growth factor: potential as novel targets in cancer therapy. Curr Oncol Rep. 2007;9:102-108. (Pubitemid 46332381)
3. Stella MC, Comoglio PM. HGF: a multifunctional growth factor controlling cell scattering. Int J Biochem Cell Biol. 1999;31: 1357-1362.
4. Ma PC, Jagadeeswaran R, Jagadeesh S, Tretiakova MS, Nallasura V, Fox EA, et al. Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res. 2005;65: 1479-1488. (Pubitemid 40270177)
5. Furge KA, Kiewlich D, Le P, Vo MN, Faure M, Howlett AR, et al. Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the c-Met receptor tyrosine kinase. Proc Natl Acad Sci U S A. 2001;98:10722-10727. (Pubitemid 32878688)
6. Olivero M, Rizzo M, Madeddu R, Casadio C, Pennacchietti S, Nicotra MR, et al. Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. Br J Cancer. 1996;74:1862-1868. (Pubitemid 27007128)
7. Lutterbach B, Zeng Q, Davis LJ, Hatch H, Hang G, Kohl NE, et al. Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival. Cancer Res. 2007;67:2081-2088. (Pubitemid 46424226)
8. Ye CL, Huang Q. Extraction of polysaccharides from herbal Scutellaria barbata D. Don (Ban-Zhi-Lian) and their antioxidant activity. Carbohyd Polym. 2012;89:1131-1137.
9. Yin XL, Zhou JB, Jie CF, Xing DM, Zhang Y. Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549. Life Sci. 2004;75:2233-2244. (Pubitemid 39120026)
10. Wang G, Wang F, Liu JK. Two new phenols from Scutellaria barbata molecules. 2011;16:1402-1408.
11. Dai SJ, Tao JY, Liu K, Jiang YT, Shen L. Neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities. Phytochem. 2006;67:1326-1330. (Pubitemid 44080266)
12. Zhang XJ, Yang SS. Experiment research of effect of Scutellaria barbata D. Don polysaccharides on anti-tumor and immune regulation in entrails. Asia-Pacific Traditional Medicine. 2008; 2:52-58.
13. Zhang XJ, Zhang J, Yang SS, Ji YB. Effects of scutellaria barbata D. Don polysaccharides on S180 tumor growth inhibition and immune capability enhancement in vivo. Qilu Pharmaceutical Affairs. 2008;10:55-57.
14. Yang XK, Yang YD, Tang SQ, Xu L, Yang GH, Xu QY, et al. Inhibitory effect of polysaccharides from Scutellaria barbata D. Don on invasion and metastasis of 95-D cells lines via regulation of C-MET and E-CAD expressions. Trop J Pharm Res. 2013; 12:517-522.
15. Song GC, Yu YJ, Wang XJ. Experiments on antitumor activity and immunological mechanisms of Scutellaria Barbata polysaccharides. Mode Tradit Chin Med Mater Med. 2011;13:641-643.
16. Jemal A, Siegel R, Ward E. Cancer statistics. CA Cancer J Clin 2007;57:43-66.
17. Wen J, Fu JH, Zhang W, Guo M. Genetic and epigenetic changes in lung carcinoma and their clinical implications. Modern Pathol. 2011;24:932-943.
18. Johnson DH. Targeted therapy in non-small cell lung cancer: myth or reality. Lung Cancer. 2003;41 Suppl1:S3-S8. (Pubitemid 36818990)
19. Salgia R, Skarin AT. Novel therapies for advanced lung cancer. Up To Date. 2003;v.11.2.
20. Ma PC, Tretiakova MS, MacKinnon AC, Ramnath N, Johnson C, Dietrich S, et al. Expression and mutational analysis of c-Met in human solid cancers. Genes Chromosomes Cancer. 2008;47: 1025-1037.
21. Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304:1497-1500. (Pubitemid 38720929)
22. Maulik G, Kijima T, Ma PC, Ghosh SK, Lin J, Shapiro GI, et al. Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer. Clin Cancer Res. 2002;8:620-627. (Pubitemid 34193985)
23. Kijima T, Maulik G, Ma PC, Madhiwala P, Schaefer E, Salgia R. Fibronectin enhances viability and alters cytoskeletal functions (with effects on the phosphatidylinositol 3-kinase pathway) in small cell lung cancer. J Cell Mol Med. 2003;7:157-164. (Pubitemid 37123601)
24. Rameh LE, Cantley LC. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem. 1999;274:8347-8350. (Pubitemid 29164617)
25. Toker A. Protein kinases as mediators of phosphoinositide 3- kinase signaling. Mol Pharmacol. 2000;57:652-658. (Pubitemid 30183703)
26. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PRJ, Reese CB, et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B. Curr Biol. 1997;7:261-269. (Pubitemid 27176852)
27. Moore SM, Rintoul RC, Walker TR, Chilvers ER, Haslett C, Sethi T. The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway. Cancer Res. 1998;58:5239-5247. (Pubitemid 28521188)
28. Maulik G, Madhiwala P, Brooks S, Ma PC, Kijima T, Tibaldi EV, et al. Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer. J Cell Mol Med. 2002;6:539-553. (Pubitemid 44149770)
29. Bowers DC, Fan S, Walter KA, Ma PC, Kijima T, Tibaldi EV, et al. Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase- and AKT-dependent pathways. Cancer Res. 2000;60: 4277-4283. (Pubitemid 30636617)
30. Zhang J. [Clinical values of Traditional Chinese medicine in improving the quality of life of cancer patients]. Zhong Hua Yi Xue Xie Zuo Za Zhi. 2000;7:735-740. (Text in Chinese)
31. Dou YQ, Feng Y, Gao LP. [Traditional Chinese medicine treatment for gastrointestinal reaction induced by chemotherapy]. Zhong Hua Lin Chuan Yi Xue Za Zhi. 2005;6:11-16. (Text in Chinese)
32. Zhang BC. [Treatment of symptoms and root causes of disease-management of the top ten symptoms in cancer patients]. Fang Ai Tian Di. 2007;20:17-18. (Text in Chinese)
33. Xu L, Chen XY. [The application and status of Traditional Chinese Medicine in palliative care in cancer]. Nan Jin Zhong Yi Yao Da Xue Xue Bao. 2004;20:88-90. (Text in Chinese)
34. Li D, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway. J Pharmacol Sci. 2007;103:56-66. (Pubitemid 46175595)