메뉴 건너뛰기




Volumn 10, Issue 1, 2016, Pages 53-62

A 3D co-culture of three human cell lines to model the inflamed intestinal mucosa for safety testing of nanomaterials

Author keywords

Caco 2; cytotoxicity; intestine; nanoparticles

Indexed keywords

COLLAGEN; GOLD NANOPARTICLE; INTERLEUKIN 1BETA; INTERLEUKIN 8; MESSENGER RNA; SILVER NANOPARTICLE; TITANIUM DIOXIDE NANOPARTICLE; METAL NANOPARTICLE; NANOMATERIAL; TITANIUM; TITANIUM DIOXIDE;

EID: 84959544878     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2015.1008065     Document Type: Article
Times cited : (87)

References (58)
  • 1
    • 84906927108 scopus 로고    scopus 로고
    • Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter
    • Alexis NE, Huang YC, Rappold AG, Kehrl H, Devlin R, Peden DB. 2014. Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter. Am J Respir Crit Care Med 190:235-7.
    • (2014) Am J Respir Crit Care Med , vol.190 , pp. 235-237
    • Alexis, N.E.1    Huang, Y.C.2    Rappold, A.G.3    Kehrl, H.4    Devlin, R.5    Peden, D.B.6
  • 3
    • 84855785145 scopus 로고    scopus 로고
    • Nanotoxicology and in vitro studies: The need of the hour
    • Arora S, Rajwade JM, Paknikar KM. 2012. Nanotoxicology and in vitro studies: the need of the hour. Toxicol Appl Pharmacol 258:151-65.
    • (2012) Toxicol Appl Pharmacol , vol.258 , pp. 151-165
    • Arora, S.1    Rajwade, J.M.2    Paknikar, K.M.3
  • 4
    • 84880641214 scopus 로고    scopus 로고
    • Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles
    • Ayala V, Herrera AP, Latorre-Esteves M, Torres-Lugo M, Rinaldi C. 2013. Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles. J Nanopart Res 15:1874.
    • (2013) J Nanopart Res , vol.15 , pp. 1874
    • Ayala, V.1    Herrera, A.P.2    Latorre-Esteves, M.3    Torres-Lugo, M.4    Rinaldi, C.5
  • 6
    • 84904578762 scopus 로고    scopus 로고
    • PH-Sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease
    • Beloqui A, Coco R, Memvanga PB, Ucakar B, des Rieux A, Preat V. 2014. pH-Sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease. Int J Pharm 473:203-12.
    • (2014) Int J Pharm , vol.473 , pp. 203-212
    • Beloqui, A.1    Coco, R.2    Memvanga, P.B.3    Ucakar, B.4    Des Rieux, A.5    Preat, V.6
  • 7
    • 82955233025 scopus 로고    scopus 로고
    • The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype
    • Bertiaux-Vandaele N, Youmba SB, Belmonte L, Lecleire S, Antonietti M, Gourcerol G, et al. 2011. The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype. Am J Gastroenterol 106:2165-73.
    • (2011) Am J Gastroenterol , vol.106 , pp. 2165-2173
    • Bertiaux-Vandaele, N.1    Youmba, S.B.2    Belmonte, L.3    Lecleire, S.4    Antonietti, M.5    Gourcerol, G.6
  • 8
    • 0035145914 scopus 로고    scopus 로고
    • Patients with inflammatory bowel disease (IBD) reveal increased induction capacity of intracellular interferon-gamma (IFN-gamma) in peripheral CD8+ lymphocytes cocultured with intestinal epithelial cells
    • Bisping G, Lugering N, Lutke-Brintrup S, Pauels HG, Schurmann G, Domschke W, Kucharzik T. 2001. Patients with inflammatory bowel disease (IBD) reveal increased induction capacity of intracellular interferon-gamma (IFN-gamma) in peripheral CD8+ lymphocytes cocultured with intestinal epithelial cells. Clin Exp Immunol 123:15-22.
    • (2001) Clin Exp Immunol , vol.123 , pp. 15-22
    • Bisping, G.1    Lugering, N.2    Lutke-Brintrup, S.3    Pauels, H.G.4    Schurmann, G.5    Domschke, W.6    Kucharzik, T.7
  • 9
    • 31344439735 scopus 로고    scopus 로고
    • Inflammatory responses of a macrophage/epithelial cell co-culture model to mono and mixed infections with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia
    • Bodet C, Chandad F, Grenier D. 2006. Inflammatory responses of a macrophage/epithelial cell co-culture model to mono and mixed infections with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. Microbes Infect 8:27-35.
    • (2006) Microbes Infect , vol.8 , pp. 27-35
    • Bodet, C.1    Chandad, F.2    Grenier, D.3
  • 10
    • 70449130499 scopus 로고    scopus 로고
    • Comparison of gene expression profiles in mice liver following intravenous injection of 4 and 100 nm-sized PEG-coated gold nanoparticles
    • Cho WS, Kim S, Han BS, Son WC, Jeong J. 2009. Comparison of gene expression profiles in mice liver following intravenous injection of 4 and 100 nm-sized PEG-coated gold nanoparticles. Toxicol Lett 191: 96-102.
    • (2009) Toxicol Lett , vol.191 , pp. 96-102
    • Cho, W.S.1    Kim, S.2    Han, B.S.3    Son, W.C.4    Jeong, J.5
  • 12
    • 51049108389 scopus 로고    scopus 로고
    • Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution
    • Dobrovolskaia MA, Aggarwal P, Hall JB, McNeil SE. 2008. Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Mol Pharm 5: 487-95.
    • (2008) Mol Pharm , vol.5 , pp. 487-495
    • Dobrovolskaia, M.A.1    Aggarwal, P.2    Hall, J.B.3    McNeil, S.E.4
  • 13
    • 34547690726 scopus 로고    scopus 로고
    • Immunological properties of engineered nanomaterials
    • Dobrovolskaia MA, McNeil SE. 2007. Immunological properties of engineered nanomaterials. Nat Nanotechnol 2:469-78.
    • (2007) Nat Nanotechnol , vol.2 , pp. 469-478
    • Dobrovolskaia, M.A.1    McNeil, S.E.2
  • 14
    • 77951626261 scopus 로고    scopus 로고
    • Inhibitory effects of Lactobacillus casei subsp. Rhamnosus on Salmonella lipopolysaccharide-induced inflammation and epithelial barrier dysfunction in a co-culture model using Caco-2/peripheral blood mononuclear cells
    • Fang HW, Fang SB, Chiang Chiau JS, Yeung CY, Chan WT, Jiang CB, et al. 2010. Inhibitory effects of Lactobacillus casei subsp. rhamnosus on Salmonella lipopolysaccharide-induced inflammation and epithelial barrier dysfunction in a co-culture model using Caco-2/peripheral blood mononuclear cells. J Med Microbiol 59:573-9.
    • (2010) J Med Microbiol , vol.59 , pp. 573-579
    • Fang, H.W.1    Fang, S.B.2    Chiang Chiau, J.S.3    Yeung, C.Y.4    Chan, W.T.5    Jiang, C.B.6
  • 15
    • 84865638405 scopus 로고    scopus 로고
    • Intestinal toxicity evaluation of TiO2 degraded surface-treated nanoparticles: A combined physico-chemical and toxicogenomics approach in caco-2 cells
    • Fisichella M, Berenguer F, Steinmetz G, Auffan M, Rose J, Prat O. 2012. Intestinal toxicity evaluation of TiO2 degraded surface-treated nanoparticles: a combined physico-chemical and toxicogenomics approach in caco-2 cells. Part Fibre Toxicol 9:18.
    • (2012) Part Fibre Toxicol , vol.9 , pp. 18
    • Fisichella, M.1    Berenguer, F.2    Steinmetz, G.3    Auffan, M.4    Rose, J.5    Prat, O.6
  • 16
    • 44849119518 scopus 로고    scopus 로고
    • Correlation of in vitro and in vivo models for the oral absorption of peptide drugs
    • Foger F, Kopf A, Loretz B, Albrecht K, Bernkop-Schnurch A. 2008. Correlation of in vitro and in vivo models for the oral absorption of peptide drugs. Amino Acids 35:233-41.
    • (2008) Amino Acids , vol.35 , pp. 233-241
    • Foger, F.1    Kopf, A.2    Loretz, B.3    Albrecht, K.4    Bernkop-Schnurch, A.5
  • 17
    • 0032214518 scopus 로고    scopus 로고
    • Biopharmaceutical characterization of oral immediate release drug products. in vitro/in vivo comparison of phenoxymethylpenicillin potassium, glimepiride and levofloxacin
    • Frick A, Moller H, Wirbitzki E. 1998. Biopharmaceutical characterization of oral immediate release drug products. In vitro/in vivo comparison of phenoxymethylpenicillin potassium, glimepiride and levofloxacin. Eur J Pharm Biopharm 46:305-11.
    • (1998) Eur J Pharm Biopharm , vol.46 , pp. 305-311
    • Frick, A.1    Moller, H.2    Wirbitzki, E.3
  • 18
    • 84155162845 scopus 로고    scopus 로고
    • Models for oral uptake of nanoparticles in consumer products
    • Frohlich E, Roblegg E. 2012. Models for oral uptake of nanoparticles in consumer products. Toxicology 291:10-17.
    • (2012) Toxicology , vol.291 , pp. 10-17
    • Frohlich, E.1    Roblegg, E.2
  • 19
    • 73449085875 scopus 로고    scopus 로고
    • Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
    • Gaiser BK, Fernandes TF, Jepson M, Lead JR, Tyler CR, Stone V. 2009. Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments. Environ Health 8:S2.
    • (2009) Environ Health , vol.8 , pp. S2
    • Gaiser, B.K.1    Fernandes, T.F.2    Jepson, M.3    Lead, J.R.4    Tyler, C.R.5    Stone, V.6
  • 22
    • 84872724877 scopus 로고    scopus 로고
    • Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14
    • Guo S, Al-Sadi R, Said HM, Ma TY. 2013. Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14. Am J Pathol 182:375-87.
    • (2013) Am J Pathol , vol.182 , pp. 375-387
    • Guo, S.1    Al-Sadi, R.2    Said, H.M.3    Ma, T.Y.4
  • 23
    • 77951891062 scopus 로고    scopus 로고
    • An impaired alveolar-capillary barrier in vitro: Effect of proinflammatory cytokines and consequences on nanocarrier interaction
    • Hermanns MI, Kasper J, Dubruel P, Pohl C, Uboldi C, Vermeersch V, et al. 2010. An impaired alveolar-capillary barrier in vitro: effect of proinflammatory cytokines and consequences on nanocarrier interaction. J R Soc Interface 7:S41-54.
    • (2010) J R Soc Interface , vol.7 , pp. S41-54
    • Hermanns, M.I.1    Kasper, J.2    Dubruel, P.3    Pohl, C.4    Uboldi, C.5    Vermeersch, V.6
  • 24
    • 79851516126 scopus 로고    scopus 로고
    • Effects of various physicochemical characteristics on the toxicities of ZnO and TiO nanoparticles toward human lung epithelial cells
    • Hsiao IL, Huang YJ. 2011. Effects of various physicochemical characteristics on the toxicities of ZnO and TiO nanoparticles toward human lung epithelial cells. Sci Total Environ 409:1219-28.
    • (2011) Sci Total Environ , vol.409 , pp. 1219-1228
    • Hsiao, I.L.1    Huang, Y.J.2
  • 25
    • 79251576161 scopus 로고    scopus 로고
    • Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: Comparison with conventional monocultures
    • Kasper J, Hermanns MI, Bantz C, Maskos M, Stauber R, Pohl C, Unger RE, Kirkpatrick JC. 2011. Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: comparison with conventional monocultures. Part Fibre Toxicol 8:6.
    • (2011) Part Fibre Toxicol , vol.8 , pp. 6
    • Kasper, J.1    Hermanns, M.I.2    Bantz, C.3    Maskos, M.4    Stauber, R.5    Pohl, C.6    Unger, R.E.7    Kirkpatrick, J.C.8
  • 26
    • 84876037765 scopus 로고    scopus 로고
    • In vitro assessment of engineered nanomaterials using a hepatocyte cell line: Cytotoxicity, pro-inflammatory cytokines and functional markers
    • Kermanizadeh A, Pojana G, Gaiser BK, Birkedal R, Bilanicova D, Wallin H, et al. 2013a. In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers. Nanotoxicology 7:301-13.
    • (2013) Nanotoxicology , vol.7 , pp. 301-313
    • Kermanizadeh, A.1    Pojana, G.2    Gaiser, B.K.3    Birkedal, R.4    Bilanicova, D.5    Wallin, H.6
  • 27
    • 84876999447 scopus 로고    scopus 로고
    • An in vitro assessment of panel of engineered nanomaterials using a human renal cell line: Cytotoxicity, pro-inflammatory response, oxidative stress and genotoxicity
    • Kermanizadeh A, Vranic S, Boland S, Moreau K, Baeza-Squiban A, Gaiser BK, Andrzejczuk LA, Stone V. 2013b. An in vitro assessment of panel of engineered nanomaterials using a human renal cell line: cytotoxicity, pro-inflammatory response, oxidative stress and genotoxicity. BMC Nephrol 14:96.
    • (2013) BMC Nephrol , vol.14 , pp. 96
    • Kermanizadeh, A.1    Vranic, S.2    Boland, S.3    Moreau, K.4    Baeza-Squiban, A.5    Gaiser, B.K.6    Andrzejczuk, L.A.7    Stone, V.8
  • 28
    • 84876545124 scopus 로고    scopus 로고
    • Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome
    • Kish L, Hotte N, Kaplan GG, Vincent R, Tso R, Ganzle M, et al. 2013. Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome. PLoS One 8:e62220.
    • (2013) PLoS One , vol.8 , pp. e62220
    • Kish, L.1    Hotte, N.2    Kaplan, G.G.3    Vincent, R.4    Tso, R.5    Ganzle, M.6
  • 32
    • 84929721955 scopus 로고    scopus 로고
    • Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices
    • [Epub ahead of print]
    • Lefebvre DE, Venema K, Gombau L, Valerio Jr LG, Raju J, Bondy GS, et al. 2014. Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices. Nanotoxicology [Epub ahead of print]. doi:10.3109/17435390.2014.948091.
    • (2014) Nanotoxicology
    • Lefebvre, D.E.1    Venema, K.2    Gombau, L.3    Valerio, L.G.4    Raju, J.5    Bondy, G.S.6
  • 33
  • 34
    • 77950196197 scopus 로고    scopus 로고
    • Fluorescent-magnetic hybrid nanoparticles induce a dosedependent increase in proinflammatory response in lung cells in vitro correlated with intracellular localization
    • Lehmann AD, Parak WJ, Zhang F, Ali Z, Rocker C, Nienhaus GU, et al. 2010. Fluorescent-magnetic hybrid nanoparticles induce a dosedependent increase in proinflammatory response in lung cells in vitro correlated with intracellular localization. Small 6:753-62.
    • (2010) Small , vol.6 , pp. 753-762
    • Lehmann, A.D.1    Parak, W.J.2    Zhang, F.3    Ali, Z.4    Rocker, C.5    Nienhaus, G.U.6
  • 35
    • 84864599083 scopus 로고    scopus 로고
    • Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model
    • Leonard F, Ali H, Collnot EM, Crielaard BJ, Lammers T, Storm G, Lehr CM. 2012. Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model. ALTEX 29:275-85.
    • (2012) ALTEX , vol.29 , pp. 275-285
    • Leonard, F.1    Ali, H.2    Collnot, E.M.3    Crielaard, B.J.4    Lammers, T.5    Storm, G.6    Lehr, C.M.7
  • 36
    • 78649921807 scopus 로고    scopus 로고
    • A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro
    • Leonard F, Collnot EM, Lehr CM. 2010. A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro. Mol Pharm 7:2103-19.
    • (2010) Mol Pharm , vol.7 , pp. 2103-2119
    • Leonard, F.1    Collnot, E.M.2    Lehr, C.M.3
  • 37
    • 79957633238 scopus 로고    scopus 로고
    • Distribution of silver in rats following 28 days of repeated ora exposure to silver nanoparticles or silver acetate
    • Loeschner K, Hadrup N, Qvortrup K, Larsen A, Gao X, Vogel U, et al. 2011. Distribution of silver in rats following 28 days of repeated ora exposure to silver nanoparticles or silver acetate. Part Fibre Toxicol 8:18.
    • (2011) Part Fibre Toxicol , vol.8 , pp. 18
    • Loeschner, K.1    Hadrup, N.2    Qvortrup, K.3    Larsen, A.4    Gao, X.5    Vogel, U.6
  • 38
    • 0035131626 scopus 로고    scopus 로고
    • The urban diet and Crohn's disease: Is there a relationship?'
    • Mahmud N, Weir DG. 2001. The urban diet and Crohn's disease: is there a relationship?' Eur J Gastroenterol Hepatol 13:93-5.
    • (2001) Eur J Gastroenterol Hepatol , vol.13 , pp. 93-95
    • Mahmud, N.1    Weir, D.G.2
  • 39
    • 77749343664 scopus 로고    scopus 로고
    • Gold nanoparticles cellular toxicity and recovery: Effect of size, concentration and exposure time
    • Mironava T, Hadjiargyrou M, Simon M, Jurukovski V, Rafailovich MH. 2010. Gold nanoparticles cellular toxicity and recovery: effect of size, concentration and exposure time. Nanotoxicology 4:120-37.
    • (2010) Nanotoxicology , vol.4 , pp. 120-137
    • Mironava, T.1    Hadjiargyrou, M.2    Simon, M.3    Jurukovski, V.4    Rafailovich, M.H.5
  • 40
    • 77950291648 scopus 로고    scopus 로고
    • Oxidative stress and inflammation response after nanoparticle exposure: Differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways
    • Muller L, Riediker M, Wick P, Mohr M, Gehr P, Rothen-Rutishauser B. 2010. Oxidative stress and inflammation response after nanoparticle exposure: differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways. J R Soc Interface 7:S27-40.
    • (2010) J R Soc Interface , vol.7 , pp. S27-40
    • Muller, L.1    Riediker, M.2    Wick, P.3    Mohr, M.4    Gehr, P.5    Rothen-Rutishauser, B.6
  • 41
    • 84873925093 scopus 로고    scopus 로고
    • Changes of the cytokine profile in inflammatory bowel diseases
    • Muzes G, Molnar B, Tulassay Z, Sipos F. 2012. Changes of the cytokine profile in inflammatory bowel diseases. World J Gastroenterol 18: 5848-61.
    • (2012) World J Gastroenterol , vol.18 , pp. 5848-5861
    • Muzes, G.1    Molnar, B.2    Tulassay, Z.3    Sipos, F.4
  • 42
    • 84883554979 scopus 로고    scopus 로고
    • Silver nanoparticle toxicity to Daphnia magna is a function of dissolved silver concentration
    • Newton KM, Puppala HL, Kitchens CL, Colvin VL, Klaine SJ. 2013. Silver nanoparticle toxicity to Daphnia magna is a function of dissolved silver concentration. Environ Toxicol Chem 32:2356-64.
    • (2013) Environ Toxicol Chem , vol.32 , pp. 2356-2364
    • Newton, K.M.1    Puppala, H.L.2    Kitchens, C.L.3    Colvin, V.L.4    Klaine, S.J.5
  • 44
    • 77649185962 scopus 로고    scopus 로고
    • Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract
    • Powell JJ, Faria N, Thomas-McKay E, Pele LC. 2010. Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimmun 34:J226-33.
    • (2010) J Autoimmun , vol.34 , pp. J226-J233
    • Powell, J.J.1    Faria, N.2    Thomas-McKay, E.3    Pele, L.C.4
  • 45
    • 58949098172 scopus 로고    scopus 로고
    • A newly developed in vitro model of the human epithelial airway barrier to study the toxic potential of nanoparticles
    • Rothen-Rutishauser B, Mueller L, Blank F, Brandenberger C, Muehlfeld C, Gehr P. 2008. A newly developed in vitro model of the human epithelial airway barrier to study the toxic potential of nanoparticles. ALTEX 25:191-6.
    • (2008) ALTEX , vol.25 , pp. 191-196
    • Rothen-Rutishauser, B.1    Mueller, L.2    Blank, F.3    Brandenberger, C.4    Muehlfeld, C.5    Gehr, P.6
  • 46
    • 35448957273 scopus 로고    scopus 로고
    • Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model
    • Rothen-Rutishauser B, Muhlfeld C, Blank F, Musso C, Geh P. 2007. Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. Part Fibre Toxicol 4:9.
    • (2007) Part Fibre Toxicol , vol.4 , pp. 9
    • Rothen-Rutishauser, B.1    Muhlfeld, C.2    Blank, F.3    Musso, C.4    Geh, P.5
  • 47
    • 16444371242 scopus 로고    scopus 로고
    • A three-dimensional cellular model of the human respiratory tract to study the interaction with particles
    • Rothen-Rutishauser BM, Kiama SG, Gehr P. 2005. A three-dimensional cellular model of the human respiratory tract to study the interaction with particles. Am J Respir Cell Mol Biol 32:281-9.
    • (2005) Am J Respir Cell Mol Biol , vol.32 , pp. 281-289
    • Rothen-Rutishauser, B.M.1    Kiama, S.G.2    Gehr, P.3
  • 48
    • 33750359116 scopus 로고    scopus 로고
    • Induction by activated macrophage-like THP-1 cells of apoptotic and necrotic cell death in intestinal epithelial Caco-2 monolayers via tumor necrosis factor-alpha
    • Satsu H, Ishimoto Y, Nakano T, Mochizuki T, Iwanaga T, Shimizu M. 2006. Induction by activated macrophage-like THP-1 cells of apoptotic and necrotic cell death in intestinal epithelial Caco-2 monolayers via tumor necrosis factor-alpha. Exp Cell Res 312:3909-19.
    • (2006) Exp Cell Res , vol.312 , pp. 3909-3919
    • Satsu, H.1    Ishimoto, Y.2    Nakano, T.3    Mochizuki, T.4    Iwanaga, T.5    Shimizu, M.6
  • 49
    • 84901740964 scopus 로고    scopus 로고
    • Development of an advanced intestinal in vitro triple culture permeability model to study transport of nanoparticles
    • Schimpel C, Teubl B, Absenger M, Meindl C, Frohlich E, Leitinger G, et al. 2014. Development of an advanced intestinal in vitro triple culture permeability model to study transport of nanoparticles. Mol Pharm 11:808-18.
    • (2014) Mol Pharm , vol.11 , pp. 808-818
    • Schimpel, C.1    Teubl, B.2    Absenger, M.3    Meindl, C.4    Frohlich, E.5    Leitinger, G.6
  • 52
    • 78649590436 scopus 로고    scopus 로고
    • Submesothelial deposition of carbon nanoparticles after toner exposition: Case report
    • Theegarten D, Boukercha S, Philippou S, Anhenn O. 2010. Submesothelial deposition of carbon nanoparticles after toner exposition: case report. Diagn Pathol 5:77.
    • (2010) Diagn Pathol , vol.5 , pp. 77
    • Theegarten, D.1    Boukercha, S.2    Philippou, S.3    Anhenn, O.4
  • 53
    • 84890412257 scopus 로고    scopus 로고
    • In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response
    • Ucciferri N, Collnot EM, Gaiser BK, Tirella A, Stone V, Domenici C, et al. 2014. In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response. Nanotoxicology 8:697-708.
    • (2014) Nanotoxicology , vol.8 , pp. 697-708
    • Ucciferri, N.1    Collnot, E.M.2    Gaiser, B.K.3    Tirella, A.4    Stone, V.5    Domenici, C.6
  • 54
    • 0029836840 scopus 로고    scopus 로고
    • HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: In vitro-in vivo correlation with permeability data from rats and humans
    • Walter E, Janich S, Roessler BJ, Hilfinger JM, Amidon GL. 1996. HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: in vitro-in vivo correlation with permeability data from rats and humans. J Pharm Sci 85:1070-6.
    • (1996) J Pharm Sci , vol.85 , pp. 1070-1076
    • Walter, E.1    Janich, S.2    Roessler, B.J.3    Hilfinger, J.M.4    Amidon, G.L.5
  • 56
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • Zeissig S, Burgel N, Gunzel D, Richter J, Mankertz J, Wahnschaffe U, et al. 2007. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56:61-72.
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Burgel, N.2    Gunzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6
  • 57
    • 84879479403 scopus 로고    scopus 로고
    • Cytotoxicity of different sized TiO2 nanoparticles in mouse macrophages
    • Zhang J, Song W, Guo J, Sun Z, Li L, Ding F, Gao M. 2012. Cytotoxicity of different sized TiO2 nanoparticles in mouse macrophages. Toxicol Ind Health 29:523-33.
    • (2012) Toxicol Ind Health , vol.29 , pp. 523-533
    • Zhang, J.1    Song, W.2    Guo, J.3    Sun, Z.4    Li, L.5    Ding, F.6    Gao, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.