An impaired alveolar-capillary barrier in vitro: Effect of proinflammatory cytokines and consequences on nanocarrier interaction

Journal of the Royal Society Interface

Volumn 7, Issue SUPPL. 1, 2010, Pages

  Hermanns, Maria Iris ^a   Kasper, Jennifer ^a   Dubruel, Peter ^b   Pohl, Christine ^a   Uboldi, Chiara ^a   Vermeersch, Vincent ^b   Fuchs, Sabine ^a   Unger, Ronald E ^a   Kirkpatrick, C James ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Alveolar capillary barrier; Bilayer; Lung injury; Nanocarrier interaction; Tight junctions

Indexed keywords

ADSORPTION; BIOLOGICAL ORGANS; BLOOD VESSELS; CELL CULTURE; GENE TRANSFER; GLYCOPROTEINS; LIVING SYSTEMS STUDIES; MONOLAYERS; NUCLEIC ACIDS; PATHOLOGY; PHYSIOLOGICAL MODELS; SELF ASSEMBLY; SODIUM;

BILAYER; CAPILLARY BARRIERS; LUNG INJURY; NANOCARRIERS; TIGHT JUNCTIONS;

ENDOTHELIAL CELLS;

GAMMA INTERFERON; POLYETHYLENEIMINE; PROTEIN ZO1; TUMOR NECROSIS FACTOR ALPHA; NANOPARTICLE;

ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL MEMBRANE PERMEABILITY; CYTOKINE RELEASE; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS; LUNG CAPILLARY; PROTEIN EXPRESSION; PROTEIN INTERACTION; ANALYSIS OF VARIANCE; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; COCULTURE; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; IMPEDANCE; LUNG ALVEOLUS CELL; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANALYSIS OF VARIANCE; BIOLOGICAL TRANSPORT; CELL LINE; COCULTURE TECHNIQUES; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; MODELS, BIOLOGICAL; NANOPARTICLES; PNEUMOCYTES; POLYETHYLENEIMINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77951891062     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2009.0288.focus     Document Type: Article

References (32)

1. Angelini, D. J., Hyun, S. W., Grigoryev, D. N., Garg, P., Gong, P., Singh, I. S., Passaniti, A., Hasday, J. D. & Goldblum, S. E. 2006 TNF-alpha increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia. Am. J. Physiol. Lung Cell. Mol. Physiol. 291, L1232-L1245. (doi:10.1152/ajplung.00109. 2006)
2. Beaurepaire, C., Smyth, D. & McKay, D. M. In press. Interferon-gamma regulation of intestinal epithelial permeability. J. Interferon Cytokine Res.
3. Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B. & Behr, J. P. 1995 A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl Acad. Sci. USA 92, 7297-7301. (doi:10.1073/pnas.92.16.7297)
4. Cavanaugh, K. J., Cohen, T. S. & Margulies, S. S. 2006 Stretch increases alveolar epithelial permeability to uncharged micromolecules. Am. J. Physiol. Cell Physiol. 290, C1179-C1188. (doi:10.1152/ajpcell.00355.2004)
5. Coyne, C. B., Kelly, M. M., Boucher, R. C. & Johnson, L. G. 2000 Enhanced epithelial gene transfer by modulation of tight junctions with sodium caprate. Am. J. Respir. Cell Mol. Biol. 23, 602-609.
6. Coyne, C. B., Vanhook, M. K., Gambling, T. M., Carson, J. L., Boucher, R. C. & Johnson, L. G. 2002 Regulation of airway tight junctions by proinflammatory cytokines. Mol. Biol. Cell 13, 3218-3234. (doi:10.1091/mbc.E02- 03-0134)
7. Crandall, E. D. & Matthay, M. A. 2001 Alveolar epithelial transport. Basic science to clinical medicine. Am. J. Respir. Crit. Care Med. 163, 1021-1029.
8. Crestani, B. & Aubier, M. 1998 Inflammatory role of alveolar epithelial cells. Kidney Int. Suppl. 65, S88-S93.
9. Delclaux, C. & Azoulay, E. 2003 Inflammatory response to infectious pulmonary injury. Eur. Respir. J. Suppl. 42, 10s-14s. (doi:10.1183/09031936.03. 00420203)
10. Doyle, S. R. & Chan, C. K. 2007 Differential intracellular distribution of DNA complexed with polyethylenimine (PEI) and PEI-polyarginine PTD influences exogenous gene expression within live COS-7 cells. Genet. Vaccines Ther. 5, 11. (doi:10.1186/1479-0556-5-11)
11. Dubruel, P., Christiaens, B., Rosseneu, M., Vandekerckhove, J., Grooten, J., Goossens, V. & Schacht, E. 2004 Buffering properties of cationic polymethacrylates are not the only key to successful gene delivery. Biomacromolecules. 5, 379-388. (doi:10.1021/bm034438d) (Pubitemid 38404473)
12. Gautam, A., Densmore, C. L., Xu, B. & Waldrep, J. C. 2000 Enhanced gene expression in mouse lung after PEI-DNA aerosol delivery. Mol. Ther. 2, 63-70. (doi:10.1006/mthe.2000.0087)
13. Gautam, A., Densmore, C. L., Golunski, E., Xu, B. & Waldrep, J. C. 2001a Transgene expression in mouse airway epithelium by aerosol gene therapy with PEI-DNA complexes. Mol. Ther. 3, 551-556. (doi:10.1006/mthe.2001.0300)
14. Gautam, A., Densmore, C. L. & Waldrep, J. C. 2001b Pulmonary cytokine responses associated with PEI-DNA aerosol gene therapy. Gene Ther. 8, 254-257. (doi:10.1038/sj.gt.3301369) (Pubitemid 32186138)
15. Gehr, P., Bachofen, M. & Weibel, E. 1978 The normal human lung: ultrastructure and morphometric estimation of diffusion capacity. Respir. Physiol. 32, 121-140. (doi:10.1016/0034-5687(78)90104-4)
16. Grosse, S., Aron, Y., Thevenot, G., Monsigny, M. & Fajac, I. 2007 Cytoskeletal involvement in the cellular trafficking of plasmid/PEI derivative complexes. J. Control. Release 122, 111-117. (doi:10.1016/j.jconrel.2007.06.015) (Pubitemid 47299144)
17. Hermanns, M. I., Unger, R. E., Kehe, K., Peters, K. & Kirkpatrick, C. J. 2004 Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro. Lab. Invest. 84, 736-752. (doi:10.1038/labinvest.3700081)
18. Hermanns, M. I., Fuchs, S., Bock, M., Wenzel, K., Mayer, E., Kehe, K., Bittinger, F. & Kirkpatrick, C. J. 2009 Primary human coculture model of alveolo-capillary unit to study mechanisms of injury to peripheral lung. Cell Tissue Res. 336, 91-105. (doi:10.1007/s00441-008-0750-1)
19. Johnson, L. G., Vanhook, M. K., Coyne, C. B., Haykal-Coates, N. & Gavett, S. H. 2003 Safety and efficiency of modulating paracellular permeability to enhance airway epithelial gene transfer in vivo. Hum. Gene Ther. 14, 729-747. (doi:10.1089/104303403765255138)
20. Koss, M., Pfeiffer II, G. R., Wang, Y., Thomas, S. T., Yerukhimovich, M., Gaarde, W. A., Doerschuk, C. M. & Wang, Q. 2006 Ezrin/radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cells. J. Immunol. 176, 1218-1227. (Pubitemid 43099726)
21. Lucas, R., Verin, A. D., Black, S. M. & Catravas, J. D. 2009 Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochem. Pharmacol. 77, 1763-1772. (doi:10.1016/j.bcp.2009.01.014)
22. Maniatis, N. A., Kotanidou, A., Catravas, J. D. & Orfanos, S. E. 2008 Endothelial pathomechanisms in acute lung injury. Vasc. Pharmacol. 49, 119-133. (doi:10.1016/j.vph.2008.06.009)
23. Mazzon, E. & Cuzzocrea, S. 2007 Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation. Respir. Res. 8, 75. (doi:10.1186/1465-9921-8-75)
24. Nilsson, K. & Wollmer, P. 1992 Pulmonary clearance of 99mTc-DTPA and 99mTc-albumin in rabbits with surfactant dysfunction and lung injury. Clin. Physiol. 12, 587-594. (doi:10.1111/j.1475-097X.1992.tb00361.x)
25. Oshima, T. et al. 2001 Interferon-gamma and interleukin-10 reciprocally regulate endothelial junction integrity and barrier function. Microvasc. Res. 61, 130-143. (doi:10.1006/mvre.2000.2288)
26. Pohl, C. et al. 2009 Barrier functions and paracellular integrity in human cell culture models of the proximal respiratory unit. Eur. J. Pharm. Biopharm. 72, 339-349. (doi:10.1016/j.ejpb.2008.07.012)
27. Prabhakar, U., Eirikis, E. & Davis, H. M. 2002 Simultaneous quantification of proinflammatory cytokines in human plasma using the LabMAP assay. J. Immunol. Methods 260, 207-218. (doi:10.1016/S0022-1759(01)00543-9) (Pubitemid 34132886)
28. Sayes, C. M., Reed, K. L. & Warheit, D. B. 2007 Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol. Sci. 97, 163-180. (doi:10.1093/toxsci/kfm018)
29. Souza, D. G. & Teixeira, M. M. 2005 The balance between the production of tumor necrosis factor-alpha and interleukin-10 determines tissue injury and lethality during intestinal ischemia and reperfusion. Mem. Inst. Oswaldo Cruz 100, 59-66. (doi:10.1590/S0074-02762005000900011)
30. Strieter, R. M. & Kunkel, S. L. 1994 Acute lung injury: the role of cytokines in the elicitation of neutrophils. J. Investig. Med. 42, 640-651.
31. Unger, R. E., Krump-Konvalinkova, V., Peters, K. & Kirkpatrick, C. J. 2002 In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R. Microvasc. Res. 64, 384-397. (doi:10.1006/mvre.2002.2434)
32. Ware, L. B. & Matthay, M. A. 2000 The acute respiratory distress syndrome. N. Engl. J. Med. 342, 1334-1349. (doi:10.1056/NEJM200005043421806)