Hydrogels 2.0: Improved properties with nanomaterial composites for biomedical applications

Biomedical Materials (Bristol)

Volumn 11, Issue 1, 2015, Pages

  Memic, Adnan ^a,b   Alhadrami, Hani A ^a   Hussain, M Asif ^a   Aldhahri, Musab ^a   Al Nowaiser, Fozia ^a   Al Hazmi, Faten ^a   Oklu, Rahmi ^c   Khademhosseini, Ali ^a,b,d,e  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD UNIVERSITY   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

biomedical applications; drug delivery; hydrogel; nanocomposite; network structure; stimuli responsive; tissue engineering

Indexed keywords

CROSSLINKING; DRUG DELIVERY; MEDICAL APPLICATIONS; NANOCOMPOSITES; NANOSTRUCTURED MATERIALS; TISSUE ENGINEERING;

BIOLOGICAL PROPERTIES; BIOMEDICAL APPLICATIONS; CROSS-LINKED POLYMERS; MULTIFUNCTIONALITY; NANOCOMPOSITE HYDROGELS; NETWORK STRUCTURES; STIMULI-RESPONSIVE;

HYDROGELS;

NANOCOMPOSITE; BIOMATERIAL; HYDROGEL; NANOCAPSULE;

ARTICLE; BIOMEDICAL DISCIPLINES, SCIENCE AND ART; DRUG DELIVERY SYSTEM; HUMAN; HYDROGEL; MECHANICS; NANOFABRICATION; NONHUMAN; SYNTHESIS; TISSUE ENGINEERING; CHEMISTRY; DEVICES; PARTICLE SIZE; PROCEDURES; ULTRASTRUCTURE;

BIOCOMPATIBLE MATERIALS; HYDROGELS; NANOCAPSULES; NANOCOMPOSITES; PARTICLE SIZE; TISSUE ENGINEERING;

EID: 84959541910     PISSN: 17486041     EISSN: 1748605X     Source Type: Journal    
DOI: 10.1088/1748-6041/11/1/014104     Document Type: Article

References (151)

1. Annabi N, Tamayol A, Uquillas J A, Akbari M, Bertassoni L E, Cha C, Camci-Unal G, Dokmeci M R, Peppas N A and Khademhosseini A 2014 25th anniversary article: rational design and applications of hydrogels in regenerative medicine Adv. Mater. 26 85-124
2. Gaharwar A K, Peppas N A and Khademhosseini A 2014 Nanocomposite hydrogels for biomedical applications Biotechnol. Bioeng. 111 441-53
3. Satarkar N S and Zach Hilt J 2008 Hydrogel nanocomposites as remote-controlled biomaterials Acta Biomater. 4 11-6
4. Soppimath K S, Aminabhavi T M, Dave A M, Kumbar S G and Rudzinski W E 2002 Stimulus-responsive 'smart' hydrogels as novel drug delivery systems Drug Dev. Indust. Pharmacy 28 957-74
5. Fisher O Z, Khademhosseini A, Langer R and Peppas N A 2010 Bioinspired materials for controlling stem cell fate Acc. Chem. Res. 43 419-28
6. Kloxin A M, Kloxin C J, Bowman C N and Anseth K S 2010 Mechanical properties of cellularly responsive hydrogels and their experimental determination Adv. Mater. 22 3484-94
7. Slaughter B V, Khurshid S S, Fisher O Z, Khademhosseini A and Peppas N A 2009 Hydrogels in regenerative medicine Adv. Mater. 21 3307-29
8. Khademhosseini A and Langer R 2007 Microengineered hydrogels for tissue engineering Biomaterials 28 5087-92
9. Discher D E, Mooney D J and Zandstra P W 2009 Growth factors, matrices, and forces combine and control stem cells Science 324 1673-7
10. Tibbitt M W and Anseth K S 2009 Hydrogels as extracellular matrix mimics for 3D cell culture Biotechnol. Bioeng. 103 655-63
11. Bencherif S A, Sands R W, Bhatta D, Arany P, Verbeke C S, Edwards D A and Mooney D J 2012 Injectable preformed scaffolds with shape-memory properties Proc. Natl Acad. Sci. USA 109 19590-5
12. Haraguchi K 2007 Nanocomposite hydrogels Curr. Opin. Solid State Mater. Sci. 11 47-54
13. Haraguchi K 2007 Nanocomposite gels: new advanced functional soft materials Macromol. Symp. 256 120-30
14. Goenka S, Sant V and Sant S 2014 Graphene-based nanomaterials for drug delivery and tissue engineering J. Control. Rel. 173 75-88
15. Schexnailder P and Schmidt G 2009 Nanocomposite polymer hydrogels Colloid Polym. Sci. 287 1-11
16. Tjong S C 2006 Structural and mechanical properties of polymer nanocomposites Mater. Sci. Eng. R 53 73-197
17. Lowman A M, Dziubla T D, Bures P and Peppas N A 2004 Structural and dynamic response of neutral and intelligent networks in biomedical environments Molecular and Cellular Foundations of Biomaterials ed N A peppas and M V Sefton (New York: Academic) pp 75-130
18. Carrow J K and Gaharwar A K 2015 Bioinspired polymeric nanocomposites for regenerative medicine Macromol. Chem. Phys. 216 248-64
19. Satarkar N S, Biswal D and Hilt J Z 2010 Hydrogel nanocomposites: a review of applications as remote controlled biomaterials Soft Matter 6 2364-71
20. Okada A and Usuki A 2006 Twenty years of polymer-clay nanocomposites Macromol. Mater. Eng. 291 1449-76
21. Shapiro J M and Oyen M L 2013 Hydrogel composite materials for tissue engineering scaffolds JOM 65 505-16
22. Haraguchi K and Takehisa T 2002 Nanocomposite hydrogels: a unique organic/inorganic network structure with extraordinary mechanical, optical, and swelling/de-swelling properties Adv. Mater. 14 1120-4
23. Haraguchi K, Li H J, Matsuda K, Takehisa T and Elliott E 2005 Mechanism of forming organic/inorganic network structures during in situ free-radical polymerization in PNIPA-clay nanocomposite hydrogels Macromolecules 38 3482-90
24. Young Yook J, Choi G H and Hack Suh D 2012 A novel method for preparing silver nanoparticle-hydrogel nanocomposites via pH-induced self-assembly Chem. Commun. 48 5001-3
25. Murali Mohan Y, Vimala K, Thomas V, Varaprasad K, Sreedhar B, Bajpai S K and Mohana Raju K 2010 Controlling of silver nanoparticles structure by hydrogel networks J.Colloid Interface Sci. 342 73-82
26. Li J, Ni X and Leong K W 2003 Injectable drug-delivery systems based on supramolecular hydrogels formed by poly(ethylene oxide)s and alpha-cyclodextrin J. Biomed. Mater. Res. A 65 196-202
27. Ma D and Zhang L-M 2013 Novel biosensing platform based on self-assembled supramolecular hydrogel Mater. Sci. Eng. C 33 2632-8
28. Ma D and Zhang L M 2008 Fabrication and modulation of magnetically supramolecular hydrogels J. Phys. Chem. B 112 6315-21
29. Sahu A, Choi W I and Tae G 2012 A stimuli-sensitive injectable graphene oxide composite hydrogel Chem. Commun. 48 5820-2
30. Chen Y, Bilgen B, Pareta R A, Myles A J, Fenniri H, Ciombor D M, Aaron R K and Webster T J 2010 Self-assembled rosette nanotube/hydrogel composites for cartilage tissue engineering Tissue Eng. Methods C 16 1233-43
31. Chen Y Y, Wu H C, Sun J S, Dong G C and Wang T W 2013 Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 29 3721-9
32. Wickremasinghe N C, Kumar V A and Hartgerink J D 2014 Two-step self-assembly of liposome-multidomain peptide nanofiber hydrogel for time-controlled release Biomacromolecules 15 3587-95
33. Haraguchi K, Farnworth R, Ohbayashi A and Takehisa T 2003 Compositional effects on mechanical properties of nanocomposite hydrogels composed of poly (N,N-dimethylacrylamide) and clay Macromolecules 36 5732-41
34. Haraguchi K, Takehisa T and Fan S 2002 Effects of clay content on the properties of nanocomposite hydrogels composed of poly(N-isopropylacrylamide) and clay Macromolecules 35 10162-71
35. Haraguchi K and Li H J 2006 Mechanical properties and structure of polymer-clay nanocomposite gels with high clay content Macromolecules 39 1898-905
36. Haraguchi K, Uyama K and Tanimoto H 2011 Self-healing in nanocomposite hydrogels Macromol. Rapid Commun. 32 1253-8
37. Wang Q, Mynar J L, Yoshida M, Lee E, Lee M, Okuro K, Kinbara K and Aida T 2010 High-water-content mouldable hydrogels by mixing clay and a dendritic molecular binder Nature 463 339-43
38. Haraguchi K and Song L 2007 Microstructures formed in co-cross-linked networks and their relationships to the optical and mechanical properties of PNIPA/clay nanocomposite gels Macromolecules 40 5526-36
39. Liang L, Liu J and Gong X 2000 Thermosensitive poly (N-isopropylacrylamide)-clay nanocomposites with enhanced temperature response Langmuir 16 9895-9
40. Peppas N A, Hilt J Z, Khademhosseini A and Langer R 2006 Hydrogels in biology and medicine: from molecular principles to bionanotechnology Adv. Mater. 18 1345-60
41. Hoyle C E and Bowman C N 2010 Thiol-ene click chemistry Angew. Chem. 49 1540-73
42. Hoyle C E, Lowe A B and Bowman C N 2010 Thiol-click chemistry: a multifaceted toolbox for small molecule and polymer synthesis Chem. Soc. Rev. 39 1355-87
43. DeForest C A and Anseth K S 2011 Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions Nat. Chem. 3 925-31
44. Azagarsamy M A and Anseth K S 2013 Bioorthogonal click chemistry: an indispensable tool to create multifaceted cell culture scaffolds ACS Macro Lett. 2 5-9
45. Cha C, Shin S R, Gao X, Annabi N, Dokmeci M R, Tang X S and Khademhosseini A 2014 Controlling mechanical properties of cell-laden hydrogels by covalent incorporation of graphene oxide Small 10 514-23
46. Lian X, Jin J, Tian J and Zhao H 2010 Thermoresponsive nanohydrogels cross-linked by gold nanoparticles ACS Appl. Mater. Interfaces 2 2261-8
47. Sontjens S H, Nettles D L, Carnahan M A, Setton L A and Grinstaff M W 2006 Biodendrimer-based hydrogel scaffolds for cartilage tissue repair Biomacromolecules 7 310-6
48. Balazs A C, Emrick T and Russell T P 2006 Nanoparticle polymer composites: where two small worlds meet Science 314 1107-10
49. Caruso F 2001 Nanoengineering of particle surfaces Adv. Mater. 13 11-22
50. Skardal A, Zhang J, McCoard L, Oottamasathien S and Prestwich G D 2010 Dynamically crosslinked gold nanoparticle-hyaluronan hydrogels Adv. Mater. 22 4736
51. O'Brien F J 2011 Biomaterials and scaffolds for tissue engineering Mater. Today 14 88-95
52. Shibayama M 2012 Structure-mechanical property relationship of tough hydrogels Soft Matter 8 8030-8
53. Nichol J W, Koshy S T, Bae H, Hwang C M, Yamanlar S and Khademhosseini A 2010 Cell-laden microengineered gelatin methacrylate hydrogels Biomaterials 31 5536-44
54. Annabi N, Mithieux S M, Zorlutuna P, Camci-Unal G, Weiss A S and Khademhosseini A 2013 Engineered cell-laden human protein-based elastomer Biomaterials 34 5496-505
55. Luo Y L, Zhang C H, Chen Y S and Yang W 2009 Preparation and characterisation of polyacrylamide/MWCNTs nanohybrid hydrogels with microporous structures Mater. Res. Innov. 13 18-27
56. Lin W-C, Fan W, Marcellan A, Hourdet D and Creton C 2010 Large strain and fracture properties of poly(dimethylacrylamide)/silica hybrid hydrogels Macromolecules 43 2554-63
57. Naficy S, Brown H R, Razal J M, Spinks G M and Whitten P G 2011 Progress toward robust polymer hydrogels Aust. J. Chem. 64 1007-25
58. Kabiri K, Omidian H, Zohuriaan-Mehr M J and Doroudiani S 2011 Superabsorbent hydrogel composites and nanocomposites: a review Polym. Compos. 32 277-89
59. El-Fiqi A, Lee J H, Lee E-J and Kim H-W 2013 Collagen hydrogels incorporated with surface-aminated mesoporous nanobioactive glass: improvement of physicochemical stability and mechanical properties is effective for hard tissue engineering Acta Biomater. 9 9508-21
60. Cha C, Shin S R, Annabi N, Dokmeci M R and Khademhosseini A 2013 Carbon-based nanomaterials: multifunctional materials for biomedical engineering ACS Nano 7 2891-7
61. Zhang L, Wang Z, Li Y, Gao J, Liu Y, Xu C and Wang W 2011 High strength graphene oxide/polyvinyl alcohol composite hydrogels J. Mater. Chem. 21 10399-406
62. Das S, Irin F, Ma L, Bhattacharia S K, Hedden R C and Green M J 2013 Rheology and morphology of pristine graphene/polyacrylamide gels ACS Appl. Mater. Interfaces 5 8633-40
63. Skelton S, Bostwick M, O'Connor K, Konst S, Casey S and Lee B P 2013 Biomimetic adhesive containing nanocomposite hydrogel with enhanced materials properties Soft Matter 9 3825-33
64. Gaharwar A K, Dammu S A, Canter J M, Wu C-J and Schmidt G 2011 Highly extensible, tough, and elastomeric nanocomposite hydrogels from poly(ethylene glycol) and hydroxyapatite nanoparticles Biomacromolecules 12 1641-50
65. Zhu A, Shi Z, Jin J, Li G and Jiang J 2012 Synthesis and properties of polyacrylamide-based conducting gels with enhanced mechanical strength J. Macromol. Sci. B: Phys. 51 2183-90
66. Shin S R et al 2013 Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators ACS Nano 7 2369-80
67. Ostrovidov S et al 2014 Myotube formation on gelatin nanofibers - multi-walled carbon nanotubes hybrid scaffolds Biomaterials 35 6268-77
68. Shin S R et al 2012 Carbon nanotube reinforced hybrid microgels as scaffold materials for cell encapsulation ACS Nano 6 362-72
69. Dvir T, Timko B P, Brigham M D, Naik S R, Karajanagi S S, Levy O, Jin H, Parker K K, Langer R and Kohane D S 2011 Nanowired 3D cardiac patches Nat. Nanotechnol. 6 720-5
70. Janovak L and Dekany I 2010 Optical properties and electric conductivity of gold nanoparticle-containing, hydrogel-based thin layer composite films obtained by photopolymerization Appl. Surf. Sci. 256 2809-17
71. Zhao X L, Ding X B, Deng Z H, Zheng Z H, Peng Y X and Long X P 2005 Thermo switchable electronic properties of a gold nanoparticle/hydrogel composite Macromol. Rapid Commun. 26 1784-7
72. Abdel-Halim E S and Al-Deyab S S 2014 Electrically conducting silver/guar gum/poly(acrylic acid) nanocomposite Int. J. Biol. Macromol. 69 456-63
73. Alshangiti D M and Madani M 2014 Nano-Ag poping induced changes in the optical behavior and thermal stability of acrylic acid-grafted poly vinyl alcohol copolymer films Polym.-Plast. Technol. Eng. 53 1385-91
74. Lee W-F and Tsao K-T 2010 Effect of silver nanoparticles content on the various properties of nanocomposite hydrogels by in situ polymerization J. Mater. Sci. 45 89-97
75. Devaki S J, Narayanan R K and Sarojam S 2014 Electrically conducting silver nanoparticle-polyacrylic acid hydrogel by in situ reduction and polymerization approach Mater. Lett. 116 135-8
76. Arslantunali D, Budak G and Hasirci V 2014 Multiwalled CNT-pHEMA composite conduit for peripheral nerve repair J. Biomed. Mater. Res. A 102 828-41
77. Bajpai A K, Bajpai J and Soni S N 2011 Electroactive actuation and conductive behavior of polyaniline-impregnated blood compatible nanocomposites J. Compos. Mater. 45 485-97
78. Dispenza C, Sabatino M A, Niconov A, Chmielewska D and Spadaro G 2012 E-beam crosslinked, biocompatible functional hydrogels incorporating polyaniline nanoparticles Radiat. Phys. Chem. 81 1456-9
79. Mahloniya R G, Bajpai J and Bajpai A K 2012 Electrical actuation of ionic hydrogels based on polyvinyl alcohol grafted with poly(2-acrylamido-2-methyl-1-propanesulfonic acid-co-acrylonitrile) chains Polym. Compos. 33 129-37
80. Morais J M, Papadimitrakopoulos F and Burgess D J 2010 Biomaterials/tissue interactions: possible solutions to overcome foreign body response AAPS J. 12 188-96
81. Lee K Y and Mooney D J 2001 Hydrogels for tissue engineering Chem. Rev. 101 1869-80
82. Hoare T R and Kohane D S 2008 Hydrogels in drug delivery: progress and challenges Polymer 49 1993-2007
83. Meenach S A, Anderson A A, Suthar M, Anderson K W and Hilt J Z 2009 Biocompatibility analysis of magnetic hydrogel nanocomposites based on poly(N-isopropylacrylamide) and iron oxide J. Biomed. Mater. Res. A 91 903-9
84. Macedo F A, Nunes E H M, Vasconcelos W L, Santos R A, Sinisterra R D and Cortes M E 2012 A biodegradable porous composite scaffold of PCL/BCP containing Ang-(1-7) for bone tissue engineering Cerâmica 58 481-8
85. Marsich E, Travan A, Donati I, Di Luca A, Benincasa M, Crosera M and Paoletti S 2011 Biological response of hydrogels embedding gold nanoparticles Colloids Surf. B: Biointerfaces 83 331-9
86. Duncan R 2003 The dawning era of polymer therapeutics Nat. Rev. Drug Discovery 2 347-60
87. Zhang S 2002 Emerging biological materials through molecular self-assembly Biotechnol. Adv. 20 321-39
88. Kumar P T S, Srinivasan S, Lakshmanan V-K, Tamura H, Nair S V and Jayakumar R 2011 Synthesis, characterization and cytocompatibility studies of alpha-chitin hydrogel/nano hydroxyapatite composite scaffolds Int. J. Biol. Macromol. 49 20-31
89. Kumar P T S, Srinivasan S, Lakshmanan V-K, Tamura H, Nair S V and Jayakumar R 2011 Beta-chitin hydrogel/nano hydroxyapatite composite scaffolds for tissue engineering applications Carbohydrate Polym. 85 584-91
90. Rahmany M B and Van Dyke M 2013 Biomimetic approaches to modulate cellular adhesion in biomaterials: a review Acta Biomater. 9 5431-7
91. Vu L T, Jain G, Veres B D and Rajagopalan P 2014 Cell migration on planar and 3D matrices: a hydrogel-based perspective Tissue Eng. B: Rev. 21 67-74
92. Rape A D and Kumar S 2014 A composite hydrogel platform for the dissection of tumor cell migration at tissue interfaces Biomaterials 35 8846-53
93. Anderson S B, Lin C C, Kuntzler D V and Anseth K S 2011 The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels Biomaterials 32 3564-74
94. Miller J S, Shen C J, Legant W R, Baranski J D, Blakely B L and Chen C S 2010 Bioactive hydrogels made from step-growth derived PEG-peptide macromers Biomaterials 31 3736-43
95. Chan G and Mooney D J 2008 New materials for tissue engineering: towards greater control over the biological response Trends Biotechnol. 26 382-92
96. Borselli C, Cezar C A, Shvartsman D, Vandenburgh H H and Mooney D J 2011 The role of multifunctional delivery scaffold in the ability of cultured myoblasts to promote muscle regeneration Biomaterials 32 8905-14
97. Hokugo A, Saito T, Li A, Sato K, Tabata Y and Jarrahy R 2014 Stimulation of bone regeneration following the controlled release of water-insoluble oxysterol from biodegradable hydrogel Biomaterials 35 5565-71
98. Billard A, Pourchet L, Malaise S, Alcouffe P, Montembault A and Ladaviere C 2015 Liposome-loaded chitosan physical hydrogel: toward a promising delayed-release biosystem Carbohydrate Polym. 115 651-7
99. Wu Z, Zou X, Yang L, Lin S, Fan J, Yang B, Sun X, Wan Q, Chen Y and Fu S 2014 Thermosensitive hydrogel used in dual drug delivery system with paclitaxel-loaded micelles for in situ treatment of lung cancer Colloids Surf. B: Biointerfaces 122 90-8
100. Byeon H J, Choi S H, Choi J S, Kim I, Shin B S, Lee E S, Park E S, Lee K C and Youn Y S 2014 Four-arm PEG cross-linked hyaluronic acid hydrogels containing PEGylated apoptotic TRAIL protein for treating pancreatic cancer Acta Biomater. 10 142-50
101. Fu S, Ni P, Wang B, Chu B, Zheng L, Luo F, Luo J and Qian Z 2012 Injectable and thermo-sensitive PEG-PCL-PEG copolymer/collagen/n-HA hydrogel composite for guided bone regeneration Biomaterials 33 4801-9
102. Kim S S, Sun Park M, Jeon O, Yong Choi C and Kim B S 2006 Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering Biomaterials 27 1399-409
103. Poursamar S A, Azami M and Mozafari M 2011 Controllable synthesis and characterization of porous polyvinyl alcohol/hydroxyapatite nanocomposite scaffolds via an in situ colloidal technique Colloids Surf. B: Biointerfaces 84 310-6
104. Song W, Markel D C, Jin X, Shi T and Ren W 2012 Poly(vinyl alcohol)/collagen/hydroxyapatite hydrogel: properties and in vitro cellular response J. Biomed. Mater. Res. A 100A 3071-9
105. Zhang L, Rodriguez J, Raez J, Myles A J, Fenniri H and Webster T J 2009 Biologically inspired rosette nanotubes and nanocrystalline hydroxyapatite hydrogel nanocomposites as improved bone substitutes Nanotechnology 20 175101
106. Roy D, Cambre J N and Sumerlin B S 2010 Future perspectives and recent advances in stimuli-responsive materials Prog. Polym. Sci. 35 278-301
107. Satarkar N and Hilt J 2008 Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release J. Control. Rel. 130 246-51
108. Frimpong R A and Hilt J Z 2010 Magnetic nanoparticles in biomedicine: synthesis, functionalization and applications Nanomedicine 5 1401-14
109. Satarkar N S, Zhang W, Eitel R E and Hilt J Z 2009 Magnetic hydrogel nanocomposites as remote controlled microfluidic valves Lab chip 9 1773-9
110. Bajpai A K and Gupta R 2011 Magnetically mediated release of ciprofloxacin from polyvinyl alcohol based superparamagnetic nanocomposites J. Mater. Sci. Mater. Med. 22 357-69
111. Balazs A C, Emrick T and Russell T P 2006 Nanoparticle polymer composites: where two small worlds meet Science 314 1107-10
112. Zhang D, Sun P, Li P, Xue A, Zhang X, Zhang H and Jin X 2013 A magnetic chitosan hydrogel for sustained and prolonged delivery of Bacillus Calmette-Guerin in the treatment of bladder cancer Biomaterials 34 10258-66
113. Pankhurst Q A, Connolly J, Jones S K and Dobson J 2003 Applications of magnetic nanoparticles in biomedicine J. Phys. D: Appl. Phys. 36 R167-81
114. Tabatabaei S N, Lapointe J and Martel S 2009 Hydrogel encapsulated magnetic nanoparticles as hyperthermic actuators for microrobots designed to operate in the vascular network IEEE/RSJ Int. Conf. on Intelligent Robots and Systems pp 546-51
115. 4 nanoparticles for hyperthermia IEEE Trans. Magn. 42 3566-8
116. Masters K S, Shah D N, Leinwand L A and Anseth K S 2005 Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells Biomaterials 26 2517-25
117. Radisic M, Malda J, Epping E, Geng W, Langer R and Vunjak-Novakovic G 2006 Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue Biotechnol. Bioeng. 93 332-43
118. Radisic M, Park H, Shing H, Consi T, Schoen F J, Langer R, Freed L E and Vunjak-Novakovic G 2004 Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds Proc. Natl Acad. Sci. USA 101 18129-34
119. Song F, Li X, Wang Q, Liao L and Zhang C 2014 Nanocomposite hydrogels and their applications in drug delivery and tissue engineering J. Biomed. Nanotechnol. 10 1-13
120. Bettinger C J, Langer R and Borenstein J T 2009 Engineering substrate topography at the micro- and nanoscale to control cell function Angew. Chem. Int. Edn 48 5406-15
121. Pok S, Vitale F, Eichmann S L, Benavides O M, Pasquali M and Jacot J G 2014 Biocompatible carbon nanotube-chitosan scaffold matching the electrical conductivity of the heart ACS Nano 8 9822-32
122. Sapir Y, Polyak B and Cohen S 2014 Cardiac tissue engineering in magnetically actuated scaffolds Nanotechnology 25 014009
123. Pok S, Myers J D, Madihally S V and Jacot J G 2013 A multilayered scaffold of a chitosan and gelatin hydrogel supported by a PCL core for cardiac tissue engineering Acta Biomater. 9 5630-42
124. Pina S, Oliveira J M and Reis R L 2015 Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review Adv. Mater. 27 1143-69
125. Im O, Li J, Wang M, Zhang L G and Keidar M 2012 Biomimetic 3D nanocrystalline hydroxyapatite and magnetically synthesized single-walled carbon nanotube chitosan nanocomposite for bone regeneration Int. J. Nanomed. 7 2087-99
126. Lee W-F and Chen Y-C 2004 Effect of bentonite on the physical properties and drug-release behavior of poly(AA-co-PEGMEA)/bentonite nanocomposite hydrogels for mucoadhesive J. Appl. Polym. Sci. 91 2934-41
127. Jiang Y, Li B, Chen X and Zhu M 2012 Preparation and characterization of a prolonged and sustained drug delivery system: linear polyacrylamide in poly(N-isopropylacrylamide)/clay hydrogels J. Appl. Polym. Sci. 125 E148-56
128. Popescu M T, Mourtas S, Pampalakis G, Antimisiaris S G and Tsitsilianis C 2011 pH-responsive hydrogel/liposome soft nanocomposites for tuning drug release Biomacromolecules 12 3023-30
129. Joshi N and Grinstaff M 2008 Applications of dendrimers in tissue engineering Curr. Top. Med. Chem. 8 1225-36
130. Zhang H, Patel A, Gaharwar A K, Mihaila S M, Iviglia G, Mukundan S, Bae H, Yang H and Khademhosseini A 2013 Hyperbranched polyester hydrogels with controlled drug release and cell adhesion properties Biomacromolecules 14 1299-310
131. Desai P N, Yuan Q and Yang H 2010 Synthesis and characterization of photocurable polyamidoamine dendrimer hydrogels as a versatile platform for tissue engineering and drug delivery Biomacromolecules 11 666-73
132. Lu H D, Soranno D E, Rodell C B, Kim I L and Burdick J A 2013 Secondary photocrosslinking of injectable shear-thinning dock-and-lock hydrogels Adv. Healthc. Mater. 2 1028-36
133. Ekenseair A K, Boere K W, Tzouanas S N, Vo T N, Kasper F K and Mikos A G 2012 Structure-property evaluation of thermally and chemically gelling injectable hydrogels for tissue engineering Biomacromolecules 13 2821-30
134. Gaharwar A K, Avery R K, Assmann A, Paul A, McKinley G H, Khademhosseini A and Olsen B D 2014 Shear-thinning nanocomposite hydrogels for the treatment of hemorrhage ACS Nano 8 9833-42
135. Kokabi M, Sirousazar M and Hassan Z M 2007 PVA-clay nanocomposite hydrogels for wound dressing Eur. Polym. J. 43 773-81
136. Salmawi K M E 2007 Gamma radiation-induced crosslinked PVA/chitosan blends for wound dressing J. Macromol. Sci. A: Pure Appl. Chem. 44 541-6
137. Hutson C B, Nichol J W, Aubin H, Bae H, Yamanlar S, Al-Haque S, Koshy S T and Khademhosseini A 2011 Synthesis and characterization of tunable poly(ethylene glycol): gelatin methacrylate composite hydrogels Tissue Eng. A 17 1713-23
138. Durst C A, Cuchiara M P, Mansfield E G, West J L and Grande-Allen K J 2011 Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves Acta Biomater. 7 2467-76
139. Liu J, Cui L, Kong N, Barrow C J and Yang W 2014 RAFT controlled synthesis of graphene/polymer hydrogel with enhanced mechanical property for pH-controlled drug release Eur. Polym. J. 50 9-17
140. Nimmo C M, Owen S C and Shoichet M S 2011 Diels-alder click cross-linked hyaluronic acid hydrogels for tissue engineering Biomacromolecules 12 824-30
141. Hu X, Li D, Zhou F and Gao C 2011 Biological hydrogel synthesized from hyaluronic acid, gelatin and chondroitin sulfate by click chemistry Acta Biomater. 7 1618-26
142. Anderson S B, Lin C-C, Kuntzler D V and Anseth K S 2011 The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels Biomaterials 32 3564-74
143. Pasqui D, Atrei A, Giani G, De Cagna M and Barbucci R 2011 Metal oxide nanoparticles as cross-linkers in polymeric hybrid hydrogels Mater. Lett. 65 392-5
144. Zhong S and Yung L Y L 2009 Enhanced biological stability of collagen with incorporation of PAMAM dendrimer J. Biomed. Mater. Res. A 91A 114-22
145. Jayaramudu T, Raghavendra G M, Varaprasad K, Sadiku R and Raju K M 2013 Development of novel biodegradable Au nanocomposite hydrogels based on wheat: for inactivation of bacteria Carbohydrate Polym. 92 2193-200
146. Salgueiro A M, Daniel-da-Silva A L, Fateixa S and Trindade T 2013 κ-Carrageenan hydrogel nanocomposites with release behavior mediated by morphological distinct Au nanofillers Carbohydrate Polym. 91 100-9
147. Webster T J, Siegel R W and Bizios R 2001 Nanoceramic surface roughness enhances osteoblast and osteoclast functions for improved orthopaedic/dental implant efficacy Scr. Mater. 44 1639-42
148. Price R L, Gutwein L G, Kaledin L, Tepper F and Webster T J 2003 Osteoblast function on nanophase alumina materials: influence of chemistry, phase, and topography J. Biomed. Mater. Res. A 67 1284-93
149. Chen Y-Y, Wu H-C, Sun J-S, Dong G-C and Wang T-W 2013 Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery Langmuir 29 3721-9
150. 2-graphene hydrogel with improved adsorption capacities and photocatalytic and electrochemical activities ACS Appl. Mater. Interfaces 5 2227-33
151. Zhang E, Wang T, Zhao L, Sun W, Liu X and Tong Z 2014 Fast self-healing of graphene oxide-hectorite clay-poly(N,N-dimethylacrylamide) hybrid hydrogels realized by near-infrared irradiation ACS Appl. Mater. Interfaces 6 22855-61