Injectable drug-delivery systems based on supramolecular hydrogels formed by poly(ethylene oxide)s and α-cyclodextrin

Journal of Biomedical Materials Research - Part A

Volumn 65, Issue 2, 2003, Pages 196-202

  Li, Jun ^a   Ni, Xiping ^a   Leong, Kam W ^a,b  

^a INSTITUTE OF MATERIALS RESEARCH AND ENGINEERING   (Singapore)

^b Johns Hopkins University   (United States)

Author keywords

Cyclodextrin; Drug delivery; Hydrogel; in vitro release kinetics; Injectable; Poly(ethylene oxide); Rheology, thixotropic; Supramolecule; X ray diffraction

Indexed keywords

BIOCOMPATIBILITY; CROSSLINKING; DRUG PRODUCTS; GELATION; HYDROGELS; IMPLANTS (SURGICAL); MOLECULAR WEIGHT; POLYETHYLENE OXIDES; PROTEINS; SORPTION; SUPRAMOLECULAR CHEMISTRY; THERMAL EFFECTS; X RAY DIFFRACTION ANALYSIS;

DRUG DELIVERY SYSTEMS;

BIOMEDICAL ENGINEERING;

ALPHA CYCLODEXTRIN; BIOMATERIAL; DEXTRAN; MACROGOL; ORGANIC SOLVENT; PROTEIN; REAGENT; ALPHA CYCLODEXTRIN DERIVATIVE; ALPHA-CYCLODEXTRIN; CYCLODEXTRIN; DRUG CARRIER; MACROGOL DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABLE IMPLANT; CONCENTRATION (PARAMETERS); CONTROLLED DRUG RELEASE; COVALENT BOND; DRUG DELIVERY SYSTEM; ENCAPSULATION; FLOW KINETICS; GELATINIZATION; GELATION; HYDROGEL; INJECTION; KINETICS; MACROMOLECULE; MOLECULAR WEIGHT; NEEDLE; PROTEIN ASSEMBLY; PROTEIN CROSS LINKING; ROOM TEMPERATURE; THIXOTROPY; WATER CONTENT; X RAY DIFFRACTION; CHEMISTRY; SHEAR STRENGTH; VISCOSITY;

ALPHA-CYCLODEXTRINS; CYCLODEXTRINS; DRUG CARRIERS; HYDROGELS; INJECTIONS; KINETICS; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; SHEAR STRENGTH; VISCOSITY; X-RAY DIFFRACTION;

EID: 0346139503     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.10444     Document Type: Article

References (33)

1. Park H, Park K. Biocompatibility issues of implantable drug delivery systems. Pharm Res 1996;13:1770-1776.
2. Kim SW, Bae YH, Okano T. Hydrogels-Swelling, drug loading, and release. Pharm Res 1992;9:283-290.
3. Park K, Shalaby WSW, Park H. Biodegradable hydrogels for drug delivery. Lancaster: Technomic; 1993.
4. Heller J. Polymers for controlled parenteral delivery of peptides and proteins. Adv Drug Del Rev 1993;10:163-204.
5. Kamath KR, Park K. Biodegradable hydrogels in drug delivery. Adv Drug Del Rev 1993;11:59-84.
6. Hubbell JA. Hydrogel systems for barriers and local drug delivery in the control of wound healing. J Controlled Release 1996;39:305-313.
7. Hennink WE, Franssen O, van Dijk-Wolthuis WNE, Talsma H. Dextrin hydrogels for the controlled release of proteins. J Controlled Release 1997;48:107-114.
8. Peppas NA. Hydrogels and drug delivery. Curr Opin Colloid Interface Sci 1997;2:531-537.
9. Peppas NA, Keys KB, Torres-Lugo M, Lowman AM. Poly(ethylene glycol)-containing hydrogels in drug delivery. J Controlled Release 1999;62:81-87.
10. Graham NB. Poly(ethylene oxide) and related hydrogels. In: Peppas NA, editor. Hydrogels in medicine and pharmacy. II. Boca Raton, Florida: CRC Press; 1987. p 95-113.
11. Harris JM. Poly(ethylene glycol) chemistry: Biotechnical and biomedical applications. New York: Plenum Press; 1992.
12. Apicella A, Cappello B, Del Nobile MA, La Rotonda MI, Mensitieri GL, Nicolais S, Seccia S. Poly(ethylene oxide)-based delivery systems. In: Ottenbrite M, editor. Polymeric drugs and drug administration. Washington DC: American Chemical Society; 1994. p 111-125.
13. Stringer JL, Peppas NA. Diffusion of small molecular weight drugs in radiation-crosslinked poly(ethylene oxide) hydrogels. J Controlled Release 1996;42:195-202.
14. Bromberg L. Crosslinked poly(ethylene glycol) networks as reservoirs for protein delivery. J Appl Polym Sci 1996;59:459-466.
15. Zhao X, Harris JM. Novel degradable poly(ethylene glycol) hydrogels for controlled release of protein. J Pharm Sci 1998; 87:1450-1458.
16. Alexandridis P, Hatton TA. Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: Thermodynamics, structure, dynamics, and modeling. Coll Surfaces 1995;96:1-46.
17. Bromberg LE, Ron ES. Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery. Adv Drug Del Rev 1998;31:197-221.
18. Chen GH, Hoffman AS. Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH. Nature 1995;373:49-52.
19. Jeong B, Bae YH, Lee DS, Kim SW. Biodegradable block copolymers as injectable drug-delivery systems. Nature 1997;388: 860-862.
20. Jeong B, Bae YH, Kim SW. Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J Controlled Release 2000;63:155-163.
21. de Jong SJ, De Smedt SC, Wahls MWC, Demeester J, Kettenesvan den Bosch JJ, Hennink WE. Novel self-assembled hydrogels by stereocomplex formation in aqueous solution of enantiomeric lactic acid oligomers grafted to dextran. Macromolecules 2000;33:3680-3686.
22. de Jong SJ, De Smedt SC, Demeester J, van Nostrum CF, Kettenesvan den Bosch JJ, Hennink WE. Biodegradable hydrogels based on stereocomplex formation between lactic acid oligomers grafted to dextran. J Controlled Release 2001;72:47-56.
23. Petka WA, Harden JL, McGrath KP, Wirtz D, Tirrell DA, Reversible hydrogels from self-assembling artificial proteins. Science 1998:281:389-392.
24. Wang C, Stewart RJ, Kopecek J. Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains. Nature 1999;397:417-420.
25. Szeitli J. Cyclodextrins and their inclusion complexes. Buda pest: Akademiai Kiado; 1982.
26. Wenz G. Cyclodextrins as building-blocks for supramolecular structures and functional units. Angew Chem Int Ed Engl 1994;33:803-822.
27. Szejtli J. Introduction and general overview of cyclodextrin chemistry. Chem Rev 1998;98:1743-1754.
28. Harada A, Li J, Kamachi M. The molecular necklace: A rotaxane containing many α-cyclodextrins. Nature 1992;356:325-327.
29. Harada A, Li J, Kamachi M. Double stranded inclusion complexes of cyclodextrin threaded on poly(ethylene glycol). Nature 1994;370:126-128.
30. Li J, Li X, Toh KC, Ni X, Zhou Z, Leong KW. Inclusion complexation and formation of polypseudorotaxanes between poly[(ethylene oxide)-ran-(propylene oxide)] and cyclodextrins. Macromolecules 2001;34:8829-8831.
31. Li J, Harada A, Kamachi M. Sol-gel transition during complex formation between α-cyclodextrin and high molecular weight poly(ethylene glycol)s in aqueous solution. Polym J 1994;26: 1019-1026.
32. Takeo K, Kuge T. Complexes of stachy materials with organic compounds. V. X-ray diffraction of α-cyclodextrin complexes. Agric Biol Chem 1970;34:1787-1794.
33. Li J, Li X, Zhou Z, Ni X, Leong KW. Formation of supramolecular hydrogels induced by inclusion complexation between pluronics and cyclodextrin. Macromolecules 2001;34:72367237.