Stimulation of bone regeneration following the controlled release of water-insoluble oxysterol from biodegradable hydrogel

Biomaterials

Volumn 35, Issue 21, 2014, Pages 5565-5571

  Hokugo, Akishige ^a   Saito, Takashi ^b   Li, Andrew ^a   Sato, Keisuke ^b   Tabata, Yasuhiko ^b   Jarrahy, Reza ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Bone regeneration; Controlled release; Gelatin hydrogel; Hydroxycholesterol; Oxysterol; Water insoluble drug

Indexed keywords

BIOMATERIALS; BONE; GRAFTING (CHEMICAL); OPTIMIZATION; REPAIR; SCAFFOLDS (BIOLOGY);

BONE REGENERATION; CONTROLLED RELEASE; GELATIN HYDROGELS; HYDROXYCHOLESTEROL; OXYSTEROLS; WATER-INSOLUBLE DRUG;

HYDROGELS;

BONE MORPHOGENETIC PROTEIN; BONE PROSTHESIS; DELAYED RELEASE FORMULATION; GELATIN; HYDROGEL; LACTIC ACID; MICELLE; POLYMER; WATER;

ANIMAL; BONE PROSTHESIS; BONE REGENERATION; CELL CULTURE; CHEMISTRY; DELAYED RELEASE FORMULATION; DISEASE MODEL; DRUG DELIVERY SYSTEM; DRUG EFFECTS; GENETICS; HYDROGEL; METABOLISM; MICELLE; MOUSE; PHARMACOLOGY; PROCEDURES; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; BONE SUBSTITUTES; CELLS, CULTURED; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; GELATIN; HYDROGEL; LACTIC ACID; MICE; MICELLES; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; WATER;

EID: 84899475617     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.03.018     Document Type: Article

References (19)

1. Conway J.D. Autograft and nonunions: morbidity with intramedullary bone graft versus iliac crest bone graft. Orthop Clin North Am 2010, 41:75-84.
2. Garrett M.P., Kakarla U.K., Porter R.W., Sonntag V.K. Formation of painful seroma and edema after the use of recombinant human bone morphogenetic protein-2 in posterolateral lumbar spine fusions. Neurosurgery 2010, 66:1044-1049. discussion 9.
3. Shah M.M., Smyth M.D., Woo A.S. Adverse facial edema associated with off-label use of recombinant human bone morphogenetic protein-2 in cranial reconstruction for craniosynostosis. Case report. JNeurosurg Pediatr 2008, 1:255-257.
4. Bjorkhem I., Meaney S., Diczfalusy U. Oxysterols in human circulation: which role do they have?. Curr Opin Lipidol 2002, 13:247-253.
5. Kha H.T., Basseri B., Shouhed D., Richardson J., Tetradis S., Hahn T.J., et al. Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat. JBone Min Res 2004, 19:830-840.
6. Hokugo A., Sorice S., Yalom A., Lee J.C., Li A., Zuk P., et al. Invitro study of a novel oxysterol for osteogenic differentiation on rabbit bone marrow stromal cells. Plast Reconstr Surg 2013, 132:70-80e.
7. Johnson J.S., Meliton V., Kim W.K., Lee K.B., Wang J.C., Nguyen K., et al. Novel oxysterols have pro-osteogenic and anti-adipogenic effects invitro and induce spinal fusion invivo. JCell Biochem 2011, 112:1673-1684.
8. Hokugo A., Sorice S., Parhami F., Yalom A., Li A., Zuk P., et al. Anovel oxysterol promotes bone regeneration in rabbit cranial bone defects. JTissue Eng Regen Med 2013, [in press].
9. Bradford M.M. Arapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
10. Saito T., Tabata Y. Preparation of gelatin hydrogels incorporating low-molecular-weight heparin for anti-fibrotic therapy. Acta Biomater 2012, 8:646-652.
11. Tanigo T., Takaoka R., Tabata Y. Sustained release of water-insoluble simvastatin from biodegradable hydrogel augments bone regeneration. JControl Release 2010, 143:201-206.
12. Savic R., Eisenberg A., Maysinger D. Block copolymer micelles as delivery vehicles of hydrophobic drugs: micelle-cell interactions. JDrug Target 2006, 14:343-355.
13. Shi B., Fang C., You M.X., Zhang Y., Fu S.K., Pei Y.Y. Stealth MePEG-PCL micelles: effects of polymer composition on micelle physicochemical characteristics, invitro drug release, invivo pharmacokinetics in rats and biodistribution in S-180 tumor bearing mice. Colloid Polym Sci 2005, 283:954-967.
14. Gonzalez-Lopez J., Sandez-Macho I., Concheiro A., Alvarez-Lorenzo C. Poloxamines and poloxamers as polymeric micellar carriers for simvastatin: interactions at the air-water interface and in bulk solution. JPhys Chem C 2010, 114:1181-1189.
15. Tabata Y. Biomaterial technology for tissue engineering applications. JRoyal Soc Interface 2009, 6:S311-S324.
16. Tanaka A., Hasegawa T., Morimoto K., Bao W., Yu J., Okita Y., et al. Controlled release of ascorbic acid from gelatin hydrogel attenuates abdominal aortic aneurysm formation in rat experimental abdominal aortic aneurysm model. JVasc Surg 2013.
17. Wang J., Tauchi Y., Deguchi Y., Morimoto K., Tabata Y., Ikada Y. Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H.pylori. Drug Deliv 2000, 7:237-243.
18. Gosain A.K., Santoro T.D., Song L.S., Capel C.C., Sudhakar P.V., Matloub H.S. Osteogenesis in calvarial defects: contribution of the dura, the pericranium, and the surrounding bone in adult versus infant animals. Plast Reconstr Surg 2003, 112:515-527.
19. Takagi K., Urist M.R. The reaction of the dura to bone morphogenetic protein (BMP) in repair of skull defects. Ann Surg 1982, 196:100-109.