Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves

Acta Biomaterialia

Volumn 7, Issue 6, 2011, Pages 2467-2476

  Durst, Christopher A ^a   Cuchiara, Michael P ^a   Mansfield, Elizabeth G ^a   West, Jennifer L ^a   Grande Allen, K Jane ^a  

^a Rice University   (United States)

Author keywords

Flexure and bending mechanics; Heparin; Hydrogel; Polyethylene glycol diacrylate; Tissue engineered heart valve

Indexed keywords

BENDING TESTS; BIOMECHANICS; CELLS; CYTOLOGY; DEFORMATION; HEART; MESH GENERATION; POLYETHYLENE GLYCOLS; POLYSACCHARIDES; SCAFFOLDS (BIOLOGY); STIFFNESS; TISSUE;

'CURRENT; BENDING MECHANICS; DIACRYLATES; FLEXURAL STIFFNESS; FLEXURE AND BENDING MECHANIC; HEART VALVES; POLY (ETHYLENE GLYCOL) DIACRYLATES; TISSUE ENGINEERED HEART VALVE; TISSUE-ENGINEERED HEART; VALVE REPLACEMENT;

HYDROGELS;

HEPARIN; POLY(ETHYLENE GLYCOL) DIACRYLATE; TISSUE SCAFFOLD; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ENCAPSULATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; HEART VALVE; HYDROGEL; IMMUNOFLUORESCENCE; IN VITRO STUDY; MOLECULAR WEIGHT; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; TISSUE ENGINEERING;

EID: 79955573479     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2011.02.018     Document Type: Article

References (39)

1. Stock UA, Mayer Jr JE. Tissue engineering of cardiac valves on the basis of PGA/ PLA co-polymers. J Long Term Effect Med Implants 2001;11:249-60. (Pubitemid 34211358)
2. Engelmayr Jr GC, Rabkin E, Sutherland FW, Schoen FJ, Mayer Jr JE, Sacks MS. The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue. Biomaterials 2005;26:175-87. (Pubitemid 38789100)
3. Sodian R, Hoerstrup SP, Sperling JS, Martin DP, Daebritz S, Mayer Jr JE, et al. Evaluation of biodegradable, three-dimensional matrices for tissue engineering of heart valves. Asaio J 2000;46:107-10. (Pubitemid 30062655)
4. Sodian R, Hoerstrup SP, Sperling JS, Daebritz S, Martin DP, Moran AM, et al. Early in vivo experience with tissue-engineered trileaflet heart valves. Circulation 2000;102:III22-9.
5. Mol A, Bouten CV, Baaijens FP, Zund G, Turina MI, Hoerstrup SP. Review article: tissue engineering of semilunar heart valves: current status and future developments. J Heart Valve Dis 2004;13:272-80.
6. Mol A, Rutten MC, Driessen NJ, Bouten CV, Zund G, Baaijens FP, et al. Autologous human tissue-engineered heart valves: prospects for systemic application. Circulation 2006;114:I152-8.
7. Engelmayr Jr GC, Hildebrand DK, Sutherland FW, Mayer Jr JE, Sacks MS. A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials. Biomaterials 2003;24:2523-32. (Pubitemid 36410329)
8. Nemir S, Hayenga HN, West JL. PEGDA hydrogels with patterned elasticity: novel tools for the study of cell response to substrate rigidity. Biotechnol Bioeng 2010;105:636-44.
9. Hahn MS, Miller JS, West JL. Three-dimensional biochemical and biomechanical patterning of hydrogels for guiding cell behavior. Adv Mater 2006;18:2679-84. (Pubitemid 44664101)
10. Lee SH, Moon JJ, Miller JS, West JL. Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration. Biomaterials 2007;28: 3163-70. (Pubitemid 46602516)
11. Hoerstrup SP, Sodian R, Daebritz S, Wang J, Bacha EA, Martin DP, et al. Functional living trileaflet heart valves grown in vitro. Circulation 2000;102:III44-9.
12. Burg KJ, Holder Jr WD, Culberson CR, Beiler RJ, Greene KG, Loebsack AB, et al. Comparative study of seeding methods for three-dimensional polymeric scaffolds. J Biomed Mater Res 2000;51:642-9. (Pubitemid 30450723)
13. Mol A, van Lieshout MI, Dam-de Veen CG, Neuenschwander S, Hoerstrup SP, Baaijens FP, et al. Fibrin as a cell carrier in cardiovascular tissue engineering applications. Biomaterials 2005;26:3113-21. (Pubitemid 39647246)
14. Benton JA, Kern HB, Anseth KS. Substrate properties influence calcification in valvular interstitial cell culture. J Heart Valve Dis 2008;17:689-99.
15. Cushing MC, Liao JT, Jaeggli MP, Anseth KS. Material-based regulation of the myofibroblast phenotype. Biomaterials 2007;28:3378-87. (Pubitemid 46735971)
16. Hahn MS, McHale MK, Wang E, Schmedlen RH, West JL. Physiologic pulsatile flow bioreactor conditioning of poly(ethylene glycol)-based tissue engineered vascular grafts. Ann Biomed Eng 2007;35:190-200. (Pubitemid 46122175)
17. Leslie-Barbick JE, Moon JJ, West JL. Covalently-immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly(ethylene glycol) diacrylate hydrogels. J Biomater Sci 2009;20:1763-79.
18. Weber LM, Anseth KS. Hydrogel encapsulation environments functionalized with extracellular matrix interactions increase islet insulin secretion. Matrix Biol 2008;27:667-73.
19. Peyton SR, Raub CB, Keschrumrus VP, Putnam AJ. The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells. Biomaterials 2006;27:4881-93. (Pubitemid 43866921)
20. Benoit DS, Durney AR, Anseth KS. The effect of heparin-functionalized PEG hydrogels on three-dimensional human mesenchymal stem cell osteogenic differentiation. Biomaterials 2007;28:66-77. (Pubitemid 44427907)
21. Temenoff JS, Athanasiou KA, LeBaron RG, Mikos AG. Effect of poly(ethylene glycol) molecular weight on tensile and swelling properties of oligo(poly(ethylene glycol) fumarate) hydrogels for cartilage tissue engineering. J Biomed Mater Res 2002;59:429-37. (Pubitemid 34037486)
22. Cuchiara MP, Allen AC, Chen TM, Miller JS, West JL. Multilayer microfluidic PEGDA hydrogels. Biomaterials 2010;31:5491-7.
23. Cloyd JM, Malhotra NR, Weng L, Chen W, Mauck RL, Elliott DM. Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds. Eur Spine J 2007;16:1892-8. (Pubitemid 350105326)
24. Stephens EH, Chu CK, Grande-Allen KJ. Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical load and age: relevance to an age-specific tissue-engineered heart valve. Acta Biomater 2008;4:1148-60.
25. Mirnajafi A, Raymer J, Scott MJ, Sacks MS. The effects of collagen fiber orientation on the flexural properties of pericardial heterograft biomaterials. Biomaterials 2005;26:795-804. (Pubitemid 39179964)
26. Bryant SJ, Chowdhury TT, Lee DA, Bader DL, Anseth KS. Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng 2004;32:407-17.
27. Almany L, Seliktar D. Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures. Biomaterials 2005;26:2467-77. (Pubitemid 39600699)
28. Smeds KA, Grinstaff MW. Photocrosslinkable polysaccharides for in situ hydrogel formation (vol. 54, p. 115, 2000). J Biomed Mat Res 2001;55:254-5.
29. Gloeckner DC, Billiar KL, Sacks MS. Effects of mechanical fatigue on the bending properties of the porcine bioprosthetic heart valve. Asaio J 1999;45:59-63. (Pubitemid 30428363)
30. Messier Jr RH, Bass BL, Aly HM, Jones JL, Domkowski PW, Wallace RB, et al. Dual structural and functional phenotypes of the porcine aortic valve interstitial population: characteristics of the leaflet myofibroblast. J Surg Res 1994;57:1-21. (Pubitemid 24243231)
31. Cruise GM, Scharp DS, Hubbell JA. Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels. Biomaterials 1998;19:1287-94. (Pubitemid 28391475)
32. Benton JA, Deforest CA, Vivekanandan V, Anseth KS. Photocrosslinking of gelatin macromers to synthesize porous hydrogels that promote valvular interstitial cell function. Tissue Eng Part A 2009;15:3221-30.
33. Masters KS, Shah DN, Leinwand LA, Anseth KS. Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells. Biomaterials 2005;26:2517-25. (Pubitemid 39600704)
34. Benton JA, Fairbanks BD, Anseth KS. Characterization of valvular interstitial cell function in three dimensional matrix metalloproteinase degradable PEG hydrogels. Biomaterials 2009;30:6593-603.
35. Thubrikar MJ. The aortic valve. Boca Raton, FL: CRC Press; 1990.
36. Merryman WD, Huang HY, Schoen FJ, Sacks MS. The effects of cellular contraction on aortic valve leaflet flexural stiffness. J Biomech 2006;39:88-96. (Pubitemid 41585012)
37. Jossang T, Feder J, Rosenqvist E. Photon correlation spectroscopy of human IgG. J Protein Chem 1988;7:165-71.
38. Beamish JA, Zhu J, Kottke-Marchant K, Marchant RE. The effects of monoacrylated poly(ethylene glycol) on the properties of poly(ethylene glycol) diacrylate hydrogels used for tissue engineering. J Biomed Mater Res A 2010;92:441-50.
39. Jones RM. Mechanics of composite materials. New York: Hemisphere! Publishing Corp.; 1975.