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Volumn 10, Issue 6, 2015, Pages 481-489

Inhalation of nanoparticle-based drug for lung cancer treatment: Advantages and challenges

Author keywords

Inhalation; Liposome; Lung cancer; Nanoparticle

Indexed keywords

ANTINEOPLASTIC AGENT; GELATIN; LIPOSOME; NANOPARTICLE;

EID: 84959541739     PISSN: 18180876     EISSN: 2221285X     Source Type: Journal    
DOI: 10.1016/j.ajps.2015.08.009     Document Type: Review
Times cited : (162)

References (73)
  • 1
    • 85009445231 scopus 로고    scopus 로고
    • Cancer Research UK crukorg/cancerstats 2013.
    • (2013)
  • 3
    • 3142592957 scopus 로고    scopus 로고
    • Office of the Surgeon General (US); Office on Smoking and Health (US); Atlanta, GA
    • Centers for Disease Control and Prevention (US) The Health Consequences of Smoking: A Report of the Surgeon General 2004, Office of the Surgeon General (US); Office on Smoking and Health (US); Atlanta, GA.
    • (2004) The Health Consequences of Smoking: A Report of the Surgeon General
  • 4
    • 77956265766 scopus 로고    scopus 로고
    • Small cell lung cancer: past, present, and future
    • Rodriguez E., Lilenbaum R. Small cell lung cancer: past, present, and future. Curr Oncol Rep 2010, 12:327-334.
    • (2010) Curr Oncol Rep , vol.12 , pp. 327-334
    • Rodriguez, E.1    Lilenbaum, R.2
  • 5
    • 78650236850 scopus 로고    scopus 로고
    • Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC
    • Chang A. Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC. Lung Cancer 2011, 71:3-10.
    • (2011) Lung Cancer , vol.71 , pp. 3-10
    • Chang, A.1
  • 6
    • 77954142509 scopus 로고    scopus 로고
    • Radiotherapy in small-cell lung cancer: where should it go?
    • Paumier A., Le Péchoux C. Radiotherapy in small-cell lung cancer: where should it go?. Lung Cancer 2010, 69:133-140.
    • (2010) Lung Cancer , vol.69 , pp. 133-140
    • Paumier, A.1    Le Péchoux, C.2
  • 7
    • 0346238665 scopus 로고    scopus 로고
    • Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer
    • Arriagada R., Bergman B., Dunant A., et al. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. NEJM 2004, 350:351-360.
    • (2004) NEJM , vol.350 , pp. 351-360
    • Arriagada, R.1    Bergman, B.2    Dunant, A.3
  • 8
    • 17344384668 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer
    • Sandler A.B., Nemunaitis J., Denham C., et al. Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2000, 18:122.
    • (2000) J Clin Oncol , vol.18 , pp. 122
    • Sandler, A.B.1    Nemunaitis, J.2    Denham, C.3
  • 9
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • Schiller J.H., Harrington D., Belani C.P., et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. NEJM 2002, 346:92-98.
    • (2002) NEJM , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3
  • 10
    • 0031861215 scopus 로고    scopus 로고
    • Randomized trial comparing cisplatin with cisplatin plus vinorelbine in the treatment of advanced non-small-cell lung cancer: a Southwest Oncology Group study
    • Wozniak A.J., Crowley J.J., Balcerzak S.P., et al. Randomized trial comparing cisplatin with cisplatin plus vinorelbine in the treatment of advanced non-small-cell lung cancer: a Southwest Oncology Group study. J Clin Oncol 1998, 16:2459-2465.
    • (1998) J Clin Oncol , vol.16 , pp. 2459-2465
    • Wozniak, A.J.1    Crowley, J.J.2    Balcerzak, S.P.3
  • 11
    • 13844270526 scopus 로고    scopus 로고
    • Preparation of in vivo cleavable agglomerated liposomes suitable for modulated pulmonary drug delivery
    • Karathanasis E., Ayyagari A.L., Bhavane R., et al. Preparation of in vivo cleavable agglomerated liposomes suitable for modulated pulmonary drug delivery. J Control Release 2005, 103:159-175.
    • (2005) J Control Release , vol.103 , pp. 159-175
    • Karathanasis, E.1    Ayyagari, A.L.2    Bhavane, R.3
  • 13
    • 84881377924 scopus 로고    scopus 로고
    • Pulmonary drug delivery: from generating aerosols to overcoming biological barriers - therapeutic possibilities and technological challenges
    • Ruge C.A., Kirch J., Lehr C.M. Pulmonary drug delivery: from generating aerosols to overcoming biological barriers - therapeutic possibilities and technological challenges. Lancet Respir Med 2013, 1:402-413.
    • (2013) Lancet Respir Med , vol.1 , pp. 402-413
    • Ruge, C.A.1    Kirch, J.2    Lehr, C.M.3
  • 15
  • 17
    • 39849093893 scopus 로고    scopus 로고
    • The effect of core composition in biodegradable oligomeric micelles as taxane formulations
    • Carstens M.G., de Jong P.H.J.L.F., van Nostrum C.F., et al. The effect of core composition in biodegradable oligomeric micelles as taxane formulations. Eur J Pharm Biopharm 2008, 68:596-606.
    • (2008) Eur J Pharm Biopharm , vol.68 , pp. 596-606
    • Carstens, M.G.1    de Jong, P.H.J.L.F.2    van Nostrum, C.F.3
  • 20
    • 34648825412 scopus 로고    scopus 로고
    • Encapsulation of gemcitabine lipophilic derivatives into polycyanoacrylate nanospheres and nanocapsules
    • Stella B., Arpicco S., Rocco F., et al. Encapsulation of gemcitabine lipophilic derivatives into polycyanoacrylate nanospheres and nanocapsules. Int J Pharmaceut 2007, 344:71-77.
    • (2007) Int J Pharmaceut , vol.344 , pp. 71-77
    • Stella, B.1    Arpicco, S.2    Rocco, F.3
  • 22
    • 23144465464 scopus 로고    scopus 로고
    • Solubility enhancement of cox-2 inhibitors using various solvent systems
    • Seedher N., Bhatia S. Solubility enhancement of cox-2 inhibitors using various solvent systems. Aaps Pharmscitech 2003, 4:36-44.
    • (2003) Aaps Pharmscitech , vol.4 , pp. 36-44
    • Seedher, N.1    Bhatia, S.2
  • 23
    • 22244488749 scopus 로고    scopus 로고
    • Oral delivery of peptide drugs: barriers and developments
    • Hamman J.H., Enslin G.M., Kotze A.F. Oral delivery of peptide drugs: barriers and developments. Biodrugs 2005, 19:165-177.
    • (2005) Biodrugs , vol.19 , pp. 165-177
    • Hamman, J.H.1    Enslin, G.M.2    Kotze, A.F.3
  • 25
    • 66849097677 scopus 로고    scopus 로고
    • Mucus, phlegm, and sputum in cystic fibrosis
    • Rubin B.K. Mucus, phlegm, and sputum in cystic fibrosis. Respir Care 2009, 54:726-732.
    • (2009) Respir Care , vol.54 , pp. 726-732
    • Rubin, B.K.1
  • 26
    • 84864130324 scopus 로고    scopus 로고
    • Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery
    • Ensign L.M., Schneider C., Suk J.S., et al. Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery. Adv Mater 2012, 24:3887-3894.
    • (2012) Adv Mater , vol.24 , pp. 3887-3894
    • Ensign, L.M.1    Schneider, C.2    Suk, J.S.3
  • 27
    • 0028858935 scopus 로고
    • Macromolecular mechanisms of sputum inhibition of tobramycin activity
    • Hunt B.E., Weber A., Berger A., et al. Macromolecular mechanisms of sputum inhibition of tobramycin activity. Antimicrob Agents Chemother 1995, 39:34-39.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 34-39
    • Hunt, B.E.1    Weber, A.2    Berger, A.3
  • 28
    • 60149089459 scopus 로고    scopus 로고
    • Barrier properties of mucus
    • Cone R.A. Barrier properties of mucus. Adv Drug Deliv Rev 2009, 61:75-85.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 75-85
    • Cone, R.A.1
  • 29
  • 30
    • 84908261253 scopus 로고    scopus 로고
    • Improving the efficacy of inhaled drugs in cystic fibrosis: challenges and emerging drug delivery strategies
    • d'Angelo I., Conte C., La Rotonda M.I., et al. Improving the efficacy of inhaled drugs in cystic fibrosis: challenges and emerging drug delivery strategies. Adv Drug Deliv Rev 2014, 75:92-111.
    • (2014) Adv Drug Deliv Rev , vol.75 , pp. 92-111
    • d'Angelo, I.1    Conte, C.2    La Rotonda, M.I.3
  • 31
    • 26944439522 scopus 로고    scopus 로고
    • The lungs as a portal of entry for systemic drug delivery
    • Patton J.S., Fishburn C.S., Weers J.G. The lungs as a portal of entry for systemic drug delivery. Proc Am Thorac Soc 2004, 1:338-344.
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 338-344
    • Patton, J.S.1    Fishburn, C.S.2    Weers, J.G.3
  • 32
    • 0017574136 scopus 로고
    • Lung pH and pulmonary absorption of nonvolatile drugs in the rat
    • Schanker L.S., Less M.J. Lung pH and pulmonary absorption of nonvolatile drugs in the rat. Drug Metabol Dispos 1977, 5:174-178.
    • (1977) Drug Metabol Dispos , vol.5 , pp. 174-178
    • Schanker, L.S.1    Less, M.J.2
  • 33
    • 66449095059 scopus 로고    scopus 로고
    • Current advances in research and clinical applications of PLGA-based nanotechnology
    • Lü J.-M., Wang X., Marin-Muller C., et al. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn 2009, 9:325-341.
    • (2009) Expert Rev Mol Diagn , vol.9 , pp. 325-341
    • Lü, J.-M.1    Wang, X.2    Marin-Muller, C.3
  • 34
    • 33748498232 scopus 로고    scopus 로고
    • Pros and cons of the liposome platform in cancer drug targeting
    • Gabizon A.A., Shmeeda H., Zalipsky S. Pros and cons of the liposome platform in cancer drug targeting. J Liposome Res 2006, 16:175-183.
    • (2006) J Liposome Res , vol.16 , pp. 175-183
    • Gabizon, A.A.1    Shmeeda, H.2    Zalipsky, S.3
  • 35
    • 71049139855 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: a modern formulation approach in drug delivery system
    • Mukherjee S., Ray S., Thakur R.S. Solid lipid nanoparticles: a modern formulation approach in drug delivery system. Indian J Pharm Sci 2009, 71:349-358.
    • (2009) Indian J Pharm Sci , vol.71 , pp. 349-358
    • Mukherjee, S.1    Ray, S.2    Thakur, R.S.3
  • 36
    • 79952763932 scopus 로고    scopus 로고
    • Aerosol drug delivery: developments in device design and clinical use
    • Dolovich M.B., Dhand R. Aerosol drug delivery: developments in device design and clinical use. Lancet 2011;377:1032-1045.
    • (2011) Lancet , vol.377 , pp. 1032-1045
    • Dolovich, M.B.1    Dhand, R.2
  • 37
    • 84929726759 scopus 로고    scopus 로고
    • Nebulization as a delivery method for mAbs in respiratory diseases
    • Respaud R., Vecellio L., Diot P., et al. Nebulization as a delivery method for mAbs in respiratory diseases. Expert Opin Drug Deliv 2015, 12:1027-1039.
    • (2015) Expert Opin Drug Deliv , vol.12 , pp. 1027-1039
    • Respaud, R.1    Vecellio, L.2    Diot, P.3
  • 38
    • 38449089896 scopus 로고    scopus 로고
    • Use of respimat(®) soft Mist™ inhaler in COPD patients
    • Anderson P. Use of respimat(®) soft Mist™ inhaler in COPD patients. Int J Chronic Obstruct Pulmon Dis 2006, 1:251-259.
    • (2006) Int J Chronic Obstruct Pulmon Dis , vol.1 , pp. 251-259
    • Anderson, P.1
  • 39
    • 84904597808 scopus 로고    scopus 로고
    • Recent advances in curcumin nanoformulation for cancer therapy
    • Lee W.-H., Loo C.-Y., Young P.M., et al. Recent advances in curcumin nanoformulation for cancer therapy. Expert Opin Drug Deliv 2014, 11:1183-1201.
    • (2014) Expert Opin Drug Deliv , vol.11 , pp. 1183-1201
    • Lee, W.-H.1    Loo, C.-Y.2    Young, P.M.3
  • 40
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: an emerging treatment modality for cancer
    • Davis M.E., Chen Z., Shin D.M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov 2008, 7:771-782.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.2    Shin, D.M.3
  • 41
    • 67349106708 scopus 로고    scopus 로고
    • Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer
    • Tomoda K., Ohkoshi T., Hirota K., et al. Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer. Colloids Surf B Biointerfaces 2009, 71:177-182.
    • (2009) Colloids Surf B Biointerfaces , vol.71 , pp. 177-182
    • Tomoda, K.1    Ohkoshi, T.2    Hirota, K.3
  • 42
    • 33745904988 scopus 로고    scopus 로고
    • Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles
    • Azarmi S., Tao X., Chen H., et al. Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particles. Int J Pharm 2006, 319:155-161.
    • (2006) Int J Pharm , vol.319 , pp. 155-161
    • Azarmi, S.1    Tao, X.2    Chen, H.3
  • 43
    • 84861225755 scopus 로고    scopus 로고
    • Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer
    • Kim I., Byeon H.J., Kim T.H., et al. Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer. Biomaterials 2012, 33:5574-5583.
    • (2012) Biomaterials , vol.33 , pp. 5574-5583
    • Kim, I.1    Byeon, H.J.2    Kim, T.H.3
  • 44
    • 84879093304 scopus 로고    scopus 로고
    • Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer
    • Kim I., Byeon H.J., Kim T.H., et al. Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer. Biomaterials 2013, 34:6444-6453.
    • (2013) Biomaterials , vol.34 , pp. 6444-6453
    • Kim, I.1    Byeon, H.J.2    Kim, T.H.3
  • 45
    • 84912527370 scopus 로고    scopus 로고
    • Synergistic co-delivery of doxorubicin and paclitaxel by porous PLGA microspheres for pulmonary inhalation treatment
    • Feng T., Tian H., Xu C., et al. Synergistic co-delivery of doxorubicin and paclitaxel by porous PLGA microspheres for pulmonary inhalation treatment. Eur J Pharm Biopharm 2014, 88:1086-1093.
    • (2014) Eur J Pharm Biopharm , vol.88 , pp. 1086-1093
    • Feng, T.1    Tian, H.2    Xu, C.3
  • 46
    • 84929759496 scopus 로고    scopus 로고
    • Nano- and micro-based inhaled drug delivery systems for targeting alveolar macrophages
    • Lee W.-H., Loo C.-Y., Traini D., et al. Nano- and micro-based inhaled drug delivery systems for targeting alveolar macrophages. Expert Opin Drug Deliv 2015, 12:1009-1026.
    • (2015) Expert Opin Drug Deliv , vol.12 , pp. 1009-1026
    • Lee, W.-H.1    Loo, C.-Y.2    Traini, D.3
  • 47
    • 0034787791 scopus 로고    scopus 로고
    • Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model
    • Koshkina N.V., Waldrep J.C., Roberts L.E., et al. Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model. Clin Cancer Res 2001, 7:3258-3262.
    • (2001) Clin Cancer Res , vol.7 , pp. 3258-3262
    • Koshkina, N.V.1    Waldrep, J.C.2    Roberts, L.E.3
  • 48
    • 85009465549 scopus 로고    scopus 로고
    • Development of a bone targeted thermosensitive liposomal doxorubicin formulation based on a bisphosphonate modified non-ionic surfactant
    • Song H., Zhang J., Liu X., et al. Development of a bone targeted thermosensitive liposomal doxorubicin formulation based on a bisphosphonate modified non-ionic surfactant. Pharm Dev Technol 2015;15:1-8.
    • (2015) Pharm Dev Technol , vol.15 , pp. 1-8
    • Song, H.1    Zhang, J.2    Liu, X.3
  • 49
    • 84855826986 scopus 로고    scopus 로고
    • Liposomal formulations of Etoposide and Docetaxel for p53 mediated enhanced cytotoxicity in lung cancer cell lines
    • Jinturkar K.A., Anish C., Kumar M.K., et al. Liposomal formulations of Etoposide and Docetaxel for p53 mediated enhanced cytotoxicity in lung cancer cell lines. Biomaterials 2012, 33:2492-2507.
    • (2012) Biomaterials , vol.33 , pp. 2492-2507
    • Jinturkar, K.A.1    Anish, C.2    Kumar, M.K.3
  • 50
    • 1942533024 scopus 로고    scopus 로고
    • Cyclosporin a aerosol improves the anticancer effect of paclitaxel aerosol in mice
    • Koshkina N.V., Golunski E., Roberts L.E., et al. Cyclosporin a aerosol improves the anticancer effect of paclitaxel aerosol in mice. J Aerosol Med 2004, 17:7-14.
    • (2004) J Aerosol Med , vol.17 , pp. 7-14
    • Koshkina, N.V.1    Golunski, E.2    Roberts, L.E.3
  • 51
    • 0033911323 scopus 로고    scopus 로고
    • 9-nitrocamptothecin liposome aerosol treatment of melanoma and osteosarcoma lung metastases in mice
    • Koshkina N.V., Kleinerman E.S., Waldrep C., et al. 9-nitrocamptothecin liposome aerosol treatment of melanoma and osteosarcoma lung metastases in mice. Clin Cancer Res 2000, 6:2876-2880.
    • (2000) Clin Cancer Res , vol.6 , pp. 2876-2880
    • Koshkina, N.V.1    Kleinerman, E.S.2    Waldrep, C.3
  • 52
    • 0034502530 scopus 로고    scopus 로고
    • 9-nitrocamptothecin liposome aerosol treatment of human cancer subcutaneous xenografts and pulmonary cancer metastases in mice
    • Knight V., Kleinerman E.S., Waldrep J.C., et al. 9-nitrocamptothecin liposome aerosol treatment of human cancer subcutaneous xenografts and pulmonary cancer metastases in mice. Ann N Y Acad Sci 2000, 922:151-163.
    • (2000) Ann N Y Acad Sci , vol.922 , pp. 151-163
    • Knight, V.1    Kleinerman, E.S.2    Waldrep, J.C.3
  • 53
    • 1842479077 scopus 로고    scopus 로고
    • Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(S)-camptothecin in patients with advanced pulmonary malignancies
    • Verschraegen C.F., Gilbert B.E., Loyer E., et al. Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(S)-camptothecin in patients with advanced pulmonary malignancies. Clin Cancer Res 2004, 10:2319-2326.
    • (2004) Clin Cancer Res , vol.10 , pp. 2319-2326
    • Verschraegen, C.F.1    Gilbert, B.E.2    Loyer, E.3
  • 55
    • 34247897230 scopus 로고    scopus 로고
    • Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung
    • Wittgen B.P.H., Kunst P.W.A., van der Born K., et al. Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung. Clin Cancer Res 2007, 13:2414-2421.
    • (2007) Clin Cancer Res , vol.13 , pp. 2414-2421
    • Wittgen, B.P.H.1    Kunst, P.W.A.2    van der Born, K.3
  • 56
    • 0033795671 scopus 로고    scopus 로고
    • Inhalational interleukin-2 liposomes for pulmonary metastases: a phase I clinical trial
    • Skubitz K.M., Anderson P.M. Inhalational interleukin-2 liposomes for pulmonary metastases: a phase I clinical trial. Anticancer Drugs 2000, 11:555-563.
    • (2000) Anticancer Drugs , vol.11 , pp. 555-563
    • Skubitz, K.M.1    Anderson, P.M.2
  • 57
    • 34247110629 scopus 로고    scopus 로고
    • Gelatin nanoparticles and their biofunctionalization
    • WILEY-VCH Verla GmbH & Co. KGaA, Weinheim, C.S.S.R. Kumar (Ed.)
    • Kommareddy S., Shenoy D.B., Amiji M.M. Gelatin nanoparticles and their biofunctionalization. Nanotechnologies for the life sciences 2005, 330-352. WILEY-VCH Verla GmbH & Co. KGaA, Weinheim. C.S.S.R. Kumar (Ed.).
    • (2005) Nanotechnologies for the life sciences , pp. 330-352
    • Kommareddy, S.1    Shenoy, D.B.2    Amiji, M.M.3
  • 58
    • 84887288919 scopus 로고    scopus 로고
    • Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research
    • Elzoghby A.O. Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research. J Control Release 2013, 172:1075-1091.
    • (2013) J Control Release , vol.172 , pp. 1075-1091
    • Elzoghby, A.O.1
  • 59
    • 79952694703 scopus 로고    scopus 로고
    • Paclitaxel gelatin nanoparticles for intravesical bladder cancer therapy
    • Lu Z., Yeh T.-K., Wang J., et al. Paclitaxel gelatin nanoparticles for intravesical bladder cancer therapy. J Urol 2011, 185:1478-1483.
    • (2011) J Urol , vol.185 , pp. 1478-1483
    • Lu, Z.1    Yeh, T.-K.2    Wang, J.3
  • 60
    • 67349255031 scopus 로고    scopus 로고
    • The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation
    • Tseng C.-L., Su W.-Y., Yen K.-C., et al. The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation. Biomaterials 2009, 30:3476-3485.
    • (2009) Biomaterials , vol.30 , pp. 3476-3485
    • Tseng, C.-L.1    Su, W.-Y.2    Yen, K.-C.3
  • 61
    • 82055208336 scopus 로고    scopus 로고
    • Lung-targeted delivery system of curcumin loaded gelatin microspheres
    • Cao F., Ding B., Sun M., et al. Lung-targeted delivery system of curcumin loaded gelatin microspheres. Drug Deliv 2011, 18:545-554.
    • (2011) Drug Deliv , vol.18 , pp. 545-554
    • Cao, F.1    Ding, B.2    Sun, M.3
  • 62
    • 84875242332 scopus 로고    scopus 로고
    • Anticancer activity of resveratrol-loaded gelatin nanoparticles on NCI-H460 non-small cell lung cancer cells
    • Karthikeyan S., Rajendra Prasad N., Ganamani A., et al. Anticancer activity of resveratrol-loaded gelatin nanoparticles on NCI-H460 non-small cell lung cancer cells. Biomed Prev Nutr 2013, 3:64-73.
    • (2013) Biomed Prev Nutr , vol.3 , pp. 64-73
    • Karthikeyan, S.1    Rajendra Prasad, N.2    Ganamani, A.3
  • 63
    • 0036241251 scopus 로고    scopus 로고
    • Gelatin nanoparticles produced by a simple W/O emulsion as delivery system for methotrexate
    • Cascone M., Lazzeri L., Carmignani C., et al. Gelatin nanoparticles produced by a simple W/O emulsion as delivery system for methotrexate. J Mater Sci Mater Med 2002, 13:523-526.
    • (2002) J Mater Sci Mater Med , vol.13 , pp. 523-526
    • Cascone, M.1    Lazzeri, L.2    Carmignani, C.3
  • 64
    • 34447280627 scopus 로고    scopus 로고
    • Development of gelatin nanoparticles with biotinylated EGF conjugation for lung cancer targeting
    • Tseng C.-L., Wang T.-W., Dong G.-C., et al. Development of gelatin nanoparticles with biotinylated EGF conjugation for lung cancer targeting. Biomaterials 2007, 28:3996-4005.
    • (2007) Biomaterials , vol.28 , pp. 3996-4005
    • Tseng, C.-L.1    Wang, T.-W.2    Dong, G.-C.3
  • 65
    • 42749095149 scopus 로고    scopus 로고
    • Targeting efficiency and biodistribution of biotinylated-EGF-conjugated gelatin nanoparticles administered via aerosol delivery in nude mice with lung cancer
    • Tseng C.-L., Wu S.Y.-H., Wang W.-H., et al. Targeting efficiency and biodistribution of biotinylated-EGF-conjugated gelatin nanoparticles administered via aerosol delivery in nude mice with lung cancer. Biomaterials 2008, 29:3014-3022.
    • (2008) Biomaterials , vol.29 , pp. 3014-3022
    • Tseng, C.-L.1    Wu, S.Y.-H.2    Wang, W.-H.3
  • 66
    • 79951942271 scopus 로고    scopus 로고
    • Inhalable nanoparticles, a non-invasive approach to treat lung cancer in a mouse model
    • Roa W.H., Azarmi S., Al-Hallak M.H.D.K., et al. Inhalable nanoparticles, a non-invasive approach to treat lung cancer in a mouse model. J Control Release 2011, 150:49-55.
    • (2011) J Control Release , vol.150 , pp. 49-55
    • Roa, W.H.1    Azarmi, S.2    Al-Hallak, M.H.D.K.3
  • 67
    • 84861834609 scopus 로고    scopus 로고
    • Distribution of effervescent inhalable nanoparticles after pulmonary delivery: an in vivo study
    • Al-Hallak M.H.D.K., Sarfraz M.K., Azarmi S., et al. Distribution of effervescent inhalable nanoparticles after pulmonary delivery: an in vivo study. Ther Deliv 2012, 3:725-734.
    • (2012) Ther Deliv , vol.3 , pp. 725-734
    • Al-Hallak, M.H.D.K.1    Sarfraz, M.K.2    Azarmi, S.3
  • 68
    • 84897504262 scopus 로고    scopus 로고
    • Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy
    • Kaminskas L.M., McLeod V.M., Ryan G.M., et al. Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy. J Control Release 2014, 183:18-26.
    • (2014) J Control Release , vol.183 , pp. 18-26
    • Kaminskas, L.M.1    McLeod, V.M.2    Ryan, G.M.3
  • 69
    • 84912076277 scopus 로고    scopus 로고
    • Inhalable self-assembled albumin nanoparticles for treating drug-resistant lung cancer
    • Choi S.H., Byeon H.J., Choi J.S., et al. Inhalable self-assembled albumin nanoparticles for treating drug-resistant lung cancer. J Control Release 2015, 197:199-207.
    • (2015) J Control Release , vol.197 , pp. 199-207
    • Choi, S.H.1    Byeon, H.J.2    Choi, J.S.3
  • 70
    • 81255143432 scopus 로고    scopus 로고
    • Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA
    • Taratula O., Garbuzenko O.B., Chen A.M., et al. Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA. J Drug Target 2011, 19:900-914.
    • (2011) J Drug Target , vol.19 , pp. 900-914
    • Taratula, O.1    Garbuzenko, O.B.2    Chen, A.M.3
  • 71
    • 84892675615 scopus 로고    scopus 로고
    • Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA
    • Taratula O., Kuzmov A., Shah M., et al. Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA. J Control Release 2013, 171:349-357.
    • (2013) J Control Release , vol.171 , pp. 349-357
    • Taratula, O.1    Kuzmov, A.2    Shah, M.3
  • 72
    • 77952670687 scopus 로고    scopus 로고
    • Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers
    • Patlolla R.R., Chougule M., Patel A.R., et al. Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. J Control Release 2010, 144:233-241.
    • (2010) J Control Release , vol.144 , pp. 233-241
    • Patlolla, R.R.1    Chougule, M.2    Patel, A.R.3
  • 73
    • 33745026711 scopus 로고    scopus 로고
    • Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles
    • Hitzman C.J., Wattenberg L.W., Wiedmann T.S. Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles. J Pharm Sci 2006, 95:1196-1211.
    • (2006) J Pharm Sci , vol.95 , pp. 1196-1211
    • Hitzman, C.J.1    Wattenberg, L.W.2    Wiedmann, T.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.