9-Nitrocamptothecin liposome aerosol treatment of human cancer subcutaneous xenografts and pulmonary cancer metastases in mice

Annals of the New York Academy of Sciences

Volumn 922, Issue , 2000, Pages 151-163

  Knight, Vernon ^a   Kleinerman, Eugenie S ^b   Waldrep, Clifford ^a,b   Giovanella, Beppino C ^c   Gilbert, Brian E ^a   Koshkina, Nadezhda V ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c St Joseph's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN DERIVATIVE; DILAUROYLPHOSPHATIDYLCHOLINE; LIPOSOME; RUBITECAN;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER GROWTH; COLON CANCER; CONFERENCE PAPER; CONTROLLED STUDY; DRUG FORMULATION; LUNG METASTASIS; MELANOMA; MOUSE; NEBULIZATION; NONHUMAN; OSTEOSARCOMA; TREATMENT OUTCOME; TUMOR XENOGRAFT;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 0034502530     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb07033.x     Document Type: Conference Paper

References (25)

1. Protocols for the treatment of human tumor xenografts with camptothecins
2. Development of invasive tumors in the "nude" mouse after injection of cultured human melanoma cells
3. Pharmacokinetics of the in vivo and in vitro conversion of 9-nitro-20(S)-camptothecin to 9-amino-20(S)-camptothecin in humans, dogs, and mice
4. Efficacy of camptothecin congeners in the treatment of human breast carcinoma xenografts
5. Partial characterization of human leukemia U-937 cell sublines resistant to 9-nitrocamptothecin
6. Cyclosporin A liposome aerosol: Lack of acute toxicity in rats with a high incidence of underlying pneumonitis
7. Tolerance of volunteers to cyclosporine A-dilauroylphosphatidylcholine liposome aerosol
8. Pulmonary delivery of antiviral drugs in liposome aerosols
9. Aerosolized AmBisome treatment of pulmonary Cryptococcus neoformans infection in mice
10. Aerosolized amphotericin B-liposomes for treatment of systemic Candida infections in mice
11. Aerosolized liposomal amphotericin B for treatment of pulmonary and systemic Cryptococcus neoformans infections in mice
12. Anti-cancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice
13. A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies
14. 9-Nitrocamptothecin liposome aerosol treatment of melanoma and osteosarcoma lung metastases in mice
15. Protocols for the treatment of human tumor xenografts with camptothecins
16. Animal models for studying the action of topoisomerase I targeted drugs
17. Distribution of camptothecin after delivery as a liposome aerosol or following intramuscular injection in mice
18. Mechanisms of macromolecule absorption by the lungs
19. Deposition and initial translocation of inhaled particles in small laboratory animals
20. A phase I clinical and pharmacological study of oral 9-nitrocamptothecin, a novel water-insoluble topoisomerase I inhibitor
21. 99mTechnetium as a marker of liposomal deposition and clearance in the human lung
22. 99mtechnetium-labelled beclomethasone dipropionate dilauroylphosphatidylcholine liposome aerosol in normal volunteers
23. Pulmonary uptake of liposomal phosphatidylcholine upon intrathecal administration to rats
24. Feasibility, phase I, and pharmacological study of aerosolized liposomal 9-nitro-20(s)-camptothecin (L9NC) in patients with advanced malignancies in the lungs