Ligand-induced expansion of the S1′ site in the anthrax toxin lethal factor

FEBS Letters

Volumn 589, Issue 24, 2015, Pages 3836-3841

  Maize, Kimberly M ^a   Kurbanov, Elbek K ^a   Johnson, Rodney L ^a   Amin, Elizabeth Ambrose ^a   Finzel, Barry C ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Anthrax; Conformational change; Lethal factor; Ligand induced; Structure based drug design; Zinc hydrolase

Indexed keywords

ANTHRAX TOXIN; HYDROXAMIC ACID DERIVATIVE; BACTERIAL ANTIGEN; BACTERIAL TOXIN; LIGAND; MATRIX METALLOPROTEINASE INHIBITOR; TYROSINE;

ARTICLE; BACILLUS ANTHRACIS; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME CONFORMATION; ENZYME INHIBITION; LETHAL GENE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION;

ANTIGENS, BACTERIAL; BACTERIAL TOXINS; BINDING SITES; LIGANDS; MATRIX METALLOPROTEINASE INHIBITORS; MODELS, MOLECULAR; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 84959528536     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2015.11.005     Document Type: Article

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