Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo

Journal of Neuroscience

Volumn 35, Issue 21, 2015, Pages 8291-8296

  Sivakumaran, Sudhir ^a,b   Cardarelli, Ross A ^c   Maguire, Jamie ^a   Kelley, Matt R ^a   Silayeva, Liliya ^c   Morrow, Danielle H ^a   Mukherjee, Jayanta ^c   Moore, Yvonne E ^a   Mather, Robert J ^c   Duggan, Mark E ^c   Brandon, Nicholas J ^c   Dunlop, John ^c   Zicha, Stephen ^c   Moss, Stephen J ^a,c,d   Deeb, Tarek Z ^c  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Chloride; GABAA; KCC2; Seizures; Slices; VU0463271

Indexed keywords

POTASSIUM CHLORIDE COTRANSPORTER 2; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; [N CYCLOPROPYL N (4 METHYL 2 THIAZOLYL) 2 [(6 PHENYL 3 PYRIDAZINYL)THIO]ACETAMIDE]; COTRANSPORTER; LOOP DIURETIC AGENT; POTASSIUM-CHLORIDE SYMPORTERS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPIKE WAVE; SYNAPTIC INHIBITION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; HEK293 CELL LINE; HUMAN; MEMBRANE POTENTIAL; NEWBORN; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SYNAPTIC TRANSMISSION;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; HEK293 CELLS; HIPPOCAMPUS; HUMANS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM POTASSIUM CHLORIDE SYMPORTER INHIBITORS; SYMPORTERS; SYNAPTIC TRANSMISSION;

EID: 84930268145     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5205-14.2015     Document Type: Article

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