Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal

Epilepsia

Volumn 56, Issue 9, 2015, Pages 1355-1365

  Joshi, Suchitra ^a   Rajasekaran, Karthik ^a   Hawk, Kyle M ^a   Brar, Jasmit ^a   Ross, Brittany M ^a   Tran, Christine A ^a   Chester, Stephen J ^a   Goodkin, Howard P ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Benzodiazepine; FK506; Okadaic acid; Phosphatase

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; DIAZEPAM; LITHIUM; N METHYL DEXTRO ASPARTIC ACID; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PILOCARPINE; POTASSIUM; TACROLIMUS; 4 AMINOBUTYRIC ACID RECEPTOR; AMINO ACID RECEPTOR STIMULATING AGENT; ANTICONVULSIVE AGENT; ENZYME INHIBITOR; IMMUNOSUPPRESSIVE AGENT; N METHYLASPARTIC ACID; PHOSPHATASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DENSITOMETRY; DRUG EFFICACY; DRUG POTENCY; ELECTROENCEPHALOGRAPHY; ENZYME INHIBITION; EPILEPTIC STATE; GRANULE CELL; HIPPOCAMPAL NEURONAL CULTURE; HIPPOCAMPAL SLICE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SLICE CULTURE; SYNAPTIC INHIBITION; VIDEORECORDING; WESTERN BLOTTING; WHOLE CELL PATCH CLAMP; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; HIPPOCAMPUS; IN VITRO STUDY; METABOLISM; NERVE CELL; NEWBORN; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PROTEIN TRANSPORT; SPRAGUE DAWLEY RAT; STATUS EPILEPTICUS;

ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; CELLS, CULTURED; DIAZEPAM; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; IMMUNOSUPPRESSIVE AGENTS; IN VITRO TECHNIQUES; N-METHYLASPARTATE; NEURONS; OKADAIC ACID; ORGAN CULTURE TECHNIQUES; PHOSPHORIC MONOESTER HYDROLASES; PILOCARPINE; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA; STATUS EPILEPTICUS; TACROLIMUS;

EID: 84940957819     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.13098     Document Type: Article

References (39)

1. Goodkin HP, Kapur J,. The impact of diazepam's discovery on the treatment and understanding of status epilepticus. Epilepsia 2009; 50: 2011-2018.
2. A receptors during status epilepticus. J Neurosci 2008; 28: 2527-2538.
3. A receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosci 2005; 25: 7724-7733.
4. A receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J Neurosci 2008; 28: 376-384.
5. A receptor function in CA1 pyramidal neurons. Ann Neurol 1995; 38: 893-900.
6. A receptors. J Neurosci 1997; 17: 7532-7540.
7. Rajasekaran K, Todorovic M, Kapur J,. Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus. Ann Neurol 2012; 72: 91-102.
8. Naylor DE, Liu H, Niquet J, et al., Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus. Neurobiol Dis 2013; 54: 225-238.
9. A receptor trafficking-mediated plasticity of inhibitory synapses. Neuron 2011; 70: 385-409.
10. Kurz JE, Sheets D, Parsons JT, et al., A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus. J Neurochem 2001; 78: 304-315.
11. Kurz JE, Rana A, Parsons JT, et al., Status epilepticus-induced changes in the subcellular distribution and activity of calcineurin in rat forebrain. Neurobiol Dis 2003; 14: 483-493.
12. Marsden KC, Shemesh A, Bayer KU, et al., Selective translocation of Ca2 + /calmodulin protein kinase IIalpha (CaMKIIalpha) to inhibitory synapses. Proc Natl Acad Sci USA 2010; 107: 20559-20564.
13. A receptors. Hybridoma (Larchmt) 2011; 30: 537-542.
14. Goodkin HP, Liu X, Holmes GL,. Diazepam terminates brief but not prolonged seizures in young, naive rats. Epilepsia 2003; 44: 1109-1112.
15. Raol YH, Lapides DA, Keating JG, et al., A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol 2009; 65: 326-336.
16. Ishihara H, Martin BL, Brautigan DL, et al., Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun 1989; 159: 871-877.
17. A receptor function by N-methyl- d -aspartate-mediated calcium influx in isolated CA1 pyramidal cells. Neuroscience 1994; 62: 813-828.
18. A receptor responses by NMDA application in hippocampal neurones acutely isolated from the adult guinea-pig. J Physiol 1995; 482 (Pt 2): 353-362.
19. Walton NY, Treiman DM,. Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. Exp Neurol 1988; 101: 267-275.
20. Jones DM, Esmaeil N, Maren S, et al., Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. Epilepsy Res 2002; 50: 301-312.
21. Loscher W,. Molecular mechanisms of drug resistance in status epilepticus. Epilepsia 2009; 50 (Suppl 12): 19-21.
22. Hasson H, Kim M, Moshe SL,. Effective treatments of prolonged status epilepticus in developing rats. Epilepsy Behav 2008; 13: 62-69.
23. Seress L, Ribak CE,. The development of GABAergic neurons in the rat hippocampal formation. An immunocytochemical study. Brain Res Dev Brain Res 1988; 44: 197-209.
24. A-receptor subtypes during postnatal development: an immunohistochemical study. J Neurosci 1994; 14: 5302-5324.
25. Kapur J, Macdonald RL,. Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acid A receptor pharmacological properties. Mol Pharmacol 1999; 55: 444-452.
26. Cohen AS, Lin DD, Coulter DA,. Protracted postnatal development of inhibitory synaptic transmission in rat hippocampal area CA1 neurons. J Neurophysiol 2000; 84: 2465-2476.
27. Shorvon S, Ferlisi M,. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain 2011; 134: 2802-2818.
28. Kowalski RG, Ziai WC, Rees RN, et al., Third-line antiepileptic therapy and outcome in status epilepticus: the impact of vasopressor use and prolonged mechanical ventilation. Crit Care Med 2012; 40: 2677-2684.
29. Hocker SE, Britton JW, Mandrekar JN, et al., Predictors of outcome in refractory status epilepticus. JAMA Neurol 2013; 70: 72-77.
30. Sutter R, Marsch S, Fuhr P, et al., Anesthetic drugs in status epilepticus: risk or rescue? A 6-year cohort study. Neurology 2014; 82: 656-664.
31. Lu YM, Mansuy IM, Kandel ER, et al., Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP. Neuron 2000; 26: 197-205.
32. Wang J, Liu S, Haditsch U, et al., Interaction of calcineurin and type-A GABA receptor γ2 subunits produces long-term depression at CA1 inhibitory synapses. J Neurosci 2003; 23: 826-836.
33. A receptor phosphorylation, activity, and cell-surface stability. J Neurosci 2004; 24: 522-530.
34. A receptor endocytosis in the basolateral amygdala is critical to the reinstatement of fear memory measured by fear-potentiated startle. J Neurosci 2011; 31: 8851-8861.
35. AR diffusion dynamics. Neuron 2009; 62: 670-682.
36. A receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunit. Proc Natl Acad Sci USA 2010; 107: 16679-16684.
37. Sanchez RM, Dai W, Levada RE, et al., AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brain. J Neurosci 2005; 25: 3442-3451.
38. Matsuda S, Koyasu S,. Regulation of MAPK signaling pathways through immunophilin-ligand complex. Curr Top Med Chem 2003; 3: 1358-1367.
39. Sanchez Fernandez I, Abend NS, Agadi S, et al., Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). Seizure 2014; 23: 87-97.