Pediatric super-refractory status epilepticus treated with allopregnanolone

Annals of Neurology

Volumn 76, Issue 6, 2014, Pages 911-915

  Broomall, Eileen ^a   Natale, JoAnne E ^b   Grimason, Michele ^a   Goldstein, Joshua ^a   Smith, Craig M ^a   Chang, Celia ^c   Kanes, Stephen ^d   Rogawski, Michael A ^c   Wainwright, Mark S ^a,e  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Department of Pediatrics ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Sage Therapeutics Inc   (United States)

^e Ann and Robert H Lurie Children's Hospital of Chicago   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANESTHETIC AGENT; CYCLOPHOSPHAMIDE; ETIRACETAM; FELBAMATE; IMMUNOGLOBULIN; KETAMINE; LORAZEPAM; MAGNESIUM; METHYLPREDNISOLONE; MIDAZOLAM; PENTOBARBITAL; PHENOBARBITAL; PHENYTOIN; PROPOFOL; RITUXIMAB; RUFINAMIDE; STEROID; ELTANOLONE;

ADD ON THERAPY; ARTICLE; CASE REPORT; CHILD; CONTINUOUS INFUSION; DRUG DOSE INCREASE; DRUG INFUSION; DRUG MEGADOSE; ELECTROENCEPHALOGRAPHY; EPILEPSY; EPILEPTIC STATE; FEMALE; HUMAN; IMMUNOTHERAPY; INTRAVENOUS DRUG ADMINISTRATION; KETOGENIC DIET; PLASMAPHERESIS; REHABILITATION CARE; SCHOOL CHILD; SEIZURE; SUPER REFRACTORY STATUS EPILEPTICUS; BLOOD; PRESCHOOL CHILD; STATUS EPILEPTICUS; TREATMENT OUTCOME;

CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; PREGNANOLONE; STATUS EPILEPTICUS; TREATMENT OUTCOME;

EID: 84913596032     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24295     Document Type: Article

References (16)

1. Ferlisi M, Shorvon S. The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy. Brain 2012;135(pt 8):2314-2328.
2. Hocker S, Wijdicks EF, Rabinstein AA. Refractory status epilepticus: new insights in presentation, treatment, and outcome. Neurol Res 2013;35:163-168.
3. Naylor DE, Liu H, Wasterlain CG. Trafficking of GABAA receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosci 2005;25:7724-7733.
4. Reddy DS, Rogawski MA. Neurosteroids-endogenous regulators of seizure susceptibility and role in the treatment of epilepsy. In: Noebels JL, Avoli M, Rogawski MA, et al, eds. Jasper's basic mechanisms of the epilepsies contemporary neurology series 80. New York, NY: Oxford University Press, 2012:984-1002.
5. Kokate TG, Cohen AL, Karp E, et al. Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. Neuropharmacology 1996;35:1049-1056.
6. Rogawski MA, Loya CM, Reddy K, et al. Neuroactive steroids for the treatment of status epilepticus. Epilepsia 2013;54 (suppl 6): 93-98.
7. Brickley SG, Mody I. Extrasynaptic GABA A receptors: their function in the CNS and implications for disease. Neuron 2012;73:23-34.
8. Vaitkevicius H, Ng M, Moura L, et al. Successful allopregnanolone treatment of new onset refractory status epilepticus (NORSE) syndrome: first in man experience. Epilepsia 2013;54(suppl 6):106-124.
9. Timby E, Balgå rd M, Nyberg S, et al. Pharmacokinetic and behavioral effects of allopregnanolone in healthy women. Psychopharmacology (Berl) 2006;186:414-424.
10. Riviello JJ Jr, Claassen J, LaRoche SM, et al. Treatment of status epilepticus: an international survey of experts. Neurocrit Care 2013;18:193-200.
11. Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain 2011;134(pt 10):2802-2818.
12. Kokate TG, Svensson BE, Rogawski MA. Anticonvulsant activity of neurosteroids: correlation with c-aminobutyric acid-evoked chloride current potentiation. J Pharmacol Exp Ther 1994;270:1223-1229.
13. Ginsberg G, Hattis D, Sonawane B, et al. Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature. Toxicol Sci 2002;66:185-200.
14. Bialer M, Johannessen SI, Levy RH, et al. Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI). Epilepsy Res 2013;103:2-30.
15. Kerrigan JF, Shields WD, Nelson TY, et al. Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial. Epilepsy Res 2000;42:133-139.
16. University of California, Davis. Allopregnanolone for the treatment of traumatic brain injury. Available at: http://clinicaltrials.gov/ct2/ show/NCT01673828. Accessed September 3, 2014.