βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function

Genes and Development

Volumn 30, Issue 5, 2016, Pages 502-507

  Arnes, Luis ^a   Akerman, Ildem ^b,c   Balderes, Dina A ^a   Ferrer, Jorge ^b,c   Sussel, Lori ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Long noncoding RNA; Pancreas development; cell

Indexed keywords

BETA CELL LONG INTERGENIC NONCODING RNA 1; LONG UNTRANSLATED RNA; UNCLASSIFIED DRUG; BETALINC1 LONG NONCODING RNA, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOCRINE CELL; GENE DELETION; GENE EXPRESSION; GENOMICS; MOUSE; NONHUMAN; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; CELL LINE; CYTOLOGY; EMBRYOLOGY; ENDOCRINE SYSTEM; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; GLUCOSE INTOLERANCE; HUMAN; METABOLISM; PANCREAS ISLET BETA CELL;

ANIMALS; CELL LINE; ENDOCRINE SYSTEM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKOUT TECHNIQUES; GLUCOSE INTOLERANCE; HUMANS; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; RNA, LONG NONCODING; TRANSCRIPTION FACTORS;

EID: 84959504301     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.273821.115     Document Type: Article

References (25)

1. Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. 2009. Cooperative transcriptional regulationof the essential pancreatic islet gene NeuroD1 (β2) by Nkx2.2 and neurogenin3. J Biol Chem 284: 31236-31248.
2. Arda HE, Benitez CM, Kim SK. 2013. Gene regulatory networks governingpancreas development. Dev Cell 25: 5-13.
3. Arnes L, Sussel L. 2015. Epigenetic modifications and long noncodingRNAs influence pancreas development and function. Trends Genet31: 290-299.
4. Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L. 2012. Ghrelin expressionin the mouse pancreas defines a unique multipotent progenitorpopulation. PLoS One 7: e52026.
5. Batista PJ, Chang HY. 2013. Long noncoding RNAs: cellular address codesin development and disease. Cell 152: 1298-1307.
6. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, et al. 2005. The transcriptionallandscape of the mammalian genome. Science 309: 1559-1563.
7. Caudron-Herger M, Cook PR, Rippe K, Papantonis A. 2015. Dissecting thenascent human transcriptome by analysing the RNA content of transcriptionfactories. Nucleic Acids Res 43: e95.s
8. Clark MB, Johnston RL, Inostroza-Ponta M, Fox AH, Fortini E, Moscato P, Dinger ME, Mattick JS. 2012. Genome-wide analysis of long noncodingRNA stability. Genome Res 22: 885-898.
9. Gu C, Stein GH, Pan N, Goebbels S, Hornberg H, Nave KA, Herrera P, White P, Kaestner KH, Sussel L, et al. 2010. Pancreatic β cells requireNeuroD to achieve and maintain functional maturity. Cell Metab11: 298-310.
10. Jia S, Ivanov A, Blasevic D, Muller T, Purfurst B, SunW, ChenW, Poy MN, Rajewsky N, Birchmeier C. 2015. Insm1 cooperates with Neurod1 andFoxa2 to maintain mature pancreatic β-cell function. EMBO J 34:1417-1433.
11. Khoo C, Yang J, Weinrott SA, Kaestner KH, Naji A, Schug J, Stoffers DA.2012. Research resource: the pdx1 cistrome of pancreatic islets. MolEndocrinol 26: 521-533.
12. KuGM,KimH,VaughnIW,HangauerMJ,MyungOHC,GermanMS McManusMT.2012.Researchresource:RNA-seqrevealsuniquefeaturesofthepancreatic β-cell transcriptome. Mol Endocrinol 26: 1783-1792.
13. Mastracci TL, Lin CS, Sussel L. 2013. Generation of mice encoding a conditionalallele of Nkx2.2. Transgenic Res 22: 965-972.
14. Mattick JS. 2001. Non-coding RNAs: the architects of eukaryotic complexity.EMBO Rep 2: 986-991.
15. Moran I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakic N, Garcia-Hurtado J, Rodriguez-Segui S, et al. 2012. Human βcell transcriptome analysis uncovers lncRNAs that are tissue-specific,dynamically regulated, and abnormally expressed in type 2 diabetes.Cell Metab 16: 435-448.
16. Pan FC, Wright C. 2011. Pancreas organogenesis: from bud to plexus togland. Dev Dyn 240: 530-565.
17. Papantonis A, Kohro T, Baboo S, Larkin JD, Deng B, Short P, Tsutsumi S, Taylor S, Kanki Y, Kobayashi M, et al. 2012. TNFα signals through specializedfactories where responsive coding and miRNA genes are transcribed.EMBO J 31: 4404-4414.
18. Pasquali L, Gaulton KJ, Rodriguez-Segui SA, Mularoni L, Miguel-EscaladaI, Akerman I, Tena JJ, Moran I, Gomez-Marin C, van de Bunt M, et al.2014. Pancreatic islet enhancer clusters enriched in type 2 diabetesrisk-associated variants. Nat Genet 46: 136-143.
19. Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R. 2006. FoxA2, Nkx2.2, and PDX-1 regulate isletβ-cell-specific mafA expression through conserved sequences locatedbetween base pairs-8118 and-7750 upstream from the transcriptionstart site. Mol Cell Biol 26: 5735-5743.
20. Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, et al. 2013. Multipleknockout mouse models reveal lincRNAs are required for life andbrain development. Elife 2: e01749.
21. Schoenfelder S, Sexton T, Chakalova L, Cope NF, Horton A, Andrews S, Kurukuti S, Mitchell JA, Umlauf D, Dimitrova DS, et al. 2010. Preferentialassociations between co-regulated genes reveal a transcriptionalinteractome in erythroid cells. Nat Genet 42: 53-61.
22. Shen Y, Yue F, McCleary DF, Ye Z, Edsall L, Kuan S, Wagner U, Dixon J, Lee L, Lobanenkov VV, et al. 2012. A map of the cis-regulatory sequencesin the mouse genome. Nature 488: 116-120.
23. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS. 1998. Mice lacking the homeodomaintranscription factor Nkx2.2 have diabetes due to arrested differentiationof pancreatic β cells. Development 125: 2213-2221.
24. Vance KW, Sansom SN, Lee S, Chalei V, Kong L, Cooper SE, Oliver PL, Ponting CP. 2014. The long non-coding RNA Paupar regulatesthe expression of both local and distal genes. EMBO J 33: 296-311.
25. Xu Z, Lefevre GM, Gavrilova O, Foster St Claire MB, Riddick G, Felsenfeld G. 2014. Mapping of long-range INS promoter interactions reveals arole for calcium-activated chloride channelANO1 in insulin secretion.Proc Natl Acad Sci 111: 16760-16765.