-
1
-
-
84887942578
-
Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics
-
3843585 24261963
-
Akinleye A, Avvaru P, Furqan M, Song Y, Liu D. Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics. J Hematol Oncol. 2013;6(1):88.
-
(2013)
J Hematol Oncol
, vol.6
, Issue.1
, pp. 88
-
-
Akinleye, A.1
Avvaru, P.2
Furqan, M.3
Song, Y.4
Liu, D.5
-
2
-
-
84876249574
-
MEK and the inhibitors: From bench to bedside
-
3626705 1:CAS:528:DC%2BC3sXmvFejurg%3D 23587417
-
Akinleye A, Furqan M, Mukhi N, Ravella P, Liu D. MEK and the inhibitors: From bench to bedside. J Hematol Oncol. 2013;6(1):27.
-
(2013)
J Hematol Oncol
, vol.6
, Issue.1
, pp. 27
-
-
Akinleye, A.1
Furqan, M.2
Mukhi, N.3
Ravella, P.4
Liu, D.5
-
3
-
-
84889058668
-
STAT inhibitors for cancer therapy
-
4029528 24308725
-
Furqan M, Akinleye A, Mukhi N, Mittal V, Chen Y, Liu D. STAT inhibitors for cancer therapy. J Hematol Oncol. 2013;6(1):90.
-
(2013)
J Hematol Oncol
, vol.6
, Issue.1
, pp. 90
-
-
Furqan, M.1
Akinleye, A.2
Mukhi, N.3
Mittal, V.4
Chen, Y.5
Liu, D.6
-
4
-
-
85064289101
-
Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application
-
3776247 24252238
-
Furqan M, Mukhi N, Lee B, Liu D. Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application. Biomark Res. 2013;1(1):5.
-
(2013)
Biomark Res
, vol.1
, Issue.1
, pp. 5
-
-
Furqan, M.1
Mukhi, N.2
Lee, B.3
Liu, D.4
-
5
-
-
84876953788
-
B-Raf and the inhibitors: From bench to bedside
-
3646677 1:CAS:528:DC%2BC3sXotFWrsLw%3D 23617957
-
Huang T, Karsy M, Zhuge J, Zhong M, Liu D. B-Raf and the inhibitors: From bench to bedside. J Hematol Oncol. 2013;6(1):30.
-
(2013)
J Hematol Oncol
, vol.6
, Issue.1
, pp. 30
-
-
Huang, T.1
Karsy, M.2
Zhuge, J.3
Zhong, M.4
Liu, D.5
-
6
-
-
84875359668
-
Targeting p53 by small molecules in hematological malignancies
-
3614876 1:CAS:528:DC%2BC3sXmsFGmsLY%3D 23531342
-
Saha M, Qiu L, Chang H. Targeting p53 by small molecules in hematological malignancies. J Hematol Oncol. 2013;6(1):23.
-
(2013)
J Hematol Oncol
, vol.6
, Issue.1
, pp. 23
-
-
Saha, M.1
Qiu, L.2
Chang, H.3
-
7
-
-
84896692766
-
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
-
4161365 1:CAS:528:DC%2BC2cXkvVyqtLs%3D 24450857
-
Furman RR, Sharman JP, Coutre SE, Cheson BD, Pagel JM, Hillmen P, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med. 2014;370(11):997-1007.
-
(2014)
N Engl J Med
, vol.370
, Issue.11
, pp. 997-1007
-
-
Furman, R.R.1
Sharman, J.P.2
Coutre, S.E.3
Cheson, B.D.4
Pagel, J.M.5
Hillmen, P.6
-
8
-
-
84894552888
-
Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
-
1:CAS:528:DC%2BC2cXlt1ems74%3D 24401022
-
Goede V, Fischer K, Busch R, Engelke A, Eichhorst B, Wendtner CM, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med. 2014;370(12):1101-10.
-
(2014)
N Engl J Med
, vol.370
, Issue.12
, pp. 1101-1110
-
-
Goede, V.1
Fischer, K.2
Busch, R.3
Engelke, A.4
Eichhorst, B.5
Wendtner, C.M.6
-
9
-
-
84871770952
-
A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
-
3549734 1:CAS:528:DC%2BC3sXitlSmsr0%3D 23286345
-
Mellor J, Brown M, Irving H, Zalcberg J, Dobrovic A. A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer. J Hematol Oncol. 2013;6(1):1.
-
(2013)
J Hematol Oncol
, vol.6
, Issue.1
, pp. 1
-
-
Mellor, J.1
Brown, M.2
Irving, H.3
Zalcberg, J.4
Dobrovic, A.5
-
10
-
-
84908213051
-
New antibody approaches to lymphoma therapy
-
4172963 25355407
-
Suresh T, Lee L, Joshi J, Barta S. New antibody approaches to lymphoma therapy. J Hematol Oncol. 2014;7(1):58.
-
(2014)
J Hematol Oncol
, vol.7
, Issue.1
, pp. 58
-
-
Suresh, T.1
Lee, L.2
Joshi, J.3
Barta, S.4
-
11
-
-
84938574282
-
AFM13: A first-in-class tetravalent bispecific anti-CD30/CD16A antibody for NK cell-mediated immunotherapy
-
4522136 26231785
-
Wu J, Fu J, Zhang M, Liu D. AFM13: A first-in-class tetravalent bispecific anti-CD30/CD16A antibody for NK cell-mediated immunotherapy. J Hematol Oncol. 2015;8:96.
-
(2015)
J Hematol Oncol
, vol.8
, pp. 96
-
-
Wu, J.1
Fu, J.2
Zhang, M.3
Liu, D.4
-
12
-
-
78049515807
-
Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas
-
1:CAS:528:DC%2BC3cXhtl2gsbbE 21047225
-
Younes A, Bartlett NL, Leonard JP, Kennedy DA, Lynch CM, Sievers EL, et al. Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N Engl J Med. 2010;363(19):1812-21.
-
(2010)
N Engl J Med
, vol.363
, Issue.19
, pp. 1812-1821
-
-
Younes, A.1
Bartlett, N.L.2
Leonard, J.P.3
Kennedy, D.A.4
Lynch, C.M.5
Sievers, E.L.6
-
13
-
-
84929505415
-
Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): A randomised, multicentre, open-label phase 3 trial
-
1:CAS:528:DC%2BC2MXmsFSgurc%3D 25882396
-
Hillmen P, Robak T, Janssens A, Babu KG, Kloczko J, Grosicki S, et al. Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): A randomised, multicentre, open-label phase 3 trial. Lancet. 2015;385(9980):1873-83.
-
(2015)
Lancet
, vol.385
, Issue.9980
, pp. 1873-1883
-
-
Hillmen, P.1
Robak, T.2
Janssens, A.3
Babu, K.G.4
Kloczko, J.5
Grosicki, S.6
-
14
-
-
84925221855
-
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
-
4348009 25482239
-
Ansell SM, Lesokhin AM, Borrello I, Halwani A, Scott EC, Gutierrez M, et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med. 2015;372(4):311-9.
-
(2015)
N Engl J Med
, vol.372
, Issue.4
, pp. 311-319
-
-
Ansell, S.M.1
Lesokhin, A.M.2
Borrello, I.3
Halwani, A.4
Scott, E.C.5
Gutierrez, M.6
-
15
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
25891174
-
Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015;372(21):2018-28.
-
(2015)
N Engl J Med
, vol.372
, Issue.21
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
Leighl, N.4
Balmanoukian, A.S.5
Eder, J.P.6
-
16
-
-
84927150740
-
Immune checkpoint blockade in cancer therapy
-
1:CAS:528:DC%2BC2MXhsFKmt7%2FN 25605845
-
Postow MA, Callahan MK, Wolchok JD. Immune checkpoint blockade in cancer therapy. J Clin Oncol. 2015;33(17):1974-82.
-
(2015)
J Clin Oncol
, vol.33
, Issue.17
, pp. 1974-1982
-
-
Postow, M.A.1
Callahan, M.K.2
Wolchok, J.D.3
-
17
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
25891304
-
Postow MA, Chesney J, Pavlick AC, Robert C, Grossmann K, McDermott D, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med. 2015;372(21):2006-17.
-
(2015)
N Engl J Med
, vol.372
, Issue.21
, pp. 2006-2017
-
-
Postow, M.A.1
Chesney, J.2
Pavlick, A.C.3
Robert, C.4
Grossmann, K.5
McDermott, D.6
-
18
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
1:CAS:528:DC%2BC2MXisFGqsLg%3D 25399552
-
Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4):320-30.
-
(2015)
N Engl J Med
, vol.372
, Issue.4
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
Dutriaux, C.4
Maio, M.5
Mortier, L.6
-
19
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
1:CAS:528:DC%2BC2MXhtFyrsbrF 25891173
-
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med. 2015;372(26):2521-32.
-
(2015)
N Engl J Med
, vol.372
, Issue.26
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
Arance, A.4
Grob, J.J.5
Mortier, L.6
-
20
-
-
84884698526
-
The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies
-
3851976 24283718
-
Shi L, Chen S, Yang L, Li Y. The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies. J Hematol Oncol. 2013;6(1):74.
-
(2013)
J Hematol Oncol
, vol.6
, Issue.1
, pp. 74
-
-
Shi, L.1
Chen, S.2
Yang, L.3
Li, Y.4
-
21
-
-
84978025178
-
Ibrutinib for B cell malignancies
-
3913970 24472371
-
Novero A, Ravella P, Chen Y, Dous G, Liu D. Ibrutinib for B cell malignancies. Exp Hematol Oncol. 2014;3(1):4.
-
(2014)
Exp Hematol Oncol
, vol.3
, Issue.1
, pp. 4
-
-
Novero, A.1
Ravella, P.2
Chen, Y.3
Dous, G.4
Liu, D.5
-
22
-
-
84883160397
-
Ibrutinib and novel BTK inhibitors in clinical development
-
3751776 1:CAS:528:DC%2BC3sXhsVagtrjI 23958373
-
Akinleye A, Chen Y, Mukhi N, Song Y, Liu D. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol. 2013;6:59.
-
(2013)
J Hematol Oncol
, vol.6
, pp. 59
-
-
Akinleye, A.1
Chen, Y.2
Mukhi, N.3
Song, Y.4
Liu, D.5
-
23
-
-
84904252369
-
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
-
4134521 24881631
-
Byrd JC, Brown JR, O'Brien S, Barrientos JC, Kay NE, Reddy NM, et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med. 2014;371(3):213-23.
-
(2014)
N Engl J Med
, vol.371
, Issue.3
, pp. 213-223
-
-
Byrd, J.C.1
Brown, J.R.2
O'Brien, S.3
Barrientos, J.C.4
Kay, N.E.5
Reddy, N.M.6
-
24
-
-
84879748062
-
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
-
3772525 1:CAS:528:DC%2BC3sXhtFygu7zN 23782158
-
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum KA, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med. 2013;369(1):32-42.
-
(2013)
N Engl J Med
, vol.369
, Issue.1
, pp. 32-42
-
-
Byrd, J.C.1
Furman, R.R.2
Coutre, S.E.3
Flinn, I.W.4
Burger, J.A.5
Blum, K.A.6
-
25
-
-
84879813079
-
Chimeric antigen receptor-engineered T cells for cancer immunotherapy: Progress and challenges
-
3706354 1:CAS:528:DC%2BC3sXht1ajurvF 23829929
-
Han E, Li X-l, Wang C-r, Li T-f, Han S-Y. Chimeric antigen receptor-engineered T cells for cancer immunotherapy: Progress and challenges. J Hematol Oncol. 2013;6(1):47.
-
(2013)
J Hematol Oncol
, vol.6
, Issue.1
, pp. 47
-
-
Han, E.1
Li, X.-L.2
Wang, C.-R.3
Li, T.-F.4
Han, S.-Y.5
-
26
-
-
84874027123
-
Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
-
23243285
-
Haso W, Lee DW, Shah NN, Stetler-Stevenson M, Yuan CM, Pastan IH, et al. Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood. 2012;121(7):1165-74.
-
(2012)
Blood
, vol.121
, Issue.7
, pp. 1165-1174
-
-
Haso, W.1
Lee, D.W.2
Shah, N.N.3
Stetler-Stevenson, M.4
Yuan, C.M.5
Pastan, I.H.6
-
27
-
-
84969420302
-
Novel chimeric antigen receptor T cells for the treatment of CD19-negative relapses occurring after CD19-targeted immunotherapies
-
Ruella M, Barrett D, Kenderian SS, Shestova O, Hofmann TJ, Scholler J, et al. Novel chimeric antigen receptor T cells for the treatment of CD19-negative relapses occurring after CD19-targeted immunotherapies. Blood. 2014;124(21):966.
-
(2014)
Blood
, vol.124
, Issue.21
, pp. 966
-
-
Ruella, M.1
Barrett, D.2
Kenderian, S.S.3
Shestova, O.4
Hofmann, T.J.5
Scholler, J.6
-
28
-
-
84940096918
-
Chimeric antigen receptor (CAR)-directed adoptive immunotherapy: A new era in targeted cancer therapy
-
1:CAS:528:DC%2BC2cXjtlCrtb4%3D
-
Chen Y, Liu D. Chimeric antigen receptor (CAR)-directed adoptive immunotherapy: A new era in targeted cancer therapy. Stem Cell Investig. 2014;1:2.
-
(2014)
Stem Cell Investig
, vol.1
, pp. 2
-
-
Chen, Y.1
Liu, D.2
-
29
-
-
84877669593
-
The basic principles of chimeric antigen receptor design
-
3667586 1:CAS:528:DC%2BC3sXlvVCit7c%3D 23550147
-
Sadelain M, Brentjens R, Riviere I. The basic principles of chimeric antigen receptor design. Cancer Discov. 2013;3(4):388-98.
-
(2013)
Cancer Discov
, vol.3
, Issue.4
, pp. 388-398
-
-
Sadelain, M.1
Brentjens, R.2
Riviere, I.3
-
30
-
-
84899744468
-
A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells
-
24670809
-
Reusch U, Burkhardt C, Fucek I, Le Gall F, Le Gall M, Hoffmann K, et al. A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells. MAbs. 2014;6(3):728-73.
-
(2014)
MAbs
, vol.6
, Issue.3
, pp. 728-773
-
-
Reusch, U.1
Burkhardt, C.2
Fucek, I.3
Le Gall, F.4
Le Gall, M.5
Hoffmann, K.6
-
31
-
-
84933505755
-
A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma
-
4528081 1:CAS:528:DC%2BC2MXhtlehsLrM 25887777
-
Rothe A, Sasse S, Topp MS, Eichenauer DA, Hummel H, Reiners KS, et al. A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma. Blood. 2015;125(26):4024-31.
-
(2015)
Blood
, vol.125
, Issue.26
, pp. 4024-4031
-
-
Rothe, A.1
Sasse, S.2
Topp, M.S.3
Eichenauer, D.A.4
Hummel, H.5
Reiners, K.S.6
-
32
-
-
84899473907
-
A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies
-
4021825 24731302
-
Breton C, Nahimana A, Aubry D, Macoin J, Moretti P, Bertschinger M, et al. A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies. J Hematol Oncol. 2014;7(1):33.
-
(2014)
J Hematol Oncol
, vol.7
, Issue.1
, pp. 33
-
-
Breton, C.1
Nahimana, A.2
Aubry, D.3
MacOin, J.4
Moretti, P.5
Bertschinger, M.6
-
33
-
-
84938628792
-
Blinatumomab: A bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia
-
4558758 26337639
-
Wu J, Fu J, Zhang M, Liu D. Blinatumomab: A bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia. J Hematol Oncol. 2015;8:104.
-
(2015)
J Hematol Oncol
, vol.8
, pp. 104
-
-
Wu, J.1
Fu, J.2
Zhang, M.3
Liu, D.4
-
34
-
-
0021679848
-
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
-
1:CAS:528:DyaL2MXhvVyjug%3D%3D 6093263
-
Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science. 1984;226(4678):1097-9.
-
(1984)
Science
, vol.226
, Issue.4678
, pp. 1097-1099
-
-
Tsujimoto, Y.1
Finger, L.R.2
Yunis, J.3
Nowell, P.C.4
Croce, C.M.5
-
35
-
-
0033971901
-
Bcl-2 family: Life-or-death switch
-
1:CAS:528:DC%2BD3cXltVCksQ%3D%3D 10648802
-
Tsujimoto Y, Shimizu S. Bcl-2 family: Life-or-death switch. FEBS Lett. 2000;466(1):6-10.
-
(2000)
FEBS Lett
, vol.466
, Issue.1
, pp. 6-10
-
-
Tsujimoto, Y.1
Shimizu, S.2
-
36
-
-
0032418092
-
Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria?
-
1:CAS:528:DyaK1MXhtVChtbk%3D 9990505
-
Tsujimoto Y. Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria? Genes Cells. 1998;3(11):697-707.
-
(1998)
Genes Cells
, vol.3
, Issue.11
, pp. 697-707
-
-
Tsujimoto, Y.1
-
37
-
-
0036006511
-
Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death
-
134234 1:CAS:528:DC%2BD3MXptlOitb0%3D 11739725
-
McClintock DS, Santore MT, Lee VY, Brunelle J, Budinger GR, Zong WX, et al. Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Mol Cell Biol. 2002;22(1):94-104.
-
(2002)
Mol Cell Biol
, vol.22
, Issue.1
, pp. 94-104
-
-
McClintock, D.S.1
Santore, M.T.2
Lee, V.Y.3
Brunelle, J.4
Budinger, G.R.5
Zong, W.X.6
-
38
-
-
0037380884
-
Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria
-
1:CAS:528:DC%2BD3sXisFaisbg%3D 12670894
-
Yamaguchi H, Bhalla K, Wang HG. Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. Cancer Res. 2003;63(7):1483-9.
-
(2003)
Cancer Res
, vol.63
, Issue.7
, pp. 1483-1489
-
-
Yamaguchi, H.1
Bhalla, K.2
Wang, H.G.3
-
39
-
-
0029950290
-
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
-
1:CAS:528:DyaK28XmtlKiu7Y%3D 8879205
-
Susin SA, Zamzami N, Castedo M, Hirsch T, Marchetti P, Macho A, et al. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med. 1996;184(4):1331-41.
-
(1996)
J Exp Med
, vol.184
, Issue.4
, pp. 1331-1341
-
-
Susin, S.A.1
Zamzami, N.2
Castedo, M.3
Hirsch, T.4
Marchetti, P.5
MacHo, A.6
-
40
-
-
0031037897
-
The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
-
1:CAS:528:DyaK2sXhtlKjtro%3D 9027315
-
Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science. 1997;275(5303):1132-6.
-
(1997)
Science
, vol.275
, Issue.5303
, pp. 1132-1136
-
-
Kluck, R.M.1
Bossy-Wetzel, E.2
Green, D.R.3
Newmeyer, D.D.4
-
41
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
1:CAS:528:DyaK2sXhtlKjs70%3D 9027314
-
Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, et al. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science. 1997;275(5303):1129-32.
-
(1997)
Science
, vol.275
, Issue.5303
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.2
Bhalla, K.3
Kim, C.N.4
Ibrado, A.M.5
Cai, J.6
-
42
-
-
0032575688
-
The Bcl-2 protein family: Arbiters of cell survival
-
1:CAS:528:DyaK1cXlvVegsb8%3D 9735050
-
Adams JM, Cory S. The Bcl-2 protein family: Arbiters of cell survival. Science. 1998;281(5381):1322-6.
-
(1998)
Science
, vol.281
, Issue.5381
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
43
-
-
0032146987
-
Bcl-2-family proteins: The role of the BH3 domain in apoptosis
-
1:CAS:528:DyaK1cXltlehurY%3D 9704409
-
Kelekar A, Thompson CB. Bcl-2-family proteins: The role of the BH3 domain in apoptosis. Trends Cell Biol. 1998;8(8):324-30.
-
(1998)
Trends Cell Biol
, vol.8
, Issue.8
, pp. 324-330
-
-
Kelekar, A.1
Thompson, C.B.2
-
44
-
-
0031918223
-
BCL-2 family: Regulators of cell death
-
1:CAS:528:DyaK1cXislyntLs%3D 9597135
-
Chao DT, Korsmeyer SJ. BCL-2 family: Regulators of cell death. Annu Rev Immunol. 1998;16:395-419.
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 395-419
-
-
Chao, D.T.1
Korsmeyer, S.J.2
-
45
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
1:CAS:528:DC%2BD2MXks1Ogtb0%3D 15902208
-
Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 2005;435(7042):677-81.
-
(2005)
Nature
, vol.435
, Issue.7042
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
-
46
-
-
34147142477
-
A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma
-
1:CAS:528:DC%2BD2sXjvVaqsro%3D 17016430
-
Chauhan D, Velankar M, Brahmandam M, Hideshima T, Podar K, Richardson P, et al. A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma. Oncogene. 2007;26(16):2374-80.
-
(2007)
Oncogene
, vol.26
, Issue.16
, pp. 2374-2380
-
-
Chauhan, D.1
Velankar, M.2
Brahmandam, M.3
Hideshima, T.4
Podar, K.5
Richardson, P.6
-
47
-
-
34250770481
-
ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells
-
1:CAS:528:DC%2BD2sXms1Wms74%3D 17460700
-
Kline MP, Rajkumar SV, Timm MM, Kimlinger TK, Haug JL, Lust JA, et al. ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia. 2007;21(7):1549-60.
-
(2007)
Leukemia
, vol.21
, Issue.7
, pp. 1549-1560
-
-
Kline, M.P.1
Rajkumar, S.V.2
Timm, M.M.3
Kimlinger, T.K.4
Haug, J.L.5
Lust, J.A.6
-
48
-
-
33750628289
-
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
-
1:CAS:528:DC%2BD28Xht1Glu7nJ 17097560
-
Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006;10(5):375-88.
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 375-388
-
-
Konopleva, M.1
Contractor, R.2
Tsao, T.3
Samudio, I.4
Ruvolo, P.P.5
Kitada, S.6
-
49
-
-
41349123507
-
BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia
-
Del Gaizo MV, Schlis KD, Sallan SE, Armstrong SA, Letai A. BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. Blood. 2008;111(4):2300-9.
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 2300-2309
-
-
Del Gaizo, M.V.1
Schlis, K.D.2
Sallan, S.E.3
Armstrong, S.A.4
Letai, A.5
-
50
-
-
84856616427
-
Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: In vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737
-
1:CAS:528:DC%2BC38XhvVOqsbw%3D 22138435
-
Ishitsuka K, Kunami N, Katsuya H, Nogami R, Ishikawa C, Yotsumoto F, et al. Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: In vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737. Cancer Lett. 2012;317(2):218-25.
-
(2012)
Cancer Lett
, vol.317
, Issue.2
, pp. 218-225
-
-
Ishitsuka, K.1
Kunami, N.2
Katsuya, H.3
Nogami, R.4
Ishikawa, C.5
Yotsumoto, F.6
-
51
-
-
56649120608
-
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
-
2582212 1:CAS:528:DC%2BD1cXhsVCmu7%2FL 19004807
-
Mason KD, Vandenberg CJ, Scott CL, Wei AH, Cory S, Huang DC, et al. In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas. Proc Natl Acad Sci USA. 2008;105(46):17961-6.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.46
, pp. 17961-17966
-
-
Mason, K.D.1
Vandenberg, C.J.2
Scott, C.L.3
Wei, A.H.4
Cory, S.5
Huang, D.C.6
-
52
-
-
77149178712
-
The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs
-
1:CAS:528:DC%2BC3cXjt1entLs%3D 20038611
-
High LM, Szymanska B, Wilczynska-Kalak U, Barber N, O'Brien R, Khaw SL, et al. The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs. Mol Pharmacol. 2010;77(3):483-94.
-
(2010)
Mol Pharmacol
, vol.77
, Issue.3
, pp. 483-494
-
-
High, L.M.1
Szymanska, B.2
Wilczynska-Kalak, U.3
Barber, N.4
O'Brien, R.5
Khaw, S.L.6
-
53
-
-
34548814971
-
Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
-
1:CAS:528:DC%2BD2sXhtVGjtbbO 17536015
-
Kang MH, Kang YH, Szymanska B, Wilczynska-Kalak U, Sheard MA, Harned TM, et al. Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. Blood. 2007;110(6):2057-66.
-
(2007)
Blood
, vol.110
, Issue.6
, pp. 2057-2066
-
-
Kang, M.H.1
Kang, Y.H.2
Szymanska, B.3
Wilczynska-Kalak, U.4
Sheard, M.A.5
Harned, T.M.6
-
54
-
-
42349109916
-
Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program
-
18085673
-
Lock R, Carol H, Houghton PJ, Morton CL, Kolb EA, Gorlick R, et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008;50(6):1181-9.
-
(2008)
Pediatr Blood Cancer
, vol.50
, Issue.6
, pp. 1181-1189
-
-
Lock, R.1
Carol, H.2
Houghton, P.J.3
Morton, C.L.4
Kolb, E.A.5
Gorlick, R.6
-
55
-
-
55749084366
-
ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
-
1:CAS:528:DC%2BD1cXht1ensb%2FO 18852130
-
Ackler S, Xiao Y, Mitten MJ, Foster K, Oleksijew A, Refici M, et al. ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo. Mol Cancer Ther. 2008;7(10):3265-74.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.10
, pp. 3265-3274
-
-
Ackler, S.1
Xiao, Y.2
Mitten, M.J.3
Foster, K.4
Oleksijew, A.5
Refici, M.6
-
56
-
-
84919686238
-
Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts
-
4154988 1:CAS:528:DC%2BC2cXhsVyku77E 25013123
-
Suryani S, Carol H, Chonghaile TN, Frismantas V, Sarmah C, High L, et al. Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts. Clin Cancer Res. 2014;20(17):4520-31.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.17
, pp. 4520-4531
-
-
Suryani, S.1
Carol, H.2
Chonghaile, T.N.3
Frismantas, V.4
Sarmah, C.5
High, L.6
-
57
-
-
84866978330
-
Navitoclax (ABT-263) and bendamustine +/-rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo
-
3575786 1:CAS:528:DC%2BC38XhsFekurbN 22624727
-
Ackler S, Mitten MJ, Chen J, Clarin J, Foster K, Jin S, et al. Navitoclax (ABT-263) and bendamustine +/-rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012;167(4):881-91.
-
(2012)
Br J Pharmacol
, vol.167
, Issue.4
, pp. 881-891
-
-
Ackler, S.1
Mitten, M.J.2
Chen, J.3
Clarin, J.4
Foster, K.5
Jin, S.6
-
58
-
-
77956225330
-
The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo
-
1:CAS:528:DC%2BC3cXhtVSmt7bE 20099064
-
Ackler S, Mitten MJ, Foster K, Oleksijew A, Refici M, Tahir SK, et al. The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo. Cancer Chemother Pharmacol. 2010;66(5):869-80.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, Issue.5
, pp. 869-880
-
-
Ackler, S.1
Mitten, M.J.2
Foster, K.3
Oleksijew, A.4
Refici, M.5
Tahir, S.K.6
-
59
-
-
78649630259
-
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: A phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
-
3025495 1:CAS:528:DC%2BC3cXhsVyhsLbN 21094089
-
Wilson WH, O'Connor OA, Czuczman MS, LaCasce AS, Gerecitano JF, Leonard JP, et al. Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: A phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. Lancet Oncol. 2010;11(12):1149-59.
-
(2010)
Lancet Oncol
, vol.11
, Issue.12
, pp. 1149-1159
-
-
Wilson, W.H.1
O'Connor, O.A.2
Czuczman, M.S.3
LaCasce, A.S.4
Gerecitano, J.F.5
Leonard, J.P.6
-
60
-
-
84863116430
-
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase I study of navitoclax in patients with relapsed or refractory disease
-
1:CAS:528:DC%2BC38XkvVCitrg%3D 22184378
-
Roberts AW, Seymour JF, Brown JR, Wierda WG, Kipps TJ, Khaw SL, et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol. 2012;30(5):488-96.
-
(2012)
J Clin Oncol
, vol.30
, Issue.5
, pp. 488-496
-
-
Roberts, A.W.1
Seymour, J.F.2
Brown, J.R.3
Wierda, W.G.4
Kipps, T.J.5
Khaw, S.L.6
-
61
-
-
33947223337
-
Bcl-2 family proteins are essential for platelet survival
-
1:CAS:528:DC%2BD2sXktlOitro%3D 17205078
-
Zhang H, Nimmer PM, Tahir SK, Chen J, Fryer RM, Hahn KR, et al. Bcl-2 family proteins are essential for platelet survival. Cell Death Differ. 2007;14(5):943-51.
-
(2007)
Cell Death Differ
, vol.14
, Issue.5
, pp. 943-951
-
-
Zhang, H.1
Nimmer, P.M.2
Tahir, S.K.3
Chen, J.4
Fryer, R.M.5
Hahn, K.R.6
-
62
-
-
33947227522
-
Programmed anuclear cell death delimits platelet life span
-
1:CAS:528:DC%2BD2sXkslGms7Y%3D 17382885
-
Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, et al. Programmed anuclear cell death delimits platelet life span. Cell. 2007;128(6):1173-86.
-
(2007)
Cell
, vol.128
, Issue.6
, pp. 1173-1186
-
-
Mason, K.D.1
Carpinelli, M.R.2
Fletcher, J.I.3
Collinge, J.E.4
Hilton, A.A.5
Ellis, S.6
-
63
-
-
84873540049
-
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
-
1:CAS:528:DC%2BC3sXjslagtQ%3D%3D 23291630
-
Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013;19(2):202-8.
-
(2013)
Nat Med
, vol.19
, Issue.2
, pp. 202-208
-
-
Souers, A.J.1
Leverson, J.D.2
Boghaert, E.R.3
Ackler, S.L.4
Catron, N.D.5
Chen, J.6
-
64
-
-
84883767136
-
ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets
-
1:CAS:528:DC%2BC3sXhsVOhu7fF 23826785
-
Vogler M, Dinsdale D, Dyer MJ, Cohen GM. ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets. Br J Haematol. 2013;163(1):139-42.
-
(2013)
Br J Haematol
, vol.163
, Issue.1
, pp. 139-142
-
-
Vogler, M.1
Dinsdale, D.2
Dyer, M.J.3
Cohen, G.M.4
-
65
-
-
84895788062
-
Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia
-
3975047 1:CAS:528:DC%2BC2cXks1Oju7s%3D 24346116
-
Pan R, Hogdal LJ, Benito JM, Bucci D, Han L, Borthakur G, et al. Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia. Cancer Discov. 2014;4(3):362-75.
-
(2014)
Cancer Discov
, vol.4
, Issue.3
, pp. 362-375
-
-
Pan, R.1
Hogdal, L.J.2
Benito, J.M.3
Bucci, D.4
Han, L.5
Borthakur, G.6
-
66
-
-
84902076004
-
Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199
-
1:CAS:528:DC%2BC2cXhsVCnt7k%3D 24402163
-
Khaw SL, Merino D, Anderson MA, Glaser SP, Bouillet P, Roberts AW, et al. Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199. Leukemia. 2014;28(6):1207-15.
-
(2014)
Leukemia
, vol.28
, Issue.6
, pp. 1207-1215
-
-
Khaw, S.L.1
Merino, D.2
Anderson, M.A.3
Glaser, S.P.4
Bouillet, P.5
Roberts, A.W.6
-
67
-
-
84877929526
-
ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia
-
3606065 1:CAS:528:DC%2BC3sXltVyqt7k%3D 23341542
-
Vandenberg CJ, Cory S. ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia. Blood. 2013;121(12):2285-8.
-
(2013)
Blood
, vol.121
, Issue.12
, pp. 2285-2288
-
-
Vandenberg, C.J.1
Cory, S.2
-
68
-
-
84919701827
-
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
-
1:CAS:528:DC%2BC2MXlvFCj 25301704
-
Peirs S, Matthijssens F, Goossens S, Van de Walle I, Ruggero K, de Bock CE, et al. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. Blood. 2014;124(25):3738-47.
-
(2014)
Blood
, vol.124
, Issue.25
, pp. 3738-3747
-
-
Peirs, S.1
Matthijssens, F.2
Goossens, S.3
Van De Walle, I.4
Ruggero, K.5
De Bock, C.E.6
-
69
-
-
85012868598
-
Activity of ABT-199 and acquired resistance in follicular lymphoma cells\
-
Bodo J, Zhao X, Smith MR, Hsi ED. Activity of ABT-199 and acquired resistance in follicular lymphoma cells. Blood. 2014;124(21):3635-5.
-
(2014)
Blood.
, vol.124
, Issue.21
, pp. 3635-3645
-
-
Bodo, J.1
Zhao, X.2
Smith, M.R.3
Hsi, E.D.4
-
70
-
-
84959473907
-
Cooperative targeting of Bcl-2 family proteins by ABT-199 (GDC-0199) and tyrosine kinase inhibitors to eradicate blast crisis CML and CML stem/progenitor cells
-
Carter BZ, Mak PY, Mu H, Zhou H, Mak DH, Schober WD, et al. Cooperative targeting of Bcl-2 family proteins by ABT-199 (GDC-0199) and tyrosine kinase inhibitors to eradicate blast crisis CML and CML stem/progenitor cells. Blood. 2014;124(21):512-2.
-
(2014)
Blood.
, vol.124
, Issue.21
, pp. 512-522
-
-
Carter, B.Z.1
Mak, P.Y.2
Mu, H.3
Zhou, H.4
Mak, D.H.5
Schober, W.D.6
-
71
-
-
84940203249
-
Synergistic cytotoxicity of ibrutinib and the BCL2 antagonist, ABT-199(GDC-0199) in mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL): Molecular analysis reveals mechanisms of target interactions
-
Portell CA, Axelrod M, Brett LK, Gordon VL, Capaldo B, Xing JC, et al. Synergistic cytotoxicity of ibrutinib and the BCL2 antagonist, ABT-199(GDC-0199) in mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL): Molecular analysis reveals mechanisms of target interactions. Blood. 2014;124(21):509-9.
-
(2014)
Blood.
, vol.124
, Issue.21
, pp. 509-519
-
-
Portell, C.A.1
Axelrod, M.2
Brett, L.K.3
Gordon, V.L.4
Capaldo, B.5
Xing, J.C.6
-
72
-
-
84907920216
-
SINE (selective inhibitor of nuclear export)-translational science in a new class of anti-cancer agents
-
4197302 25281264
-
Gerecitano J. SINE (selective inhibitor of nuclear export)-translational science in a new class of anti-cancer agents. J Hematol Oncol. 2014;7(1):67.
-
(2014)
J Hematol Oncol
, vol.7
, Issue.1
, pp. 67
-
-
Gerecitano, J.1
-
73
-
-
84928653228
-
Nucleo-cytoplasmic transport as a therapeutic target of cancer
-
4272779 25476752
-
Gravina G, Senapedis W, McCauley D, Baloglu E, Shacham S, Festuccia C. Nucleo-cytoplasmic transport as a therapeutic target of cancer. J Hematol Oncol. 2014;7(1):85.
-
(2014)
J Hematol Oncol
, vol.7
, Issue.1
, pp. 85
-
-
Gravina, G.1
Senapedis, W.2
McCauley, D.3
Baloglu, E.4
Shacham, S.5
Festuccia, C.6
-
74
-
-
84907934952
-
XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCA)
-
4283114 25284315
-
Gravina G, Tortoreto M, Mancini A, Addis A, Di Cesare E, Lenzi A, et al. XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa). J Hematol Oncol. 2014;7(1):46.
-
(2014)
J Hematol Oncol
, vol.7
, Issue.1
, pp. 46
-
-
Gravina, G.1
Tortoreto, M.2
Mancini, A.3
Addis, A.4
Di Cesare, E.5
Lenzi, A.6
-
75
-
-
84924149342
-
Selective inhibitors of nuclear export (SINE)-A novel class of anti-cancer agents
-
4200201 25316614
-
Parikh K, Cang S, Sekhri A, Liu D. Selective inhibitors of nuclear export (SINE)-a novel class of anti-cancer agents. J Hematol Oncol. 2014;7(1):78.
-
(2014)
J Hematol Oncol
, vol.7
, Issue.1
, pp. 78
-
-
Parikh, K.1
Cang, S.2
Sekhri, A.3
Liu, D.4
-
76
-
-
84978024579
-
Selective inhibitors of nuclear export (SINE) in hematological malignancies
-
4350974 25745591
-
Das A, Wei G, Parikh K, Liu D. Selective inhibitors of nuclear export (SINE) in hematological malignancies. Exp Hematol Oncol. 2015;4:7.
-
(2015)
Exp Hematol Oncol
, vol.4
, pp. 7
-
-
Das, A.1
Wei, G.2
Parikh, K.3
Liu, D.4
-
77
-
-
84959491426
-
Selective inhibitor of nuclear export selinexor (KPT-330) and BCL2 inhibitor ABT-199 enhance the anti-lymphoma effect of BTK inhibitor ibrutinib in mantle cell lymphoma
-
Tabe Y, Harada M, Miyamae Y, Kazuno S, Fujimura T, Ueno T, et al. Selective inhibitor of nuclear export selinexor (KPT-330) and BCL2 inhibitor ABT-199 enhance the anti-lymphoma effect of BTK inhibitor ibrutinib in mantle cell lymphoma. Blood. 2014;124(21):2254-4.
-
(2014)
Blood.
, vol.124
, Issue.21
, pp. 2254-2264
-
-
Tabe, Y.1
Harada, M.2
Miyamae, Y.3
Kazuno, S.4
Fujimura, T.5
Ueno, T.6
-
78
-
-
84891953787
-
Homoharringtonine and omacetaxine for myeloid hematological malignancies
-
3884015 24387717
-
Lu S, Wang J. Homoharringtonine and omacetaxine for myeloid hematological malignancies. J Hematol Oncol. 2014;7(1):2.
-
(2014)
J Hematol Oncol
, vol.7
, Issue.1
, pp. 2
-
-
Lu, S.1
Wang, J.2
-
79
-
-
0027480450
-
MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2
-
46331 1:CAS:528:DyaK3sXks1CmtL8%3D 7682708
-
Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci USA. 1993;90(8):3516-20.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, Issue.8
, pp. 3516-3520
-
-
Kozopas, K.M.1
Yang, T.2
Buchan, H.L.3
Zhou, P.4
Craig, R.W.5
-
80
-
-
84959535035
-
MCL1 targeting agent homoharringtonine exerts strong cytotoxicity towards diffuse large B-cell lymphoma (DLBCL) cells and synergizes with BCL2 targeting agent ABT199 in eliminating BCL2-positive DLBCL cells
-
Klanova M, Andera L, Soukup J, Jan B, Svadlenka J, Benesova S, et al. MCL1 targeting agent homoharringtonine exerts strong cytotoxicity towards diffuse large B-cell lymphoma (DLBCL) cells and synergizes with BCL2 targeting agent ABT199 in eliminating BCL2-positive DLBCL cells. Blood. 2014;124(21):3645-5.
-
(2014)
Blood.
, vol.124
, Issue.21
, pp. 3645-3655
-
-
Klanova, M.1
Andera, L.2
Soukup, J.3
Jan, B.4
Svadlenka, J.5
Benesova, S.6
-
81
-
-
84896479968
-
Bcl-2 inhibitor ABT-199 (GDC-0199) monotherapy shows anti-tumor activity including complete remissions in high-risk relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL)
-
Davids MS, Pagel JM, Kahl BS, Wierda WG, Miller TP, Gerecitano JF, et al. Bcl-2 inhibitor ABT-199 (GDC-0199) monotherapy shows anti-tumor activity including complete remissions in high-risk relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). Blood. 2013;122(21):872-2.
-
(2013)
Blood.
, vol.122
, Issue.21
, pp. 872-882
-
-
Davids, M.S.1
Pagel, J.M.2
Kahl, B.S.3
Wierda, W.G.4
Miller, T.P.5
Gerecitano, J.F.6
-
82
-
-
84901703060
-
Management of chronic lymphocytic leukemia
-
4040893 1:CAS:528:DC%2BC2cXhvFKhu7zF 24881042
-
Ghia P, Hallek M. Management of chronic lymphocytic leukemia. Haematologica. 2014;99(6):965-72.
-
(2014)
Haematologica
, vol.99
, Issue.6
, pp. 965-972
-
-
Ghia, P.1
Hallek, M.2
-
83
-
-
84907061764
-
ABT-199 (GDC-0199) in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): High complete-response rate and durable disease control
-
Seymour JF, Davids MS, Pagel JM, Kahl BS, Wierda WG, Puvvada S, et al. ABT-199 (GDC-0199) in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL): High complete-response rate and durable disease control. ASCO Meeting Abstr. 2014;32(15-suppl):7015.
-
(2014)
ASCO Meeting Abstr
, vol.32
, Issue.15
, pp. 7015
-
-
Seymour, J.F.1
Davids, M.S.2
Pagel, J.M.3
Kahl, B.S.4
Wierda, W.G.5
Puvvada, S.6
-
84
-
-
84910091007
-
Phase I study of ABT-199 (GDC-0199) in patients with relapsed/refractory (R/R) non-Hodgkin lymphoma (NHL): Responses observed in diffuse large B-cell (DLBCL) and follicular lymphoma (FL) at higher cohort doses
-
Davids MS, Seymour JF, Gerecitano JF, Kahl BS, Pagel JM, Wierda WG, et al. Phase I study of ABT-199 (GDC-0199) in patients with relapsed/refractory (R/R) non-Hodgkin lymphoma (NHL): Responses observed in diffuse large B-cell (DLBCL) and follicular lymphoma (FL) at higher cohort doses. ASCO Meeting Abstr. 2014;32(15-suppl):8522.
-
(2014)
ASCO Meeting Abstr
, vol.32
, Issue.15
, pp. 8522
-
-
Davids, M.S.1
Seymour, J.F.2
Gerecitano, J.F.3
Kahl, B.S.4
Pagel, J.M.5
Wierda, W.G.6
-
85
-
-
84928333417
-
A phase 2 study of ABT-199 (GDC-0199) in patients with acute myelogenous leukemia (AML)
-
Konopleva M, Pollyea DA, Potluri J, Chyla BJ, Busman T, McKeegan E, et al. A phase 2 study of ABT-199 (GDC-0199) in patients with acute myelogenous leukemia (AML). Blood. 2014;124(21):118-8.
-
(2014)
Blood.
, vol.124
, Issue.21
, pp. 118-128
-
-
Konopleva, M.1
Pollyea, D.A.2
Potluri, J.3
Chyla, B.J.4
Busman, T.5
McKeegan, E.6
-
86
-
-
84925500858
-
ABT-199 (GDC-0199) combined with rituximab (R) in patients (pts) with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL): Interim results of a phase 1b study
-
Ma S, Seymour JF, Lanasa MC, Kipps TJ, Barrientos JC, Davids MS, et al. ABT-199 (GDC-0199) combined with rituximab (R) in patients (pts) with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL): Interim results of a phase 1b study. ASCO Meeting Abstr. 2014;32(15-suppl):7013.
-
(2014)
ASCO Meeting Abstr
, vol.32
, Issue.15
, pp. 7013
-
-
Ma, S.1
Seymour, J.F.2
Lanasa, M.C.3
Kipps, T.J.4
Barrientos, J.C.5
Davids, M.S.6
-
87
-
-
84925484937
-
Determination of recommended phase 2 dose of ABT-199 (GDC-0199) combined with rituximab (R) in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)
-
Roberts AW, Ma S, Brander DM, Kipps TJ, Barrientos JC, Davids MS, et al. Determination of recommended phase 2 dose of ABT-199 (GDC-0199) combined with rituximab (R) in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL). Blood. 2014;124(21):325-5.
-
(2014)
Blood.
, vol.124
, Issue.21
, pp. 325-335
-
-
Roberts, A.W.1
Ma, S.2
Brander, D.M.3
Kipps, T.J.4
Barrientos, J.C.5
Davids, M.S.6
-
88
-
-
84959513915
-
Multicenter, phase III, open-label, randomized study in relapsed/refractory CLL to evaluate the benefit of GDC-0199 (ABT-199) plus rituximab compared with bendamustine plus rituximab
-
Mobasher M, Huang J, Elstrom RL, Elhamy M, Bernaards C, Hallek MJ, et al. Multicenter, phase III, open-label, randomized study in relapsed/refractory CLL to evaluate the benefit of GDC-0199 (ABT-199) plus rituximab compared with bendamustine plus rituximab. ASCO Meeting Abstr. 2014;32(15-suppl):TPS7120.
-
(2014)
ASCO Meeting Abstr
, vol.32
, Issue.15
, pp. TPS7120
-
-
Mobasher, M.1
Huang, J.2
Elstrom, R.L.3
Elhamy, M.4
Bernaards, C.5
Hallek, M.J.6
-
89
-
-
84927657286
-
The BCL-2 inhibitor ABT-199 (GDC-0199) in combination with bendamustine and rituximab in patients with relapsed or refractory non-Hodgkin's lymphoma
-
de Vos S, Flowers CR, Wang D, Swinnen LJ, Fowler N, Reid E, et al. The BCL-2 inhibitor ABT-199 (GDC-0199) in combination with bendamustine and rituximab in patients with relapsed or refractory non-Hodgkin's lymphoma. Blood. 2014;124(21):1722.
-
(2014)
Blood
, vol.124
, Issue.21
, pp. 1722
-
-
De Vos, S.1
Flowers, C.R.2
Wang, D.3
Swinnen, L.J.4
Fowler, N.5
Reid, E.6
-
90
-
-
84928325130
-
Preliminary results of a phase 1b study (GO28440) combining GDC-0199 (ABT-199) with bendamustine/rituximab in patients with relapsed/refractory or previously untreated chronic lymphocytic leukemia
-
Salles GA, Boyd TE, Morschhauser F, Wendtner C-M, Lymp J, Hilger J, et al. Preliminary results of a phase 1b study (GO28440) combining GDC-0199 (ABT-199) with bendamustine/rituximab in patients with relapsed/refractory or previously untreated chronic lymphocytic leukemia. Blood. 2014;124(21):3337.
-
(2014)
Blood
, vol.124
, Issue.21
, pp. 3337
-
-
Salles, G.A.1
Boyd, T.E.2
Morschhauser, F.3
Wendtner, C.-M.4
Lymp, J.5
Hilger, J.6
-
91
-
-
84928349892
-
Preliminary results of a phase 1b study (GP28331) combining GDC-0199 (ABT-199) and obinutuzumab in patients with relapsed/refractory or previously untreated chronic lymphocytic leukemia
-
Flinn I, Brunvand M, Dyer MJ, Hillman P, Jones J, Lymp J, et al. Preliminary results of a phase 1b study (GP28331) combining GDC-0199 (ABT-199) and obinutuzumab in patients with relapsed/refractory or previously untreated chronic lymphocytic leukemia. Blood. 2014;124(21):4687.
-
(2014)
Blood
, vol.124
, Issue.21
, pp. 4687
-
-
Flinn, I.1
Brunvand, M.2
Dyer, M.J.3
Hillman, P.4
Jones, J.5
Lymp, J.6
-
92
-
-
85031892164
-
A phase 2 open-label study of the efficacy of ABT-199 (GDC-0199) in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) harboring 17p deletion
-
Wierda WG, Seymour JF, Roberts AW, Puvvada S, Davids MS, Wong S, et al. A phase 2 open-label study of the efficacy of ABT-199 (GDC-0199) in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) harboring 17p deletion. ASCO Meeting Abstr. 2014;32(15-suppl):TPS7121.
-
(2014)
ASCO Meeting Abstr
, vol.32
, Issue.15
, pp. TPS7121
-
-
Wierda, W.G.1
Seymour, J.F.2
Roberts, A.W.3
Puvvada, S.4
Davids, M.S.5
Wong, S.6
-
93
-
-
84903647814
-
Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma
-
1:CAS:528:DC%2BC2cXhtFegu7bL 24786774
-
Fresquet V, Rieger M, Carolis C, Garcia-Barchino MJ, Martinez-Climent JA. Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma. Blood. 2014;123(26):4111-9.
-
(2014)
Blood
, vol.123
, Issue.26
, pp. 4111-4119
-
-
Fresquet, V.1
Rieger, M.2
Carolis, C.3
Garcia-Barchino, M.J.4
Martinez-Climent, J.A.5
-
94
-
-
84927631832
-
MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies
-
1:CAS:528:DC%2BC2MXhtFOitbY%3D 25590803
-
Choudhary GS, Al-Harbi S, Mazumder S, Hill BT, Smith MR, Bodo J, et al. MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies. Cell Death Dis. 2015;6:e1593.
-
(2015)
Cell Death Dis
, vol.6
, pp. e1593
-
-
Choudhary, G.S.1
Al-Harbi, S.2
Mazumder, S.3
Hill, B.T.4
Smith, M.R.5
Bodo, J.6
-
95
-
-
84938596484
-
Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors
-
25957396
-
Thijssen R, Slinger E, Weller K, Geest CR, Beaumont T, van Oers MH, et al. Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors. Haematologica. 2015;100(8):e302-6.
-
(2015)
Haematologica
, vol.100
, Issue.8
, pp. e302-e306
-
-
Thijssen, R.1
Slinger, E.2
Weller, K.3
Geest, C.R.4
Beaumont, T.5
Van Oers, M.H.6
|