-
1
-
-
84887577888
-
Genetic and epigenetic alterations of myeloproliferative disorders
-
Milosevic JD, Kralovics R. Genetic and epigenetic alterations of myeloproliferative disorders. Int J Hematol 2013; 97: 183-197.
-
(2013)
Int J Hematol
, vol.97
, pp. 183-197
-
-
Milosevic, J.D.1
Kralovics, R.2
-
2
-
-
84890372480
-
Somatic mutations of calreticulin in myeloproliferative neoplasms
-
Klampfl T, Gisslinger H, Harutyunyan AS, Nivarthi H, Rumi E, Milosevic JD et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med 2013; 369: 2379-2390.
-
(2013)
N Engl J Med
, vol.369
, pp. 2379-2390
-
-
Klampfl, T.1
Gisslinger, H.2
Harutyunyan, A.S.3
Nivarthi, H.4
Rumi, E.5
Milosevic, J.D.6
-
3
-
-
84890328032
-
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
-
Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med 2013; 369: 2391-2405.
-
(2013)
N Engl J Med
, vol.369
, pp. 2391-2405
-
-
Nangalia, J.1
Massie, C.E.2
Baxter, E.J.3
Nice, F.L.4
Gundem, G.5
Wedge, D.C.6
-
4
-
-
84958162239
-
Presence of atypical thrombopoietin receptor (MPL) mutations in triple negative essential thrombocythemia patients
-
Cabagnols X, Favale F, Pasquier F, Messaoudi K, Defour JP, Ianotto JC et al. Presence of atypical thrombopoietin receptor (MPL) mutations in triple negative essential thrombocythemia patients. Blood 2015; 127: 333-342.
-
(2015)
Blood
, vol.127
, pp. 333-342
-
-
Cabagnols, X.1
Favale, F.2
Pasquier, F.3
Messaoudi, K.4
Defour, J.P.5
Ianotto, J.C.6
-
5
-
-
84958213572
-
Whole exome sequencing identifies novel MPL and JAK2 mutations in triple negative myeloproliferative neoplasms
-
Milosevic Feenstra JD, Nivarthi H, Gisslinger H, Leroy E, Rumi E, Chachoua I et al. Whole exome sequencing identifies novel MPL and JAK2 mutations in triple negative myeloproliferative neoplasms. Blood 2015; 127: 325-332.
-
(2015)
Blood
, vol.127
, pp. 325-332
-
-
Milosevic Feenstra, J.D.1
Nivarthi, H.2
Gisslinger, H.3
Leroy, E.4
Rumi, E.5
Chachoua, I.6
-
6
-
-
84905990634
-
Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis
-
Rumi E, Pietra D, Pascutto C, Guglielmelli P, Martínez-Trillos A, Casetti I et al. Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis. Blood 2014; 124: 1062-1069.
-
(2014)
Blood
, vol.124
, pp. 1062-1069
-
-
Rumi, E.1
Pietra, D.2
Pascutto, C.3
Guglielmelli, P.4
Martínez-Trillos, A.5
Casetti, I.6
-
7
-
-
84897568260
-
Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia
-
Rotunno G, Mannarelli C, Guglielmelli P, Pacilli A, Pancrazzi A, Pieri L et al. Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia. Blood 2014; 123: 1552-1555.
-
(2014)
Blood
, vol.123
, pp. 1552-1555
-
-
Rotunno, G.1
Mannarelli, C.2
Guglielmelli, P.3
Pacilli, A.4
Pancrazzi, A.5
Pieri, L.6
-
9
-
-
53249123632
-
-
IARC: Lyon France
-
Swerdlow SH, Campo E, Harris NL, Jaffe E, Pileri S, Stein H et al. WHO Classification of Tumors of the Haematopoietic and Lymphoid Tissues. IARC: Lyon, France, 2008.
-
(2008)
WHO Classification of Tumors of the Haematopoietic and Lymphoid Tissues
-
-
Swerdlow, S.H.1
Campo, E.2
Harris, N.L.3
Jaffe, E.4
Pileri, S.5
Stein, H.6
-
10
-
-
84857728705
-
European Bone Marrow Working Group trial on reproducibility of World Health Organization criteria to discriminate essential thrombocythemia from prefibrotic primary myelofibrosis
-
Buhr T, Hebeda K, Kaloutsi V, Porwit A, Van der Walt J, Kreipe H. European Bone Marrow Working Group trial on reproducibility of World Health Organization criteria to discriminate essential thrombocythemia from prefibrotic primary myelofibrosis. Haematologica 2012; 97: 360-365.
-
(2012)
Haematologica
, vol.97
, pp. 360-365
-
-
Buhr, T.1
Hebeda, K.2
Kaloutsi, V.3
Porwit, A.4
Van Der Walt, J.5
Kreipe, H.6
-
11
-
-
84940024481
-
Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells
-
Lu M, Xia L, Liu YC, Hochman T, Bizzari L, Aruch D et al. Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells. Blood 2015; 126: 972-982.
-
(2015)
Blood
, vol.126
, pp. 972-982
-
-
Lu, M.1
Xia, L.2
Liu, Y.C.3
Hochman, T.4
Bizzari, L.5
Aruch, D.6
-
12
-
-
83455201579
-
TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms
-
Fleischman AG, Aichberger KJ, Luty SB, Bumm TG, Petersen CL, Doratotaj S et al. TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms. Blood 2011; 118: 6392-6398.
-
(2011)
Blood
, vol.118
, pp. 6392-6398
-
-
Fleischman, A.G.1
Aichberger, K.J.2
Luty, S.B.3
Bumm, T.G.4
Petersen, C.L.5
Doratotaj, S.6
-
13
-
-
84925298525
-
JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response
-
Kleppe M, Kwak M, Koppikar P, Riester M, Keller M, Bastian L et al. JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response. Cancer Discov 2015; 5: 316-331.
-
(2015)
Cancer Discov
, vol.5
, pp. 316-331
-
-
Kleppe, M.1
Kwak, M.2
Koppikar, P.3
Riester, M.4
Keller, M.5
Bastian, L.6
-
14
-
-
81255189474
-
IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development
-
Reynaud D, Pietras E, Barry-Holson K, Mir A, Binnewies M, Jeanne M et al. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell 2011; 20: 661-673.
-
(2011)
Cancer Cell
, vol.20
, pp. 661-673
-
-
Reynaud, D.1
Pietras, E.2
Barry-Holson, K.3
Mir, A.4
Binnewies, M.5
Jeanne, M.6
-
15
-
-
84929145889
-
Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells
-
Welner RS, Amabile G, Bararia D, Czibere A, Yang H, Zhang H et al. Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells. Cancer Cell 2015; 27: 671-681.
-
(2015)
Cancer Cell
, vol.27
, pp. 671-681
-
-
Welner, R.S.1
Amabile, G.2
Bararia, D.3
Czibere, A.4
Yang, H.5
Zhang, H.6
-
16
-
-
30844443469
-
Pathogenesis of myelofibrosis with myeloid metaplasia
-
Tefferi A. Pathogenesis of myelofibrosis with myeloid metaplasia. J Clin Oncol 2005; 23: 8520-8530.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8520-8530
-
-
Tefferi, A.1
-
17
-
-
84856515296
-
Identification of oncostatin M as a JAK2 V617F-dependent amplifier of cytokine production and bone marrow remodeling in myeloproliferative neoplasms
-
Hoermann G, Cerny-Reiterer S, Herrmann H, Blatt K, Bilban M, Gisslinger H et al. Identification of oncostatin M as a JAK2 V617F-dependent amplifier of cytokine production and bone marrow remodeling in myeloproliferative neoplasms. FASEB J 2012; 26: 894-906.
-
(2012)
FASEB J
, vol.26
, pp. 894-906
-
-
Hoermann, G.1
Cerny-Reiterer, S.2
Herrmann, H.3
Blatt, K.4
Bilban, M.5
Gisslinger, H.6
-
18
-
-
10544255357
-
Differential expression of transforming growth factor-beta, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia
-
Le Bousse-Kerdiles MC, Chevillard S, Charpentier A, Romquin N, Clay D, Smadja-Joffe F et al. Differential expression of transforming growth factor-beta, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia. Blood 1996; 88: 4534-4546.
-
(1996)
Blood
, vol.88
, pp. 4534-4546
-
-
Le Bousse-Kerdiles, M.C.1
Chevillard, S.2
Charpentier, A.3
Romquin, N.4
Clay, D.5
Smadja-Joffe, F.6
-
19
-
-
0031010071
-
Elevated levels of basic fibroblast growth factor in mega-karyocytes and platelets from patients with idiopathic myelofibrosis
-
Martyre MC, Le Bousse-Kerdiles MC, Romquin N, Chevillard S, Praloran V, Demory JL et al. Elevated levels of basic fibroblast growth factor in mega-karyocytes and platelets from patients with idiopathic myelofibrosis. Bri J Haematol 1997; 97: 441-448.
-
(1997)
Bri J Haematol
, vol.97
, pp. 441-448
-
-
Martyre, M.C.1
Le Bousse-Kerdiles, M.C.2
Romquin, N.3
Chevillard, S.4
Praloran, V.5
Demory, J.L.6
-
20
-
-
42049091013
-
Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines
-
Bock O, Hoftmann J, Theophile K, Hussein K, Wiese B, Schlue J et al. Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines. Am J Pathol 2008; 172: 951-960.
-
(2008)
Am J Pathol
, vol.172
, pp. 951-960
-
-
Bock, O.1
Hoftmann, J.2
Theophile, K.3
Hussein, K.4
Wiese, B.5
Schlue, J.6
-
21
-
-
84936862080
-
Phase 2 trial of PRM-151, an anti-fibrotic agent, in patients with myelofibrosis: Stage 1 results
-
Verstovsek S, Mesa RA, Foltz LM, Gupta V, Mascarenhas JO, Ritchie EK et al. Phase 2 trial of PRM-151, an anti-fibrotic agent, in patients with myelofibrosis: stage 1 results. Blood 2014; 124: 713-713.
-
(2014)
Blood
, vol.124
, pp. 713
-
-
Verstovsek, S.1
Mesa, R.A.2
Foltz, L.M.3
Gupta, V.4
Mascarenhas, J.O.5
Ritchie, E.K.6
-
22
-
-
27244435229
-
Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases
-
Panteli KE, Hatzimichael EC, Bouranta PK, Katsaraki A, Seferiadis K, Stebbing J et al. Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases. Br J Haematol 2005; 130: 709-715.
-
(2005)
Br J Haematol
, vol.130
, pp. 709-715
-
-
Panteli, K.E.1
Hatzimichael, E.C.2
Bouranta, P.K.3
Katsaraki, A.4
Seferiadis, K.5
Stebbing, J.6
-
23
-
-
0025946285
-
Suppression of chronic myelogenous leukemia colony growth by interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptors: A novel application for inhibitors of IL-1 activity
-
Estrov Z, Kurzrock R, Wetzler M, Kantarjian H, Blake M, Harris D et al. Suppression of chronic myelogenous leukemia colony growth by interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptors: a novel application for inhibitors of IL-1 activity. Blood 1991; 78: 1476-1484.
-
(1991)
Blood
, vol.78
, pp. 1476-1484
-
-
Estrov, Z.1
Kurzrock, R.2
Wetzler, M.3
Kantarjian, H.4
Blake, M.5
Harris, D.6
-
24
-
-
79954433836
-
Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: A comprehensive cytokine profiling study
-
Tefferi A, Vaidya R, Caramazza D, Finke C, Lasho T, Pardanani A. Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study. J Clin Oncol 2011; 29: 1356-1363.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1356-1363
-
-
Tefferi, A.1
Vaidya, R.2
Caramazza, D.3
Finke, C.4
Lasho, T.5
Pardanani, A.6
-
25
-
-
84885613426
-
Elevated C-reactive protein is associated with shortened leukemia-free survival in patients with myelofibrosis
-
Barbui T, Carobbio A, Finazzi G, Guglielmelli P, Salmoiraghi S, Rosti V et al. Elevated C-reactive protein is associated with shortened leukemia-free survival in patients with myelofibrosis. Leukemia 2013; 27: 2084-2086.
-
(2013)
Leukemia
, vol.27
, pp. 2084-2086
-
-
Barbui, T.1
Carobbio, A.2
Finazzi, G.3
Guglielmelli, P.4
Salmoiraghi, S.5
Rosti, V.6
-
26
-
-
77956696835
-
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofi-brosis
-
Verstovsek S, Kantarjian H, Mesa RA, Pardanani AD, Cortes-Franco J, Thomas DA et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofi-brosis. N Engl J Med 2010; 363: 1117-1127.
-
(2010)
N Engl J Med
, vol.363
, pp. 1117-1127
-
-
Verstovsek, S.1
Kantarjian, H.2
Mesa, R.A.3
Pardanani, A.D.4
Cortes-Franco, J.5
Thomas, D.A.6
-
27
-
-
73949084969
-
Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: A prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
-
Kroger N, Holler E, Kobbe G, Bornhauser M, Schwerdtfeger R, Baurmann H et al. Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Blood 2009; 114: 5264-5270.
-
(2009)
Blood
, vol.114
, pp. 5264-5270
-
-
Kroger, N.1
Holler, E.2
Kobbe, G.3
Bornhauser, M.4
Schwerdtfeger, R.5
Baurmann, H.6
-
28
-
-
79551644817
-
Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: Different role of C-reactive protein and pentraxin 3
-
Barbui T, Carobbio A, Finazzi G, Vannucchi AM, Barosi G, Antonioli E et al. Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3. Haematologica 2011; 96: 315-318.
-
(2011)
Haematologica
, vol.96
, pp. 315-318
-
-
Barbui, T.1
Carobbio, A.2
Finazzi, G.3
Vannucchi, A.M.4
Barosi, G.5
Antonioli, E.6
-
29
-
-
0034672149
-
Polymorphonuclear leukocyte activation and hemostasis in patients with essential thrombocythemia and polycythemia vera
-
Falanga A, Marchetti M, Evangelista V, Vignoli A, Licini M, Balicco M et al. Polymorphonuclear leukocyte activation and hemostasis in patients with essential thrombocythemia and polycythemia vera. Blood 2000; 96: 4261-4266.
-
(2000)
Blood
, vol.96
, pp. 4261-4266
-
-
Falanga, A.1
Marchetti, M.2
Evangelista, V.3
Vignoli, A.4
Licini, M.5
Balicco, M.6
-
30
-
-
0036878184
-
Markers of platelet activation and platelet-leukocyte interaction in patients with myeloproliferative syndromes
-
Villmow T, Kemkes-Matthes B, Matzdorff AC. Markers of platelet activation and platelet-leukocyte interaction in patients with myeloproliferative syndromes. Thromb Res 2002; 108: 139-145.
-
(2002)
Thromb Res
, vol.108
, pp. 139-145
-
-
Villmow, T.1
Kemkes-Matthes, B.2
Matzdorff, A.C.3
-
31
-
-
17844390356
-
Leukocyte-platelet interaction in patients with essential thrombocythemia and polycythemia vera
-
Falanga A, Marchetti M, Vignoli A, Balducci D, Barbui T. Leukocyte-platelet interaction in patients with essential thrombocythemia and polycythemia vera. Exp Hematol 2005; 33: 523-530.
-
(2005)
Exp Hematol
, vol.33
, pp. 523-530
-
-
Falanga, A.1
Marchetti, M.2
Vignoli, A.3
Balducci, D.4
Barbui, T.5
-
32
-
-
52649131772
-
The natural history and treatment outcome of blast phase BCR-ABL-myelopro-liferative neoplasms
-
Tam CS, Nussenzveig RM, Popat U, Bueso-Ramos CE, Thomas DA, Cortes JA et al. The natural history and treatment outcome of blast phase BCR-ABL-myelopro-liferative neoplasms. Blood 2008; 112: 1628-1637.
-
(2008)
Blood
, vol.112
, pp. 1628-1637
-
-
Tam, C.S.1
Nussenzveig, R.M.2
Popat, U.3
Bueso-Ramos, C.E.4
Thomas, D.A.5
Cortes, J.A.6
-
33
-
-
84859584516
-
Perspectives on chronic inflammation in essential thrombo-cythemia, polycythemia vera, and myelofibrosis: Is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?
-
Hasselbalch HC. Perspectives on chronic inflammation in essential thrombo-cythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer? Blood 2012; 119: 3219-3225.
-
(2012)
Blood
, vol.119
, pp. 3219-3225
-
-
Hasselbalch, H.C.1
-
34
-
-
16244420688
-
Association of celiac disease and intestinal lymphomas and other cancers
-
Catassi C, Bearzi I, Holmes GK. Association of celiac disease and intestinal lymphomas and other cancers. Gastroenterology 2005; 128: S79-S86.
-
(2005)
Gastroenterology
, vol.128
, pp. S79-S86
-
-
Catassi, C.1
Bearzi, I.2
Holmes, G.K.3
-
35
-
-
78649368287
-
Inflammatory bowel disease as a risk factor for colorectal cancer
-
Lukas M. Inflammatory bowel disease as a risk factor for colorectal cancer. Dig Dis 2010; 28: 619-624.
-
(2010)
Dig Dis
, vol.28
, pp. 619-624
-
-
Lukas, M.1
-
36
-
-
84892530527
-
A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis?
-
Hasselbalch HC. A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis? Leuk Res 2014; 38: 263-266.
-
(2014)
Leuk Res
, vol.38
, pp. 263-266
-
-
Hasselbalch, H.C.1
-
37
-
-
84875279909
-
The role of cytokines in the initiation and progression of mye-lofibrosis
-
Hasselbalch HC. The role of cytokines in the initiation and progression of mye-lofibrosis. Cytokine Growth Factor Rev 2013; 24: 133-145.
-
(2013)
Cytokine Growth Factor Rev
, vol.24
, pp. 133-145
-
-
Hasselbalch, H.C.1
-
38
-
-
84872424841
-
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
-
Hasselbalch HC. Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development? Leuk Res 2013; 37: 214-220.
-
(2013)
Leuk Res
, vol.37
, pp. 214-220
-
-
Hasselbalch, H.C.1
-
39
-
-
84856911269
-
A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2
-
Kaufmann KB, Grunder A, Hadlich T, Wehrle J, Gothwal M, Bogeska R et al. A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2. J Exp Med 2012; 209: 35-50.
-
(2012)
J Exp Med
, vol.209
, pp. 35-50
-
-
Kaufmann, K.B.1
Grunder, A.2
Hadlich, T.3
Wehrle, J.4
Gothwal, M.5
Bogeska, R.6
-
40
-
-
20244365505
-
Gene expression profiling in polycythaemia vera: Overexpression of transcription factor NF-E2
-
Goerttler PS, Kreutz C, Donauer J, Faller D, Maiwald T, Marz E et al. Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2. Br J Haematol 2005; 129: 138-150.
-
(2005)
Br J Haematol
, vol.129
, pp. 138-150
-
-
Goerttler, P.S.1
Kreutz, C.2
Donauer, J.3
Faller, D.4
Maiwald, T.5
Marz, E.6
-
41
-
-
77955507360
-
AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent over-expression of NF-E2
-
Wang W, Schwemmers S, Hexner EO, Pahl HL. AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent over-expression of NF-E2. Blood 2010; 116: 254-266.
-
(2010)
Blood
, vol.116
, pp. 254-266
-
-
Wang, W.1
Schwemmers, S.2
Hexner, E.O.3
Pahl, H.L.4
-
42
-
-
84879557768
-
MPN patients harbor recurrent truncating mutations in transcription factor NF-E2
-
Jutzi JS, Bogeska R, Nikoloski G, Schmid CA, Seeger TS, Stegelmann F et al. MPN patients harbor recurrent truncating mutations in transcription factor NF-E2. J Exp Med 2013; 210: 1003-1019.
-
(2013)
J Exp Med
, vol.210
, pp. 1003-1019
-
-
Jutzi, J.S.1
Bogeska, R.2
Nikoloski, G.3
Schmid, C.A.4
Seeger, T.S.5
Stegelmann, F.6
-
43
-
-
84945950010
-
The hen or the egg: Inflammatory aspects of murine MPN models
-
Jutzi JS, Pahl HL. The hen or the egg: inflammatory aspects of murine MPN models. Mediators Inflamm 2015; 2015: 101987.
-
(2015)
Mediators Inflamm
, vol.2015
, pp. 101987
-
-
Jutzi, J.S.1
Pahl, H.L.2
-
44
-
-
84879562933
-
Transcription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms
-
Wehrle J, Seeger TS, Schwemmers S, Pfeifer D, Bulashevska A, Pahl HL. Transcription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms. Haematologica 2013; 98: 1073-1080.
-
(2013)
Haematologica
, vol.98
, pp. 1073-1080
-
-
Wehrle, J.1
Seeger, T.S.2
Schwemmers, S.3
Pfeifer, D.4
Bulashevska, A.5
Pahl, H.L.6
-
45
-
-
77955512131
-
Of mice and men: Human RNA polymerase III promoter U6 is more efficient than its murine homologue for shRNA expression from a lentiviral vector in both human and murine progenitor cells
-
Roelz R, Pilz IH, Mutschler M, Pahl HL. Of mice and men: human RNA polymerase III promoter U6 is more efficient than its murine homologue for shRNA expression from a lentiviral vector in both human and murine progenitor cells. Exp Hematol 2010; 38: 792-797.
-
(2010)
Exp Hematol
, vol.38
, pp. 792-797
-
-
Roelz, R.1
Pilz, I.H.2
Mutschler, M.3
Pahl, H.L.4
-
46
-
-
84887163019
-
Bone marrow injury induced via oxidative stress in mice by inhalation exposure to formaldehyde
-
Zhang Y, Liu X, McHale C, Li R, Zhang L, Wu Y et al. Bone marrow injury induced via oxidative stress in mice by inhalation exposure to formaldehyde. PLoS One 2013; 8: e74974.
-
(2013)
PLoS One
, vol.8
, pp. e74974
-
-
Zhang, Y.1
Liu, X.2
McHale, C.3
Li, R.4
Zhang, L.5
Wu, Y.6
-
47
-
-
84942050633
-
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
-
Zhang Q, Zhao K, Shen Q, Han Y, Gu Y, Li X et al. Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6. Nature 2015; 525: 389-393.
-
(2015)
Nature
, vol.525
, pp. 389-393
-
-
Zhang, Q.1
Zhao, K.2
Shen, Q.3
Han, Y.4
Gu, Y.5
Li, X.6
-
48
-
-
84976334364
-
Smoking and Philadelphia-negative chronic myeloproliferative neoplasms
-
e-pub ahead of print 18 September 2015;
-
Sorensen AL, Hasselbalch HC. Smoking and Philadelphia-negative chronic myeloproliferative neoplasms. Eur J Haematol 2015; e-pub ahead of print 18 September 2015; doi:10.1111/ejh.12684.
-
(2015)
Eur J Haematol
-
-
Sorensen, A.L.1
Hasselbalch, H.C.2
-
49
-
-
84873368311
-
Interferon and the treatment of poly-cythemia vera, essential thrombocythemia and myelofibrosis
-
Silver RT, Kiladjian JJ, Hasselbalch HC. Interferon and the treatment of poly-cythemia vera, essential thrombocythemia and myelofibrosis. Expert Rev Hematol 2013; 6: 49-58.
-
(2013)
Expert Rev Hematol
, vol.6
, pp. 49-58
-
-
Silver, R.T.1
Kiladjian, J.J.2
Hasselbalch, H.C.3
-
50
-
-
84966575349
-
Minimal residual disease after long-term interferon-alpha2 treatment. A report on hematological, molecular, and histomorphological response patterns in ten patients with essential thrombocythemia and polycythemia vera
-
e-pub ahead of print 18 June 2015
-
Utke Rank C, Weis Bjerrum O, Larsen TS, Kjær L, de Stricker K, Riley CH et al. Minimal residual disease after long-term interferon-alpha2 treatment. A report on hematological, molecular, and histomorphological response patterns in ten patients with essential thrombocythemia and polycythemia vera. Leuk Lymph 2015; e-pub ahead of print 18 June 2015.
-
(2015)
Leuk Lymph
-
-
Utke Rank, C.1
Weis Bjerrum, O.2
Larsen, T.S.3
Kjær, L.4
De Stricker, K.5
Riley, C.H.6
-
51
-
-
84942253314
-
The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis
-
Deininger M, Radich J, Burn TC, Huber R, Paranagama D, Verstovsek S. The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis. Blood 2015; 126: 1551-1554.
-
(2015)
Blood
, vol.126
, pp. 1551-1554
-
-
Deininger, M.1
Radich, J.2
Burn, T.C.3
Huber, R.4
Paranagama, D.5
Verstovsek, S.6
-
52
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 2012; 366: 799-807.
-
(2012)
N Engl J Med
, vol.366
, pp. 799-807
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
Levy, R.S.4
Gupta, V.5
DiPersio, J.F.6
-
53
-
-
84857837774
-
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
-
Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med 2012; 366: 787-798.
-
(2012)
N Engl J Med
, vol.366
, pp. 787-798
-
-
Harrison, C.1
Kiladjian, J.J.2
Al-Ali, H.K.3
Gisslinger, H.4
Waltzman, R.5
Stalbovskaya, V.6
-
54
-
-
84928476375
-
Ruxolitinib versus standard therapy for the treatment of polycythemia vera
-
Vannucchi AM, Kiladjian JJ, Griesshammer M, Masszi T, Durrant S, Passamonti F et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med 2015; 372: 426-435.
-
(2015)
N Engl J Med
, vol.372
, pp. 426-435
-
-
Vannucchi, A.M.1
Kiladjian, J.J.2
Griesshammer, M.3
Masszi, T.4
Durrant, S.5
Passamonti, F.6
-
55
-
-
84937426733
-
CHZ868, a type II JAK2 inhibitor, reverses type i JAK inhibitor persistence and demonstrates efficacy in myeloproliferative neoplasms
-
Meyer SC, Keller MD, Chiu S, Koppikar P, Guryanova OA, Rapaport F et al. CHZ868, a type II JAK2 inhibitor, reverses type I JAK inhibitor persistence and demonstrates efficacy in myeloproliferative neoplasms. Cancer Cell 2015; 28: 15-28.
-
(2015)
Cancer Cell
, vol.28
, pp. 15-28
-
-
Meyer, S.C.1
Keller, M.D.2
Chiu, S.3
Koppikar, P.4
Guryanova, O.A.5
Rapaport, F.6
-
56
-
-
84897556667
-
Improved targeting of JAK2 leads to increased therapeutic efficacy in myelo-proliferative neoplasms
-
Bhagwat N, Koppikar P, Keller M, Marubayashi S, Shank K, Rampal R et al. Improved targeting of JAK2 leads to increased therapeutic efficacy in myelo-proliferative neoplasms. Blood 2014; 123: 2075-2083.
-
(2014)
Blood
, vol.123
, pp. 2075-2083
-
-
Bhagwat, N.1
Koppikar, P.2
Keller, M.3
Marubayashi, S.4
Shank, K.5
Rampal, R.6
-
57
-
-
84906938292
-
Rationale for combination therapy in myelofibrosis
-
Mascarenhas J. Rationale for combination therapy in myelofibrosis. Best Pract Res Clin Haematol 2014; 27: 197-208.
-
(2014)
Best Pract Res Clin Haematol
, vol.27
, pp. 197-208
-
-
Mascarenhas, J.1
-
58
-
-
0032076183
-
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
-
Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD et al. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 1998; 93: 373-383.
-
(1998)
Cell
, vol.93
, pp. 373-383
-
-
Rodig, S.J.1
Meraz, M.A.2
White, J.M.3
Lampe, P.A.4
Riley, J.K.5
Arthur, C.D.6
-
59
-
-
0037138370
-
Signaling through the JAK/STAT pathway, recent advances and future challenges
-
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002; 285: 1-24.
-
(2002)
Gene
, vol.285
, pp. 1-24
-
-
Kisseleva, T.1
Bhattacharya, S.2
Braunstein, J.3
Schindler, C.W.4
-
60
-
-
79952333359
-
Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis
-
Pardanani A, Gotlib JR, Jamieson C, Cortes JE, Talpaz M, Stone RM et al. Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis. J Clin Oncol 2011; 29: 789-796.
-
(2011)
J Clin Oncol
, vol.29
, pp. 789-796
-
-
Pardanani, A.1
Gotlib, J.R.2
Jamieson, C.3
Cortes, J.E.4
Talpaz, M.5
Stone, R.M.6
-
61
-
-
84896917435
-
An open-label, phase II study of the JAK1 inhibitor INCB039110 in patients with myelofibrosis
-
Mascarenhas J, Talpaz M, Gupta V, Savona M, Coughlin P, Winton E et al. An open-label, phase II study of the JAK1 inhibitor INCB039110 in patients with myelofibrosis. Blood 2013; 122: 663-663.
-
(2013)
Blood
, vol.122
, pp. 663
-
-
Mascarenhas, J.1
Talpaz, M.2
Gupta, V.3
Savona, M.4
Coughlin, P.5
Winton, E.6
-
62
-
-
79955947379
-
The renaissance of interferon therapy for the treatment of myeloid malignancies
-
Kiladjian J-J, Mesa RA, Hoffman R. The renaissance of interferon therapy for the treatment of myeloid malignancies. Blood 2011; 117: 4706-4715.
-
(2011)
Blood
, vol.117
, pp. 4706-4715
-
-
Kiladjian, J.-J.1
Mesa, R.A.2
Hoffman, R.3
-
63
-
-
79959232873
-
Recombinant interferon-alpha may retard progression of early primary myelofibrosis: A preliminary report
-
Silver RT, Vandris K, Goldman JJ. Recombinant interferon-alpha may retard progression of early primary myelofibrosis: a preliminary report. Blood 2011; 117: 6669-6672.
-
(2011)
Blood
, vol.117
, pp. 6669-6672
-
-
Silver, R.T.1
Vandris, K.2
Goldman, J.J.3
-
64
-
-
84942983937
-
Recombinant interferon-alpha in myelofibrosis reduces bone marrow fibrosis, improves its morphology and is associated with clinical response
-
Pizzi M, Silver RT, Barel A, Orazi A. Recombinant interferon-alpha in myelofibrosis reduces bone marrow fibrosis, improves its morphology and is associated with clinical response. Mod Pathol 2015; 28: 1315-1323.
-
(2015)
Mod Pathol
, vol.28
, pp. 1315-1323
-
-
Pizzi, M.1
Silver, R.T.2
Barel, A.3
Orazi, A.4
-
65
-
-
84886850069
-
JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα
-
Hasan S, Lacout C, Marty C, Cuingnet M, Solary E, Vainchenker W et al. JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα. Blood 2013; 122: 1464-1477.
-
(2013)
Blood
, vol.122
, pp. 1464-1477
-
-
Hasan, S.1
Lacout, C.2
Marty, C.3
Cuingnet, M.4
Solary, E.5
Vainchenker, W.6
-
66
-
-
84879728130
-
Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera
-
Mullally A, Bruedigam C, Poveromo L, Heidel FH, Purdon A, Vu T et al. Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood 2013; 121: 3692-3702.
-
(2013)
Blood
, vol.121
, pp. 3692-3702
-
-
Mullally, A.1
Bruedigam, C.2
Poveromo, L.3
Heidel, F.H.4
Purdon, A.5
Vu, T.6
-
67
-
-
77952955507
-
Interferon-alpha targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway
-
Lu M, Zhang W, Li Y, Berenzon D, Wang X, Wang J et al. Interferon-alpha targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway. Exp Hematol 2010; 38: 472-480.
-
(2010)
Exp Hematol
, vol.38
, pp. 472-480
-
-
Lu, M.1
Zhang, W.2
Li, Y.3
Berenzon, D.4
Wang, X.5
Wang, J.6
-
68
-
-
79551491928
-
Philadelphia-negative classical myeloproliferative neoplasms: Critical concepts and management recommendations from European LeukemiaNet
-
Barbui T, Barosi G, Birgegard G, Cervantes F, Finazzi G, Griesshammer M et al. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol 2011; 29: 761-770.
-
(2011)
J Clin Oncol
, vol.29
, pp. 761-770
-
-
Barbui, T.1
Barosi, G.2
Birgegard, G.3
Cervantes, F.4
Finazzi, G.5
Griesshammer, M.6
-
69
-
-
84896384320
-
Perspectives on the impact of JAK-inhibitor therapy upon inflammation-mediated comorbidities in myelofibrosis and related neoplasms
-
Hasselbalch HC. Perspectives on the impact of JAK-inhibitor therapy upon inflammation-mediated comorbidities in myelofibrosis and related neoplasms. Expert Rev Hematol 2014; 7: 203-216.
-
(2014)
Expert Rev Hematol
, vol.7
, pp. 203-216
-
-
Hasselbalch, H.C.1
-
70
-
-
84920858525
-
Combination therapy with interferon and JAK1-2 inhibitor is feasible: Proof of concept with rapid reduction in JAK2V617F-allele burden in polycythemia vera
-
Bjorn ME, de Stricker K, Kjaer L, Ellemann K, Hasselbalch HC. Combination therapy with interferon and JAK1-2 inhibitor is feasible: proof of concept with rapid reduction in JAK2V617F-allele burden in polycythemia vera. Leuk Res Rep 2014; 3: 73-75.
-
(2014)
Leuk Res Rep
, vol.3
, pp. 73-75
-
-
Bjorn, M.E.1
De Stricker, K.2
Kjaer, L.3
Ellemann, K.4
Hasselbalch, H.C.5
|